Transfection Agent Induced Nanoparticle Cell Loading by Karin Montet-Abou, Xavier Montet, Ralph Weissleder, Lee Josephson

“…Loading cells with magnetic nanoparticles, and tracking their fate in vivo by high resolution MRI, is an attractive approach for enhancing the efficacy of cell-based therapies including those utilizing hematopoietic stem cells, neuroprogenitor cells, and T cells. The transfection agent (internalization agent) assisted loading with the Feridex IV ® nanoparticle is an attractive method of loading because of the low cost of materials, and possible low regulatory barriers for eventual clinical use. …”
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Age-Adjusted Schedules of Venetoclax and Hypomethylating Agents to Treat Extremely Elderly Patients with Acute Myeloid Leukemia by Aaron M. Lee, Aaron M. Goodman, James K. Mangan

“…BCL-2 has been identified as an antiapoptotic protein and promotes survival of leukemia stem cells. Recently, the United States FDA has approved venetoclax, a selective oral BCL-2 inhibitor, for use in conjunction with hypomethylating agents (azacitidine or decitabine) or low-dose cytarabine as a first-line treatment option for those AML patients ineligible for standard induction chemotherapy. …”
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RNA-binding proteins as versatile metabolic regulators by Ellie Koletsou, Ina Huppertz

“…Abstract Metabolic shifts are a hallmark of numerous biological processes, including the differentiation of stem cells along a specific lineage and the activation of diverse cell types, such as immune cells. …”
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Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders by Yuesheng Tu, Weixin Zheng, Zichu Ding, Jie Xiang, Qinfeng Yang, Yuchen Liu, Jue Cao, Yuling Shen, Zinan Tang, Shen Lin, Lei Fan, Yaowen Xu, Bin Chen

“…This study explored a novel tannic acid-thioctic acid (TATA) hydrogel, enriched with exosomes derived from bone marrow mesenchymal stem cells, as a therapeutic strategy for enhancing skin wound healing in a hemophilia model. …”
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Effects of melatonin on planaria head regeneration are dependent on both timing and duration of exposure by Simon C. Beeching, Hanna E. Ruland, Katelyn M. Sparks

“…Head regeneration in planaria is a remarkable phenomenon in which stem cells (neoblasts) migrate to the wound site, proliferate, then differentiate into all functional tissue types within days of injury. …”
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Cancer stem-like cells stay in a plastic state ready for tumor evolution by Jiali Xu, Houde Zhang, Zhihao Nie, Wenyou He, Yichao Zhao, Zhenhui Huang, Lin Jia, Zhiye Du, Baotong Zhang, Siyuan Xia

“…Generally, CSCs come from the malignant transformation of somatic stem cells or the de-differentiation of other cancer cells. …”
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Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies by Marie-Noëlle Giraud, Anne Géraldine Guex, Hendrik T. Tevaearai

“…The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. It has, however, been postulated that the efficiency of injected cells could possibly be hindered by the mechanical trauma due to the injection and their low survival in the hostile environment. …”
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Strategies to Overcome Intrinsic and Acquired Resistance to Chemoradiotherapy in Head and Neck Cancer by Tycho de Bakker, Anouk Maes, Tatiana Dragan, Philippe Martinive, Sébastien Penninckx, Dirk Van Gestel

“…In this review, we will discuss how overexpression of efflux pumps, perturbation of apoptosis-related factors, increased expression of antioxidants, glucose metabolism, metallotheionein expression, increased DNA repair, cancer stem cells, epithelial-mesenchymal transition, non-coding RNA and the tumour microenvironment contribute towards resistance of HNC to chemotherapy and/or radiotherapy. …”
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Biologic Augmentation of the Ulnar Collateral Ligament in the Elbow of a Professional Baseball Pitcher by James K. Hoffman, Nicole M. Protzman, Amit D. Malhotra

“…A construct comprising a dermal allograft, platelet rich plasma (PRP), and mesenchymal stem cells (MSCs) has been shown to successfully improve healing in the rotator cuff. …”
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PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs by Serena Vella, Pier Giulio Conaldi, Tullio Florio, Aldo Pagano

“…PPAR ligands are endowed with antitumoral effects, mainly acting on cancer stem cells, and constitute a possible add-on therapy to antiblastic drugs, in particular for NB with unfavourable prognosis. …”
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Diagnostic and Treatment Challenges of Paroxysmal Nocturnal Hemoglobinuria in Uganda by Boniface Amanee Elias Lumori, Daniel Muyanja

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disorder of the hematopoietic stem cells which is often underdiagnosed. Its incidence is about 5 cases per million inhabitants in a year, and currently, there are only 1610 patients in the International PNH Registry. …”
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Micro-channels array device fabricated via two photon lithography for cell migration studies in Neuroblastoma metastatic disseminationAll original data are available at: . by Sara Micheli, Caterina Piunti, Elisa Varaschin, Marianna Peditto, Maria Luz Suarez, Marco Sorgato, Elisa Cimetta

“…Neuroblastoma (NB) and human Mesenchymal Stem Cells (MSCs) represent the main tumor and its primary metastatic site. …”
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The regulatory role of placental extracellular vesicle on trophoblast and endothelial cell functions by Kunfeng Bai, Kunfeng Bai, Xintong Li, Yanjie Guo, Ye Shang, Leqian Lin, Philip C. N. Chiu, Philip C. N. Chiu, Cheuk-Lun Lee

“…This study aims to isolate placental EVs (pEVs) from placental explant to examine their regulatory roles on EVT and endothelial cell functions. pEVs were successfully isolated from ex vivo cultured placental explant, which were capable to be internalized by EVTs and endothelial cells. pEVs stimulated the differentiation of trophoblast stem cells (TSCs) and enhanced the migration and invasion abilities of EVTs via CD147 receptor. …”
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Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL by Lavinia Arseni, Gianluca Sigismondo, Haniyeh Yazdanparast, Johanne U. Hermansen, Norman Mack, Sibylle Ohl, Verena Kalter, Murat Iskar, Mathias Kalxdorf, Dennis Friedel, Mandy Rettel, Yashna Paul, Ingo Ringshausen, Eric Eldering, Julie Dubois, Arnon P. Kater, Marc Zapatka, Philipp M. Roessner, Eugen Tausch, Stephan Stilgenbauer, Sascha Dietrich, Mikhail M. Savitski, Sigrid S. Skånland, Jeroen Krijgsveld, Peter Lichter, Martina Seiffert

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Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury by Baoguo Liu, Sumei Liu, Dejun Sun

“…In our study, we systematically investigated the differentiation of neural stem cells (NSCs) in vitro and functional recovery in injured rats in vivo following Taxol treatment. …”
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The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…TGFβ1 is a member of a large growth factor family including activins/inhibins and bone morphogenic proteins (BMPs) that have a potent growth regulatory and immunomodulatory functions in normal skin homeostasis, regulation of epidermal stem cells, extracellular matrix production, angiogenesis, and inflammation. …”
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Resolving the Two “Bony” Faces of PPAR-γ by Beata Lecka-Czernik, Larry J. Suva

“…Osteoblasts and adipocytes are derived from marrow mesenchymal stroma/stem cells (MSC). The milieu of intracellular and extracellular signals that controls MSC lineage allocation is diverse. …”
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Plucked Human Hair Shafts and Biomolecular Medical Research by Kevin Schembri, Christian Scerri, Duncan Ayers

“…The plucked hair shaft offers such advantages. The use of stem cells found in hair follicles cells is gaining momentum in the field of regenerative medicine. …”
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A synthetic chronogenetic gene circuit for programmed circadian drug delivery by Lara Pferdehirt, Anna R. Damato, Kristin L. Lenz, Maria F. Gonzalez-Aponte, Daniel Palmer, Qing-Jun Meng, Erik D. Herzog, Farshid Guilak

“…Gene circuits were transduced into induced pluripotent stem cells that were tissue-engineered into cartilage constructs. …”
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Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer by L. S. Franco, S. Arunachalam, A. Chauhan, S. A. Kareff, P. L. Hallenbeck

“…It is especially attractive given its selective expression on the surface of solid tumor cells and associated stromal cells, such as cancer stem cells, invasive cancer cells, and immune cells, such as macrophages, angiogenic endothelial cells, pericytes, and cancer-associated fibroblasts. …”
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