3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis by Sayan Deb Dutta, Jeong Man An, Jin Hexiu, Aayushi Randhawa, Keya Ganguly, Tejal V. Patil, Thavasyappan Thambi, Jangho Kim, Yong-kyu Lee, Ki-Taek Lim

“…Transcriptomic (RNA-Seq) and real-time PCR (qRT-PCR) study revealed that co-culture of fibroblast/keratinocyte/stem cells/endothelial cells in a 3D bioprinted COL@d-ECM/M2-Exo hydrogel upregulated the skin-associated signature biomarkers through various regulatory pathways during epidermis remodeling and downregulated the mitogen-activated protein kinase (MAPK) signaling pathway after 7 days. …”
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Viral encephalitis and seizures cause rapid depletion of neuronal progenitor cells and alter neurogenesis in the adult mouse dentate gyrus by Alberto Pauletti, Polina Gurlo, Edna Weiß, Ana Beatriz DePaula-Silva, Karen S. Wilcox, Sonja Bröer

“…Given that epilepsy conventionally correlates with hippocampal sclerosis and neuronal degeneration, a potentially innovative avenue for therapeutic intervention involves fostering adult neurogenesis, a process primarily occurring within the subgranular zone of the dentate gyrus (DG) through the differentiation of neural stem cells (NSC). While experimental seizures induced by chemoconvulsants or electrical stimulation transiently enhance neurogenesis, the effects of encephalitis and the resultant virus-induced seizures remain inadequately understood. …”
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PDZRN3 regulates adipogenesis of mesenchymal progenitors in muscle by Hiroki Iida, Minako Kawai-Takaishi, Yoshihiro Miyagawa, Yasuhiko Takegami, Akiyoshi Uezumi, Takeshi Honda, Shiro Imagama, Tohru Hosoyama

“…Results: PDZRN3 was more expressed in MPs than in muscle stem cells, and its expression profile of PDZRN3 fluctuated with the adipogenic differentiation of MPs. …”
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Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma by Brandon Wee Siang Phon, Shalini Sundramurthi Chelliah, Dina El-Rabie Osman, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin

“…Staple GBM phenotypes, such as GBM stem cells and increased activation of the PI3K/Akt/NF-κB pathway, have been implicated in the expression of several ABC transporters. …”
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Identification of glutamine as a potential therapeutic target in dry eye disease by Xiaoniao Chen, Chuyue Zhang, Fei Peng, Lingling Wu, Deyi Zhuo, Liqiang Wang, Min Zhang, Zhaohui Li, Lei Tian, Ying Jie, Yifei Huang, Xinji Yang, Xiaoqi Li, Fengyang Lei, Yu Cheng

“…Our study demonstrated that co-treatment with mesenchymal stem cells (MSCs) and thymosin beta-4 (Tβ4) yielded the best therapeutic outcome against dry eye, surpassing monotherapy outcomes. …”
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Surface prereacted glass-ionomer particles incorporated into resin composites promote biocompatibility for restoration of subgingival dental defects by Yueyi Yang, Jing Huang, Xuchen Hu, Meiling Jing, Yujie Zhang, Chenci Xu, Wenduo Tan, Xiaoyu Liu, Chenguang Niu, Zhengwei Huang

“…Periodontal ligament stem cells were considered as seed cells that harbored great potential for periodontal regeneration. …”
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Four cardiomyopathy patients with a heterozygous DSG2 p.Arg119Ter variant by Takuya Sumida, Shou Ogawa, Shuichiro Higo, Yuki Kuramoto, Ryo Eto, Yoshihiko Ikeda, Congcong Sun, Junjun Li, Li Liu, Tomoka Tabata, Yoshihiro Asano, Mikio Shiba, Yasuhiro Akazawa, Daisuke Nakamura, Takafumi Oka, Tomohito Ohtani, Yasushi Sakata

“…A microforce test using human cardiomyocytes differentiated from induced pluripotent stem cells (iPSC-CMs) demonstrated reduced contractility in iPSC-CMs carrying a heterozygous truncating variant in DSG2. …”
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<i>Weizmannia coagulans</i> BC99 Attenuates Oxidative Stress Induced by Acute Alcoholic Liver Injury via Nrf2/SKN-1 Pathway and Liver Metabolism Regulation by Ying Wu, Cheng Li, Yinyin Gao, Jie Zhang, Yao Dong, Lina Zhao, Yuwan Li, Shaobin Gu

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Editorial: The Artificial Intelligence in Translational Medicine and Biomedical Research, How Future Can be Shaped?!! by Karzan Abdulmuhsin Mohammad

“…Attempts toward drug discovery, wound recoveries and self-proliferating stem cells were made. Most recently, scientists at Tufts University and Harvard University’s Wyss Institute have designed and created living small robots from cells of human trachea. …”
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Physical, chemical and biological properties of MTA Angelus and novel AGM MTA: an in vitro analysis by Sara Nashibi, Parisa Amdjadi, SeyedehSana Ahmadi, Sara Hekmatian, Maryam Torshabi

“…Moreover, the cytotoxicity was assessed through the MTT assay on human dental pulp stem cells (hDPSCs) after 24 and 72 h of exposure to the set/fresh status of various dilutions of MTA extracts, following the ISO 10993-12 standard. …”
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麝香组分诱导成年大鼠骨髓间质干细胞体外定向分化为神经元样细胞的能力 by 肖庆忠, 李浩威, 黄少华

“…收稿日期:2002 -08 -18 　　　　摘　要:【目的】探讨麝香组分体外诱导成年大鼠骨髓间质干细胞(adult rat bone marrow mesenchymal stem cells , rBMMSCs) 定向分化为神经元样细胞的能力。【方法】分别采用含麝香多肽或麝香酮的L-DMEM 培养基体外定向诱导第5 代至10 代的rBMMSCs , 并分别应用相差显微镜观察神经元样细胞和免疫细胞组化检测神经元样细胞所表达的神经干细胞特异性标 志(nestin)、神经元特异性标志[ 神经元特异性烯醇化酶(neuron specific enolase , NSE)和神经丝蛋白(neurofilament , NF)] 及星 形胶质细胞特异性标志[ 胶质纤维酸性蛋白(glia fiber acid pro tein , GFAP)] , 并进行神经元样细胞记数分析。…”
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Problems of healing chronic wounds by N. M. Babenko, O. B. Litvinova, S. B. Pavlov, M. V. Kumechko, V. V. Komarchuk

“…One of the most promising areas of wound treatment is the development of methods for targeted activation of stem cells. However, there are still insufficient data for the practical application of this method. …”
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Synthesis and Evaluation of PCL/Chitosan/CQD‐Fe Magnetic Nanocomposite for Wound Healing: Emphasis on Gene Expression by Elham Maghareh Abed, Fatemeh Yazdian, Abbas Akhavan Sepahi, Behnam Rasekh

“…The viability of the L929 fibroblast stem cells was obtained. The antibacterial effect, biocompatibility, and wound healing efficiency of the scaffold were investigated through minimum inhibitory concentration (MIC), (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT), and tissue analysis. …”
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ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress by Jenna L. Carter, Yongwei Su, Eman T. Al-Antary, Jianlei Zhao, Xinan Qiao, Guan Wang, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Steven A. Buck, Maik Hüttemann, Joshua E. Allen, Varun V. Prabhu, Jay Yang, Jeffrey W. Taub, Yubin Ge

“…While this is an important treatment option, many patients fail to achieve complete remission and of those that do, majority relapse. Leukemia stem cells (LSCs) are believed to be responsible for AML relapse and can be targeted through oxidative phosphorylation reduction. …”
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Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis by Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi

“…Mertk, a member of the TAM (Tyro, Axl, Mertk) family of RTKs, was also overexpressed in Met cells, which led to increased MAPK activation, epithelial–mesenchymal transition (EMT), and enrichment of cancer stem cells. Braf-mutant Met cells developed resistance to BRAFV600E inhibitor PLX4720, but remained sensitive to β-catenin inhibitor PKF118-310.ConclusionWe have identified several overexpressed genes/pathways in thyroid cancer metastasis, making them attractive therapeutic targets. …”
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Characteristic of the active substance of the Saccharomyces cerevisiae preparation having radioprotective properties by G. S. Ritter, V. P. Nikolin, N. A. Popova, A. S. Proskurina, P. E. Kisaretova, O. S. Taranov, T. D. Dubatolova, E. V. Dolgova, E. A. Potter, S. S. Kirikovich, Y. R. Efremov, S. I. Bayborodin, M. V. Romanenko, M. I. Meschaninova, A. G. Venyaminova, N. A. Kolchanov, S. S. Bogachev

“…It is supposed that the radioprotective effect of double-stranded RNA is associated with the participation of RNA molecules in the correct repair of radiation-damaged chromatin in blood stem cells. The hematopoietic pluripotent cells that have survived migrate to the periphery, reach the spleen and actively proliferate. …”
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High spatial resolution gene expression profiling and characterization of neuroblasts migrating in the peri-injured cortex using photo-isolation chemistry by Takuya Miyamoto, Kazuya Kuboyama, Mizuki Honda, Mizuki Honda, Yasuyuki Ohkawa, Shinya Oki, Shinya Oki, Kazunobu Sawamoto, Kazunobu Sawamoto

“…In the ventricular-subventricular-zone (V-SVZ) of the postnatal mammalian brain, immature neurons (neuroblasts) are generated from neural stem cells throughout their lifetime. These V-SVZ-derived neuroblasts normally migrate to the olfactory bulb through the rostral migratory stream, differentiate into interneurons, and are integrated into the preexisting olfactory circuit. …”
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TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes by Wenrui Sun, Jianchao Zhang, Shuang Li, Wanrong Fu, Yangyang Liu, Mengduan Liu, Jianzeng Dong, Xiaoyan Zhao, Xiaowei Li

“…Methods In this study, we generated a TAB2 compound heterozygous knockout cell line in induced pluripotent stem cells (iPSCs) derived from a healthy individual using CRISPR/Cas9 technology. …”
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BRCA1 is involved in sustaining rapid antler growth possibly via balancing of the p53/endoplasmic reticulum stress signaling pathway by Qianqian Guo, Zhen Wang, Jiping Li, Chao Ma, Junjun Zheng, Hengxing Ba, Guokun Zhang, Chunyi Li

“…Antler regeneration is based on the proliferation and differentiation of antler stem cells (AnSCs). Results We identified 39 hub genes which may function in regulating the balance between rapid proliferation and genomic stability in the AnSCs during antler regeneration. …”
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Identification of SETD4 as an Onco‐Immunological Biomarker Encompassing the Tumor Microenvironment, Prognoses, and Therapeutic Responses in Various Human Cancers by Yuyun Zhong, Ruiqi Wang, Zijie Huang, Zhaoting Hu, Bin Peng, Bin Chen, Liyue Sun

“…Previous reports have demonstrated its function in the quiescence of cancer stem cells as well as drug resistance in several cancers. …”
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