Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation by Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

“…Advanced models such as tumor spheroids, patient organoids and microfluidic devices offer unique possibilities to reconstitute intricate cellular interactions, ECM dynamics as well as physiological gradients found in the OSCC TME. …”
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Nanoparticle-bands enabled strength-ductility synergy in wrought Al-Cu alloys by Yunfeng Hu, Mojia Li, Jiaheng Li, Yingbo Zhang, Dongdi Yin, Ying Zeng, Hui Chen

“…This paper adopts a novel composite thermomechanical processing technique (pre-annealing, semi-solid isothermal treatment, and post double extrusion) to fabricate a high strength-ductility Al-4.5 wt% Cu binary alloy via the spheroidization and nano-crystallization of the primary phase (Al2Cu). …”
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Simulation and analysis of the solidification characteristics of a Si-Mo ductile iron by Çelik G.A., Tzini M.-I. T., Polat Ş., Aristeidakis J S., Atapek Ş.H., Sarafoglou P.I., Haidemenopoulos G.N.

“…The structural integrity of cast Si-Mo alloys under these service conditions is attributed to their microstructure consisting of spheroidal graphite and Mo-rich carbide embedded in a ferritic matrix. …”
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Interconnected TiO2 Nanowire Networks for PbS Quantum Dot Solar Cell Applications by Fan Xu, Jaime Benavides, Xin Ma, Sylvain G. Cloutier

“…We present a simple method for the fabrication of an interconnected porous TiO2 nanostructured film via dip coating in a colloidal suspension of ultrathin TiO2 nanowires followed by high-temperature annealing. The spheroidization of the nanowires and the fusing of the loosely packed nanowire films at the contact points lead to the formation of nanopores. …”
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Osteogenic differentiation of mesenchymal stem cells in cell-laden culture of self-assembling peptide hydrogels by Faye Fouladgar, Robert Powell, Vishalakshi Irukuvarjula, Akhila Joy, Xiao Li, Neda Habibi

“…Scaffold stiffness impacted cell viability which softer scaffolds (100 Pa) favored higher viability. MSC formed spheroids in 3D hydrogel and showed spread morphology in 2D overlayers. …”
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PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma by Valentin Van den bossche, Julie Vignau, Engy Vigneron, Isabella Rizzi, Hannah Zaryouh, An Wouters, Jérôme Ambroise, Steven Van Laere, Simon Beyaert, Raphaël Helaers, Cédric van Marcke, Lionel Mignion, Elise Y. Lepicard, Bénédicte F. Jordan, Céline Guilbaud, Olivier Lowyck, Hajar Dahou, Antonella Mendola, Manon Desgres, Léo Aubert, Isabelle Gerin, Guido T. Bommer, Romain Boidot, Perrine Vermonden, Aurélien Warnant, Yvan Larondelle, Jean-Pascal Machiels, Olivier Feron, Sandra Schmitz, Cyril Corbet

“…This metabolic shift makes cetuximab-resistant HNSCC cells particularly sensitive to a pharmacological inhibition of either carnitine palmitoyltransferase 1A (CPT1A) or PPARα in 3D spheroids and tumor xenografts in mice. Importantly, the PPARα-related gene signature, in human clinical datasets, correlates with lower response to anti-EGFR therapy and poor survival in HNSCC patients, thereby validating its clinical relevance. …”
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Multivariate Analysis, Mass Balance Techniques, and Statistical Tests as Tools in Igneous Petrology: Application to the Sierra de las Cruces Volcanic Range (Mexican Volcanic Belt) by Fernando Velasco-Tapia

“…In this locality, the volcanic activity (3.7 to 0.5 Ma) was dominantly dacitic, but the presence of spheroidal andesitic enclaves and/or diverse disequilibrium features in majority of lavas confirms the operation of magma mixing/mingling. …”
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Low-Intensity Light-Responsive Anticancer Activity of Platinum(II) Complex Nanocolloids on 2D and 3D In Vitro Cancer Cell Model by Viviana Vergaro, Francesca Baldassarre, Federica De Castro, Danilo Migoni, Maria Michela Dell’Anna, Piero Mastrorilli, Francesco Paolo Fanizzi, Giuseppe Ciccarella

“…Furthermore, our nanocolloids were validated in 3D in vitro spheroids using confocal microscopy and cytofluorimetric assay to compare their behavior on culture in 2D monolayers. …”
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Joint DOA-delay estimation approach based on atomic norm by XU Ming, TANG Qian

“…Finally, in order to solve the problem that the sub-matrix in the positive semi-definite matrix caused by arbitrary linear arrays was a non-Toeplitz matrix structure and could not be decomposed by Vandermonde, a Hermitian set about the geometric structure of the hydrophone was defined, and the prolate spheroidal wave functions were used to solve the semi-definite programming problem to obtain a joint estimate of DOA and delay. …”
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N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex by Seyedsajad Moazzeni, Kelly Kyker-Snowman, Rick I. Cohen, Huan Wang, Ran Li, David I. Shreiber, Jeffrey D. Zahn, Zheng Shi, Hao Lin

“…Inhibition of Rac1 activity decreases tension polarization and leads to reduced coherence in both small clusters and spheroids. These results provide a pathway to reconcile opposing theories for tissue surface tension generation and perspectives in cancer treatment.…”
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Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment by Julia Günter, Petra Wolint, Annina Bopp, Julia Steiger, Elena Cambria, Simon P. Hoerstrup, Maximilian Y. Emmert

“…Of great interest is the use of so-called microtissues or spheroids, which have evolved from their traditional role as in vitro models to their novel role as therapeutic agents. …”
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A process inspired by fractals for embedding digital codes into additively manufactured components for supply chain security by Saber Nemati, Ali Mahmoudi, Kyungmin Ham, Tie Siemers, Shengmin Guo, Josephine Gutekunst, Joachim Schulz, Ian Taylor, Michele Maasberg, Leslie G. Butler

“…The codes were configured as either ellipsoids or prolate spheroids in patterns given by the Cantor dust fractal. …”
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Analysis of tensile properties in tempered martensite steels with different cementite particle size distributions by Kengo Sawai, Keiya Sugiura, Toshio Ogawa, Ta-Te Chen, Fei Sun, Yoshitaka Adachi

“…Moreover, gradient-weighted class activation mapping (Grad-CAM) suggested that fine cementite particles and coarse and spheroidal cementite particles are the dominant factors for tensile strength and total elongation, respectively.…”
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Maraviroc/cisplatin combination inhibits gastric cancer tumoroid growth and improves mice survival by Bárbara Mora-Lagos, María Elena Reyes, Lorena Lobos-Gonzalez, Matías del Campo, Kurt Buchegger, Louise Zanella, Ismael Riquelme, Carmen Gloria Ili, Priscilla Brebi

“…This study aimed to determine the effects induced by the CCR5 using Maraviroc (MVC), a highly selective CCR5 antagonist, on CDDP-resistant AGS cells (AGS R-CDDP), tumoroids (3D tumor spheroids), and animal models. Results The combined CDDP and MVC treatment reduced cell viability and inhibited tumoroid formation in AGS R-CDDP cells. …”
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Effect of chemical composition and T6 heat treatment on the mechanical properties and fracture behaviour of Al-Si alloys for IC engine components by Vuksanović D., Asanović V., Šćepanović J., Radonjić D.

“…After T6 treatment of the Al-11Si alloy, almost half of the intermetallics quantity presented the Al3Ni phase, while the iron-based phases were observed in a small amount. Spheroidized eutectic silicon, a smaller portion of Al5Cu2Mg8Si6, and a more considerable quantity of Al3(Fe,Mn,Cu,Ni,Co) were detected for T6 specimens of the Al-12.5Si alloy. …”
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CRYβB2 alters cell adhesion to promote invasion in a triple-negative breast cancer cell line by Amr A. Waly, London Harper, Jodie M. Fleming, Lindsey M. Costantini

“…Results We utilized the SUM159 cells with stable CRYβB2 overexpression in a 3D-culture tumor spheroids model in our investigation. A quantitative 3D invasion assay demonstrated that CRYβB2 overexpression significantly enhanced invasion (median invasion %; SUM159 = 0.14 and SUM159 + CRYβB2 = 0.33). …”
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True cancer stem cells exhibit relative degrees of dormancy and genomic stability by Sanford H. Barsky, Krista Mcphail, Justin Wang, Jordan Dillard, Crystal J. Beard, Yin Ye

“…The subpopulation with the retained fluorescent microspheres and exhibiting genomic stability was significantly smaller in size than their GFP-expressing and genomically unstable counterparts. Sorting Mary-X spheroids on the basis of either CD133 or ALDH positivity further enriched for this subpopulation. …”
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Evaluation of the Antitumor Effects of Platinum-Based [Pt(η1-C2H4-OR)(DMSO)(phen)]+ (R = Me, Et) Cationic Organometallic Complexes on Chemoresistant Pancreatic Cancer Cell Lines... by Erika Stefàno, Luca Giulio Cossa, Federica De Castro, Erik De Luca, Viviana Vergaro, Giulia My, Gianluca Rovito, Danilo Migoni, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…Moreover, phenanthroline-containing complexes caused a rapid loss of mitochondria membrane potential, ΔΨM, if compared to cisplatin, probably due to their cationic and lipophilic properties. On 3D tumor spheroids, 1 and 2 significantly reduced migrated area more than cisplatin, confirming an antimetastatic ability.…”
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Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs by Khushboo Agrawal, Viswanath Das, Natálie Táborská, Ján Gurský, Petr Džubák, Marián Hajdúch

“…Similar to 2D cultures, senescent fibroblasts increased DNA demethylation of CRC cells in coculture spheroids, in addition to increasing the stemness of CRC cells. …”
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Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin by Zhengjian Wang, Xichun Luo, Jining Sun, Wenkun Xie, Yinchuan Piao, Yonghang Jiang, Xiuyuan Chen

“…This study represents a significant advancement in the processing of silk fibroin film, offering a complementary approach to fabricating short, spiral-shaped silk fibroin particles with a high surface-area-to-volume ratio compared to traditional spheroids, which holds great potential for enhancing drug-loading efficiency in high-precision drug delivery systems.…”
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