Cellular Contractility Profiles of Human Diabetic Corneal Stromal Cells by Thi N. Lam, Sarah E. Nicholas, Alexander Choi, Jian-Xing Ma, Dimitrios Karamichos

“…Cell lysates were upregulated in the myofibroblast-associated marker, α-smooth muscle actin, in T2DMs on day 9, corresponding to the significant increase in contractility rate observed at the same time point. …”
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Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology by Yin-Feng Zhang, Hai-Ming Xu, Fei Yu, Man Wang, Meng-Yang Li, Tao Xu, Yan-Yan Gao, Jian-Xun Wang, Pei-Feng Li

“…PPARs are inhibited by miRNAs at posttranscriptional mechanisms in the progress of pulmonary hypertension and vascular dysfunction involving cell proliferation/apoptosis, communication, and normal function of endothelial cells and vascular smooth muscle cells. In the development of atherosclerosis and stroke, the activation of PPARs could change the transcripts of target miRNA through miRNA signalling. …”
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A current review on animal models of anti-asthmatic drugs screening by Shivam Singh, Sunita Kularia, Shivakshi Shukla, Mithilesh Singh, Manish Kumar, Ashish Kumar Sharma

“…Asthma is a chronic inflammatory respiratory condition characterised by airway constriction, smooth muscle spasm, and severe morbidity. It affects around 300 million people globally, with children being especially vulnerable. …”
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First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors by Fumito Saijo, Kaoru Sato, Tomoko Handa, Yoichi Narushima, Naoki Matsumura, Noriyuki Iwama, Fumie Nakayama, Hiromi Tokumura

“…Immunohistochemical staining showed that the tumor was negative for CD34, c-kit, and S-100 and positive for desmin and α-smooth muscle actin. No recurrence had been observed 1 year after surgery without adjuvant chemotherapy. …”
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Cancer-associated fibroblasts and their role in tumor progression by M. S. Ermakov, A. A. Nushtaeva, V. A. Richter, O. A. Koval

“…In activated CAFs, alpha-smooth muscle actin (α-SMA) is synthetized de novo and various proteases and fibronectin are produced. …”
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Rare Site of an Inflammatory Myofibroblastic Tumor at the Epididymis: A Case Report by Lange A, Dominiak N, Petros FG

“…Histology confirmed a 2.4 cm inflammatory myofibroblastic tumors with scattered positivity for smooth muscle actin, negative pancytokeratin, and negative anaplastic lymphoma kinase. …”
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CB-MNCs@ CS/HEC/GP promote wound healing in aged murine pressure ulcer model by Zhi-cheng Yang, He Lin, Guo-jun Liu, Hui Pan, Jun-lu Zhu, Xiao-hong Zhang, Feng Gao, Zhong Wang, Zhi-hao Wang

“…Further investigation revealed that CB-MNCs@CS/HEC/GP exerted therapeutic effects by promoting changes in cell types, including fibroblasts, endothelial cells, keratinocytes, and smooth muscle cells. Conclusion CB-MNCs@CS/HEC/GP enhanced the delivery efficiency of CB-MNCs, preserved the cell viability, and contributed to pressure ulcer wound healing. …”
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Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis by Zhe Hou, Li Deng, Fei Fang, Ting Zhao, Yaojia Zhang, Gang Li, Michael Z. Miao, Yongcang Zhang, Hongchi Yu, Xiaoheng Liu

“…However, the phenotypic switching of vascular smooth muscle cells was not affected by exposure to these EVs. …”
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Quantitative Analysis of the Multicomponent and Spectrum–Effect Correlation of the Antispasmodic Activity of Shaoyao-Gancao Decoction by Yanli Xu, Chenxi Li, Ting Chen, Xiaochun Li, Xiaoyu Wu, Qili Zhang, Lei Zhao

“…Furthermore, data on the antispasmodic effect were extracted through in vitro smooth muscle contraction assay. Grey relational analysis combined with partial least square regression was used to study the spectrum–effect correlation of SGD. …”
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Vascular Protective Effects of Morinda citrifolia Leaf Extract on Postmenopausal Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Microscopic Level by C. L. G. Chong, Faizah Othman, Farida Hussan

“…The untreated OVX group showed evident histological and ultrastructural features of vascular inflammation such as blood cells accumulation in the lumen, vacuolation of the endothelial cells, subendothelial space widening, elastic fibres disruption, increased intima media thickness (IMT), smooth muscle cells fragmentation, and perivascular adipose tissue (PVAT) deposition. …”
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Atractylenolide-I prevents abdominal aortic aneurysm formation through inhibiting inflammation by Shuxiao Chen, Xiaotian Liu, Xincheng Zhou, Weixiao Lin, Minting Liu, Haoran Ma, Keli Zhong, Qiming Ma, Chengjian Qin, Chengjian Qin

“…Moreover, ATL-I restrained loss of smooth muscle cells and elastic fiber degradation by suppressing MMP-2 and MMP-9 expression. …”
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Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells by Laura Hyväri, Sari Vanhatupa, Heidi T. Halonen, Minna Kääriäinen, Susanna Miettinen

“…Additionally, MRTF-A inhibition affected the protein amounts of α-smooth muscle actin (α-SMA), myosin light chain (MLC), and phosphorylated MLC suggesting that MRTF-A would regulate differentiation through SRF activity. …”
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An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor by Sanjivini V. Jacob, John D. Reith, Angerika Y. Kojima, William D. Williams, Chen Liu, Lizette Vila Duckworth

“…Tumor cells showed immunoreactivity for smooth muscle actin and anaplastic lymphoma kinase 1 (ALK1). …”
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tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination by Chao Wang, Bing Yu, Han Zhou, Huanting Li, Shifang Li, Xiaolu Li, Wentao Wang, Yugong Feng, Tao Yu

“…In this study, we identified that the transfer RNA-Asp-GTC derived fragment (tRF-AspGTC) is highly expressed in the IA tissues of both humans and mice. tRF-AspGTC promotes IA formation by facilitating the phenotypic switching of vascular smooth muscle cells, increasing of matrix metalloproteinase 9 expression, and inducing of oxidative stress and inflammatory responses. …”
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Spinal cord injury induces transient activation of hepatic stellate cells in rat liver by Inmaculada Fernandez-Canadas, Alejandro Badajoz, Jesús Jimenez-Gonzalez, Martin Wirenfeldt, Beatriz Paniagua-Torija, Clara Bravo-Jimenez, Mar Del Cerro, Angel Arevalo-Martin, Daniel Garcia-Ovejero

“…This is followed by a morphological and phenotypical transformation into alpha-smooth muscle actin (ACTA2/SMA) immunoreactive myofibroblast-like cells, peaking at 14 days post-injury and returning to control-like levels at later timepoints (45 days post-injury). …”
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The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s Disease by Aldona Sokołowska, Julia Buszek, Piotr Czerniak, Adrianna Antoszewska, Weronika Bargiel, Dominika Bąk, Halszka Wajdowicz, Mateusz Warzocha

“…Concurrently, lncRNAs regulate gene expression through transcriptional and post-transcriptional mechanisms, influencing cellular processes such as macrophage polarization and smooth muscle cell proliferation. Beyond atherosclerosis, these mediators are implicated in the pathogenesis of other inflammatory diseases, including sarcoidosis and Alzheimer's disease. …”
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Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats by Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying

“…Immunohistochemistry and Western blotting were performed to observe changes in proteins related to pulmonary fibrosis (α-smooth muscle actin (α-SMA) and matrix metalloproteinase 12 (MMP12)) and autophagy (P62 and mechanistic target of rapamycin (mTOR)). …”
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SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration by Zhen-Zhen Guo, Qun-An Cao, Zong-Zhuang Li, Li-Ping Liu, Zhi Zhang, Ya-Juan Zhu, Guang Chu, Qiu-Yan Dai

“…In vitro, nicotine induced the expression of MCP-1 and RANTES in both RAW264.7 (mouse macrophage) and MOVAS (mouse vascular smooth muscle) cells in a dose-dependent manner; expression was upregulated by 0.5 ng/mL nicotine but strongly downregulated by 500 ng/mL nicotine. …”
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Diet Supplementation Influences Ghrelin System Expression in the Skin Appendages of the Sheep by Margherita Maranesi, Cecilia Dall’Aglio, Sara Moscatelli, Elisa Palmioli, Paola Coliolo, Daniele Marini, Gabriella Guelfi, Paola Scocco, Francesca Mercati

“…Indeed, the ligand was localized in the hair follicles whereas the receptor was also observed in sweat glands and smooth muscle cells. The expression of both genes was significantly higher in the Exp group (3.6 and 2.9 folds respectively, <i>p</i> < 0.05) compared with the MxF group. …”
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Endoplasmic reticulum protein TXNDC5 modulates thyroid eye disease TGF-β1-induced myofibroblast transdifferentiation by Albert Y Wu, Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai

“…Moreover, TXNDC5 knockdown of attenuated TGFβ1 (5 ng/mL)-induced myofibroblast transdifferentiation and extracellular matrix protein upregulation whereas increasing TXNDC5 expression by a recombinant protein of TXNDC5 (rhTXNDC5) addition increased alpha smooth muscle actin, fibronectin and connective tissue growth factor protein expression.Conclusion In conclusion, targeting TXNDC5 may be a novel therapeutic approach against TGF-β1-induced myofibroblast transdifferentiation in TED orbital fibroblasts.…”
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