Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases by Leilei Chen, Qingqing Shen, Yingjuan Liu, Yunqi Zhang, Liping Sun, Xizhen Ma, Ning Song, Junxia Xie

“…However, an imbalance in metal ions, whether excessive or insufficient, is detrimental and can contribute to neuronal death through oxidative stress, ferroptosis, cuproptosis, cell senescence, or neuroinflammation. These processes have been found to be involved in the pathological mechanisms of neurodegenerative diseases. …”
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Iron metabolism in rheumatic diseases by Aliakbar Givian, Amin Azizan, Ahmadreza Jamshidi, Mahdi Mahmoudi, Elham Farhadi

“…Altered iron homeostasis can contribute to disease progression through ROS production, fibrosis, inflammation, abnormal bone homeostasis, NETosis and cell senescence. In this review, we have focused on the iron metabolism in rheumatic disease and its role in disease progression.…”
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Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? by Claus Desler, Thomas Lau Hansen, Jane Bruun Frederiksen, Maiken Lise Marcker, Keshav K. Singh, Lene Juel Rasmussen

“…If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. …”
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Mitochondrial quality control: a pathophysiological mechanism and potential therapeutic target for chronic obstructive pulmonary disease by Mengjiao Xu, Peng Feng, Peng Feng, Jun Yan, Lei Li

“…Mitochondrial dysfunction plays a pivotal role in the pathogenesis of COPD, contributing toinflammatory response, oxidative stress, cellular senescence. However, therapeutic strategies targeting mitochondria remain underexplored. …”
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scCamAge: A context-aware prediction engine for cellular age, aging-associated bioactivities, and morphometrics by Vishakha Gautam, Subhadeep Duari, Saveena Solanki, Mudit Gupta, Aayushi Mittal, Sakshi Arora, Anmol Aggarwal, Anmol Kumar Sharma, Sarthak Tyagi, Rathod Kunal Pankajbhai, Arushi Sharma, Sonam Chauhan, Shiva Satija, Suvendu Kumar, Sanjay Kumar Mohanty, Juhi Tayal, Nilesh Kumar Dixit, Debarka Sengupta, Anurag Mehta, Gaurav Ahuja

“…Finally, we enhanced the generalizability of scCamAge by retraining it on human fibroblast senescence datasets, which improved its ability to predict senescent cells.…”
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Analysis of stomatal characteristics of maize hybrids and their parental inbred lines during critical reproductive periods by Changyu Zhang, Changyu Zhang, Yu Jin, Yu Jin, Jinglu Wang, Jinglu Wang, Ying Zhang, Ying Zhang, Yanxin Zhao, Xianju Lu, Xianju Lu, Wei Song, Xinyu Guo, Xinyu Guo

“…Throughout the growth cycle, stomatal density remained stable during vegetative growth, decreased during reproductive growth with smaller size and narrower shape, and continued to decline while increasing in size and tending towards a rounded shape during senescence. Remarkably, hybrid 728 differed notably from its parents in stomatal phenotype, particularly during senescence. …”
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Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration by Peisheng Liu, Hao Guo, Xiaoyao Huang, Anqi Liu, Ting Zhu, Chenxi Zheng, Fei Fu, Kaichao Zhang, Shijie Li, Xinyan Luo, Jiongyi Tian, Yan Jin, Kun Xuan, Bingdong Sui

“…However, the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive. …”
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Feline Neural Progenitor Cells I: Long-Term Expansion under Defined Culture Conditions by Jing Yang, Jinmei Wang, Ping Gu, X. Joann You, Henry Klassen

“…Cells in standard DMEM/F12-based medium ceased to proliferate by 1-month, whereas the cells in the Ultraculture-based medium continued to grow for at least 5 months (end of study) with no evidence of senescence. The Ultraculture-based cultures expressed lower levels of progenitor and lineage-associated markers under proliferation conditions but retained multipotency as evidenced by the ability to differentiate into neurons and glia following growth factor removal in the presence of FBS. …”
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Cell-marking techniques for cell lineage tracing by A. M. Yunusova, N. R. Battulin

“…Most adult tissues are maintained by a combination of highly dynamic processes of senescence, apoptosis and rejuvenation with new cells constantly arising from dispersed depots of stem cells. …”
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Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model by Samuel de Mattos Alves, Paulo Noronha Lisboa-Filho, Carolina Letícia Zilli Vieira, Marina Piacenti-Silva

“…In addition to genetic background, endocrine disruption, and cellular senescence, management of the gut microbiota has emerged as a key element in the diagnosis, progression, and treatment of AD, as certain bacterial metabolites can travel through the bloodstream and cross the blood-brain barrier. …”
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Secretion of One Adipokine Nampt/Visfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells by Yi-Ching Lin, Hui-Chung Wu, Chen-Chung Liao, Yi-Chih Chou, Shwu-Fen Pan, Chi-Ming Chiu

“…Nampt/visfatin acts in both intracellular and extracellular compartments to regulate multiple biological roles, including NAD metabolism, cancer, inflammation, and senescence. However, its function in chronic inflammation and carcinogenesis in hepatocellular carcinoma (HCC) has not been well-defined. …”
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Organophosphorus Nerve Agents: Types, Toxicity, and Treatments by Sudisha Mukherjee, Rinkoo Devi Gupta

“…The current research on the promising treatments specifically the catalytic bioscavengers including several wild-type organophosphate hydrolases such as paraoxonase and phosphotriesterase, phosphotriesterase-like lactonase, methyl parathion hydrolase, organophosphate acid anhydrolase, diisopropyl fluorophosphatase, human triphosphate nucleotidohydrolase, and senescence marker protein has been widely discussed. …”
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Development of a spontaneous model of renal interstitial fibrosis in NOD/SCID mice: Aging-induced pathogenesis. by Lihua Qiu, Zhaoxia Ma, Jinyan Li, Zhen Wu, Longmei Dai, Ruimin Long, Linlin Hu, Jianxiu Sun, Min Hu, Yanjiao Li

“…SA-β-gal activity and P21 gene expression levels increased, confirming renal cell senescence in the model mice. Additionally, an increase in α-SMA staining indicated an increase in epithelial-mesenchymal transition. …”
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Estimation of Phenology Stages of Rapeseed Using Remote Sensing Vegetation Indices and Digital Camera Images Index by Akbar Mirahmadi, Hojjatollah Yazdan Panah, Mehdi Momeni

“…The results showed that the curves obtained from the indices of NDVI, EVI, GCC show all four stages of remote sensing phenology – green-up, dormancy, maturity, and senescence - well, but the Greenness index did not show the dormancy stage well. …”
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Immune aging and infectious diseases by Ruochan Chen, Ju Zou, Jiawang Chen, Ling Wang, Rui Kang, Daolin Tang, Sihan Zhou, Xiuyuan Hao

“…These changes would impair defense mechanisms, increase susceptibility to infections and reduce vaccine efficacy in older adults. Cellular senescence exacerbates these issues by releasing pro-inflammatory factors, further perpetuating chronic inflammation. …”
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An Evaluation of the Effects of Delayed Parasitism on Daily and Lifetime Fecundity of <i>Aphidius ervi</i> Haliday by Vincenzo Trotta, Paolo Fanti, Roberto Rosamilia, Donatella Battaglia

“…Our results show how the parasitoid senescence is associated with the loss of reproductive capacity, as the late field release of parasitoids reduces their total parasitism. …”
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The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review by Lize Evens, Hanne Beliën, Dorien Deluyker, Annelies Bronckaers, Pascal Gervois, Marc Hendrikx, Virginie Bito

“…AGEs are also endogenously formed in our body and accumulate with senescence and in pathological situations. Whether AGEs have an impact on stem cell viability in regenerative medicine remains unclear, and research on the effect of AGEs on stem cell proliferation and apoptosis is still ongoing. …”
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Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors by Jeong-Kee Yoon, Mi-Lan Kang, Joo Hyun Park, Kyoung-Mi Lee, Young Min Shin, Jin Woo Lee, Hyun Ok Kim, Hak-Joon Sung

“…However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. …”
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Postharvest Analysis of Lowland Transgenic Tomato Fruits Harboring hpRNAi-ACO1 Construct by Bita Behboodian, Zainon Mohd Ali, Ismanizan Ismail, Zamri Zainal

“…The plant hormone, ethylene, is an important regulator which involved in regulating fruit ripening and flower senescence. In this study, RNA interference (RNAi) technology was employed to silence the genes involved in ethylene biosynthetic pathway. …”
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Plant traits, growth stage, and ash mass load control the vulnerability of potato, corn, and wheat crops to volcanic ashfall by Noa Ligot, Lauriane Barthélemi, Hugues Falys, Bruno Godin, Patrick Bogaert, Pierre Delmelle

“…Distinct impact mechanisms were identified for each crop, including premature flower abscission, irreversible leaf yellowing, desiccation and senescence, and stalk lodging. Exposure of potato, corn, and wheat plants to ash mass loads >1 kg m−2 significantly reduced yield, but production quality was largely unaffected. …”
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