Circular RNAs as a novel class of potential therapeutic and diagnostic biomarkers in reproductive biology/diseases by Wanyu Song, Xiuli Chen, Haiying Wu, Neda Rahimian

“…CircRNAs are integral pieces in multiple cellular functions, including moving substances within the nucleus, silencing one X chromosome, cell death, the ability of stem cells to differentiate into different cell types, and the process of gene expression inherited from parental genes. …”
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Effects of Pentoxifylline in a Rat Model of Manganism: Evaluation of the Possible Toxicity by Romina Tanideh, Omid Farshad, Akram Jamshidzadeh, Aida Iraji

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First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood by A. Jensen, E. Hamelmann

“…Therefore, based on experimental evidence, we explored the therapeutic potential of human cord blood, known to contain stem cells, to examine the functional neuroregeneration in a child with cerebral palsy after cardiac arrest. …”
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A hypothesis about interrelations of epigenetic factors and transposable elements in memory formation by R. N. Mustafin

“…The hypothesis is confirmed by research into transposon activation in neuronal stem cells during neuronal differentiation. These changes occur in the hippocampus dentate gyrus, where a pronounced activity of transposons and their insertion near neuron-specific genes have been detected. …”
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Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review by Aref Yarahmadi, Hamed Afkhami, Ali Javadi, Mojtaba Kashfi

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Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenance by Jonathan O. Nelson, Alyssa Slicko, Amelie A. Raz, Yukiko M. Yamashita

“…Through single-cell RNA sequencing, we find that male germline stem cells (GSCs), the major cell type that undergoes rDNA CN expansion, have reduced InR expression when rDNA CN is low. …”
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IL-17 Mildly Rescued the Impaired Proliferation of Alveolar Epithelial Cells Induced by LCN2 Overexpression by Tingting Lv, Ziliang Hou, Kaiyuan Yang, Jinxiang Wang

“…Alveolar type 2 (AT2) cells as the stem cells of alveolar epithelium participate in the repair process after alveolar injury. …”
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Effect of fecal microbiota transplantation on ulcerative colitis model in rats: The gut–brain axis by Mahdis Morshedbak, Kaveh Rahimi, Mohammad Reza Tabandeh

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Development of Delivery Systems Enhances the Potency of Cell-Based HIV-1 Therapeutic Vaccine Candidates by Amin Hadi, Abbas Rastgoo, Maryam Eskandarian, Nooshin Haghighipour, Azam Bolhassani

“…Cell viability and low nucleic acid expression are the problems related to dendritic cells (DCs) and mesenchymal stem cells (MSCs), which are transfected with plasmid DNA. …”
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Substituted piperazine conjugated to quinoline-thiosemicarbazide as potent α-glucosidase inhibitors to target hyperglycemia by Mehran Ghasemi, Mohammad Mahdavi, Maryam Dehghan, Mohammadreza Eftekharian, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Aida Iraji, Ahmed Al-Harrasi

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Long-Term Stability and Osteogenic Activity of Recycled Polysulfone-Calcium Silicate Bone Implants In Vitro by Chi-Nan Chang, Yun-Ru Huang, Shinn-Jyh Ding

“…We evaluated the phase, morphology, weight loss, and three-point bending strength of the PSF-based composites after they were soaked in dynamic simulated body fluid (SBF) at pH levels of 7.4 and 5.0 for up to 12 months. Human mesenchymal stem cells (hMSCs) were utilized to assess the osteogenic activity of these composites. …”
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Mini review of spatially fractionated radiation therapy for cancer management by Shrikant B. Mali

“…Hypoxic subvolumes, a subpopulation of cancer stem cells, and inherent or acquired radioresistance define tumour aggressiveness and metastatic potential, which remain a therapeutic challenge. …”
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Skip Regulates TGF-β1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells by Victor Villar, Jelena Kocic, Juan F. Santibanez

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Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C deCarvalho

“…In this study, we employed an integrative multi-omics approach, including targeted proteomics, transcriptomics, genomics, and DNA methylation profiling, to investigate the response of a representative panel of GBM patient-derived cancer stem cells (CSCs) to astrocytic differentiation and RT and TMZ treatments. …”
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Mechanism of Nerve Regeneration after Ischemic Stroke Induced by Exercise Intervention by TENG Lili, ZHANG Mei, SONG Wenjing, ZHU Luwen

“…Based on the plasticity of the central nervous system, exercise intervention can play a neuroprotective role in the brain through multi-levels, multi-pathways and multi-targets, such as regulating synaptic budding, connection and transmission efficiency, improving the functional connection between regenerative axons and target cells, promoting angiogenesis and protecting the integrity of neurovascular units, regulating related inhibitory nerve regeneration factors, and inducing the expression of various nerve growth factors related to nerve regeneration and promoting the proliferation of neural stem cells, so as to participate in the regulation of central nervous rege-neration environment, and improve the damaged nerve function after ischemia.…”
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A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity by Lanlin Zhang, Jiangyuan Du, Qian Song, Chufan Zhang, Xianghua Wu

“…These effects were closely related to the induction of the expression of distinct ICD hallmarks by RB in both bulk cancer cells and cancer stem cells (CSCs), especially calreticulin (CRT), thus enhancing immune effector cell (i.e., CD4+, CD8+, and memory T cells) infiltration and attenuating the accumulation of immunosuppressive cells (i.e., Tregs, macrophages, and myeloid-derived suppressor cells (MDSCs)) in the TME. …”
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Vitronectin regulates focal adhesion turnover and migration of human placenta-derived MSCs under nutrient stress by Srishti Dutta Gupta, Nitish Pal, Malancha Ta

“…At sites of tissue damage and wound healing, the mesenchymal stem cells (MSCs) are often challenged by nutrient availability due to blood supply disruption. …”
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Overexpression of microRNA-211 in Functional Dyspepsia via Downregulation of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) by Increasing Phosphorylation of p38 MAPK Pathwa... by Jue Wang, Sai Gu, Bo Qin

“…Overexpression of miRNA-211 suppresses the differentiation of bone marrow stem cells into intestinal ganglion cells via downregulation of GDNF, a regulator of intestine barrier function. …”
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B-doped nano-hydroxyapatite facilitates proliferation and differentiation of osteoblasts by Qiao Kang, Wenhao Wang, Shengtao Wu, Ganggang Hu

“…Human bone marrow mesenchymal stem cells (hBMSCs) were subjected to flow cytometry, alizarin red S staining, and cell counting kit-8 assay for proliferation and differentiation determination. …”
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The Role of Silymarin in Mitigating Inflammation and Cognitive Impairment Induced by Ovariectomy in Wistar Rats by Razieh Moalefshahri, Hossein Javid, Fatemeh Gheybi, Somaye Fallahnezhad, Seyed Isaac Hashemy

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