Preparation and Evaluation of Gelatin-Chitosan-Nanobioglass 3D Porous Scaffold for Bone Tissue Engineering by Kanchan Maji, Sudip Dasgupta, Krishna Pramanik, Akalabya Bissoyi

“…GCB 30 scaffold was shown to be noncytotoxic and supported mesenchymal stem cell attachment, proliferation, and differentiation as indicated by MTT assay and RUNX-2 expression. …”
Get full text

Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan by Jun Yamada, Kunikazu Tsuji, Kazumasa Miyatake, Yu Matsukura, Kahaer Abula, Makiko Inoue, Ichiro Sekiya, Takeshi Muneta

Get full text

TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6 by Sheng Luo, Wenjin Wang, Jingfang Feng, Rui Li

“…As a novel core part of pluripotency circuitry, testicular expression 10 (TEX10) plays an actively noticeable effect on reprogramming, early embryo development, and embryonic stem cell self-renewal. Nevertheless, TEX10 expressions and functions within bladder carcinoma are still not known. …”
Get full text

Allografting for Bosutinib, Imatinib, Nilotinib, Dasatinib, and Interferon Resistant Chronic Myeloid Leukemia without ABL Kinase Mutation by B. Uz, O. Bektas, E. Eliacik, H. Goker, Y. Erbilgin, M. Sayitoglu, N. Sayinalp, S. Aksu, Y. Buyukasik, O. Ozcebe, I. C. Haznedaroglu

“…The aim of this paper is to report a patient with complicated CML resistant to treatment and progressed despite the administration of bosutinib, imatinib mesylate, nilotinib, dasatinib, interferon alpha 2a, cytotoxic chemotherapy, and allogeneic hematopoietic stem cell transplantation. The striking point of this case story is that no Abl kinase domain mutation against TKIs has been detected during this very complicated disease course of CML. …”
Get full text

Proteomics and Its Current Application in Biomedical Area: Concise Review by Semira Gobena, Bemrew Admassu, Mebrie Zemene Kinde, Abebe Tesfaye Gessese

“…In the biomedical field, proteomics finds widespread application in cancer research and diagnosis, stem cell studies, and the diagnosis and research of both infectious and noninfectious diseases. …”
Get full text

Lenalidomide-Associated Immune Thrombocytopenia: A Case Report and Review of the Literature by William Forehand III, Germame Ajebo, Michael Toscano, Anand Jillella, Paul Dainer

“…Here, we review the literature on lenalidomide-associated ITP and report upon a 59-year-old man who was administered lenalidomide due to concern of progressive multiple myeloma more than a year following his having undergone an autologous hematopoietic stem cell transplant. His platelet count precipitously declined and lead to his hospitalization. …”
Get full text

Between Charybdis and Scylla—an Odyssey in AL amyloidosis: insights and learnings from a narrative review and case report series by Hani Sabbour, Ahmad Alhuraiji, Amr Hanbali, Faraz Khan, Jawahir Alameri, Sultan Alzaher, Dania Mohty, Giovanni Palladini

“…In addition, patients without significant cardiac involvement may benefit from rapid initial treatment with daratumumab along with cyclophosphamide-bortezomib-dexamethasone, which can render patients eligible for autologous stem cell transplant (ASCT) or in some instances means they can forgo ASCT completely. …”
Get full text

Single-cell RNA sequencing identifies the expression of hemoglobin in chondrocyte cell subpopulations in osteoarthritis by Zhihao Zhang, Ting He, Hongwen Gu, Yuanhang Zhao, Shilei Tang, Kangen Han, Yin Hu, Hongwei Wang, Hailong Yu

Get full text

Mitotic chromatin marking governs the segregation of DNA damage by Juliette Ferrand, Juliette Dabin, Odile Chevallier, Matteo Kane-Charvin, Ariana Kupai, Joel Hrit, Scott B. Rothbart, Sophie E. Polo

“…We propose that this mechanism may help preserve the integrity of stem cell compartments during asymmetric cell divisions.…”
Get full text

miR-468-3p suppresses osteogenic differentiation of BMSCs by targeting Runx2 and inhibits bone formation by Tao Fang, Ranxi Zhang, Feng Song, Xueru Chu, Qin Fu, Qianqian Wu

“…Abstract An improved understanding of the molecular actions underpinning bone marrow mesenchymal stem cell (BMSC) differentiation could highlight new therapeutics for osteoporosis (OP). …”
Get full text

Platinum nanoparticles decorated on electrodeposited Ti3C2Tx MXene nanosheets as an ultrasensitive biosensor for CA15–3 detection by Sepideh Shafaei, Rahim Mohammad-Rezaei, Balal Khalilzadeh, Ibrahim Isildak

Get full text

Molecular dynamics simulations reveal key roles of the LIF receptor in the assembly of human LIF signaling complex by Bo Gao, Hanrui Liu, Mengkai Zhu, Shun Zhang, Meiniang Wang, Yijun Ruan, Yue Zheng

“…Leukemia inhibitory factor (LIF) is a critical cytokine involved in various biological processes, including stem cell self-renewal, inflammation, and cancer progression. …”
Get full text

Necrotizing Fasciitis in Paroxysmal Nocturnal Hemoglobinuria by Pusem Patir, Yakup Isik, Yigit Turk, Mehmet Can Ugur, Cengiz Ceylan, Gulnur Gorgun, Nihal Mete Gokmen, Guray Saydam, Fahri Sahin

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, progressive, and life-threatening hematopoietic stem cell disorder characterized by complement-mediated intravascular hemolysis and a prothrombotic state. …”
Get full text

Generation, interrogation, and future applications of microglia-containing brain organoids by Julia Di Stefano, Federica Di Marco, Ilaria Cicalini, Una FitzGerald, Damiana Pieragostino, Marleen Verhoye, Peter Ponsaerts, Elise Van Breedam

“…Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function. …”
Get full text

Immune Gene Expression Profiling in Individuals with Turner Syndrome, Graves’ Disease, and a Healthy Female by Single-Cell RNA Sequencing: A Comparative Study by Soo Yeun Sim, In-Cheol Baek, Won Kyoung Cho, Min Ho Jung, Tai-Gyu Kim, Byung-Kyu Suh

Get full text

Unusual Presentation with Orbital Mass in a Child with Precursor B-Cell Acute Lymphoblastic Leukemia by Lalita Sathitsamitphong, Rungrote Natesirinilkul, Worawut Choeyprasert, Pimlak Charoenkwan

“…The role of upfront hematopoietic stem cell transplantation remains inconclusive. The previously reported prognosis of ALL with orbital involvement is poor.…”
Get full text

Research prospects for kidney xenotransplantation: a bibliometric analysis by Shujun Yang, Mingtao Zhang, Hao Wei, Bin Zhang, Jiang Peng, Panfeng Shang, Shengkun Sun

“…We found that ‘co-stimulation blockade’, ‘xenograft survival’, ‘pluripotent stem cell’, ‘translational research’, and ‘genetic engineering’ were likely to be the focus of attention in the coming years.Conclusions This study screened global publications related to xenogeneic kidney transplantation; analyzed their literature metrology characteristics; identified the most cited articles in the research field; understood the current situation, hot spots, and trends of global research; and provided future development directions for researchers and practitioners.…”
Get full text

Hemophagocytic syndrome: Laboratory and molecular characterization by Nooran Salem Yaseen, Sadiq Khalaf Ali, Hussam Saadi Aziz

“…CONCLUSION: Early diagnosis of HLH is often challenging; this study should increase awareness of the prevalence of familial HLH among infants; such cases require early recognition and referral to hematopoietic stem cell transplantation.…”
Get full text

Assessment of the Effects of Albendazole-Loaded Sulfonated Graphene Oxide on Echinococcus granulosus Protoscoleces: An In Vitro Investigation by Mohammad Reza Lashkarizadeh, Mohammad Shafie’ei, Mahdiyeh Lashkarizadeh, Seyed Mohammad Mousavi, Ghazaleh Sheibani, Zahra Akbari, Haniyeh Daneshafruz, Ali Derakhshani, Faham Khamesipour

Get full text

三七总皂甙诱导骨髓间质干细胞分化为神经元样细胞 by 撒亚莲, 李海标

“…摘　要:【目的】用三七总皂甙(total Panax notoginseng saponins)在体外定向诱导SD 青年鼠骨髓间质干细胞(mesenchymal stem cell , rMSC)分化为神经元样细胞。【方法】用低糖DMEM 冲洗骨髓腔, 收集骨髓细胞悬液, 接种在塑料培养瓶中。 …”
Get full text