Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation by Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d’Azzo

“…When Neu1 is deficient/downregulated, Trem2-FL remains sialylated, accumulates intracellularly, and is excessively cleaved into a C-terminal fragment (Trem2-CTF) and an extracellular soluble domain (sTrem2), enhancing their signaling capacities. Sialylated Trem2-FL (Sia-Trem2-FL) does not hinder Trem2-FL-DAP12-Syk complex assembly but impairs signal transduction through Syk, ultimately abolishing Trem2-dependent phagocytosis. …”
Get full text

TIKROVĖS POSTMODERNIOS GRIMASOS by Audronė Žukauskaitė

“…Judith'os Butler ir Charles'o Shepherdsono kritika atskleidė Žižeko pozicijos prieštaringumą: net jei teigiame, jog tikrovė sukuria diskurso ribas, šias ribas galime aptikti tik remdamiesi diskursyviomis praktikomis. …”
Get full text

Sicurezza, qualità e continuità delle cure in ambito chirurgico: analisi sul processo di handover infermieristico by Domenico Lombardi Fortino, Patrizia Santoiemma, Giovanni Lagalla, Flavia Carle

“…Lo studio ha inoltre identificato informazioni specifiche ritenute essenziali dagli infermieri sia per le fasi pre-operatorie che post-operatorie.  …”
Get full text

Changes in Chemical Composition, Sources, and Health Risk of PM2.5 with Sand Storm at a Small City in North China by Jihong Wei, Ting Hou, Zhiyong Li, Songtao Guo, Zhenxin Li

“…Seven sources including construction dust (CD), biomass burning (BB), secondary inorganic aerosols (SIA), industrial emissions (IN), vehicle emissions (VE), coal combustion (CC), and soil dust (SD) were recognized by positive matrix factorization (PMF) model. …”
Get full text

Le mutilazioni genitali femminili e l’ostetrica: uno studio osservazionale tra formazione e competenza by Chaymae Ahnou, Rosanna De Serio, Chiara Gatti, Fabia Pioli, Gloria D'Angelo, Tania Miconi, Renato Rocchi, Stefano Marcelli

“…Lo studio evidenzia come le ostetriche possano non essere adeguatamente preparate da parte delle Università ad affrontare casi di mutilazioni genitali femminili, nonostante sia un fenomeno in aumento, anche a causa della situazione migratoria in Italia. …”
Get full text

Le pratiche turistiche dell’infanzia: una prospettiva rinnovata ? by Fiorella Dallari, Alessia Mariotti

“…Le pratiche turistiche dell’infanzia e dell’adolescenza costituiscono un tema trascurato nella ricerca turistica, sebbene la traiettoria di vita sino ai 17/18 anni sia da considerarsi importante per l’impatto psicologico e sociale nella formazione della soggettività. …”
Get full text

ETIKOS PAGRINDIMO PROBLEMA POSTMODERNIOJOJE KULTŪROJE by Jūratė Micevičiūtė

“…Ispanė A. Cortina papildė šią teoriją svarstymu apie praktinį jos pritaikomumą - minimumų etikų samprata. …”
Get full text

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China by Chunting Zhou, Wei Song, Zhiying Yin, Sheng Li, Xiaoying Gong, Quanjun Fang, Shuangqing Wang

“…The mumps incidence significantly declined following the introduction of one-dose MMR. The SIA using MM led to a rapid reduction of mumps cases. …”
Get full text

ETIKOS PAGRINDIMO PROBLEMA POSTMODERNIOJOJE KULTŪROJE by Jūratė Micevičiūtė

“…Ispanė A. Cortina papildė šią teoriją svarstymu apie praktinį jos pritaikomumą - minimumų etikų samprata. …”
Get full text

WINTER HARDINESS OF BREAD WHEAT FROM THE VIR COLLECTION IN ENVIRONMENTS OF THE NORTHWESTERN AND CENTRAL BLACK SOIL REGIONS OF RUSSIA by N. S. Lysenko, V. F. Loseva, O. P. Mitrofanova

“…In 2006/2007, in Pushkin, a high and a very high degree of winter hardiness was displayed by 114 accessions with the origin from Rus­sia and the former USSR as well as by 12 accessions from foreign countries. …”
Get full text

Stature estimation and sex determination from contemporary Northeastern Thai clavicles using discriminant function and linear regression analyses by Chanasorn Poodendaen, Poonikha Namwongsakool, Sitthichai Iamsaard, Nareelak Tangsrisakda, Rarinthron Samrid, Chadaporn Chaimontri, Worrawit Boonthai, Suthat Duangchit

“…Materials and method: Four hundred dry clavicles (200 males, 200 females) identified for sex and height before body donation were measured for six standardized parameters including maximum length of clavicle (MaxL), anterior-posterior width at the acromion end surface (APA), anterior-posterior width at the sternal end surface (APS), superior-inferior width at the acromion end surface (SIA), superior-inferior width at the sternal end surface (SIS), and circumference at the mid-shaft of clavicle (CirMid), respectively. …”
Get full text

Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy by Jian Cheng, Miaomiao Sun, Xiao Dong, Yang Yang, Xiaohan Qin, Xing Zhou, Yongcheng Fu, Yuanyuan Wang, Jingyue Wang, Da Zhang

“…Additionally, SLC1A5 negatively regulated ST8SIA1, a gene crucial for GD2 biosynthesis, suggesting that SLC1A5 inhibition may enhance GD2-directed immunotherapies. …”
Get full text

Poutníci a jejich peníze na cestě do Říma. Zamyšlení nad edicí Il Libro del pellegrino (Siena, 1382–1446) by Roman Zaoral

“…Seven pilgrims from the lands of the Bohemian Crown are mentioned in the entries from 1384–1433: two come from Bohemia, four from Moravia and one from Sile- sia. Further two other pilgrims with an ambiguous geographic assignment seem to be con- sidered. …”
Get full text

COMPETENZE CHIAVE PER IL CURRICOLO VERTICALE: L’OPINIONE DEGLI INSEGNANTI E I MATERIALI DIDATTICI by Matteo La Grassa, Monica Barni

“…In questo contributo si presentano i primi risultati di una indagine qualitativa, condotta in istituti scolastici della Toscana, che ha inteso verificare quale conoscenza e quale importanza sia data in ambito educativo alle Competenze chiave per l’apprendimento permanente descritte dalla Raccomandazione europea del 2006 e aggiornate dalla Raccomandazione del 2018 e se è presente all’interno di scuole una progettualità sistematica su tali competenze e se siano date le condizioni per un loro effettivo sviluppo in ottica verticale e trasversale alle varie discipline.  …”
Get full text

Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy by Hanyu Zhu, Moyan Liu, Hanjie Yu, Xiawei Liu, Yaogang Zhong, Jian Shu, Xinle Fu, Guangyan Cai, Xiangmei Chen, Wenjia Geng, Xiaoli Yang, Minghui Wu, Zheng Li, Dong Zhang

“…The results showed that expression levels of Siaα2-6Gal/GalNAc recognized by SNA exhibited significantly increased tendency with the development of diabetic nephropathy; moreover, SNA blotting indicated glycoproteins (90 kDa, 70 kDa, and 40 kDa) in urine may contribute to this alteration. …”
Get full text

Assessment of the southern polar and subpolar warming in the PMIP4 last interglacial simulations using paleoclimate data syntheses by Q. Gao, Q. Gao, Q. Gao, E. Capron, L. C. Sime, R. H. Rhodes, R. Sivankutty, X. Zhang, B. L. Otto-Bliesner, M. Werner

“…The hosed 128 ka HadCM3 simulation captures much of the warming and sea ice loss shown in the four data syntheses at 127 ka relative to preindustrial: south of 40° S, modeled annual sea surface temperature (SST) rises by 1.3 <span class="inline-formula">±</span> 0.6 °C, while reconstructed average anomalies range from 2.2 to 2.7 °C; modeled summer SST increases by 1.1 <span class="inline-formula">±</span> 0.7 °C, close to the 1.2–2.2 °C reconstructed average anomalies; September sea ice area (SIA) is reduced by 40 <span class="inline-formula"><i>%</i></span>, similar to the reconstructed 40 <span class="inline-formula">%</span> reduction of sea ice concentration (SIC); over the Antarctic Ice Sheet, modeled annual surface air temperature (SAT) increases by 2.6 <span class="inline-formula">±</span> 0.4 °C, even larger than reconstructed average anomalies of 2.2 °C. …”
Get full text

COLLABORAZIONE INTERPROFESSIONALE E ORGANIZZAZIONE SANITARIA: uno studio esplorativo sulle sfide e opportunità per i professionisti della riabilitazione. by Simone Sottana, Andrea Vianello, Matteo Tognin, Deborah Mazzarotto, Marco Ceccato, Daria Visintin, Riccardo Martignon, Francesca Magaton Rizzi, Noemi Pasquon, Lucia Savietto

“…Tuttavia, mancano studi dettagliati che esplorino come la collaborazione interprofessionale sia percepita e attuata in Italia, lasciando un significativo vuoto nella letteratura e presentando numerose opportunità per future ricerche. …”
Get full text

Levels, Chemical Compositions, and Sources of PM2.5 of Rural and Urban Area under the Impact of Wheat Harvest by Zhiyong Li, Ziyuan Yue, Dingyuan Yang, Lei Wang, Xin Wang, Zhenxin Li, Yutong Wang, Lan Chen, Songtao Guo, Jinsong Yao, Xiao Lou, Xiaolin Xu, Jinye Wei

“…., coal combustion (CC), vehicle exhaust (VE), industrial sources (ISs), biomass burning (BB), secondary inorganic aerosol (SIA), and fugitive dust (FD). FD dominated ARS during DWH and exhibited an increase at UA during AWH, and the contribution of BB at both sites rose between DWH and AWH, which can be ascribed to the burning of biomass for maize planting. …”
Get full text

Zeydîyye Mezhebi, İmamet Anlayışı ve Sahabe Hakkındaki Görüşleri by Mehmet Ümit

“…Zeydiyye, Şia’nın Ehl-i Sünnet’e en yakın kolu olup, sahâbe hakkındaki görüşleri imâmet anlayışları çerçevesinde şekillenmiştir. …”
Get full text

Çağdaş Nusayrî Şeyhlerinin Eserlerinde Tanrı Tasavvuru ve Hz. Ali Algısı by Mehmet Kubat, Mehmet Hanifi Yoldaş

“…Bu iddiaya mukabil hem mutedil Şiî fırka tarihçileri hem de Ehl-i sünnete mensup İslâm mezhepleri tarihçileri Nusayrîliği Şîa’nın gulât fırkalarından saymakta ve İslâm dairesi dışında kabul etmektedirler. …”
Get full text