Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis by Aadit P. Shah, Kiran R. Majeti, Freja K. Ekman, Sridhar Selvaraj, Devesh Sharma, Roshani Sinha, Eric Soupene, Prathamesh Chati, Sofia E. Luna, Carsten T. Charlesworth, Travis McCreary, Benjamin J. Lesch, Tammy Tran, Simon N. Chu, Matthew H. Porteus, M. Kyle Cromer

“…By integrating synEPOR at the endogenous EPOR locus in O-negative induced pluripotent stem cells, we achieve equivalent erythroid differentiation, transcriptomic changes, and hemoglobin production using small molecules compared to EPO-supplemented cultures. …”
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Implant failure of the Compress prosthesis: a case report by Hiroshi Koike, Kunihiro Ikuta, Hiroshi Urakawa, Tomohisa Sakai, Takeo Fujito, Yoshihiro Nishida, Shiro Imagama

“…Abstract Background The Compress is designed to achieve bone formation and stability by applying pressure at the bone–implant interface, minimizing the likelihood of aseptic loosening, which is a complication of stem implants. Herein, we report two cases of implant failure using the Compress. …”
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Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience by P. R. Shah, A. V. Vanikar, M. R. Gumber, H. V. Patel, V. B. Kute, S. M. Godara, H. L. Trivedi

“…TIP consisted of 1 donor-specific transfusion, peripheral blood stem cell infusion, portal infusion of bone marrow, and target-specific irradiation. …”
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Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway by Jianjian Wang, Wen Yu, Yuxin Zhang, Bo Chen, Zhaoxiang Meng

“…It promoted chondrogenic differentiation of mesenchymal stem cells, inhibited angiogenesis, enhanced PHD2 expression, and suppressed the production of HIF-1α and VEGFA. …”
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Effectivity of Musa paradisiaca extract to control Saprolegnia sp. infection on giant gourami larvae by Sri Nuryati, Nadia Aulia, , Rahman

“…Challenge test was performed for 14 days by giving Saprolegnia sp. spores at the density of 104 cells/mL and banana stem extract. The treatment dose of 0.16 g/L has showen survival 100% than positive control  after the challenge test.   …”
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Bioprinting approaches in cardiac tissue engineering to reproduce blood-pumping heart function by Minji Kim, Dong Gyu Hwang, Jinah Jang

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Report of joint hypermobility in malignant hyperthermia susceptible patients: Observational study with a case-control descriptive design by Rita CCS. Santos, Larissa FCDMS. Lima, Pâmela V. Andrade, Joilson M. Santos, Leonardo Galleni, Antonio FR. Junior, Lucas S. Souza, Beny Schmidt, Acary SB. Oliveira, José LG. Amaral, Mariz Vainzof, Helga CA. Silva

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Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain by Darine Villela, Claudia K. Suemoto, Renata Leite, Carlos Augusto Pasqualucci, Lea T. Grinberg, Peter Pearson, Carla Rosenberg

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Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies by Camilla T. Ekanger, Camilla T. Ekanger, Camilla T. Ekanger, Nilima Dinesh Kumar, Rosanne W. Koutstaal, Fan Zhou, Martin Beukema, Joanna Waldock, Simon P. Jochems, Noa Mulder, Cécile A. C. M. van Els, Cécile A. C. M. van Els, Othmar G. Engelhardt, Nathalie Mantel, Kevin P. Buno, Karl Albert Brokstad, Karl Albert Brokstad, Agnete S. T. Engelsen, Agnete S. T. Engelsen, Rebecca J. Cox, Rebecca J. Cox, Barbro N. Melgert, Barbro N. Melgert, Anke L. W. Huckriede, Puck B. van Kasteren

“…Therefore, we applied a collaborative approach to harmonize several aspects of experimental methodology between different research laboratories, aiming to assess the comparability of different models of human airway epithelium in the context of respiratory viral infections.MethodsIn this study, we compared three different models of human respiratory epithelium: a primary human bronchial epithelial cell-derived ALI transwell model, and two airway organoid models established from human airway- and lung-derived adult stem cells. …”
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Dopamine‐conjugated extracellular vesicles induce autophagy in Parkinson's disease by Jae Hoon Sul, Sol Shin, Hark Kyun Kim, Jihoon Han, Junsik Kim, Soyoung Son, Jungmi Lee, Seung Hyun Baek, Yoonsuk Cho, Jeongmi Lee, Jinsu Park, Donghoon Ahn, Sunyoung Park, Leon F. Palomera, Jeein Lim, Jongho Kim, Chanhee Kim, Seungsu Han, Ka Young Chung, Sangho Lee, Tae‐in Kam, Yunjong Lee, Jeongyun Kim, Jae Hyung Park, Dong‐Gyu Jo

“…In this study, we engineered dopamine onto the surface of adipose‐derived stem cell EVs (Dopa‐EVs) utilizing a facile, two‐step cross‐linking approach. …”
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More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration by Sihui Ouyang, Xiong Wu, Li Meng, Xuerui Jing, Liying Qiao, Jia She, Kai Zheng, Xianhua Chen, Fusheng Pan

“…Mg-Ag alloys with different Ag contents were engineered to facilitate the cell migration of murine fibroblasts (L929) and the osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs). …”
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A Nomogram Based on Circulating Inflammatory Factors for Predicting Prognosis of Newly Diagnosed Multiple Myeloma Patients by Wang M, Yue X, Ding Y, Cai Z, Xiao H, Huang H, He J

“…Mowang Wang,1– 4,* Xiaoyan Yue,5,* Yingying Ding,5,* Zhen Cai,1,4 Haowen Xiao,5 He Huang,1– 4 Jingsong He1,4 1Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 2Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang Province, People’s Republic of China; 3Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China; 4Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang Province, People’s Republic of China; 5Department of Hematology and Cell Therapy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: He Huang; Jingsong He, Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang Province, 310006, People’s Republic of China, Email huanghe@zju.edu.cn; hejingsong@zju.edu.cnPurpose: The growth and survival of multiple myeloma (MM) cells depend heavily on bone marrow microenvironment, where inflammation emerges as a significant feature and is commonly associated with unfavorable prognosis in MM. …”
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Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage by Jiao Lv, Miao-Miao Chen, Zhi-Hao Mu, Fang Wang, Zhong-Yi Qian, Lei Zhou, Qiu-Ting Guo, Zhi-Min Zhao, Yu-Ping Pan, Xin-Yu Liao, Zhi-Hong Yang, Ning Cai, Ying-Ying Zou, Shu-De Li

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Four cardiomyopathy patients with a heterozygous DSG2 p.Arg119Ter variant by Takuya Sumida, Shou Ogawa, Shuichiro Higo, Yuki Kuramoto, Ryo Eto, Yoshihiko Ikeda, Congcong Sun, Junjun Li, Li Liu, Tomoka Tabata, Yoshihiro Asano, Mikio Shiba, Yasuhiro Akazawa, Daisuke Nakamura, Takafumi Oka, Tomohito Ohtani, Yasushi Sakata

“…A microforce test using human cardiomyocytes differentiated from induced pluripotent stem cells (iPSC-CMs) demonstrated reduced contractility in iPSC-CMs carrying a heterozygous truncating variant in DSG2. …”
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Implant-Prosthetic Rehabilitation in Bilateral Agenesis of Maxillary Lateral Incisors with a Mini Split Crest by M. M. Figliuzzi, A. Giudice, S. Pileggi, D. Pacifico, M. Marrelli, M. Tatullo, L. Fortunato

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NLRP7 maintains the genomic stability during early human embryogenesis via mediating alternative splicing by Zhongliang Chen, Liangxia Jiang, Min Su, Qibing Zeng, Peng Luo, Liangzhao Chu

“…Here, we show that NLRP7 knockout affects the genetic stability, resulting in increased DNA damage in both human embryonic stem cells and blastoids, making embryonic cells in blastoids more susceptible to apoptosis. …”
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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

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Oxidative Stress, Epigenetics, Environment, and Epidemiology of Diabetic Retinopathy by Goran Petrovski, Kai Kaarniranta, Daniel Petrovič

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Extracorporeal photopheresis in stiff person syndrome by Yandy Marx Castillo-Aleman, Pierre Christophe Krystkowiak

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Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms by Zdenek Krejcik, David Kundrat, Jiri Klema, Andrea Hrustincova, Iva Trsova, Monika Belickova, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Michaela Dostalova Merkerova

“…Methods In this study, we examined TE and piRNA expression through parallel RNA and small RNA sequencing of CD34+ hematopoietic stem cells from MDS patients. Results Comparative analysis of TE and piRNA expression between MDS and control samples revealed several significantly dysregulated molecules. …”
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