Measurement of antibiotic removal efficiency of ZnO-WO3 nanocomposite and its validation through residual antimicrobial activity by Shraddha Shukla, Shashi Kant Shukla, Prashansha Singh, Himanshu Pandey, Anupam Dikshit, Avinash C. Pandey

“…The characterization study revealed the presence of Zn, O and W and confirms the shape of the particle is flaky and spheroidal. The prepared ZnO-WO3 nanocomposite has been utilized for the degradation of antibiotic residues of 10 mg l−1 concentration (AMX, AZT and OFX) with different catalyst concentrations of 10 %, 20 %, 30 % and 40 %. …”
Get full text

Antibacterial Effect of Silver Nanoparticles Synthesized Using Murraya koenigii (L.) against Multidrug-Resistant Pathogens by Faizan Abul Qais, Anam Shafiq, Haris M. Khan, Fohad M. Husain, Rais A. Khan, Bader Alenazi, Ali Alsalme, Iqbal Ahmad

“…The nanoparticles were predominantly found to be spheroidal with particle size distribution in the range of 5–20 nm. …”
Get full text

Nerve regeneration using a Bio 3D conduit derived from umbilical cord-Derived mesenchymal stem cells in a rat sciatic nerve defect model. by Terunobu Iwai, Ryosuke Ikeguchi, Tomoki Aoyama, Takashi Noguchi, Koichi Yoshimoto, Daichi Sakamoto, Kazuaki Fujita, Yudai Miyazaki, Shizuka Akieda, Tokiko Nagamura-Inoue, Fumitaka Nagamura, Koichi Nakayama, Shuichi Matsuda

“…<h4>Methods</h4>A Bio 3D conduit was fabricated using a Bio 3D printer by placing UC-MSC spheroids into thin needles according to predesigned 3D data. …”
Get full text

S100A13-driven interaction between pancreatic adenocarcinoma cells and cancer-associated fibroblasts promotes tumor progression through calcium signaling by Liuyuan Xia, Xin Guo, Dong Lu, Yixin Jiang, Xiaohui Liang, Yiwen Shen, Jiayi Lin, Lijun Zhang, Hongzhuan Chen, Jinmei Jin, Xin Luan, Weidong Zhang

“…Furthermore, silencing S100A13 in CAFs markedly slowed PAAD progression in both tumor spheroids and Balb/c nude mice. Conclusions Together, our findings underscore the critical role of CAFs-derived S100A13 in PAAD progression and suggest that targeting S100A13 may offer a promising therapeutic strategy for PAAD.…”
Get full text

Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation by Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida

“…The combination of ivermectin and the ERK5 inhibitor AX15836 synergistically reduced cell viability and colony formation ability in A375 and HeLa cells and was more effective than single treatments in preventing the growth of A375 and HeLa spheroids. The increased reduction of cell viability upon the same combination was also observed in patient‐derived metastatic melanoma cells. …”
Get full text

Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism by Kelley C. Larson, Frederick W. Gergits, Abigail J. Renoux, Elizabeth J. Weisman, Borislav Dejanovic, Liyue Huang, Bhaumik Pandya, Donald G. McLaren, Berkley A. Lynch, Richard Fisher, Evan Thackaberry, David Gray, Francois Gaudreault, Christian Mirescu

“…Abstract Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP). CSF1R-ALSP is caused by heterozygous loss-of-function mutations in the colony stimulating factor 1 receptor (CSF1R) gene, which encodes a receptor required for the differentiation of myeloid cells, as well as for microglial survival and proliferation. …”
Get full text

Functional differentiation of human dental pulp stem cells into neuron-like cells exhibiting electrophysiological activity by B. Pardo-Rodríguez, A. M. Baraibar, I. Manero-Roig, J. Luzuriaga, J. Salvador-Moya, Y. Polo, R. Basanta-Torres, F. Unda, S. Mato, Gaskon Ibarretxe, Jose Ramon Pineda

“…In addition, hDPSCs previously grown as spheroids in serum-free medium exhibited in vitro expression of neuronal markers such as doublecortin (DCX), neuronal nuclear antigen (NeuN), Ankyrin-G and MAP2 after neurodifferentiation. …”
Get full text

Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies by Dean A Lee, Jeremiah L Oyer, Md Faqrul Hasan, Tayler J Croom-Perez, Liza D Robles-Carrillo, Sanjana Kumar, Brendan W Andersen, Brian P Tullius, Alicja J Copik, Amanda R Campbell, Thomas A Dieffenthaller, Catherine A Cash, Jonathan E Eloriaga, Meisam Naeimi Kararoudi

“…The effect of the Fc-component of anti-TIGIT on NK-cell fratricide was determined by co-culturing WT and TIGIT KO NK cells with Fc-active and Fc-inactive anti-TIGIT.Results TIGIT KO increased the cytotoxicity of NK cells against multiple cancer cell lines including spheroids. TIGIT KO NK cells upregulated mTOR complex 1 (mTORC1) signaling and had better metabolic fitness with an increased basal glycolytic rate when co-cultured with cancer cells compared with WT NK cells. …”
Get full text

Analysis of the long-range transport of the volcanic plume from the 2021 Tajogaite/Cumbre Vieja eruption to Europe using TROPOMI and ground-based measurements by P. Hedelt, J. Reichardt, F. Lauermann, B. Weiß, N. Theys, A. Redondas, A. Barreto, O. Garcia, D. Loyola

“…For the first time, an optical particle model is utilized that assumes an irregular, non-spheroidal shape of the aerosol particles. According to the analysis, the volcanic aerosol consisted solely of fine-mode inorganic, solid, and irregularly shaped particles – the presence of large aerosol particles or wildfire aerosols could be excluded. …”
Get full text

AI-NAOS: an AI-based nonspherical aerosol optical scheme for the chemical weather model GRAPES_Meso5.1/CUACE by X. Wang, L. Bi, H. Wang, Y. Wang, W. Han, X. Shen, X. Zhang

“…Specifically, the AI-NAOS considers black carbon (BC) to be fractal aggregates and models soil dust (SD) as super-spheroids, encapsulated partially or completely with hygroscopic aerosols such as sulfate, nitrate, and aerosol water. …”
Get full text