BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes by Honggang Xu, Bin Xu

“…In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and noncoding RNAs in exosomes may play a major role. …”
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Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer by Yun Teng, Hongmei Zhao, Guoqing Xue, Guohui Zhang, Yanbin Huang, Wei Guo, Kun Zou, Lijuan Zou

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Small Extracellular Vesicles Secreted by iPSC-Derived MSCs Ameliorate Pulmonary Inflammation and Lung Injury Induced by Sepsis through Delivery of miR-125b-5p by Wei Peng, Yun Yang, Jiaquan Chen, Zeyao Xu, Yuanlei Lou, Qi Li, Ning Zhao, Kejian Qian, Fen Liu

“…Small extracellular vesicles, secreted by mesenchymal stem cells (MSCs), derived from human-induced pluripotent stem cells (iMSC-sEV), possess striking advantages when incorporated MSCs and iPSCs, which are considered extremely promising cell-free therapeutic agents. …”
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Matched Unrelated Donor Hematopoietic Cell Transplantation: Increased Usage and Improvements in Clinical Outcomes in Canada by Matthew D. Seftel, Grace Musto, David Allan, Oliver Bucher, Kevin Hay, Ivan Pasic, Tony Truong, Kristjan Paulson

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Synthesis and characterization of a magnetic bacterial cellulose-chitosan nanocomposite and evaluation of its applicability for osteogenesis by Nahid Rezazadeh, Effat Alizadeh, Somaieh Soltani, Soodabeh Davaran, Neda Esfandiari

“…The cytotoxicity and osteogenic differentiation of the nanocomposite were studied using human adipose-derived mesenchymal stem cells (ADSCs) and alizarin red staining. One-way ANOVA with Tukey's multiple comparisons test was used for statistical analysis. …”
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What Is New in Glaucoma: From Treatment to Biological Perspectives by Raffaele Nuzzi, Paola Marolo, Alessia Nuzzi

“…On the other hand, the most recent approaches to treat glaucoma outcomes in its advanced stages include electrical stimulation, stem cells, exosomes, extracellular vesicles, and growth factors. …”
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The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors by Lucia D’Amico, Ilaria Roato

“…Indeed, bone and immune system are strictly linked to each other because bone regulates the hematopoietic stem cells from which all cells of the immune system derive, and many immunoregulatory cytokines influence the fate of bone cells. …”
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How does the tea L-theanine buffer stress and anxiety by Liwen Wang, Margaret Brennan, Shiming Li, Hui Zhao, Klaus W. Lange, Charles Brennan

“…This review focuses on the relaxation effect of L-theanine, including animal models and the latest human trials as well as the potential molecular mechanisms regarding neuron stem cells. The biological efficacy of dietary L-theanine in the food matrix has been further discussed in this review in relation to the physiological changes in the gastrointestinal tract and bindings of L-theanine with other food components.…”
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Melatonin and its physiological and therapeutic effects: A review by Stefanović Bojana V., Spasojević Nataša M., Ferizović Harisa N., Janković Milica D., Virijević Kristina M., Dronjak Slađana S.

“…In the near future, melatonin will be a promising agent to control the fate of mesenchymal stem cells by regulating the generation of reactive oxygen species and the release of immune factors in regenerative medicine. …”
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Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone Metastases by Ilaria Roato

“…Moreover, immune system and bone have a bidirectional relationship: bone cells express surface molecules ruling the expansion of hemopoietic stem cells from which all cells of the mammalian immune system derive, and various immunoregulatory cytokines influence the fate of bone cells. …”
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Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy by Ying-Gang Zhu, Jie-Ming Qu, Jing Zhang, Hong-Ni Jiang, Jin-Fu Xu

“…More scientists are focusing on therapies involving stem cells, which have self-renewing capabilities and differentiate into multiple cell lineages, and, genomics therapy which has the potential to upregulate expression of anti-inflammatory mediators. …”
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PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma by Osamu Kimura, Yasuteru Kondo, Tooru Shimosegawa

“…In this paper, we have summarized the relevance of PPARs to the pathogenesis of HCC and cancer stem cells and possible therapeutic options through modifying PPAR signaling.…”
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Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway by Xin Ma, Meng Li, Yuanyuan Zhang, Tingting Xu, Xinchen Zhou, Mengqi Qian, Zhiren Yang, Xinyan Han

“…A. muciniphila was identified as a key strain in FMT to promote the proliferation and differentiation of intestinal stem cells by mediating the Wnt/β-catenin signaling pathway.…”
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Biocompatible and Electroconductive Nanocomposite Scaffolds with Improved Piezoelectric Response for Bone Tissue Engineering by Sana Por Hajrezaei, Masoumeh Haghbin Nazarpak, Shahriar Hojjati Emami, Elham Shahryari

“…Scaffolds were optimized to direct osteogenic differentiation of mesenchymal stem cells. Such scaffolds can offer new strategies for the regeneration of damaged/lost bone.…”
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Current Status of Alginate in Drug Delivery by Dewi Melani Hariyadi, Nazrul Islam

“…In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. …”
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Which Are the Cells of Origin in Merkel Cell Carcinoma? by Thomas Tilling, Ingrid Moll

“…However, for several reasons, for example, heterogeneous differentiation of MCCs and postmitotic character of MCs, it is not very likely that MCC develops from differentiated MCs. Skin stem cells, probably from the epidermal lineage, are more likely to be cells of origin in MCC. …”
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Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli by Ye. A. Kogan, D. V. Vyshegorodtsev, N. M. Faizullina, T. A. Demura, A. M. Kuzminov, Yu. A. Shelygin, G. T. Sukhikh

“…At reparation cells with signs of stem cells take part.Conclusions. Original method can be applied for treatment of FAC as it delays polyps and rectal cancer development for many years.…”
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Color Transformation and Fluorescence of Prussian Blue–Positive Cells: Implications for Histologic Verification of Cells Labeled with Superparamagnetic Iron Oxide Nanoparticles by Joseph A. Frank, Heather Kalish, E. Kay Jordan, Stasia A. Anderson, Edyta Pawelczyk, Ali S. Arbab

“…Superparamagnetic iron oxide (SPIO) nanoparticles, either modified or in combination with other macromolecules, are being used for magnetic labeling of stem cells and other cells to monitor cell trafficking by magnetic resonance imaging (MRI) in experimental models. …”
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The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine by Laura Iop, Eleonora Dal Sasso, Leonardo Schirone, Maurizio Forte, Mariangela Peruzzi, Elena Cavarretta, Silvia Palmerio, Gino Gerosa, Sebastiano Sciarretta, Giacomo Frati

“…Additionally, we dissect the effects of aging on the cardiac endogenous and exogenous reservoirs of stem cells. Finally, we offer an overview on the strategies of regenerative medicine that have been advanced in the quest for heart rejuvenation.…”
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Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability by Petr Smirnov, Moritz J. Przybilla, Milena Simovic-Lorenz, R. Gonzalo Parra, Hana Susak, Manasi Ratnaparkhe, John KL. Wong, Verena Körber, Jan-Philipp Mallm, George Philippos, Martin Sill, Thorsten Kolb, Rithu Kumar, Nicola Casiraghi, Konstantin Okonechnikov, David R. Ghasemi, Kendra Korinna Maaß, Kristian W. Pajtler, Anna Jauch, Andrey Korshunov, Thomas Höfer, Marc Zapatka, Stefan M. Pfister, Wolfgang Huber, Oliver Stegle, Aurélie Ernst

“…Here we analyse single-cell genomic and transcriptomic alterations linked with chromothripsis in human p53-deficient medulloblastoma and neural stem cells (n = 9). We reconstruct the order of somatic events, identify early alterations likely linked to chromothripsis and depict the contribution of chromothripsis to malignancy. …”
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