Insights Into the Role of Bmi‐1 Deregulation in Promoting Stemness and Therapy Resistance in Glioblastoma: A Narrative Review by Fatima Shaalan, Nissrine Ballout, Wafaa Takash Chamoun

“…Bmi‐1 has a critical role in modulating the tumor microenvironment to support the plasticity of GBM stem cells.We explore Bmi‐1's involvement in maintaining glioma stem cell (GSC) proliferation and senescence evasion upon regulating the chromatin structure of several tumor suppressor genes, cell cycle inhibitors, or stem cell genes in tumor cells. …”
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Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis by Hanqing Chen, Yundi Guo, Jing Sun, Jun Dong, Qinghua Bao, Xueguang Zhang, Fengqing Fu

“…Thus, our findings suggest B7-H6 as a potential molecule for glioma stem cell targeted immunotherapy.…”
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Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity by Maïlis Darmuzey, Franck Touret, Emily Slowikowski, Ivan Gladwyn-Ng, Karan Ahuja, Lorena Sanchez-Felipe, Xavier de Lamballerie, Catherine Verfaillie, Pedro E. Marques, Johan Neyts, Suzanne J. F. Kaptein

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Synthetic Retinoid Sulfarotene Selectively Inhibits Tumor‐Repopulating Cells of Intrahepatic Cholangiocarcinoma via Disrupting Cytoskeleton by P‐Selectin/PSGL1 N‐Glycosylation Bloc... by Xiaojing Du, Zhuoran Qi, Sinuo Chen, Jinlan Wu, Ye Xu, Sunkuan Hu, Zhijie Yu, Jiayun Hou, Yuan Fang, Jinglin Xia, Xin Cao

“…Abstract Intrahepatic cholangiocarcinoma (ICC) is a highly lethal malignancy that currently lacks effective clinical treatments. Eliminating stem cell‐like cancer cells is an extremely promising but challenging strategy for treating ICC. …”
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KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons by Irune Guerra San Juan, Jessie W. Brunner, Kevin Eggan, Ruud F. Toonen, Matthijs Verhage

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Heritable human genome editing in South Africa – time for a reality check by M Ramsay, M Pepper, J de Vries, S Mahomed, E Flack-Davison

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Xanthoma Disseminatum with Tumor-Like Lesion on Face by Habib Ansarin, Hoda Berenji Ardestani, Seyed Mehdi Tabaie, Nasrin Shayanfar

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The History of Cystinosis: Lessons for Clinical Management by Paul Goodyer

“…Major conceptual break-throughs include (a) its discovery in 1903, (b) recognition of the renal Fanconi syndrome, (c) realization that tissue accumulation of cystine reflects a defective channel in the lysosomal membrane, (d) translation of this discovery to trials of cysteamine, (e) discovery of the CTNS gene, and (f) report of successful stem cell therapy in the cystinotic mouse. This paper focuses on the importance management lessons from these milestones and the potential new therapeutic strategies which may be looming in the near future.…”
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Posttransplant Lymphoproliferative Disease Presenting as an Extracranial Mass by Reuben J. Arasaratnam, Alejandro Restrepo

“…Posttransplant lymphoproliferative disease is a serious complication following stem cell and solid organ transplantation. Early recognition of the disease is important in facilitating timely therapy and improving long-term outcomes. …”
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Bioluminescence in cancer research - Applications and challenges by Shrikant B. Mali

“…BLI is also widely employed in cancer imaging, especially in light of recent advances in genetic engineering, stem cell, and gene therapy therapies. Because of their distinct benefits over standard fluorescent reporters, bioluminescent reporters are increasingly being employed in research. …”
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Role of Cold atmospheric plasma in cancer management by Shrikant B. Mali

“…Cold atmospheric plasma (CAP) has shown potential in treating skin diseases and chronic wounds, reducing tumor-cell viability and stimulating stem-cell proliferation. CAP triggers responses in tumor cells, causing epigenetic changes in DNA methylation levels and histone modification, and altering the expression and activity of non-coding RNAs, affecting cell regulatory functions. …”
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Right of reply - Response to: In defence of South Africa’s National Health Research Ethics Council guidelines on heritable human genome editing by M Ramsay, M S Pepper, J de Vries, S Mahomed, E Flack-Davison

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TLRs, Alcohol, HCV, and Tumorigenesis by Keigo Machida

“…Recent studies of HCC have centered on cancer-initiating stem cell (CSC), including detection of CSC in cancer, identification of CSC markers, and isolation of CSC from human HCC cell lines. …”
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François Gros: from antibiotics to messenger RNA by Yaniv, Moshe

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GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE by Francesco Fabozzi, Angela Mastronuzzi

“…The recognition of a germline mutation in a patient affected by a hematologic malignancy allows for a tailored treatment approach in order to minimize toxicities, and informs the donor selection for hematopoietic stem cell transplantation as well as the comorbidities evaluation and surveillance strategies. …”
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Epigenetic and gene regulatory functions of small RNAs by Cecere, Germano

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Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart by Leonard M. Eisenberg, Carol A. Eisenberg

“…Wnt proteins have major impact on embryonic development, tumor progression, and stem cell differentiation. Wnt signal transduction also influences the formation of the heart, yet many issues concerning the involvement of Wnt regulation in initiating cardiac development remain unresolved. …”
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Innovations in Lung Transplant Research and Practice: The Future is Now by Robin Vos, Robin Vos, Sandra Lindstedt, Sandra Lindstedt, Sandra Lindstedt, Sandra Lindstedt, Deborah J. Levine, Norihisa Shigemura

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Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients by Gianmarco Bagnato, Vittorio Stefoni, Alessandro Broccoli, Lisa Argnani, Cinzia Pellegrini, Beatrice Casadei, Francesca Bonifazi, Pier Luigi Zinzani

“… We report the case of 2 patients with relapsed/refractory peripheral T-cell lymphoma treated with valemetostat tosilate, a selective dual inhibitor of histone-lysine N-methyltransferases enhancer of zeste homolog 1 and 2, and subsequently bridged to allogeneic stem cell transplantation. Valemetostat led to a quick response and was well tolerated, offering as a promising bridge therapy to transplantation for patients with relapsed/refractory peripheral T-cell lymphoma which is still an unmet medical need. …”
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Vitamin A: A Key Inhibitor of Adipocyte Differentiation by Manal A. Malibary

“…Nevertheless, the functional role of RA in early tissue development and stem cell differentiation, including in adipose tissue, remains unclear. …”
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