Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway by Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi

“…Stem Cell Research & Therapy…”
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NEAT1 regulates BMSCs aging through disruption of FGF2 nuclear transport by Zifei Wang, Wenyu Zhen, Qing Wang, Yuqiang Sun, Siyu Jin, Sensen Yu, Xing Wu, Wenhao Zhang, Yulong Zhang, Fei Xu, Rui Wang, Yuxuan Xie, Wansu Sun, Jianguang Xu, Hengguo Zhang

“…Stem Cell Research & Therapy…”
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Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease by Parisa Hassanpour, Fatemeh Sadeghsoltani, Solmaz Saghebasl, Safieh Boroumand, Parisa Khanicheragh, Seyed Hossein Ahmadi Tafti, Reza Rahbarghazi, Mohammad Rahmati

“…Stem Cell Research & Therapy…”
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In vitro sperm generation from immature mouse testicular tissue using plasma rich in growth factors by Seyyed Amir Moradian, Mansoureh Movahedin

“…Stem Cell Research & Therapy…”
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Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives by Ting-ru Dong, Yu-jie Li, Shi-yu Jin, Feng-lan Yang, Ren-xue Xiong, Ye-qin Dai, Xiu-zu Song, Cui-ping Guan

“…Stem Cell Research & Therapy…”
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Peri-Implant Soft Tissue in Contact with Zirconium/Titanium Abutments from Histological and Biological Perspectives: A Concise Review by Fatma A. N. Abouel Maaty, Mai A. Ragab, Yasmin M. El-Ghazawy, Fatma I. Elfaiedi, Marwa M. S. Abbass, Israa Ahmed Radwan, Dina Rady, Sara El Moshy, Nahed Sedky Korany, Geraldine M. Ahmed, Christof E. Dörfer, Karim M. Fawzy El-Sayed

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Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy by Ekaterina Pashkina, Maria Bykova, Maria Berishvili, Yaroslav Lazarev, Vladimir Kozlov

“…Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells. …”
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Strategies to Overcome Intrinsic and Acquired Resistance to Chemoradiotherapy in Head and Neck Cancer by Tycho de Bakker, Anouk Maes, Tatiana Dragan, Philippe Martinive, Sébastien Penninckx, Dirk Van Gestel

“…In this review, we will discuss how overexpression of efflux pumps, perturbation of apoptosis-related factors, increased expression of antioxidants, glucose metabolism, metallotheionein expression, increased DNA repair, cancer stem cells, epithelial-mesenchymal transition, non-coding RNA and the tumour microenvironment contribute towards resistance of HNC to chemotherapy and/or radiotherapy. …”
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In Vitro Induction of Hypertrophic Chondrocyte Differentiation of Naïve MSCs by Strain by Thomas Jörimann, Priscilla Füllemann, Anita Jose, Romano Matthys, Esther Wehrle, Martin J. Stoddart, Sophie Verrier

“…This study explores the influence of mechanical load on naïve mesenchymal stem cell (MSC) differentiation, focusing on hypertrophic chondrocyte differentiation. …”
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Nestin Forms a Flexible Cytoskeleton by Means of a Huge Tail Domain That Is Reversibly Stretched and Contracted by Weak Forces by Ayana Yamagishi, Rina Tokuoka, Kazuki Imai, Mei Mizusawa, Moe Susaki, Koki Uchida, Saku T. Kijima, Akira Nagasaki, Daijiro Takeshita, Chiaki Yoshikawa, Taro Q. P. Uyeda, Chikashi Nakamura

“…Nestin is a type VI intermediate filament protein and a well-known neural stem cell marker. It is also expressed in high-grade cancer cells, forming copolymerized filaments with vimentin. …”
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Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review by Yu-Hsun Chang, Kun-Chi Wu, Kai-Hung Wang, Dah-Ching Ding

“…LGR6 is a marker for fallopian tube stem cells and is involved in stem cell maintenance and differentiation. …”
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G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis by Morgan G. Stykel, Shehani V. Siripala, Eric Soubeyrand, Carla L. Coackley, Ping Lu, Suelen Camargo, Sharanya Thevasenan, Gerardo Balderas Figueroa, Raphaella W.L. So, Erica Stuart, Rachi Panchal, Elissavet-Kalliopi Akrioti, Jeffery T. Joseph, Omid Haji-Ghassemi, Era Taoufik, Tariq A. Akhtar, Joel C. Watts, Scott D. Ryan

“…Using murine and human pluripotent stem cell (hPSC) models of PD coupled with human postmortem tissue, we show that accumulation of α-syn micro-aggregates impairs metabolic flux through the pentose phosphate pathway (PPP). …”
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Standard: Human gastric organoids by Fan Hong, Ronghui Tan, Ting Wang, Nanshan Zhong, Hongling Zhao, Rui-hua Xu, Lin Shen, Yingbin Liu, Xuebiao Yao, Dongxi Xiang, Lijian Hui, Jianping Xiong, Dong Gao, Bing Zhao, Zhifeng Miao, Jie Hao, Yong Li, Shijun Hu, Boqiang Fu, Guoqiang Hua, Lei Wang, Zhao-Lei Zeng, Chong Chen, Jianmin Wu, Changlin Wang, Chunnian Wang, Xianbao Zhan, Chen Song, Chunping Yu, Yingying Yang, Gengming Niu, Yalong Wang, Tongbiao Zhao, Ye-Guang Chen

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Advances in the Development and Application of Human Organoids: Techniques, Applications, and Future Perspectives by Zhangcheng Zhu, Yiwen Cheng, Xia Liu, Wenwen Ding, Jiaming Liu, Zongxin Ling, Lingbin Wu

“…Organoids are three-dimensional (3D) cell cultures derived from human pluripotent stem cells or adult stem cells that recapitulate the cellular heterogeneity, structure, and function of human organs. …”
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Single-Nucleus RNA Sequencing Reveals Cellular Transcriptome Features at Different Growth Stages in Porcine Skeletal Muscle by Ziyu Chen, Xiaoqian Wu, Dongbin Zheng, Yuling Wang, Jie Chai, Tinghuan Zhang, Pingxian Wu, Minghong Wei, Ting Zhou, Keren Long, Mingzhou Li, Long Jin, Li Chen

“…This study investigates the cellular-level transcriptional characteristics of LDM in large white pigs at two growth stages (170 days vs. 245 days) using single-nucleus RNA sequencing (snRNA-seq). We identified 56,072 cells across 12 clusters, including myofibers, fibro/adipogenic progenitor (FAP) cells, muscle satellite cells (MUSCs), and other resident cell types. …”
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Generation of live mice from haploid ESCs with germline-DMR deletions or switch by Yongjian Ma, Meng Yan, Zhenfei Xie, Hongling Zhang, Zhoujie Li, Yuanyuan Li, Suming Yang, Meiling Zhang, Wen Li, Jinsong Li

“…Here, we establish a stepwise system to reconstruct a development-related imprinting network, in which diploid embryonic stem cells (ESCs) are derived by fusing between parthenogenetic (PG)- and androgenetic (AG)-haploid embryonic stem cells (haESCs) with different DMR deletions (termed Ha-Ha-fusion system), followed by tetraploid complementation to produce all-haESC fetuses. …”
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USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression by Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, Han Liu, Zhaoxia Dai, Shu-Lan Sun, Shuyan Liu

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Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome by Gema Mondéjar-Parreño, Ana I. Moreno-Manuel, Juan Manuel Ruiz-Robles, José Jalife

“…Finally, we discuss how using human induced pluripotent stem cell technology to model ion channel trafficking and its defects may help accelerate drug discovery toward preventing life-threatening arrhythmias. …”
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CCN3: lactational bone booster by Nathan Xu, Kyle Yang, Mengjie Wang

“…Compelling evidence has been presented to show that (1) CCN3 expression in ARHERα/Kiss1 neurons fluctuates, almost exclusively appearing during lactation; (2) CCN3 stimulates mouse and human skeletal stem cell activity, increases bone remodeling and fracture repair in young and old mice of both sexes; (3) knockdown Ccn3 transcripts in the ARHKiss1 neurons in lactating dams causes devastating bone loss and failure to sustain progeny survival. …”
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Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma by Yamhilette Licón-Muñoz, Vanessa Avalos, Suganya Subramanian, Bryan Granger, Frank Martinez, Leopoldo A. García-Montaño, Samantha Varela, Drew Moore, Eddie Perkins, Michael Kogan, Stefano Berto, Muhammad O. Chohan, Christian A. Bowers, Sara G.M. Piccirillo

“…We previously showed that in 65% of patients with glioblastoma (GBM), the SVZ is a reservoir of cancer stem-like cells that contribute to treatment resistance and the emergence of recurrence. …”
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