Rare Pathology Case Report: Low-Grade Endometrial Stromal Sarcoma Forming Sex Cord– and Endometrioid Gland–Like Differentiation in Metastatic Foci by Haneen Al-Maghrabi, Ghadeer Mokhtar, Jaudah Al-Maghrabi

“…LGESS may display variants of different morphologies such as smooth muscle, fibromyxoid, sex cord-like, and endometrioid-type gland differentiation. …”
Get full text

Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms by Bruno Amato, Rita Compagna, Maurizio Amato, Raffaele Grande, Lucia Butrico, Alessio Rossi, Agostino Naso, Michele Ruggiero, Stefano de Franciscis, Raffaele Serra

“…Evidences have shown the presence of multipotent stem cells (SCs) at sites of arterial aneurysms: they can differentiate into smooth muscle cells (SMCs) and are activated after residing in a quiescent state in the vascular wall. …”
Get full text

Intestinal permeability and contractility in murine colitis by M. E. van Meeteren, J. D. van Bergeijk, A. P. M. van Dijk, C. J. A. M. Tak, M. A. C. Meijssen, F. J. Zijlstra

“…The effect of pharmacologically induced smooth muscle relaxation and contraction on permeability was tested in vitro. …”
Get full text

Ovine Progressive Pneumonia: Diagnosis and Seroprevalence in the South of Sonora, Mexico by Mercedes Yannin Borquez Cuevas, Juan Francisco Hernández Chávez, Betsy Armenta Leyva, Jesús Raymundo Cedillo Cobián, Ramón Miguel Molina Barrios

“…The histopathological study showed that lymph follicular hyperplasia, interstitial pneumonia, and smooth muscle hyperplasia were presented. The serological test demonstrated specific antibodies against the Maedi-Visna virus, and PCR analysis demonstrated a positive outcome. …”
Get full text

Inflammatory Myofibroblastic Tumor of the Nasal Septum by Yuri Okumura, Kazuhiro Nomura, Takeshi Oshima, Atsuko Kasajima, Takahiro Suzuki, Eichi Ishida, Toshimitsu Kobayashi

“…Histological examination identified spindle cells with immunoreaction for vimentin, smooth muscle actin, and anaplastic lymphoma kinase (ALK), but not for desmin and cytokeratin. …”
Get full text

Perivascular Epithelioid Cell Tumor of the Ileum Presenting as Diverticulitis by Saime Unluoglu, Umit Bayol, Nilay Korkmaz, Bekir Ozenen, Fuat Ipekci, Emel Ebru Pala

“…Nearly all PEComas show immunoreactivity for both melanocytic (HMB45 and/or Melan-A) and smooth muscle (actin and/or desmin) markers. A 36-year-old male was admitted to the hospital with acut- abdomen. …”
Get full text

Low-grade mucinous neoplasm originating from intestinal duplication: a case report and review of the literature by Huihui Yin, Jie Yu, Yunzhao Chen

“…Abstract Background Low-grade mucinous neoplasms typically originate from the appendix and are characterized by a lining of low-grade mucus-secreting columnar epithelial cells and smooth muscle. However, atypical origins can occur, as demonstrated in this case report. …”
Get full text

Extramedullary Hematopoiesis in Uterine Leiomyoma Associated with Numerous Intravascular Thrombi by Xiaoyan Cui, Deniz Peker, Heather O. Greer, Michael G. Conner, Lea Novak

“…Microscopic examination revealed benign smooth muscle consistent with leiomyoma and numerous intravascular thrombi both with areas of EMH. …”
Get full text

Monitoring Detrusor Oxygenation and Hemodynamics Noninvasively during Dysfunctional Voiding by Andrew J. Macnab, Lynn S. Stothers, Babak Shadgan

“…However, as the function of the detrusor muscle depends on its vasculature and perfusion, the underlying causes of LUTS likely include abnormalities of detrusor oxygenation and hemodynamics, and available treatment options include agents thought to act on the detrusor smooth muscle and/or vasculature. Hence, near infrared spectroscopy (NIRS), an established optical methodology for monitoring changes in tissue oxygenation and hemodynamics, has relevance as a means of expanding knowledge related to the pathophysiology of BPH and potential treatment options. …”
Get full text

Can Primary Cardiac Myxofibrosarcoma Grow Quickly from Zero to a Size Leading to Left-Sided Heart Failure within 9 Months? by Levan Karazanishvili, Eduard Limonjiani

“…Immunohistochemistry showed positivity for Epithelial membrane antigen (EMA), desmin, calretinin, Ki67, Smooth Muscle Actin (SMA), and S100. Given the rarity of cardiac malignant tumors, we thought preoperatively that this particular tumor could be a myxoma although it did not have the classical attachment point with a stalk at the interatrial septum. …”
Get full text

Intestinal Schwannoma: A Clinicopathological, Immunohistochemical, and Prognostic Study of 9 Cases by Zhenbo Shu, Chunsheng Li, Mingze Sun, Zhongmin Li

“…Immunohistochemical analysis showed that the tumor cells were positive for S-100 and negative for CD117, DOG-1, desmin, and smooth muscle actin. An average of 17 lymph nodes were found around the intestines in 4 patients, all of which demonstrated reactive hyperplasia. …”
Get full text

Coronary Artery Spasm: New Insights by Anthony Matta, Frederic Bouisset, Thibault Lhermusier, Fran Campelo-Parada, Meyer Elbaz, Didier Carrié, Jerome Roncalli

“…Multiple mechanisms such as the autonomic nervous system, endothelial dysfunction, chronic inflammation, oxidative stress, and smooth muscle hypercontractility are involved. Regardless of the limited benefits proffered by the newly emerged cardiac imaging modalities, the provocative test remains the cornerstone diagnostic tool for CAS. …”
Get full text

Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis by Rui-Qi Wei, Wen-Mei Zhang, Zhe Liang, Chunmei Piao, Guangfa Zhu

“…Significant KEGG pathway enrichment included ribosome biogenesis in eukaryotes, RNA transport, proteoglycans in cancer, dilated cardiomyopathy, rheumatoid arthritis, vascular smooth muscle contraction, focal adhesion, regulation of the actin cytoskeleton, and hypertrophic cardiomyopathy. …”
Get full text

Effects of Renal Denervation on Ouabain-Induced Hypertension in Rats by Minna Tang, Jialu Hu, Wenshu Li, Ningzhi Zhang, Sisi Ning, Yan Yan, Zhaoqiang Cui

“…RDN could inhibit the pressor effect and the myocardial remodeling induced by ouabain potentially via inhibiting catecholamine release and vascular smooth muscle cell proliferation. Clinical studies are needed to explore whether RDN may exhibit better antihypertensive effects on hypertensive patients with high plasma ouabain levels as compared to those with normal plasma ouabain levels.…”
Get full text

The Use of Regenerative Medicine in the Management of Invasive Bladder Cancer by Matthew E. Hyndman, Deborah Kaye, Nicholas C. Field, Keith A. Lawson, Norm D. Smith, Gary D. Steinberg, Mark P. Schoenberg, Trinity J. Bivalacqua

“…Clinical trials using neourinary conduits (NUC) seeded with autologous smooth muscle cells are currently in progress and may represent a significant surgical advance, potentially eliminating the complications associated with the use of gastrointestinal segments in the urinary reconstruction, simplifying the surgical procedure, and greatly facilitating recovery from cystectomy.…”
Get full text

A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice by Lifang Sun, Minjie Mao, Zhisheng Yan, Cuiyun Zuo, Xiaojie Zhang

“…Western blotting and real-time quantitative PCR were performed to determine the abundance of inducible nitric oxide synthase (iNOS), connective tissue growth factor (CTGF), alpha smooth muscle actin (α-SMA), and fibronectin (FN). In the present study, Qingfei Xieding administration significantly attenuated bleomycin-induced pulmonary fibrosis in mice by reducing lung coefficient, wet/dry, NO, HYP, and MDA as well as the expression of iNOS, CTGF, α-SMA, FN, and DNA damage. …”
Get full text

Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling by Preeti Dubey, Yingye Fang, K. Lionel Tukei, Shobhan Kuila, Xinming Liu, Annika Sahota, Antonina I. Frolova, Erin L. Reinl, Manasi Malik, Sarah K. England, Princess I. Imoukhuede

“…To address this, we developed a mathematical model examining the effects of five OXT receptor (OXTR) variants (V45L, P108A, L206V, V281M, and E339K) on OXT–OXTR binding dynamics in human embryonic kidney cells (HEK293T) and myometrial smooth muscle cells. The model was parameterized using experimentally derived, cell-specific OXTR surface localization measurements and literature-reported OXT-OXTR-binding kinetics. …”
Get full text

Morphology of the Myoepithelial Cell: Immunohistochemical Characterization from Resting to Motile Phase by Germana Beha, Giuseppe Sarli, Barbara Brunetti, Francesco Sassi, Domenico Ferrara, Cinzia Benazzi

“…Cytokeratin 19 (CK19), cytokeratin 5/6 (CK5/6), cytokeratin 14 (CK14), estrogen receptor (ER), p63 protein, vimentin (VIM), and α-smooth muscle actin (Alpha-SMA) antibodies were used on 29 neoplasms (3 benign and 3 malignant myoepithelial tumors, 7 carcinomas in benign-mixed tumors and 16 complex carcinomas) and on normal tissue of mammary glands. …”
Get full text

Androgenic Anabolic Steroids Cause Thiol Imbalance in the Vascular Endothelial Cells by Halszka Ponamarczuk, Maria Światkowska, Marcin Popielarski

“…Conclusions: These changes may be related to a thiol-disulfide imbalance and vascular endothelium dysfunction, that are often correlated with abnormal platelet aggregation, inflammation, increased vascular permeability, and vascular smooth muscle cell proliferation—all of which are observed in athletes who abuse AASs.…”
Get full text

Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression by Jie Qi, Jianguo Cui, Baobin Mi, Xiaohong Yan, Wenwen Xu, Hui Ma, Qingtan Zhang, Fang Xu

“…In this study, we used apolipoprotein E (ApoE) knockout mouse model and angiotensin II- (Ang II-) stimulated vascular smooth muscle cells (VSMCs) to elucidate the pharmacological mechanism of ISL to inhibit atherosclerosis. …”
Get full text