Expression of miR-141 and Osteogenic Gene Dlx5, Msx2 and Runx2 in Osteogenic Differentiation of BMSCs in Ovariectomized Osteoporosis Model Mice by Zhenpu WEI, Wenming ZHANG, Pan SUN, Zhiqiang WANG, Yanping LIN

“…Objective:To observe the expression difference and change trend of miR-141 and osteogenic gene Dlx5, Msx2 and Runx2 in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in the ovariectomy model group and the sham operation group, and investigate the mechanism of postmenopausal osteoporosis.Methods:Twenty 4-week-old clean C57 female mice were selected as the model group and the sham operation group according to the random number table method, and ten cases in each group. …”
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含脐血MSCs 体系扩增后的脐血重建 NOD/SCID小鼠造血的研究 by 周敦华, 张绪起, 黄绍良, 方建培, 吴燕峰, 魏著, 包蓉, 黄科, 黎阳

“…【目的】探讨含人脐血(umbilical cord blood，UCB)来源的间充质干细胞(mesenchymal stem cells，MSCs)联合造血生长因子(hematopoietic growth factors，HGFs)体系扩增后的脐血造血细胞在NOD／SCID小鼠体内植入及重建小鼠造血的能力。…”
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3D-Printed PCL-Based Scaffolds with High Nanosized Synthetic Smectic Clay Content: Fabrication, Mechanical Properties, and Biological Evaluation for Bone Tissue Engineering by Furtado ASA, Cunha MHS, Sousa LMR, Brito GC, Verde TFCL, Filgueiras LA, Sobral-Silva LA, Santana MV, Sousa GF, Santos FEP, Mendes AN, Figueredo-Silva J, Maia Filho ALM, Marciano FR, Vasconcellos LMR, Lobo AO

“…Intrinsic properties of the scaffolds revealed no cytotoxicity while enhancing bioactivity and promoting in vitro mineralization when cultured with mesenchymal stem cells in all analyzed groups. Notably, the high concentration of LAP within the PCL matrices did not induce in vitro cytotoxicity but rather stimulated in vitro mineralization and differentiation.Conclusion: This study demonstrated the feasibility of 3D printing PCL/LAP scaffolds with high concentrations of nanoceramics. …”
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The efficacy of core decompression combined with regenerative therapy in early femoral head necrosis: a systematic review and meta-analysis involving 954 subjects by Haiwei Tang, Tingxian Ling, Enze Zhao, Mingke You, Xi Chen, Gang Chen, Kai Zhou, Zongke Zhou

“…Secondary outcomes (VAS, HHS, WOMAC score and Lequesne index) showed improved results when CD was combined with other regenerative agents, such as bone mesenchymal stem cells (BMSCs) and bone morphogenetic proteins (BMPs), etc. …”
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A dual role of Cohesin in DNA DSB repair by Michael Fedkenheuer, Yafang Shang, Seolkyoung Jung, Kevin Fedkenheuer, Solji Park, Davide Mazza, Robin Sebastian, Hiroyuki Nagashima, Dali Zong, Hua Tan, Sushil Kumar Jaiswal, Haiqing Fu, Anthony Cruz, Supriya V. Vartak, Jan Wisniewski, Vittorio Sartorelli, John J. O’Shea, Laura Elnitski, Andre Nussenzweig, Mirit I. Aladjem, Fei-Long Meng, Rafael Casellas

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In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration by Omid Koohi-Hosseinabadi, Reza Shahriarirad, Amireza Dehghanian, Laleh Amini, Sajjad Barzegar, Afrooz Daneshparvar, Omid Alavi, Seyedeh-Parvin Khazraei, Saba Hosseini, Ali Arabi Monfared, Roya Khorram, Nader Tanideh, Soheil Ashkani-Esfahani

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Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof‐of‐concept study by Perrine Burdeyron, Sébastien Giraud, Maryne Lepoittevin, Nina Jordan, Sonia Brishoual, Maïté Jacquard, Virginie Ameteau, Nadège Boildieu, Estelle Lemarie, Jonathan Daniel, Frédéric Martins, Nicolas Mélis, Marine Coué, Raphaël Thuillier, Henri Leuvenink, Luc Pellerin, Thierry Hauet, Clara Steichen

“…Abstract   Among strategies to limit ischemia/reperfusion (IR) injuries in transplantation, cell therapy using stem cells to condition/repair transplanted organs appears promising. …”
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Effectiveness of a Novel Liposomal Methylglyoxal–Tobramycin Formulation in Reducing Biofilm Formation and Bacterial Adhesion by Wed Alluhaim, Manal M. Alkhulaifi, Raghad R. Alzahrani, Bahauddeen M. Alrfaei, Alaa Eldeen B. Yassin, Majed F. Alghoribi, Ahlam M. Alsaadi, Ahmed I. Al-Asmari, Ahmed J. Al-Fahad, Rizwan Ali, Naif M. Alhawiti, Majed A. Halwani

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Mechanism of Bushen Zhuangjin Decoction to Promote BMSCs Homing and Protect Articular Cartilage in Mice by the SDF-1/CXCR4 Axis by HUANG Yanfeng, MA Dezun, FU Changlong, YE Jinxia, HUANG Yunmei, LI Xihai

“…ObjectiveTo investigate the mechanism by which Bushen Zhuangjin Decoction (BZD) regulates the SDF-1/CXCR4 axis to promote the homing of bone marrow mesenchymal stem cells (BMSCs) and protect articular cartilage in mice, thereby providing experimental basis for the rehabilitation treatment of knee osteoarthritis (KOA).Methods(1) In the animal experiment, 30 SPF male C57BL/6 mice, 8 weeks old, were selected and randomly divided into sham group, model group and BZD group, with 10 mice in each group. …”
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Clinical and genetic characteristics of a total or partial congenital aniridia by N.V. Sukhanova, V.V. Kadyshev, T.A. Vasilieva, A.V. Marakhonov, L.A. Katargina, S.I. Kutsev, R.A. Zinchenko

“…</p> <p> <b>Results</b>: the most common features associated with CA included foveal hypoplasia, nystagmus, disorders of the eye lens, and limbal stem cells deficiency (LSCD). These findings were reported in more than 60% of cases. …”
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Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice by Chi Lieu Kim Nguyen, Yumeno Kuba, Hoai Thu Le, Hossam Hassan Shawki, Natsuki Mikami, Madoka Aoki, Nanako Yasuhara, Hayate Suzuki, Saori Mizuno-Iijima, Shinya Ayabe, Yuki Osawa, Tomoyuki Fujiyama, Tra Thi Huong Dinh, Miyuki Ishida, Yoko Daitoku, Yoko Tanimoto, Kazuya Murata, Woojin Kang, Masatsugu Ema, Yuji Hirao, Atsuo Ogura, Satoru Takahashi, Fumihiro Sugiyama, Seiya Mizuno

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