The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling by Kara A Nelson, Kari F Lenhart, Lauren Anllo, Stephen DiNardo

“…Niches are often found in specific positions in tissues relative to the stem cells they support. Consistency of niche position suggests that placement is important for niche function. …”
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The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment by Prince Dadson, Peter Ngum, Luis Eduardo Juarez-Orozco, Michael Ntodie, Piotr Loba

“…This review also explores the characteristics and potential applications of orbital fat-derived stem cells, with an emphasis on their regenerative abilities and anti-inflammatory effects. …”
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Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling by Da-Wei Yeh, Li-Rung Huang, Ya-Wen Chen, Chi-Ying F. Huang, Tsung-Hsien Chuang

“…Cancer stem cells (CSCs) are a small population of cancer cells that exhibit stemness. …”
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HIFU-CCL19/21 Axis Enhances Dendritic Cell Vaccine Efficacy in the Tumor Microenvironment by Bum-Seo Baek, Hyunmi Park, Ji-Woong Choi, Eun-Young Lee, Seung-Yong Seong

“…Background/Objectives: Effectively targeting treatment-resistant tumor cells, particularly cancer stem cells (CSCs) involved in tumor recurrence, remains a major challenge in immunotherapy. …”
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Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation by James K. Hoffman, Sandra Geraghty, Nicole M. Protzman

“…Therefore, host mesenchymal stem cells that infiltrate the graft from the underlying bone marrow following marrow stimulation are provided with the optimal microenvironment to undergo chondrogenesis. …”
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Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin by Xingyuan Ma, Xingyuan Ma, Chao Sun, Xiao Ding, Yuhang Zhang, Yuhang Zhang, Tingzhen Deng, Tingzhen Deng, Yatao Wang, Yatao Wang, Haijun Yang, Haijun Yang, Ruiwen Ding, Ruiwen Ding, Haotian Li, Haotian Li, Dawen Wang, Dawen Wang, Maohua Zheng, Maohua Zheng

“…Additionally, metformin affects glioma stem cells by inhibiting key pathways, including STAT3, mTOR, and AKT, and altering the tumor microenvironment. …”
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Effects of Genipin Concentration on Cross-Linked Chitosan Scaffolds for Bone Tissue Engineering: Structural Characterization and Evidence of Biocompatibility Features by Simona Dimida, Amilcare Barca, Nadia Cancelli, Vincenzo De Benedictis, Maria Grazia Raucci, Christian Demitri

“…Finally, basic biocompatibility was investigated in vitro, by evaluating proliferation of two human-derived cell lines, namely, the MG63 (human immortalized osteosarcoma) and the hMSCs (human mesenchymal stem cells), as suitable cell models for bone tissue engineering applications of biomaterials.…”
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Fabrication and characterisation of super‐paramagnetic responsive PLGA–gelatine–magnetite scaffolds with the unidirectional porous structure: a physicochemical, mechanical, and in... by Farnaz Ghorbani, Ali Zamanian, Alireza Shams, Atefeh Shamoosi, Amir Aidun

“…The evolution of rat bone marrow mesenchymal stem cells performance on the hybrid structure under a static magnetic field indicated the potential of super‐paramagnetic constructs for further pre‐clinical and clinical studies in the field of neural regeneration.…”
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Cardioprotective effects of hUCMSCs-Exosi-EGR1 MN patch in MI/RI by modulating oxidative stress and mitophagy by Chen Huang, Xun Zhang, Shi-Xiong Wu, Qing Chang, Zhi-Kun Zheng, Jing Xu

“…In an effort to address the detrimental effects of myocardial ischemia/reperfusion injury (MI/RI), this study introduces a novel therapeutic strategy that involves a microneedle (MN) patch loaded with exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs) and carrying small interfering RNA (siRNA) targeting early growth response-1 (EGR1). …”
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Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: A genomic and toxicological approach integrating molecular docking, single-cell sequencing, and expe... by Yanggang Hong, Qichao Yuan, Yi Wang, Deqi Wang, Xiaoju Guan, Congde Chen

“…Busulfan, an alkylating chemotherapeutic agent widely used to treat chronic myelogenous leukemia, is known to induce NOA through its toxic effects on spermatogonial stem cells (SSCs). This study aimed to identify key molecular targets and pathways disrupted by busulfan in the testicular environment. …”
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3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering by Damla Aykora, Ayhan Oral, Cemre Aydeğer, Metehan Uzun

“…Polymer‐based biomaterials are mostly used for the controlled release of various drugs, therapeutic agents, mesenchymal stem cells, ions, and growth factors. Polymers are now among the most preferable materials for 3D bioprinting. …”
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Naringin ameliorates H2O2-induced oxidative damage in cells and prolongs the lifespan of female Drosophila melanogaster via the insulin signaling pathway by Xiaomei Du, Kexin Wang, Xiaoyan Sang, Xiangxing Meng, Jiao Xie, Tianxin Wang, Xiaozhi Liu, Qun Huang, Nan Zhang, Hao Wang

“…Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells. Moreover, naringin down-regulated the mRNA expressions of inr, chico, pi3k, and akt-1, and up-regulated the mRNA expressions of dilp2, dilp3, dilp5, and foxo, thereby activating autophagy-related genes and increasing the number of lysosomes. …”
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Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2 by Qi Dong, Haoyuan Fu, Wenxiao Li, Xinyu Ji, Yingchao Yin, Yiran Zhang, Yanbo Zhu, Guoqiang Li, Huiyang Jia, Heng Zhang, Haofei Wang, Jinglue Hu, Ganggang Wang, Zhihao Wu, Yingze Zhang, Sujuan Xu, Zhiyong Hou

“…In this study, in vitro and in vivo models revealed delayed bone development and an osteoporosis phenotype in mice lacking FXR in bone marrow mesenchymal stem cells (BMSCs) and osteoblasts due to impaired osteoblast differentiation. …”
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Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? by Jana Karbanová, Kristina Thamm, Christine A. Fargeas, Ilker A. Deniz, Aurelio Lorico, Denis Corbeil

“…We will further discuss the molecular and cellular characteristics of prominin-1, notably those that have a direct effect on the release of prominin-1+ EVs, a process that might be directly implicated in donor cell reprogramming of stem and cancer stem cells. Prominin-1+ EVs also mediate intercellular communication during embryonic development and adult homeostasis in healthy individuals, while disseminating biological information during diseases. …”
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Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer by Riley J. Morrow, Nima Etemadi, Belinda Yeo, Matthias Ernst

“…The role of the tumor microenvironment, through tumor-associated macrophages, infiltrating lymphocytes, and cancer stem cells is also discussed, suggesting that these tumor extrinsic factors may help account for the differences in behavior between inflammatory breast cancer and noninflammatory breast cancer. …”
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Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease by Alfredo Smiriglia, Nicla Lorito, Marina Bacci, Angela Subbiani, Francesca Bonechi, Giuseppina Comito, Marta Anna Kowalik, Andrea Perra, Andrea Morandi

“…In this study, we utilized preclinical in vitro models—immortalized cell lines and hepatocyte-like cells derived from human embryonic stem cells—exposed to clinically relevant steatotic-inducing agents. …”
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Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis by Célia Alecki, Javeria Rizwan, Phuong Le, Suleima Jacob-Tomas, Mario Fernandez Comaduran, Morgane Verbrugghe, Jia Ming Stella Xu, Sandra Minotti, James Lynch, Jeetayu Biswas, Tad Wu, Heather D. Durham, Gene W. Yeo, Maria Vera

“…Stress-mediated HSPA8 mRNA localization to the dendrites is impaired by depleting fused in sarcoma—an amyotrophic lateral sclerosis-related protein—in cultured spinal cord mouse motor neurons or by expressing a pathogenic variant of heterogenous nuclear ribonucleoprotein A2/B1 in neurons derived from human induced pluripotent stem cells. These results reveal a neuronal stress response in which RNA-binding proteins increase the dendritic localization of HSPA8 mRNA to maintain proteostasis and prevent neurodegeneration.…”
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Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia by Karlijn J. Doorn, Benjamin Drukarch, Anne-Marie van Dam, Paul J. Lucassen

“…This brain region also contains stem cells that can proliferate. This is a well-regulated process that can, for example, be altered by neurodegenerative conditions. …”
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Current Advances in Pharmacotherapy and Technology for Diabetic Retinopathy: A Systematic Review by Lei Lu, Ying Jiang, Ravindran Jaganathan, Yanli Hao

“…Recently, advancements in pluripotent stem cells technology enable restoration of retinal functionalities after transplantation of these cells into animals with retinal degeneration. …”
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Random antimicrobial peptide mixtures as non-antibiotic antimicrobial agents for cultured meat industry by Idan Yakir, Einav Cohen, Sharon Schlesinger, Zvi Hayouka

“…Here we show that RPMs had no significant impact on mesenchymal stem cells (MSCs) at concentrations that effectively inhibit bacterial growth. …”
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