Merck Open Global Health Library in vitro screening against Schistosoma mansoni identified two new substances with antischistosomal activities for further development by Monique Evelyn Ueberall, Martina Berchthold, Cécile Häberli, Sven Lindemann, Thomas Spangenberg, Jennifer Keiser, Christoph G. Grevelding

“…The effects of the two lead structures were investigated in more detail by confocal laser scanning microscopy and 5-ethynyl 2´-deoxyuridine (EdU) assays to assess morphological effects and stem cell effects. Both substances showed negative effects on stem cell proliferation in S. mansoni but no further morphological changes. …”
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Integrated analysis of ATAC-seq and RNA-seq reveals ADSCP2 regulates oxidative phosphorylation pathway in hypertrophic scar fibroblasts by Qian Li, Zhe Quan, Ling Chen, Yiliang Yin, Xin Chen, Jingyun Li

“…A potential peptide, ADSCP2 (adipose-derived stem cell peptide 2, the peptide fragment of ALCAM protein), derived from adipose-derived stem cell-conditioned medium, has been identified as having the potential to mitigate hypertrophic scar formation by targeting pyruvate carboxylase. …”
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Clinical Review of Ocular Traumas Resulting in Enucleation or Evisceration in a Tertiary Eye Care Center in Hungary by Gábor Tóth, Milán Tamás Pluzsik, Béla Csákány, Gábor László Sándor, Olga Lukáts, Zoltán Zsolt Nagy, Nóra Szentmáry

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Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages by Suzanne Pickering, Harry Wilson, Enrico Bravo, Marianne R. Perera, Jeffrey Seow, Carl Graham, Nathalia Almeida, Lazaros Fotopoulos, Thomas Williams, Atlanta Moitra, Helena Winstone, Tinne A. D. Nissen, Rui Pedro Galão, Luke B. Snell, Katie J. Doores, Michael H. Malim, Stuart J. D. Neil

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Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction by Cun Li, Yifei Yu, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Shuxin Zhang, Xiaoxin Zhu, Qiaoshuai Lan, Yanlin Deng, Ying Zhou, Wei Xue, Ming Yue, Jian-Piao Cai, Cyril Chik-Yan Yip, Kenneth Kak-Yuen Wong, Xiaojuan Liu, Yang Yu, Lin Huang, Hin Chu, Jasper Fuk-Woo Chan, Hans Clevers, Kwok Yung Yuen, Jie Zhou

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Dasatinib and FLAG-IDA Is an Effective Therapy for Initial Myeloid Blast Crisis but Involves a High Risk of Opportunistic Infections by Jorge Labrador, Gerardo J. Hermida, Rodolfo Alvarez, Victor Anso, Pilar de Vicente, Mercedes Goñi, Tomas Jose Gonzalez-Lopez

“…Based on this, we present the case of a patient diagnosed with an initial nonlymphoid phenotype BC, who achieved molecular response (MR4.5) with dasatinib and FLAG-IDA, but he suffered a pulmonary aspergillosis, CMV infection, and a CMV reactivation, prior to an allogeneic hematopoietic stem cell transplantation (HSCT). In conclusion, dasatinib and FLAG-IDA is an effective therapy for initial BC. …”
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Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance by Zengfang Wang, Ruizhen Yang, Jiaojiao Zhang, Pingping Wang, Zengyan Wang, Jian Gao, Xue Liu

“…Pregnancy maintenance depends on the formation of normal placentas accompanied by trophoblast invasion and vascular remodeling. Various types of cells, such as trophoblasts, endothelial cells, immune cells, mesenchymal stem cells (MSCs), and adipocytes, mediate cell-to-cell interactions through soluble factors to maintain normal placental development. …”
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Development of a spontaneous model of renal interstitial fibrosis in NOD/SCID mice: Aging-induced pathogenesis. by Lihua Qiu, Zhaoxia Ma, Jinyan Li, Zhen Wu, Longmei Dai, Ruimin Long, Linlin Hu, Jianxiu Sun, Min Hu, Yanjiao Li

“…Implanted allogeneic or xenogeneic cells are cleared by the immune system when stem cell therapy is applied in nonimmunodeficient animal fibrosis models, affecting the effect of the intervention and making it difficult to demonstrate the survival, proliferation, differentiation, or secretion of the delivered autologous human-derived cells. …”
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Circular RNAs as a novel class of potential therapeutic and diagnostic biomarkers in reproductive biology/diseases by Wanyu Song, Xiuli Chen, Haiying Wu, Neda Rahimian

“…CircRNAs are integral pieces in multiple cellular functions, including moving substances within the nucleus, silencing one X chromosome, cell death, the ability of stem cells to differentiate into different cell types, and the process of gene expression inherited from parental genes. …”
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Vitreous Mediators in Retinal Hypoxic Diseases by Roberto dell'Omo, Francesco Semeraro, Giulio Bamonte, Francesco Cifariello, Mario R. Romano, Ciro Costagliola

“…Cytokines and chemokines are multifunctional mediators that can direct the recruitment of leukocytes to sites of inflammation, promote the process, enhance immune responses, and promote stem cell survival, development, and homeostasis. …”
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Acute Lymphoblastic Leukemia following Lenalidomide Maintenance for Multiple Myeloma: Two Cases with Unexpected Presentation and Good Prognostic Features by Abdullah M. Khan, Jameel Muzaffar, Hermant Murthy, John R. Wingard, Jan S. Moreb

“…Lenalidomide maintenance following autologous stem cell transplant (ASCT) is considered the standard of care for eligible patients with multiple myeloma (MM). …”
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Preparation and Evaluation of Gelatin-Chitosan-Nanobioglass 3D Porous Scaffold for Bone Tissue Engineering by Kanchan Maji, Sudip Dasgupta, Krishna Pramanik, Akalabya Bissoyi

“…GCB 30 scaffold was shown to be noncytotoxic and supported mesenchymal stem cell attachment, proliferation, and differentiation as indicated by MTT assay and RUNX-2 expression. …”
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An animal model of severe acute respiratory distress syndrome for translational research by Kuo-An Chu, Chia-Yu Lai, Yu-Hui Chen, Fu-Hsien Kuo, I.-Yuan Chen, You-Cheng Jiang, Ya-Ling Liu, Tsui-Ling Ko, Yu-Show Fu

“…To evaluate precisely the therapeutic effect of transplanted stem cells or medications on acute lung injury, we developed an animal model of severe ARDS with lower lung function, capable of keeping the experimental animals survive with consistent reproducibility. …”
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New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease by Florent Malard, Mohamad Mohty

“…Allogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-threatening malignant and nonmalignant hematologic disorders. …”
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The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future by S. E. Richardson, C. McNamara

“…Even in relapse, CHL patients can be salvaged with high dose chemotherapy and autologous haematopoietic stem cell transplantation (ASCT). Challenges remain, however, in finding new strategies to manage the small number of patients who continue to relapse or progress. …”
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A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia by Masayuki Nagasawa, Yuki Aoki

“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a most powerful immunotherapy for hematological malignancies. …”
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Immediate Response to Chemotherapy in an Adult Neuroblastoma Patient Presenting with Cord Compression by Nedal Bukhari, Bachar Harfouch, Majid Shallal Alotaibi, Hulayel Al-Harbi, Omar Chamdine

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RNA-binding proteins as versatile metabolic regulators by Ellie Koletsou, Ina Huppertz

“…Abstract Metabolic shifts are a hallmark of numerous biological processes, including the differentiation of stem cells along a specific lineage and the activation of diverse cell types, such as immune cells. …”
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Cone-beam Computed Tomography Evaluation Timings of Closure of Open Apex by Using Deciduous Tooth Pulp Autotransplantation for the Regenerative Endodontic Treatment of Permanent Te... by Abhinandan Patra, Sonal Gupta, Rohan Shrivastava, Sheenam Ayub, Meghali Langthasa

“…Recent developments in stem cell biology and material sciences are beneficial for new treatment methods. …”
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Peptide hormones in plants by Zhenbiao Zhang, Huibin Han, Junxiang Zhao, Zhiwen Liu, Lei Deng, Liuji Wu, Junpeng Niu, Yongfeng Guo, Guodong Wang, Xiaoping Gou, Chao Li, Chuanyou Li, Chun-Ming Liu

“…The roles of peptide hormones are implicated in, but not limited to, processes such as self-incompatibility, pollination, fertilization, embryogenesis, endosperm development, stem cell regulation, plant architecture, tissue differentiation, organogenesis, dehiscence, senescence, plant-pathogen and plant-insect interactions, and stress responses. …”
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