Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases by Partho Protim Adhikary, Temilolu Idowu, Zheng Tan, Christopher Hoang, Selina Shanta, Malti Dumbani, Leah Mappalakayil, Bhuwan Awasthi, Marcel Bermudez, January Weiner, Dieter Beule, Gerhard Wolber, Brent DG Page, Sarah Hedtrich

Subjects: Get full text

A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation by Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, Huali Li, Xingyan Pan, Feng Shu, Kun Zhang, Chengmei Huang, Na Tang, Wenting Liao

Subjects: Get full text

Discovery of novel and highly potent small molecule inhibitors targeting FLT3-ITD for the treatment of acute myeloid leukemia using structure-based virtual screening and biological... by Kun Shi, Kun Shi, Ye Hong, Ye Hong, Ye Hong, Huajing Liu, Xiaotian Yang, Fengzhen Wang, Fengzhen Wang, Yanming Zhang

Subjects: Get full text

KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET‐expressing tumor cells by Dominic Leiser, Michaela Medová, Kei Mikami, Lluís Nisa, Deborah Stroka, Andree Blaukat, Friedhelm Bladt, Daniel M. Aebersold, Yitzhak Zimmer

Subjects: Get full text

Research progress on tofacitinib in the treatment of chronic actinic dermatitis by WU Hui, SHEN Haojia, HE Zezhi, CHEN Jiaoquan, LI Runxiang, ZHU Huilan

Subjects: Get full text

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions by Mohammed Alrouji, Kumar Venkatesan, Mohammed S. Alshammari, Fahad A. Alhumaydhi, Sheeba Shafi, Sharaf E. Sharaf, Moyad Shahwan, Anas Shamsi

Subjects: Get full text

Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2) by Jane Foo, Francesco Gentile, Shabnam Massah, Helene Morin, Kriti Singh, Joseph Lee, Jason Smith, Fuqiang Ban, Eric LeBlanc, Robert Young, Natalie Strynadka, Nada Lallous, Artem Cherkasov

Subjects: Get full text

Unveiling the Anti-Angiogenic Potential of Small-Molecule (Kinase) Inhibitors for Application in Rheumatoid Arthritis by Fatemeh Khodadust, Eva M. L. Philippon, Maarten M. Steinz, Jan Piet van Hamburg, Johan van Meerloo, Judy R. van Beijnum, Gerrit Jansen, Sander W. Tas, Conny J. van der Laken

Subjects: Get full text

Identification of Potential Inhibitors of Histone Deacetylase 6 Through Virtual Screening and Molecular Dynamics Simulation Approach: Implications in Neurodegenerative Diseases by Anas Shamsi, Moyad Shahwan, Azna Zuberi, Nojood Altwaijry

Subjects: Get full text

Novel small molecule-based acetylcholinesterase (AChE) inhibitors: From biological perspective to recent developments by Anjali Sobha, Anand Ganapathy, Sangeetha Mohan, Nithya Madhusoodanan, Alansheeja D. Babysulochana, Kumaran Alaganandan, Sasidhar B. Somappa

Subjects: Get full text

Identification of potential inhibitors of Ubiquitin carboxyl-terminal hydrolase 21 from repurposed drugs: Implications in anticancer therapeutics by Anas Shamsi, Nojood Altwaijry, Moyad Shahwan, Akram Ashames, Dharmendra Kumar Yadav, Mohammad Furkan, Rizwan Hasan Khan

Subjects: Get full text

Editorial: Exploring small molecule inhibitors in cardiovascular and cerebrovascular diseases by Basveshwar Gawali, Shweta Shrivastava, R. Uday Kumar, Satyendra Kumar Rajput, Manish Kumar Jeengar

Subjects: “…small molecule inhibitors…”
Get full text

Unravelling the druggability and immunological roles of the SOCS-family proteins by Dylan M. Lynch, Beth Forrester, Thomas Webb, Alessio Ciulli

Subjects: Get full text

Interference of small compounds and Mg2+ with dsRNA-binding fluorophores compromises the identification of SARS-CoV-2 RdRp inhibitors by Susana Llanos, Bruno Di Geronimo, Ester Casajús, Elena Blanco-Romero, Rafael Fernández-Leiro, Juan Méndez

Subjects: Get full text