NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice by Si-Ting Huang, Zuo-Ming Chen, Zhe Peng, Yu Wang, Fan Yang, Yang Tang, Zi Li, Li Wan, Li Wan

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Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis by Xue Q, Pan JP, Qian D, Ji J, Fei LY, Yao S, Tan X, Fan WG

“…The principal inverse variance weighting (IVW) method was used to assess causal relationships, with sensitivity analyses, including heterogeneity and horizontal pleiotropy assessments, conducted to ensure result robustness.Results: MR analysis revealed that decreased expression of Stem Cell Factor (SCF), Macrophage Inflammatory Protein-1β (MIP-1β), and Monocyte Chemotactic Protein-1 (MCP-1) was associated with increased rosacea risk (OR = 1.54, 95% CI = 1.05– 2.26, p = 0.026). …”
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Thymus ad astra, or spaceflight-induced thymic involution by Wataru Muramatsu, Wataru Muramatsu, Maria Maryanovich, Maria Maryanovich, Maria Maryanovich, Taishin Akiyama, Taishin Akiyama, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis

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A platform for Bioengineering Tissue Membranes from cell spheroids by Quang Bach Le, Hariharan Ezhilarasu, Weng Wan Chan, Alok Tanala Patra, Priya Murugan, Shashaank Abhinav Venkatesh, Yean Kai Tay, Shin Ru Lim, Ahmad Amirul Abdul Rahim, Jia Sheng Zach Lee, Xuezhi Bi, Deepak Choudhury

“…We demonstrated this method by producing cartilage tissue membranes from human mesenchymal stem cell spheroids undergoing chondrogenic differentiation, evaluating spheroid sizes, assembly timing, fusion process and membrane thickness. …”
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Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by Tongling Huang, Zhaocheng Lu, Zihui Wang, Lixin Cheng, Lu Gao, Jun Gao, Ning Zhang, Chang-An Geng, Xiaoli Zhao, Huaiyu Wang, Chi-Wai Wong, Kelvin W. K. Yeung, Haobo Pan, William Weijia Lu, Min Guan

“…ESRRA abrogation results in enhanced SPP1 and decreased leptin secretion from both visceral adipocytes and BMAds, concertedly dictating bone marrow stromal stem cell fate commitment and restoring type H vessel formation, constituting a feed-forward loop for bone formation. …”
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Socioeconomic status and delayed surgery: impact on non-metastatic papillary thyroid carcinoma outcomes by Kun Zhang, Xinyi Wang, Jianyong Lei, Anping Su, Tao Wei, Zhihui Li, Ya-Wen Chen, Ya-Wen Chen, Ya-Wen Chen, Ya-Wen Chen, Ya-Wen Chen

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The effect of GM-CSF and predictors of treatment outcome in pediatric septic shock patients by Zhen-Hao Yu, Gui-Xiang Tian, Yao-Dong Wang, Ting-Yan Liu, Peng Shi, Jia-Yun Ying, Wei-Ming Chen, Yu-Feng Zhou, Guo-Ping Lu, Cai-Yan Zhang

“…In addition, significant predictors of treatment outcomes included hematopoietic stem cell transplantation (HSCT), lactic acid (LAC) levels, hospital-acquired septic shock (HASS), red blood cell (RBC) count, and platelet (PLT) count. …”
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MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis by Ruonan Li, Haotian Wang, Xiaolong Wang, Yanbin Yang, Kai Zhong, Xuemei Zhang, Heping Li

“…This study investigated the effect of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) isolated from umbilical cord blood and human umbilical cord plasma-derived extracellular vesicles (UCB-EVs) on wound healing and scar formation reduction. …”
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Exploring the role of inflammatory biomarkers in trigeminal neuralgia by Shenglong Lai, Haiyang Li, Yazhou Xing, Du Wu, Lin Wang, Qinghua Liang

“…Results: The present MR analysis identified significant causal associations for three inflammatory cytokines with TN. Stem cell growth factor beta (SCGF-β) (OR = 1.362, 95% CI = 1.049–1.770, p = 0.021) and Interleukin-4 (IL-4) (OR = 1.533, 95% CI = 1.014–2.316, p = 0.043) were positively associated with TN, while Interleukin-16 (IL-16) (OR = 0.720, 95% CI = 0.563–0.921, p = 0.009) had a protective effect. …”
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CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

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Circulating FGF21 is lower in South Asians compared with Europids with type 2 diabetes mellitus by Carlijn A Hoekx, Borja Martinez-Tellez, Maaike E Straat, Maurice B Bizino, Huub J van Eyk, Hildebrandus J Lamb, Johannes W A Smit, Ingrid M Jazet, Kimberly J Nahon, Laura G M Janssen, Patrick C N Rensen, Mariëtte R Boon

“…Results: Of the 73 inflammation-related proteins, the relative plasma levels of six proteins were higher (stem cell factor, caspase-8, C–C motif chemokine ligand 28, interferon-gamma, sulfotransferase 1A1 and cystatin D; q-value <0.05), while relative levels of six proteins were lower (FGF21, human fibroblast collagenase, interferon-8, C–C motif chemokine ligand 4, C–X–C motif chemokine ligand 6 and monocyte chemoattractant protein-1; q-value <0.05) in South Asians compared with Europids. …”
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Epidermal Growth Factor Promotes E6 and CCL-81 Vero Cells Proliferation Under Serum-Free Condition by Diena Delaiah, Ahmad Aswin, Helen Susilowati, Andi Yasmin Wijaya, Firdausy Kurnia Maulana, Diyantoro Diyantoro, Watchareewan Rodprasert, Yulianna Puspitasari, Yeni Dhamayanti, Suryo Kuncorojakti

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Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…Dose-dependent expression of PIK3CA H1047R in human cervical cancer and induced pluripotent stem cells corrupted the fidelity of growth factor-induced information transfer, with preferential amplification of epidermal growth factor receptor (EGFR) signaling responses compared to insulin-like growth factor 1 (IGF1) and insulin receptor signaling. …”
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Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

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Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1 by Jessica Purizaca, Adriana Contreras-Quiroz, Elisa Dorantes-Acosta, Eduardo Vadillo, Lourdes Arriaga-Pizano, Silvestre Fuentes-Figueroa, Horacio Villagomez-Barragán, Patricia Flores-Guzmán, Antonio Alvarado-Moreno, Hector Mayani, Isaura Meza, Rosaura Hernandez, Sara Huerta-Yepez, Rosana Pelayo

“…Substantial progress on understanding the cell hierarchy within ALL bone marrow (BM) has been recorded in the last few years, suggesting that both primitive cell fractions and committed lymphoid blasts with immature stem cell-like properties contain leukemia-initiating cells. …”
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Diagnosis and Treatment of Golfer's Elbow: A Review of Therapeutic Approaches by Karol Dzwonnik, Urszula Zelik, Wojciech Florczak, Joanna Śnieżna, Jakub Dziewic, Wiktoria Domino, Gabriela Trestka, Maria Przygoda, Jagienka Włodyka, Kamila Stępień, Sabina Adamczyk

“…In refractory cases, surgical options like open repair and arthroscopy, along with innovative techniques such as collagen-augmented sutures and stem cell applications, show promising results. Complementary therapies, such as ESWT, PRP, and manual therapy, further enhance outcomes, particularly in chronic cases. …”
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Polyethylene microplastic exposure adversely affects oocyte quality in human and mouse by Qiaoling Wang, Fengli Chi, Yingdong Liu, Qiurong Chang, Siyu Chen, Pengcheng Kong, Wanli Yang, Wenqiang Liu, Xiaoming Teng, Yan Zhao, Yi Guo

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Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases by Shih-Wen Huang, Yein-Gei Lai, Hao-Ting Liao, Chin-Ling Chang, Ruo-Yu Ma, Yung-Hsiang Chen, Yae-Huei Liou, Zhen-Qi Wu, Yu-Chen Wu, Ko-Jiunn Liu, Yen-Tsung Huang, Jen-Lung Yang, Ming-Shen Dai, Nan-Shih Liao

“…Furthermore, NK cell transfer augments activation of conventional dendritic cells (cDCs), Foxp3-CD4+ T cells and stem cell-like CD8+ T cells in metastatic lungs, to which IFN-γ of the transferred NK cells contributes significantly. …”
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A Novel Immune-Related lncRNA-Based Model for Survival Prediction in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Yanjun Liu, Hongkai Zhuang, Enyu Lin, Lu Xie, Xiaoqiang Feng, Kaiwen Tian, Jiayi Zeng, Jiumin Liu, Yuming Yu

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Dopamine‐conjugated extracellular vesicles induce autophagy in Parkinson's disease by Jae Hoon Sul, Sol Shin, Hark Kyun Kim, Jihoon Han, Junsik Kim, Soyoung Son, Jungmi Lee, Seung Hyun Baek, Yoonsuk Cho, Jeongmi Lee, Jinsu Park, Donghoon Ahn, Sunyoung Park, Leon F. Palomera, Jeein Lim, Jongho Kim, Chanhee Kim, Seungsu Han, Ka Young Chung, Sangho Lee, Tae‐in Kam, Yunjong Lee, Jeongyun Kim, Jae Hyung Park, Dong‐Gyu Jo

“…In this study, we engineered dopamine onto the surface of adipose‐derived stem cell EVs (Dopa‐EVs) utilizing a facile, two‐step cross‐linking approach. …”
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