Comparison of biodegradable and metal occluders in patients with PFO and migraine: study design and rationale of BioMetal Trial by Ziping Li, Jie Dong, Jing Dong, Yiming Yan, Manchen Gao, Fang Fang, Fengwen Zhang, Wenbin Ouyang, Shouzheng Wang, Chuangshi Wang, Xiangbin Pan, BioMetal investigators

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The Effects of Probiotic Supplementation on Level of Disability, Depressive Symptoms, and Cognitive Outcomes in Relapsing-Remitting Multiple Sclerosis Patients: A Randomized Double... by Amirreza Naseri, Sarvin Sanaie, Sama Rahnemayan, Reza Mosaddeghi-Heris, Malihe Talebi, Mahnaz Talebi

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Efficacy of Different Acupuncture Techniques for Pain and Dysfunction in Patients with Knee Osteoarthritis: A Randomized Controlled Trial by Jing Sun, Yi Liang, Kai-Tao Luo, Xiao-Mei Shao, Ming-Qi Tu, Xiao-Ting Wu, Fang Liu, Xin-Wei Li, Yi-Dan Chen, Qi-Fei Zhang, Cong-Hua Ji, Rong-Rong Li, Xiao-Yu Li, Fu Xu, Jian-Qiao Fang

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Clinical Trial of Sinudrain Haft Bahr Solution for Symptom Management in Mild to Moderate COVID-19 by Hamid Chegni

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Effect of different types of aerobic exercises on cancer-related fatigue among colorectal cancer patients: a meta-analysis based on randomized controlled trials by Xu Xiaoyang, Zhou Chunhui, Yang Xiaolan, Zhu Dong

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Evaluation of the effectiveness of a digital-intelligent-system-based implementation strategy in improving the quality of prehospital medical care: rationale and design of a steppe... by Lang Wang, Yali Hu, Bowen Hou, Ying Cui, Huang Zhang, Yilin Zhao, Zhuo Wang, Hui Feng, Songyun Wang, Lihua Zhu, Lilei Yu, Hong Jiang

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High-intensity resistance and impact training for patients with hormone-sensitive prostate cancer and bone metastases—study protocol of a randomized clinical trial by Anne-Mette Ragle, Marta Kramer Mikkelsen, Anders Vinther, Bo Zerahn, Carsten Bogh Juhl, Susann Theile, Kasper Madsen, Dorte Lisbet Nielsen, Peter Busch Østergren

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Nitric oxide for the prevention of postoperative acute kidney injury in patients undergoing surgery for Stanford type A aortic dissection: study protocol for a randomized controlle... by Zheyuan Chen, Xiao Han, Lingru Li, Maomao Liu, Li Yu, Sihao Cheng, Yan Yu, Nan Liu

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Self-management interventions for adult haemodialysis patients: a scoping review of randomized controlled trials by Nina Katharina Friedrich, Nico Schmitt, Helena Hruby, Christiane Kugler

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Internet-based cognitive behavioral therapy for anxiety and depressive symptoms in Brazilian emerging adults: A pilot randomized controlled trial by Juliana Maltoni, Carmem Beatriz Neufeld, Victoria Aminoff, Gerhard Andersson

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Brucea javanica oil emulsion plus supportive care for refractory advanced colorectal cancer: a pilot RCT protocol by Liyuan Fang, Yan Wang, Yuhang Fang, Runxi Wang, Yi Xie, Shuhan Yang, Suying Liu, Ying Zhang

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Combination treatment with acupoint therapy and conventional medication for non-motor symptoms in Parkinson’s disease: a systematic review and meta-analysis by Wenjiao Hu, Wenjiao Hu, Hao Zhou, Wenwen Zhu, Wenwen Zhu, Songcheng Xie, Songcheng Xie, Yue Zeng, Zhengyan Wang, Zhengyan Wang

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The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis by Shaohong Lin, Ruming Ye, Ruming Ye, Guanhong Wu, Lixia Wu, Ying Lin, Ying Lin, Dan Li, Namei Xie, Huiyue Zhang

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Parascapular sub-iliocostalis plane block for postoperative analgesia in patients with multiple rib fractures: a randomized controlled trial by Qiji Ju, Ping Li, Long Zhang, Liangguang Zhang, Guanyi Liu, Liyong Yuan, Miao Zhu

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Long-term prognosis of intracorporeal versus extracorporeal anastomosis in stage II/III colorectal cancer (INEX study): study protocol for a multicenter randomized controlled trial... by Marie Hanaoka, Hiroyasu Kagawa, Megumi Ishiguro, Akihiro Hirakawa, Masanori Tokunaga, Yusuke Kinugasa

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Healer-led vs. clinician-led training to improve personal protective equipment use among traditional healers in South Africa: a randomized controlled trial protocol by Carolyn M. Audet, Bryan E. Shepherd, Muktar H. Aliyu, Mosa Moshabela, Mariah J. Pettapiece-Phillips, Ryan G. Wagner

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Effects of photobiomodulation on multiple health outcomes: an umbrella review of randomized clinical trials by Yejun Son, Hyeri Lee, Seungyeong Yu, Hyeon Jin Kim, Jaeyu Park, Selin Woo, Hayeon Lee, Guillaume Fond, Laurent Boyer, Masoud Rahmati, Lee Smith, Guillermo F. López Sánchez, Elena Dragioti, Jiseung Kang, Tae Kim, Dong Keon Yon

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A culturally adapted mobile cognitive behavioral therapy for individuals with Hepatitis B on depression, anxiety and stress: A pilot randomized controlled trial by Chao Kei Lao, Xi Wang, Xinyi Li, Zhongqing Wang, Guangyu Zhou

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Shenmai Injection enhances short-term outcomes in ischemic stroke patients after thrombolysis via AMPKα1 by Jing Wu, Zhonghao Li, Xiaoke Dong, Jinmin Liu, Le Wang

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Protocol for a parallel-group, superiority randomized controlled trial of the PulsePoint mobile application to increase bystander resuscitation in out-of-hospital cardiac arrest by Steven C. Brooks, John M. Tallon, Sandra Jenneson, Ashish R. Panchal, Robert Grierson, Laurie J. Morrison, Damon C. Scales, Andrew Day, Lindsay O’Donnell, Randy S. Wax, Helen Connolly, Jennie Helmer, Heidi Corneil, Jim Christenson

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