ALTERNATIVES FOR PSYCHOLOGICAL ILLNESS TREATMENT AND PREVENTION IN MALAYSIA FROM THE PERSPECTIVE OF SHARIAH by Muneer Ali Abdul Rab, Abdul Manan Ismail, Hamidin Awang, Mesbahul Hoque, Nasser Ahmad Aljabri, Abdullah Ali Salim AlShibli

“… Scientific studies have revealed that a large percentage of Malaysian society suffers from psychological disorders such as depression, anxiety, stress, schizophrenia and others, which is the biggest health problem among Malaysians after heart disease. …”
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A Qualitative Study Exploring Facilitators for Improved Health Behaviors and Health Behavior Programs: Mental Health Service Users’ Perspectives by Candida Graham, Crystal Rollings, Sarah de Leeuw, Lesley Anderson, Brenda Griffiths, Nansi Long

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Prospective cohort study of the evaluation of patient benefit from the redevelopment of a complete national forensic mental health service: the Dundrum Forensic Redevelopment Evalu... by Harry G Kennedy, Mary Davoren, Ken O’Reilly, Damian Mohan

“…Patients will be rated for physical health, mental health, offending behaviours and other recovery measures relevant to the forensic hospital setting at admission to the hospital and 6 monthly thereafter.Lagged causal model analysis will be used to assess the existence and significance of potential directed relationships between the baseline measures of symptomatology of schizophrenia and violence risk and final outcome namely length of stay. …”
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The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes by Yuanyuan Gui, Geyu Zhou, Shuya Cui, Hongyu Li, Hui Lu, Hongyu Zhao

“…We identified sex-differentiated genetic effects of PRSs for schizophrenia on left amygdala volume, as well as significant sex-differentiated genetic correlations between PRSs of left amygdala and six traits in UKB. …”
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A novel machine learning methodology for the systematic extraction of chronic kidney disease comorbidities from abstracts by Eszter Sághy, Mostafa Elsharkawy, Frank Moriarty, Sándor Kovács, István Wittmann, Antal Zemplényi, Antal Zemplényi

“…The reading of the ML-selected abstracts showed that some diseases have direct causal effect on CKD, while others, like schizophrenia, has indirect causal effect on CKD.InterpretationThese findings have the potential to guide future CKD investigations, by facilitating the inclusion of a broader array of comorbidities in CKD prognostic models. …”
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Quality, topics, and demographic trends of animal systematic reviews - an umbrella review by Bernard Friedrich Hild, David Brüschweiler, Sophia Theodora Katharina Hild, Julia Bugajska, Viktor von Wyl, Marianna Rosso, Kimberley Elaine Wever, Eva Furrer, Benjamin Victor Ineichen

“…These reviews commonly focus on translational research but with notable topical gaps such as schizophrenia, other psychiatric disorders, and brain tumours. …”
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Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives by Pablo Olivero, Carlo Lozano, Ramón Sotomayor-Zárate, Nicolás Meza-Concha, Marcelo Arancibia, Claudio Córdova, Wilfredo González-Arriagada, Ricardo Ramírez-Barrantes, Ivanny Marchant

“…Thereby, altered mitochondrial functions on regulatory modulation of dendritic development, neuroinflammation, and respiratory function may underlie the development of some psychiatric conditions, such as schizophrenia, being influenced by a genetic background. …”
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The composition of peripheral immunocompetent cell subpopulations and cytokine content in the brain structures of mutant Disc1-Q31L mice by M. M. Gevorgyan, S. Ya. Zhanaeva, E. L. Alperina, T. V. Lipina, G. V. Idova

“…The DISC1 (disrupted in sсhizophrenia 1) gene is associated with brain dysfunctions, which are involved in a variety of mental disorders, such as schizophrenia, depression and bipolar disorder. This is the first study to examine the immune parameters in Disc1-Q31L mice with a point mutation in the second exon of the DISC1 gene compared to mice of the C57BL/6NCrl strain (WT, wild type). …”
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Prevalence and patient characteristics associated with cardiovascular disease risk factor screening in UK primary care for people with severe mental illness: an electronic healthca... by Robert Stewart, Ann John, Bruce Guthrie, Joseph F Hayes, David P J Osborn, Stewart William Mercer, Elvira Bramon, Naomi Launders, Caroline Anne Jackson, Matthew H Iveson

“…Background People with severe mental illness (SMI) are at increased risk of cardiovascular disease (CVD), and initiatives for CVD risk factor screening in the UK have not reduced disparities.Objectives To describe the annual screening prevalence for CVD risk factors in people with SMI from April 2000 to March 2018, and to identify factors associated with receiving no screening and regular screening.Methods We identified adults with a diagnosis of SMI (schizophrenia, bipolar disorder or ‘other psychosis’) from UK primary care records in Clinical Practice Research Datalink. …”
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Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6 by Danqing Yang, Guanxiao Qi, Daniel Delev, Uwe Maskos, Dirk Feldmeyer

“…Abstract Genetic variation in the α5 nicotinic acetylcholine receptor (nAChR) subunit of mice results in behavioral deficits linked to the prefrontal cortex (PFC). rs16969968 is the primary Single Nucleotide Polymorphism (SNP) in CHRNA5 strongly associated with nicotine dependence and schizophrenia in humans. We performed single cell-electrophysiology combined with morphological reconstructions on layer 6 (L6) excitatory neurons in the medial PFC (mPFC) of wild type (WT) rats, rats carrying the human coding polymorphism rs16969968 in Chrna5 and α5 knockout (KO) rats. …”
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COVID-19 in patients with severe mental illness: An analysis of in-patients at a psychiatric hospital in Cape Town by Haseena B. Sablay, Qhama Z. Cossie, Deirdre I. Pieterse

“…Most patients were diagnosed with schizophrenia (37%, n = 94), bipolar disorder (21%, n = 54) and schizoaffective disorder (19%, n = 49). …”
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Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthe... by Emily Eisner, Sophie Faulkner, Stephanie Allan, Hannah Ball, Daniela Di Basilio, Jennifer Nicholas, Aansha Priyam, Paul Wilson, Xiaolong Zhang, Sandra Bucci

“…Samples included people with schizophrenia spectrum psychosis (98/150, 65.3% of studies), bipolar disorder (62/150, 41.3% of studies), and clinicians (26/150, 17.3% of studies). …”
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Novel Electrochemiluminescence Sensor for Dopamine Detection Based on Perylene Diimide/CuO Nanomaterials by Qirong Tian, Xinyang Sun, Chuan Li, Lei Shang, Rongna Ma, Xiaojian Li, Liping Jia, Shuijian He, Qian Zhang, Wei Zhang, Huaisheng Wang

“…Dopamine (DA) is an important catecholamine neurotransmitter and its abnormal concentration is closely related to diseases such as hypertension, Parkinson’s disease and schizophrenia. Due to the advantages of high sensitivity and fast response for electrochemiluminescence (ECL), developing ECL sensors for detecting DA was very critical in clinical diagnosis. …”
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Impact of non-participation bias due to psychiatric illness on mortality and cardiovascular event estimates: a Danish longitudinal population study by Christian Torp-Pedersen, Mads Rasmussen, Christina Ellervik, Anders Jorgensen, Henrik E Poulsen, Zerlina Rygner

“…The most under-represented psychiatric disorders in participants were organic mental disorders (5.76 (3.90 to 8.48)), substance abuse (3.12 (2.14 to 4.54)) and schizophrenia (3.12 (2.33 to 4.18)). Overall, more non-participants used psychotropic drugs than participants (1.26 (1.21 to 1.31)), and psychiatric non-participants had higher psychiatric hospital service utilisation than psychiatric participants. …”
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Sociodemographic, clinical, and other serological profile of opioid-dependent intravenous drug users infected with hepatitis C virus: A cross-sectional study by Piyush Mahajan, Malvika Dahuja, Manjit Singh, Medi Nagapadma, M Ramasubba Reddy

“…Bipolar disorder (46.7%), schizophrenia (33.3%), and personality disorders (6.7%) were common psychiatric illnesses seen in the studied cases. …”
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Factors Contributing to the Utilization of Adult Mental Health Services in Children and Adolescents Diagnosed with Hyperkinetic Disorder by Hilario Blasco-Fontecilla, Juan J. Carballo, Rebeca Garcia-Nieto, Jorge Lopez-Castroman, Analucia A. Alegria, Ignacio Basurte-Villamor, Juncal Sevilla-Vicente, Rocio Navarro-Jimenez, Teresa Legido-Gil, Consuelo Morant-Ginestar, Miguel Angel Jimenez-Arriero, Jeronimo Saiz-Ruiz, Enrique Baca-Garcia

“…Female gender and comorbidity with affective disorders, schizophrenia, schizotypal and delusional disorders increased the risk of use of AMHS. …”
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An experimental study of the effects of SNPs in the TATA boxes of the <i>GRIN1, ASCL3</i> and <i>NOS1</i> genes on interactions with the TATA-binding protein by E. B. Sharypova, I. A. Drachkova, I. V. Chadaeva, M. P. Ponomarenko, L. K. Savinkova

“…For instance, these genes contribute to the development of schizophrenia, Alzheimer’s and Parkinson’s diseases, and epilepsy. …”
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Causal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization study by Wei Du, Biqiu Tang, Senhao Liu, Wenjing Zhang, Su Lui

“…Utilizing two-sample Mendelian randomization (MR) analysis, this study investigates the causal associations between iron level changes in 16 subcortical nuclei and eight major psychiatric disorders, including schizophrenia (SCZ), major depressive disorder (MDD), autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, bipolar disorder, anxiety disorders, obsessive-compulsive disorder, and insomnia. …”
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Effect of beetroot extract (beta vulgaris) against olanzapine on the pituitary, thyroid, and fertility in adult white male rats by Haleema Yousef ALNAHARY, Ghada L. TALEB, Naglaa Y. ABUZINADAH, Hanan Msaa AL JAMEI, Mariam ALGAMDI, Haneen Nasser AHMED, Hanan Abdulkarim SANGOUF, Anoud A. ALTHAGAFI

“…Olanzapine (OLZ) is a second-generation atypical drug that is commonly used to treat schizophrenia. However, it is known to affect male sexual functions, reproductive processes, and spermatogenesis. …”
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Impact of a Virtual Reality Intervention on Stigma, Empathy, and Attitudes Toward Patients With Psychotic Disorders Among Mental Health Care Professionals: Randomized Controlled Tr... by Jing Ling Tay, Yuanrong Qu, Lucas Lim, Rohan Puthran, Chye Lee Robert Tan, Rajkirren Rajendran, Ker Chiah Wei, Huiting Xie, Kang Sim

“…The evaluation included outcomes related to attitudes (modified attitudes toward people with schizophrenia scale), stigma (social distance scale, personal stigma scale), and empathy (empathetic concern subscale of the Interpersonal Reactivity Index). …”
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