CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma by Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Catrin Heim, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Philipp Wendel, Philipp Wendel, Philipp Wendel, Philipp Wendel, Süleyman Bozkurt, Sabine Harenkamp, Hermann Kreyenberg, Hermann Kreyenberg, Michael Merker, Michael Merker, Christian Münch, Christian Münch, Christian Münch, Elise Gradhand, Meike Vogler, Meike Vogler, Meike Vogler, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Halvard Bönig, Halvard Bönig, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger

“…Long-term co-incubation with tumor spheroids led to expansion of CAR-CIK cells and enrichment of CD3+CD56+ TNK cells. …”
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In Vivo Bioluminescence Imaging Validation of a Human Biopsy–Derived Orthotopic Mouse Model of Glioblastoma Multiforme by Monika A. Jarzabek, Peter C. Huszthy, Kai O. Skaftnesmo, Emmet McCormack, Patrick Dicker, Jochen H.M. Prehn, Rolf Bjerkvig, Annette T. Byrne

“…Luciferase-expressing spheroids were injected into the brains of immunodeficient mice. …”
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Graphite in the slag during modification of cast iron by addition alloy by V. I. Stetsenko, A. G. Solovej

“…The results and the analysis of the graphite content in the slag during modification of cast iron by spheroidizing addition alloy are given.…”
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Nanoparticle accumulation and penetration in 3D tumor models: the effect of size, shape, and surface charge by Pierre Cybulski, Maria Bravo, Maria Bravo, Jim Jui-Kai Chen, Indra Van Zundert, Sandra Krzyzowska, Farsai Taemaitree, Hiroshi Uji-i, Hiroshi Uji-i, Hiroshi Uji-i, Johan Hofkens, Johan Hofkens, Susana Rocha, Beatrice Fortuni

“…In this study, we addressed the challenge of inconsistent NP behavior by systematically evaluating NP uptake in both 2D and 3D tumor models, and NP penetration in spheroids. Our results showed that larger NPs exhibited higher internalization rates in 2D models but limited penetration in 3D spheroids. …”
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Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity. by Quanhui Dai, Kristina Preusse, Danni Yu, Rhett A Kovall, Konrad Thorner, Xinhua Lin, Raphael Kopan

“…Transcriptomic analysis of colonic spheroids uncovered no evidence of dimer-dependent target gene miss-regulation, confirmed impaired stem cell maintenance in-vitro, and discovered an elevated signature of epithelial innate immune response to symbionts, a likely underlying cause for heightened sensitivity in NDD mice. …”
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EFFECTS OF AUSTENITIZATION ON STRUCTURE FORMATION СHROMO-MOLYBDENUM-VANADIUM STEEL AFTER HIGH TEMPERING by V. A. Lutsenko, T. N. Golubenko, O. V. Lutsenko, N. A. Glazunova

“…It is shown that the decline of the austenitization temperature promotes to reduce the micro-hardness values due to the intensification of spheroidizing of pearlite after the overcooling and high tempering. …”
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Study on the Manufacturing Process of Low Temperature Ductile Iron Casting Gear Box Used for Locomotive by Kuang Yi, Fan Naize, Tian Huajun, Pei Bang, Zhao Jiadong, Ning Ke, Zhang Xiangru, Xu Sen, Xu Hui

“…Taking the QT400-18 L low temperature ductile iron gear box used for locomotive as example,through the control of the element content of the material,the graphite spheroidization is more fully. At the same time,the samples are heat treated to ensure the stability of mechanical property. …”
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Establishment of a Model of Microencapsulated SGC7901 Human Gastric Carcinoma Cells Cocultured with Tumor-Associated Macrophages by Jin-Ming Zhu, Xiu-Lian Quan, Shi-Chao Han, Xue-Jun Fan, He-Ming Li, Shan-Shan Liang, Xi Chen, Ruo-Yu Wang, Xue-Ning Ji

“…The expression of PCNA was observed outside spheroids; however, VEGF was found in the entire spheroids. …”
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Effect of residual carbon on crystallization and solidification behavior of coal gasification coarse slag by Ze Meng, Rongsheng Xu, Qian Feng, Xiongchao Lin, Mei Li

“…SEM analysis illustrates that the spheroidization phenomenon is obvious when there is residual carbon in the coarse slag, but there is no spheroidization phenomenon in the decarburized coarse slag. …”
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Three-dimensional dynamics of mesothelin-targeted CAR.CIK lymphocytes against ovarian cancer peritoneal carcinomatosis by Federica Galvagno, Valeria Leuci, Annamaria Massa, Chiara Donini, Ramona Rotolo, Sonia Capellero, Alessia Proment, Letizia Vitali, Andrea Maria Lombardi, Valentina Tuninetti, Lorenzo D’Ambrosio, Alessandra Merlini, Elisa Vigna, Giorgio Valabrega, Luca Primo, Alberto Puliafito, Dario Sangiolo

“…In a “floating-like” 3D context with floating OC spheroids, both tumor localization and killing by MSLN-CAR.CIK were significantly boosted by fluid flow. …”
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Phosphatidylserine on sperm head interact with Annexin A5 on oviduct luminal cilia to form a sperm reservoir in pigs by Lorraine Schmaltz, Elie Barakat, Renaud Fleurot, Rustem Uzbekov, Karine Reynaud, Ludivine Laffont, Guillaume Tsikis, Isabelle Mérour, Pascal Mermillod, Marie Saint-Dizier

“…Porcine ANXA5 was immunodetected with a strong signal on luminal cilia in the isthmus and in derived isthmic epithelial spheroids (IES). Exogenous PS between 0.01 and 0.1 µg/mL and recombinant porcine ANXA5 (rpANXA5) above 0.1 µg/mL inhibited sperm binding to IES without reducing sperm motility. …”
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Graphite nodules features identifications and damaging micromechanims in ductile irons by Alberto De Santis, Daniela Iacoviello, Vittorio Di Cocco

“…In this work, an automatic procedure based on an image segmentation technique is applied: this procedure is validated not only considering spheroidal graphite elements, but also considering other morphologies (e.g. lamellae).…”
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APPLICATION OF MODIFYING ALLOYING ALLOY CONTAINING NANOSIZED POWDERS OF ACTIVE ELEMENTS IN PRODUCTION OF HIGH-STRENGTH CAST IRON WITH GLOBULAR GRAPHITE by A. S. Kalinichenko, A. G. Slutsky, V. A. Sheinert

“…Scientific and practical interest is the application of alloying alloy-modifiers for secondary treatment of high-strength cast iron to stabilize the process of spheroidization graphite and achieving higher physical-mechanical properties of castings. …”
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Host-microbe computational proteomic landscape in oral cancer revealed key functional and metabolic pathways between Fusobacterium nucleatum and cancer progression by Camila Paz Muñoz-Grez, Mabel Angélica Vidal, Tamara Beatriz Rojas, Luciano Esteban Ferrada, Felipe Andrés Zuñiga, Agustin Andrés Vera, Sergio Andrés Sanhueza, Romina Andrea Quiroga, Camilo Daniel Cabrera, Barbara Evelyn Antilef, Ricardo Andrés Cartes, Milovan Paolo Acevedo, Marco Andrés Fraga, Pedro Felipe Alarcón-Zapata, Mauricio Alejandro Hernández, Alexis Marcelo Salas-Burgos, Francisco Tapia-Belmonte, Milly Loreto Yáñez, Erick Marcelo Riquelme, Wilfredo Alejandro González, Cesar Andrés Rivera, Angel Alejandro Oñate, Liliana Ivonne Lamperti, Estefanía Nova-Lamperti

“…Finally, our results showed that F. nucleatum and its metabolic derivates promote tumor spheroids growth, spheroids-derived cell detachment, epithelial-mesenchymal transition and Galectin-9 upregulation. …”
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Alloy design for additive manufacturing: Continuously reinforced Al-Ce nanocomposites by Alfred Amon, Glenn E. Bean, J.-B. Forien, Thomas Voisin, Joshua A. Hammons, Emily E. Moore, Emrah Simsek, Jibril Shittu, Katherine S. Shanks, Kelly E. Nygren, Aurélien Perron, Ryan Ott, Scott K. McCall, Hunter B. Henderson

“…The superior mechanical properties of the continuously reinforced nanocomposite were established by comparison with the spheroidized, microstructure of similar scale.…”
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The Role of Molybdenum in the Formation of the Microstructure and Properties of Al-Cu Alloys by S. Stąpór, M. Górny, Ł. Gondek, B. Gracz, M. Kawalec

“…Most of the iron-manganese phases occurred in a more spheroidal form. Additionally, tests were carried out on higher molybdenum content in the alloy. …”
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Probing late-time annihilations of oscillating asymmetric dark matter via rotation curves of galaxies by Júlia G. Mamprim, Guillermo Gambini, Luan B. Arbeletche, Marcos Olegario, Vitor de Souza

“…Abstract In this paper, we explore the Oscillating Asymmetric Dark Matter (OADM) model to address the core-cusp problem, aiming to resolve the discrepancy between the predictions of the $$\Lambda \textrm{CDM}$$ Λ CDM cosmological model and the observed dark matter profiles in dwarf spheroidal galaxies. The reactivation of dark matter annihilation during the structure formation epoch is possible if there is a small Majorana mass term that breaks the conservation of dark matter particle number, leading to oscillations between dark matter and its antiparticle. …”
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Magnetic Nanoparticles with Core Shell: Macroscopic Model and Coercive Field by O. Hudak, M. Hudak

“…We formulate the macroscopic model for the description of magnetic properties of nanoparticles with core-shell structure. The case of spheroids oriented in the same direction of polar axes is considered. …”
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E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration by Michela Tozzi, Alessia Fiore, Sara Travaglione, Francesca Marcon, Gabriella Rainaldi, Elena Angela Pia Germinario, Ilenia Laterza, Simona Donati, Daniele Macchia, Massimo Spada, Omar Leoni, Maria Cristina Quattrini, Donatella Pietraforte, Sofia Tomasoni, Filippo Torrigiani, Ranieri Verin, Paola Matarrese, Lucrezia Gambardella, Francesca Spadaro, Maria Carollo, Agostina Pietrantoni, Francesca Carlini, Concetta Panebianco, Valerio Pazienza, Filomena Colella, Donatella Lucchetti, Alessandro Sgambato, Antonella Sistigu, Federica Moschella, Marco Guidotti, Olimpia Vincentini, Zaira Maroccia, Mauro Biffoni, Roberta De Angelis, Laura Bracci, Alessia Fabbri

“…Caco-2 monolayers and 3D Caco-2 spheroids were used to evaluate permeability alterations specifically induced by CNF1, either in the presence or in the absence of inflammation. …”
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IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3 by Huiyue Dong, Huiyue Dong, Ling Zhu, Ling Zhu, Jingjing Sun, Jingjing Sun, Qiuyan Chen, Qiuyan Chen, Pengyang Liu, Pengyang Liu, Wei Zhang, Huajing Zeng, Rong Lin, Rong Lin, Zongyang Yu, Zongyang Yu, Jun Lu, Jun Lu, Jun Lu, Jun Lu

“…HT1080 cells, three-dimensional (3D) spheroids, and the xenograft mouse models were treated with IFNβ, RSL3, or IFNβ combination with RSL3 to analyze whether IFNβ enhances RSL3-induced ferroptosis.ResultsHere, we found that IFNβ could promote intracellular Fe2+ and lipid peroxidation levels, and decrease GSH levels in tumor cells. …”
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