Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation by Makenna Gargus, Benneth Ben-Azu, Benneth Ben-Azu, Antonia Landwehr, Jaclyn Dunn, Joseph P. Errico, Marie-Ève Tremblay, Marie-Ève Tremblay

“…Dysfunction of microglia, the resident innate immune cells of the brain, is associated with various neurodevelopmental disorders, including schizophrenia, attention deficit hyperactive disorder (ADHD), autism spectrum disorder (ASD), and epilepsy. …”
Get full text

Postictal Psychosis: Case Report and Literature Review by Joana Regala, João Lourenço, Francisco Moniz-Pereira, António Bento

“…Our case report describes a clinical picture of PIP, characterized by pleomorphic features, with neither Schneider’s first-rank symptoms nor negative symptoms of schizophrenia, in a longstanding epileptic female patient with a history of nonadherence to antiepileptic treatment and poorly controlled seizures. …”
Get full text

A Case of Probable Amisulpride Induced Mania after Eight Months of Therapy by Prakash Thapa, Rajasee Sharma

“…Here, we report the case of an 18-year-old male patient diagnosed with schizophrenia, who developed manic symptoms while on treatment with amisulpride. …”
Get full text

Squaring the Circle : the Extreme Left and the Labour Party by Jeremy Tranmer

“…Even though most sections of the far left have put an end to their political schizophrenia by opting for an independent stance, this decision has not led to a change in its fortunes.…”
Get full text

Transcranial Magnetic Stimulation for the Treatment of Pharmacoresistant Nondelusional Auditory Verbal Hallucinations in Dementia by Anna Marras, Stefano Pallanti

“…Auditory verbal hallucinations (AVHs) are known as a core symptom of schizophrenia, but also occur in a number of other conditions, not least in neurodegenerative disorders such as dementia. …”
Get full text

Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches by Abdul Qadir, Syed Umer Jan, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Fatima Ramzan Ali, Fahad Siddiqui, Abdul Jabbar Magsi, Ghulam Mustafa, Muhammad Talha Saleem, Shafi Mohammad, Mohammad Younis, Muhammad Arsalan

“…Abstract Clozapine is a potent serotonin receptor antagonist and commonly used for the treatment of Schizophrenia. The study aimed to develop and optimize the transdermal matrix patch of clozapine. …”
Get full text

Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators by Lulu Yao, Qiang Zhou

“…Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizophrenia, depression, and Alzheimer’s disease. Past efforts in targeting NMDARs for therapeutic intervention have largely been on inhibitors of NMDARs. …”
Get full text

Indian research on transcranial magnetic stimulation: A bibliometric analysis by Sangha Mitra Godi, Sai Krishna Tikka

“…The most researched diagnosis was schizophrenia. NIMHANS, Bengaluru, had the highest number of publications. …”
Get full text

Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist by Mahantesh Namdev Jadhav, Ganesh Rajendra Kokil, Shilpa Sudhakar Harak, Sanjay Baburao Wagh

“…Schizophrenia is a mental disorder manifested largely by disintegration of thought processes and emotional responsiveness. …”
Get full text

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent by Mitsuharu Hattori

“…However, in recent decades, its role in the adult brain has become increasingly important, and it is now clear that diminished Reelin function is involved in the pathogenesis and progression of neuropsychiatric and neurodegenerative disorders, including schizophrenia and Alzheimer’s disease (AD). Reelin activity is regulated at multiple steps, including synthesis, posttranslational modification, secretion, oligomerization, proteolytic processing, and interactions with extracellular molecules. …”
Get full text

Inflammatory Fibroid Polyp in a 48-Year-Old Male: A Rare Cause of Intussusception by Theresia Karuhanga, Caroline Ngimba, James J. Yahaya

“…Herein, we present a case of a 48-year-old male with a known history of schizophrenia who presented with mechanical intestinal obstruction following intussusception due to inflammatory fibroid polyp involving the proximal jejunojejunal part of the jejunum.…”
Get full text

Serum IL-1β, sIL-2R, IL-6, IL-8 and TNF-α in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment by Ayşe Binnur Erbağci, Hasan Herken, Oya Köylüoglu, Necat Yilmaz, Mehmet Tarakçioglu

“…Activation of the inflammatory response system and varied levels of cytokines in acute schizophrenia have been suggested by recent studies. …”
Get full text

N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth by Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D’Angelo, Larry J. Seidman, Sarah Gumlak, April Kim, Kristen A. Woodberry, Ashley Rober, Sahil Tembulkar, Kyle O’Donnell, Hesham M. Hamoda, Kara Kimball, Alexander Rotenberg, Lindsay M. Oberman, Alvaro Pascual-Leone, Matcheri S. Keshavan, Frank H. Duffy

“…Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease’s pathogenesis. …”
Get full text

Assessing the health implications of anticholinergic drugs in older people by Mariangela Boccardi, Virginia Boccardi

“…We propose practical guidelines for their use in clinical contexts such as dementia, schizophrenia, depression, anxiety, Parkinson’s disease, cardiovascular conditions, and urinary incontinence. …”
Get full text

Constrictive Pericarditis Associated with Atypical Antipsychotics by Kuan-chin Jean Chen, Aashish Goela, Patrick Teefy, L. Ray Guo

“…Pericarditis developed in our patient with a longstanding history of schizophrenia treated with atypical antipsychotics. Pericardiectomy was undertaken, and the patient's presenting symptom of shortness of breath resolved subsequently with an uneventful postoperative course.…”
Get full text

Pharma TARP: A Troubled Asset Relief Program for Novel, Abandoned Projects in the Pharmaceutical Industry by Tamas Bartfai, Graham Vaughan Lees

“…Society has a real need for the drugs that are no longer going to be developed for, among others, drug-resistant epilepsy, neuropathic and cancer pain, type-2 diabetes, obesity, and schizophrenia. The authors propose a radical response by the U.S. government and the National Institutes of Health to rescue these abandoned projects, and to continue selected programs for drug approval by the U.S. …”
Get full text

P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction by Segundo J. Guzman, Zoltan Gerevich

“…The findings discussed here may explain how P2Y1 receptor activation during brain injury, hypoxia, inflammation, schizophrenia, or Alzheimer’s disease leads to an impairment of cognitive processes. …”
Get full text

Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition? by T. A. Munshi, D. Volochniouk, T. Hassan, N. Mazhar

“…Clozapine is an atypical antipsychotic used for treatment resistant schizophrenia. Its potential to induce agranulocytosis is well known but it can also cause myocarditis. …”
Get full text

Comprehensive synthesis of mHealth interventions in psychiatry: insights from systematic, scoping, narrative reviews and content analysis by Zaakira Shahul Hameed Mahreen, Noor Azziah Zainuldin, Melvyn Weibin Zhang

“…Additionally, mHealth shows promise in managing substance use disorders and severe mental illnesses like schizophrenia, bipolar disorder and psychosis. Conclusion: Despite positive outcomes, challenges such as data privacy, user engagement and healthcare integration persist. …”
Get full text

Thiamine Deficiency in Self-Induced Refeeding Syndrome, an Undetected and Potentially Lethal Condition by Einat Hershkowitz, Alon Reshef, Olga Munich, Bracha Yosefi, Arie Markel

“…We describe a 25-years-old female patient with mental disorders and severe malnutrition who developed severe clinical manifestations and biochemical abnormalities characteristic of the refeeding syndrome, after restarting oral feeding on her own. Schizophrenia was later diagnosed. Increased awareness of this condition and its complications is necessary to prevent its detrimental complications.…”
Get full text