Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by Tongling Huang, Zhaocheng Lu, Zihui Wang, Lixin Cheng, Lu Gao, Jun Gao, Ning Zhang, Chang-An Geng, Xiaoli Zhao, Huaiyu Wang, Chi-Wai Wong, Kelvin W. K. Yeung, Haobo Pan, William Weijia Lu, Min Guan

“…ESRRA abrogation results in enhanced SPP1 and decreased leptin secretion from both visceral adipocytes and BMAds, concertedly dictating bone marrow stromal stem cell fate commitment and restoring type H vessel formation, constituting a feed-forward loop for bone formation. …”
Get full text

Effective control of southern blight and root rot of Aconitum carmichaelii Debeaux by endophytic Bacillus velezensis YN-2-6S by Qian Wang, Yujie Qiu, Siyu Wang, Yumei Gou, Hongji Hou, Tianwei Su, Lan Zou, Jing Huang

“…In this study, an endophytic bacterium YN-2-6S was isolated from the stem of A. carmichaelii. YN-2-6S was identified as Bacillus velezensis by phylogenetic analysis based on concatenated sequence of gyrA, rpoB, and recA genes. …”
Get full text

Exploring the role of inflammatory biomarkers in trigeminal neuralgia by Shenglong Lai, Haiyang Li, Yazhou Xing, Du Wu, Lin Wang, Qinghua Liang

“…Results: The present MR analysis identified significant causal associations for three inflammatory cytokines with TN. Stem cell growth factor beta (SCGF-β) (OR = 1.362, 95% CI = 1.049–1.770, p = 0.021) and Interleukin-4 (IL-4) (OR = 1.533, 95% CI = 1.014–2.316, p = 0.043) were positively associated with TN, while Interleukin-16 (IL-16) (OR = 0.720, 95% CI = 0.563–0.921, p = 0.009) had a protective effect. …”
Get full text

Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages by Jiayi Mao, Wenzheng Xia, Yanglin Wu, Minxiong Li, Yun Zhao, Peisong Zhai, Yuguang Zhang, Tao Zan, Wenguo Cui, Xiaoming Sun

“…In this study, engineered apoptotic bodies (BHB-dABs) derived from adipose stem cells loaded with β-hydroxybutyric acid (BHB) were synthesized via biosynthesis. …”
Get full text

Use of Acupuncture in the Rehabilitation Treatment of Patients with Parkinson's Disease by Julio López Argüelles, Omar Morejón Barroso

“…The practice of this technique has among its benefits: reducing signs and symptoms, improving motor functions, reducing the need for medication, minimizing medication side effects, slowing the progression of the disease, increasing dopamine levels, decreasing neuronal damage and death, increase cyclophilin levels, increase the number of stem cells and the number of neurons transformed from them, and enhance antioxidant systems. …”
Get full text

Effects of Electroacupuncture at Zusanli and Quchi on Neurological Function Recovery in Rats with Cerebral Infarction by Jiangcong HONG, Yingzheng WANG, Guangwen WU, Yulong ZOU

“…In addition, BrdU-positive cells, double positive cells of BrdU/DCX and double positive cells of BrdU/NeuN were used as markers of proliferation, migration and differentiation of neural stem cells, respectively. …”
Get full text

Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract by E. F. Barinov, O. N. Sulayeva

“…Morphology, markers, origin and stimulators of development of myofibroblasts, their involvement in formation of microniche for epithelial stem cells, kinetics of tegmental epithelium, angiogenesis, control of vascular permeability is discussed. …”
Get full text

Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy by Eleni Paizanis, Michel Hamon, Laurence Lanfumey

“…There is a growing body of evidence that neural stem cells reside in the adult central nervous system where neurogenesis occurs throughout lifespan. …”
Get full text

The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome by Ewa Dobak, Sylwia Romana Jankowska-Szabłowska, Renata Guzicka-Kazimierczak, Paulina Poter, Elżbieta Urasińska, Katarzyna Karpińska-Łukaszewicz

“…The normal subpopulation of CD34+CD38 – haematopoietic stem cells does not express CLL-1; therefore, the assessment of the expression of this protein can be used for the diagnosis of minimal residual disease. …”
Get full text

Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid Leukemia by Ayşe Gül Bayrak Tokaç, Aynur Dağlar Aday

“…FLT3 is found on hematopoietic stem cells and early progenitor cells. After binding to its ligand, activated FLT3 triggers intracellular kinase, leads to cellular proliferation, and inhibits differentiation and apoptosis.…”
Get full text

Biocompatible and Electroconductive Nanocomposite Scaffolds with Improved Piezoelectric Response for Bone Tissue Engineering by Sana Por Hajrezaei, Masoumeh Haghbin Nazarpak, Shahriar Hojjati Emami, Elham Shahryari

“…Biological characteristics of the scaffolds are also examined to check cellular attachment as well as differentiation of cultured (progenitor) cells. Scaffolds were optimized to direct osteogenic differentiation of mesenchymal stem cells. …”
Get full text

Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet by Ravinder Nagpal, Tiffany M. Newman, Shaohua Wang, Shalini Jain, James F. Lovato, Hariom Yadav

“…We used leptin-deficient (Lepob/ob) mice in comparison to C57BL/6J control mice, which are fed on identical diets, and performed comparative and correlative analyses of gut microbiome composition, gut permeability, intestinal structural changes, tight junction-mucin formation, cellular turnover, and stemness genes. We found that obesity impacted cellular turnover of the intestine with increased cell death and cell survival/proliferation gene expression with enhanced stemness, which are associated with increased intestinal permeability, changes in villi/crypt length, and decreased expression of tight junctions and mucus synthesis genes along with dysbiotic gut microbiome signature. …”
Get full text

FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss by Lijun Li, Renjin Lin, Yang Xu, Lingdi Li, Zhijun Pan, Jian Huang

“…Using a mouse model in which the ovaries were surgically removed, researchers reported that suppressing the FOXA1 gene in bone marrow stem cells (BMSCs) prevented the loss of bone density caused by ovariectomy. …”
Get full text

Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy by Bettina Zinka, Andreas Buettner, Matthias Graw

“…At forensic autopsy no other pathological findings could be diagnosed than multiple reddish, sunken areas in brain stem, mesencephalon, and pons. Histologically they presented as areas of spongiosis of the neuropil with prominent endothelial hyperplasia and vascular proliferation whereas nerve cells were well preserved. …”
Get full text

Corrigendum: Lack of Helios during neural development induces adult schizophrenia-like behaviors associated with aberrant levels of the TRIF-recruiter protein WDFY1 by Anna Sancho-Balsells, Anna Sancho-Balsells, Anna Sancho-Balsells, Anna Sancho-Balsells, Veronica Brito, Veronica Brito, Veronica Brito, Veronica Brito, Belissa Fernández, Belissa Fernández, Belissa Fernández, Belissa Fernández, Mónica Pardo, Mónica Pardo, Mónica Pardo, Mónica Pardo, Marco Straccia, Marco Straccia, Marco Straccia, Marco Straccia, Marco Straccia, Silvia Ginés, Silvia Ginés, Silvia Ginés, Silvia Ginés, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Isabel Hernández, Belén Arranz, Josep M. Canals, Josep M. Canals, Josep M. Canals, Josep M. Canals, Josep M. Canals, Albert Giralt, Albert Giralt, Albert Giralt, Albert Giralt, Albert Giralt

Get full text

Retinal Pigment Epithelium Transplantation: Past, Present, and Future by Ayyad Zartasht Khan, Tor Paaske Utheim, Jon Roger Eidet

“…Damaged RPE is associated with diseases such as age-related macular degeneration, Stargardt's macular dystrophy, and retinitis pigmentosa. RPE cells can easily be visualized in vivo, sustainable in vitro, anddifferentiated from stem cells with a relatively straightforward protocol. …”
Get full text

Circulating FGF21 is lower in South Asians compared with Europids with type 2 diabetes mellitus by Carlijn A Hoekx, Borja Martinez-Tellez, Maaike E Straat, Maurice B Bizino, Huub J van Eyk, Hildebrandus J Lamb, Johannes W A Smit, Ingrid M Jazet, Kimberly J Nahon, Laura G M Janssen, Patrick C N Rensen, Mariëtte R Boon

“…Results: Of the 73 inflammation-related proteins, the relative plasma levels of six proteins were higher (stem cell factor, caspase-8, C–C motif chemokine ligand 28, interferon-gamma, sulfotransferase 1A1 and cystatin D; q-value <0.05), while relative levels of six proteins were lower (FGF21, human fibroblast collagenase, interferon-8, C–C motif chemokine ligand 4, C–X–C motif chemokine ligand 6 and monocyte chemoattractant protein-1; q-value <0.05) in South Asians compared with Europids. …”
Get full text

Expression of miR-141 and Osteogenic Gene Dlx5, Msx2 and Runx2 in Osteogenic Differentiation of BMSCs in Ovariectomized Osteoporosis Model Mice by Zhenpu WEI, Wenming ZHANG, Pan SUN, Zhiqiang WANG, Yanping LIN

“…Objective:To observe the expression difference and change trend of miR-141 and osteogenic gene Dlx5, Msx2 and Runx2 in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in the ovariectomy model group and the sham operation group, and investigate the mechanism of postmenopausal osteoporosis.Methods:Twenty 4-week-old clean C57 female mice were selected as the model group and the sham operation group according to the random number table method, and ten cases in each group. …”
Get full text

Diagnosis and Treatment of Golfer's Elbow: A Review of Therapeutic Approaches by Karol Dzwonnik, Urszula Zelik, Wojciech Florczak, Joanna Śnieżna, Jakub Dziewic, Wiktoria Domino, Gabriela Trestka, Maria Przygoda, Jagienka Włodyka, Kamila Stępień, Sabina Adamczyk

“…In refractory cases, surgical options like open repair and arthroscopy, along with innovative techniques such as collagen-augmented sutures and stem cell applications, show promising results. Complementary therapies, such as ESWT, PRP, and manual therapy, further enhance outcomes, particularly in chronic cases. …”
Get full text

Polyethylene microplastic exposure adversely affects oocyte quality in human and mouse by Qiaoling Wang, Fengli Chi, Yingdong Liu, Qiurong Chang, Siyu Chen, Pengcheng Kong, Wanli Yang, Wenqiang Liu, Xiaoming Teng, Yan Zhao, Yi Guo

Get full text