A study of relationship between cardiac exposure dose-volume and cardiovascular autonomic dysfunction in radiotherapy by CHEN Hongyu, SU Pengyu, LUO Wenzi, PANG Dequan, WANG Feiran

“…Research indicates that after adjusting for age, gender and cardiovascular risk factors, previous radiation exposure is associated with AD manifestations such as increased resting heart rate and abnormal heart rate recovery after exercise. …”
Get full text

Toxoplasma gondii in dromedary camels (Camelus dromedarius) in Egypt: a comparative seroepidemiological study in Upper and Lower Egypt by Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy, Nady Khairy Elbarbary, David Cano-Terriza, David Cano-Terriza, Tomás Fajardo, Nada Oudah Albalawi, Débora Jiménez-Martín, Marwa M. I. Ghallab, Ahmed Gareh, Refaat Ras, Refaat Ras, Isabelle Villena, Sabry A. S. Sadek, Hajar AlQadeeb, Hind Alzaylaee, Sonia Almería, Ignacio García-Bocanegra, Ignacio García-Bocanegra

“…Additionally, the multiple logistic regression analysis highlighted the geographic region as a potential risk factor for T. gondii exposure. Thus, camels from Lower Egypt had significantly higher seroprevalence of T. gondii (19.92%, 51/256) compared to those from Upper Egypt (7.78%; 20/257; p < 0.001; odds ratio [OR] = 2.94; 95% CI: 1.70–5.10). …”
Get full text

IOP-lowering and neuroprotective treatment for glaucoma: reality and prospects by A.E. Egorov, N.G. Glazko, A.B. Movsisyan

“…It was demonstrated that elevated intraocular pressure (IOP) is still an important and well-studied risk factor for vision loss in both open-angle and angle-closure glaucoma. …”
Get full text

Exploring using HBsAg to predict interferon treatment course to achieve clinical cure in chronic hepatitis B patients: a clinical study by Fei Yan, Fei Tang, Jing Chen, YiCheng Lin, XinYu Chen, Qin Du, WeiLi Yin, Jing Liang, Lei Liu, Fang Wang, BaiGuo Xu, Qing Ye, HuiLing Xiang

“…External validation also suggests that the model can be used as a tool for initial assessment.ConclusionBaseline HBsAg in chronic hepatitis B patients were a risk factor for prolonged IFN treatment course with a positive correlation. …”
Get full text

COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation by Enrong Ran, Enrong Ran, Yutong Zou, Chuanyi Zhao, Kai Liu, Jiamin Yuan, Wenjie Yang, Lijun Zhao, Qing Yang, Jia Yang, Xuegui Ju, Linli Cai, Yanlin Lang, Xingyuan Li, Ke Liu, Fang Liu, Fang Liu

“…Cox proportional hazards regression indicated that sepsis and mechanical ventilation were major risk factors for post-discharge all-cause mortality. …”
Get full text

Effect of gender on the ocular surface after trabeculectomy by A.V. Antonova, V.P. Nikolaenko, V.V. Brzheskiy, A.Ya. Vuks

“…Gender is not an independent risk factor for surgical failure. Successful trabeculectomy results in a significant reduction in the severity of conjunctival and corneal xerosis symptoms (OSDI) for at least 2 years in both genders. …”
Get full text

Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America by Domingo Balderramo, Angelo Z. Mattos, Victoria Mulqui, Talita Chiesa, Zuly Plácido-Damián, Jaysoom Abarca, Andrea Bolomo, Yanina Carlino, Isadora Z. Bombassaro, Denusa Wiltgen, Laura Tenorio Castillo, Karina Díaz, Johana Acuña, Estela Manero, Jhon Prieto, Enrique Carrera, Javier Díaz-Ferrer, Jose D. Debes

“…In addition, moderate elevation of LFT at one week of hospitalization was an independent risk factor for overall mortality in these patients.…”
Get full text

Polymorphisms in immunosuppression-related genes are associated with AML by Mingying Li, Mingying Li, Jingjing Ye, Jingjing Ye, Mengyuan Chang, Mengyuan Chang, Lei Feng, Lei Feng, Tingting Liu, Tingting Liu, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Tao Sun, Tao Sun

“…Furthermore, rs1048801 in LILRB4 was linked to worse AML treatment response, lower OS, and may be an independent prognostic risk factor for AML. Lastly, expressions of CD163, CIITA, LILRB4, and CD200 were higher in AML patients than that in normal controls.ConclusionsOur findings on SNP associations in AML immunosuppression-related genes provide important reference points for predicting treatment outcomes in AML patients.…”
Get full text

Association of accelerated phenotypic aging, genetic risk, and lifestyle with progression of type 2 diabetes: a prospective study using multi-state model by Lulu Pan, Yahang Liu, Chen Huang, Yifang Huang, Ruilang Lin, Kecheng Wei, Ye Yao, Guoyou Qin, Yongfu Yu

“…Abstract Background Aging is a major risk factor for type 2 diabetes (T2D), but individuals of the same chronological age may vary in their biological aging rate. …”
Get full text

Exploring the impact of APOE ɛ4 on functional connectivity in Alzheimer’s disease across cognitive impairment levels by Kangli Dong, Wei Liang, Ting Hou, Zhijie Lu, Yixuan Hao, Chenrui Li, Yue Qiu, Nan Kong, Yan Cheng, Yaqi Wen, Wanyin Ma, Wenbin Zheng, Jitian Guan, Yan Lin, Kai Huang, Lu Zhang, Siya Chen, Xiangyuan Ma, Renhua Wu, Naili Wei

“…The apolipoprotein E (APOE) ɛ4 allele is a recognized genetic risk factor for Alzheimer’s Disease (AD). Studies have shown that APOE ɛ4 mediates the modulation of intrinsic functional brain networks in cognitively normal individuals and significantly disrupts the whole-brain topological structure in AD patients. …”
Get full text

Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…Results In multivariate regression analysis, the sole independent risk factor of LP was the level of SOD1 (OR 0.922, 95% CI: 0.878 ~ 0.967, P < 0.001), while smoking status (β= -0.177, 95% CI -18.645~-2.836, P = 0.008), diabetes mellitus (β= -0.191, 95% CI: -20.442~-3.592, P = 0.005), and total sialic acid (TSA) (β= -0.426, 95% CI: -0.915~ -0.433, P < 0.001) independently influenced the level of SOD1. …”
Get full text

Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis by Bing Xia, Yan-lin Lu, Jin Peng, Jing-wei Liang, Fang-qin Li, Jiu-yang Ding, Chang-wu Wan, Cui-yun Le, Jia-lin Dai, Jie-Wang, Bing Guo, Jiang Huang

“…ROC curve analysis revealed GAL8 DNA methylation as an independent risk factor for atherosclerosis: GAL8, along with inflammation-related proteins MCP-1, MMP9, and TNF-α, were upregulated in the mouse lesion group, while expression of autophagy-related proteins LC3 and Beclin1 was downregulated. …”
Get full text

Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver DiseasesSummary by Lan Zhou, Min Yan, Qin Luo, Wen Qiu, Yu-Ru Guo, Xiao-Qing Guo, Hong-Bin Yu, Jing-Ru Huo, Yan-Lin Feng, De-Ping Wang, Teng Sun, Kai-Fang Wang, Jian-Yun Shi, Xuan Shang, Mei-Na Wu, Lin Wang, Ji-Min Cao

“…Conclusions: Cholemia is a major risk factor for CRSDs in CLDs and, hence, a promising target in future clinical study.…”
Get full text

Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

“…It has long been considered risk-free until recent evidence suggests that the temporary threshold shift (TTS) induced by such exposure might be a high-risk factor for hearing loss. This study was conducted to further investigate the manner in which repeated low-intensity noise exposure contributed to hearing damage. …”
Get full text

The risk of repeated self-harm and suicide after emergency department presentation with self-harm in mental health presenters: a retrospective cohort study with data linkage in Que... by Richard A.F. Pellatt, David R. Painter, Jesse T. Young, Kairi Kõlves, Gerben Keijzers, Stuart A. Kinner, Ed Heffernan, Julia Crilly, Marc Broadbent, Amy Johnston, Melinda Martin-Khan, Paul Scuffham, Marianne Wallis, Ping Zhang

“…Summary: Background: Presentation to the emergency department (ED) with an index episode of self-harm is recognised as a risk factor for subsequent repeated self-harm and suicide. …”
Get full text

Sources and Transmission Routes of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i>: Study Design and Methodology of the SAMPAN Study by Anneloes van Veen, Selvi N. Shahab, Amber Rijfkogel, Anne F. Voor in ’t holt, Corné H. W. Klaassen, Margreet C. Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Merel Kemper, Anniek E. E. de Jong, Sima Mohammadi, Valentine Renaud, Irena Kukavica-Ibrulj, Marianne Potvin, Guillaume Q. Nguyen, Jeff Gauthier, Roger C. Levesque, Heike Schmitt, Juliëtte A. Severin

“…Screening cultures and risk factor questionnaires will be taken from healthy individuals and patients upon hospital admission. …”
Get full text

Computed tomography-guided microwave ablation for right middle lobe pulmonary nodules: a retrospective, single-center, case-control study by Yanting Hu, Guoliang Xue, Xinyu Liang, Zhichao Li, Nan Wang, Pikun Cao, Gang Wang, Haitao Zhang, Xiaohuan Zheng, Aiguang Wang, Wenhua Zhao, Cuiping Han, Zhigang Wei, Xin Ye

“…MWA for RML pulmonary nodules was identified as an independent risk factor for pneumothorax (p < 0.001). The duration of procedures (51.7 min vs. 35.3 min, p < 0.001) and post-ablation hospital stays (4.7 days vs. 2.8 days, p < 0.001) were longer in the RML group than non-RML group.Conclusions CT-guided MWA for RML pulmonary nodules showed comparable efficacy compared with other lobes, but posed a higher risk of pneumothorax complications, necessitating longer MWA procedure times and extended hospital stays.…”
Get full text

Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients by Rhian M Touyz, Ninian N Lang, Kevin G Blyth, Naveed Sattar, Patrick B Mark, Stefan Siebert, Colin Berry, Iain McInnes, Giles Roditi, Neil Basu, David Corcoran, Kenneth Mangion, Alex McConnachie, David Carrick, Jaclyn Carberry, Stuart Watkins, Paul Welsh, Sabrina Nordin, Katherine Scott, Christian Delles, Bernard Kelly, Fraser Goldie, John GF Cleland, Sharon Kean, Peter Kellman, David J Lowe, Andrew J Morrow, Antonia Ho, Rosemary Woodward, Tracey Hopkins, Ryan Wereski, Massimo Palmarini, Alasdair McIntosh, Campbell Rogers, Ammani Brown, Catherine Bagot, Kathryn Scott, Robert Sykes, Colin Church, Claire Rooney, Nicola Ryan, Clare Orange, Dirk Husmeier, Xiaoyu Luo, PETER W MACFARLANE, Heerajnarain Bulluck, Iain Findlay, Evonne McLennan, Michael Briscoe, Oliver Peck, Alastair J Rankin, Gruschen Veldtman, Varun Sharma, Kathryn McLaren, Elaine Butler, Sarah Mullen, Andrew Morrow, Patrick Mark, Daniel Doherty, Alexander Payne, Jennifer S Lees, Kaitlin J Mayne, Louise Inglis, Anna Kamdar, Hannah Bayes, Vivienne B Gibson, Lynsey Gillespie, Douglas Grieve, Pauline Hall Barrientos, Christopher McGinley, Connor Mckee, Sarah Allwood-Spiers, Sarah Weeden, Laura Knox, Lynn Abel, David Stobo, Andrew Dougherty, Liam Peng, David Barrie Stobo, Sylvia Wright, Stephen Dobbin, Keith Gillis, Sarah A Spiers, Ian Fergus, Kirsty Fallon, Lesley Gilmour, Chloe Cowan, Jurgen Van-Melckebeke, Kim Moran-Jones, Debra Stuart, Maureen Travers, Laura Dymock, Fiona Savage, Nicola Tynan, Sau Lee Chang, Mhairi Dupre, Lindsey Norton, George Bruce, Rosario Gonzalez-Lopez, Rebecca Stace, Dionne Russell, Jean Watt, Shahid Latif, Nick Hill, Amy Collinsworth, Ross McGeoch Vera Lennie, Robin P Weir

“…These features were very infrequent among a group of age-matched, sex-matched and cardiovascular risk factor-matched controls (n=29). The majority of COVID-19 cohort (68%) had less than 20% persisting radiological abnormalities, with 67% demonstrating overall improvement compared with admission imaging. …”
Get full text

ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure by Xiuru Cui, Yawei Wang, Hanlin Lu, Lei Wang, Xianwei Xie, Shenghao Zhang, Pavel Kovarik, Shuijie Li, Shanshan Liu, Qunye Zhang, Jianmin Yang, Cheng Zhang, Jinwei Tian, Yan Liu, Wencheng Zhang

“…Abstract Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. …”
Get full text

Local factors determining the response to antiangiogenic therapy with first-line drugs in macular neovascularization by V.G. Likhvantseva, S.G. Kapkova, E.B. Tretyak, S.I. Rychkova, A.S. Gevorkyan, T.E. Borisenko

“…</p> <p> <b>Keywords</b>: macular neovascularization, antiangiogenic therapy, risk factor, intraocular pressure, mean ocular perfusion pressure. …”
Get full text