Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…TMB ≥20 muts/Mb is a potential biomarker that may identify patients in whom an ICPI without chemo could be considered, even in the setting of lower PD-L1 levels. Prospective validation of these findings could increase access to chemo-sparing regimens for the first-line treatment of advanced NSCLC.…”
Get full text

Association between cardiometabolic index and risk of testosterone deficiency in adult men: a cross-sectional study by Yangyang Mei, Bo Zhang, Xiaogang Wang, Renfang Xu, Wei Xia, Yiming Chen, Xingliang Feng

“…Using CMI for early detection and timely intervention could reduce the disease burden and promote reproductive health. Further prospective studies with large sample sizes are needed to validate these findings.…”
Get full text

The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester-A primary cohort study with a scoping review. by Laura Ormesher, Jessica Catchpole, Linda Peacock, Heather Pitt, Anastasia Fabian-Hunt, Dexter Hayes, Claudia Popp, Jason M Carson, Raoul van Loon, Lynne Warrander, Karli Büchling, Alexander E P Heazell

“…Meta-analysis of three prospective studies investigating maternal haemodynamic effects of prone position found an increase in sBP and maternal heart rate, but no effect on respiratory rate, oxygen saturation or baseline fetal heart rate (though there was significant heterogeneity between studies).…”
Get full text

Wunsch nach Mitgestaltung als Berufswahlmotiv – eine qualitative Analyse zur Berufswahl von Studierenden der Sonderpädagogik by Ralf Schieferdecker, Veronika Dumbacher, Teresa Sansour, Gregor Frirdich

“…Regardless of whether reference is made to smaller learning groups, a different understanding of performance or more diverse career prospects, the opposite pole is always the mainstream teaching profession. …”
Get full text

Influence law and control mechanism of coal seam permeability on coal and gas outburst by Chaolin ZHANG, Mingliang LIU, Enyuan WANG, Peizhong WANG, Qiaozhen JIANG, Wei ZENG

“…The key lies in determining the critical value based on the actual conditions of the coal mines, and the future prospects from experimental research, theoretical analysis, and engineering practice are proposed.…”
Get full text

The correlation between cumulative cigarette consumption and infarction-related coronary spasm in patients with ST-segment elevation acute myocardial infarction across different ag... by Zhihui Kuang, Lin Lin, Ranran Kong, Zhonghua Wang, Xianjun Mao, Dingcheng Xiang

“…Further validation of our findings using prospective studies and large registries is warranted.…”
Get full text

Erratum to “The usefulness of surgical drains on short term outcomes among patients undergoing craniotomy at the Bugando Medical Centre, Mwanza Tanzania” [World Neurosurgery: X(22C... by Dennis Onsombi, Gerald Mayaya, Vladimir Herrera, Anton Manyanga, Washington Leonald, Samuel Byabato, James Lubuulwa

“…Methods: This was a prospective cohort study conducted to determine the occurrence of SFC, rate of SSI and the length of hospital stay among patients who underwent craniotomies at BMC from Feb to June 2022. …”
Get full text

Trends, challenges and solutions of digital information security in Central and Eastern Europe by Serhii Lubenets, Igor Harchenko, Tetiana Shediakova

“…Possible directions for its improvement and prospects for further scientific research on this topic are determined. …”
Get full text

Effects of the Early Start Denver Model on emotional dysregulation and behavior problems in children with Autism spectrum disorder by Wan-Xia Liu, Ling Shan, Chun-Li Li, Yu-Mo Liu, Yang Xue, Yu-Ling OuYang, Fei-Yong Jia

“…The core symptoms of children with ASD are significantly associated with emotional dysregulation and behavior problems in young children, both cross-sectionally and prospectively for the short term over time. Emotional dysregulation and behavior problems represent an important comorbidity, and could be considered as potential treatment targets for treatment for improving emotional stability in ASD.…”
Get full text

The Forgotten Hemodynamic (PCO2 Gap) in Severe Sepsis by Zouheir Ibrahim Bitar, Ossama Sajeh Maadarani, AlAsmar Mohammed El-Shably, Ragab Desouky Elshabasy, Tamer Mohamed Zaalouk

“…Method. We performed a prospective observational study and recruited 28 patients with severe sepsis and septic shock in a mixed ICU. …”
Get full text

Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B or C by Contrast-Enhanced Magnetic Resonance Imaging by René Hako, Pavol Kristian, Peter Jarčuška, Ivana Haková, Ivana Hockicková, Ivan Schréter, Martin Janičko

“…We evaluate the utility of hepatocyte-phase Gadoxetate disodium–enhanced magnetic resonance (MR) imaging in staging hepatic fibrosis and compare it with histological analysis as the reference standard (liver biopsy). Methods. Prospective cohort of 78 patients, who received Gadoxetate disodium dynamic contrast-enhanced MRI (DCE-MRI), were divided into three groups. …”
Get full text

Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-IC... by Streby KA, Tobias JD, McPhaden E, Downie S, Stanek J, Roth C, Patel PO

“…No other significant statistical differences in adverse effects were observed in patients’ receiving opioids versus opioids plus ketamine.Conclusion: Findings suggest ketamine is safe in a non-ICU setting for treatment of complex pain during anti-GD2 immunotherapy. Additional prospective studies are needed to quantify the effect of reducing opioid side effects by including ketamine in pain management plans.Keywords: anti-GD2 immunotherapy, dinutuximab, neuropathic pain, pediatric analgesia, ketamine, high-risk neuroblastoma, opioid…”
Get full text

Efficacy and Safety of Low-Dose Lenvatinib and Toripalimab in Patients With Recurrent Platinum-Resistant Ovarian Cancer: Study Protocol of a Multicenter, Open-Label, Single-Arm, Ph... by Su H, Shang X, Liu H, Wang Y, Yu Y, Xu Y, Jiang K, Feng F

“…This study is designed to further validate the efficacy and safety of the combination therapy of low-dose lenvatinib and PD-1 inhibitor toripalimab in patients with recurrent PROC.Study Design and Methods: The study is designed as a multicenter, open-label, single-arm, prospective phase II study. Patients with recurrent epithelial ovarian cancer who have disease progression either during or within 6 months after completion of platinum-based therapy will be included. …”
Get full text

LEGAL AND ECONOMIC PRINCIPLES OF THE FOREIGN POLICY OF INDEPENDENT AZERBAIJAN IN RELATION TO NEIGHBORING COUNTRIES by Katana Gafarova

“…The comparative legal method allowed to identify the characteristic similarities and differences in the international regulatory legal acts, national legislation in this sphere, as well as the prospects for improvement of legal regulation of such relations. …”
Get full text

Physicochemical characterization of biodegradable polymer polyhydroxybutyrate from halophilic bacterium local strain Halomonas elongata by W.O.S. Rizki, E. Ratnaningsih, D.G.T. Andini, S. Komariah, A.T. Simbara, R. Hertadi

“…The present study focused on the production, enhancement, and characterization of polyhydroxybutyrate from the prospective local bacterium Halomonas elongata. This research aimed to develop an environmentally sustainable material for reducing the accumulation of plastic waste in the ecosystem.METHODS: A local bacterial strain from Mud Crater Bledug Kuwu, Grobogan, Central Java, Indonesia, was isolated and identified as Halomonas elongata. …”
Get full text

Mortality Prediction Using SaO2/FiO2 Ratio Based on eICU Database Analysis by Sharad Patel, Gurkeerat Singh, Samson Zarbiv, Kia Ghiassi, Jean-Sebastien Rachoin

“…Our study is hypothesis-generating and a prospective evaluation is warranted. Take-Home Points. …”
Get full text

Association of pituitary neuroendocrine tumors and neurofibromatosis type 1: assessing causation versus coincidence. Case report by Mercedes Aguilar-Soto, Julia M. Zuarth-Vázquez, Laura Leyva-Figueroa, Karla Zarco-Ávila, Armando Gamboa-Domínguez, Aldo Eguiluz-Melendez, Laura C. Hernández-Ramírez

“…We also review the available data for and against a causal association between NF1 defects and pituitary tumors.MethodsOur patient was recruited via an ongoing prospective study of individuals with neuroendocrine neoplasms. …”
Get full text

TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury by Shubhayu Bhattacharyay, Florian D. van Leeuwen, Erta Beqiri, Cecilia A. I. Åkerlund, Lindsay Wilson, Ewout W. Steyerberg, David W. Nelson, Andrew I. R. Maas, David K. Menon, Ari Ercole, the CENTER-TBI investigators and participants

“…We extracted all heterogeneous data (2008 pre-ICU and ICU variables) collected from a prospective cohort (n = 844, 51 ICUs) of ICP-monitored TBI patients in the Collaborative European NeuroTrauma Effectiveness Research in TBI study. …”
Get full text

Analysis of Role of Haematological Parameters in Diagnosis of Grampositive and Gram-negative Urinary Tract Infection: A Case-control Study by Sudha Srinivasan, Ayeesha Sithika Thajudeen, Kundhavai Chandrasekaran, Vijayashree Raghavan, D Roshini

“…Materials and Methods: This prospective case-control study was conducted at Chettinad Hospital and Research Institute (tertiary care centre), Chengalpattu, Tamil Nadu, India between January 2023 and July 2023, included 105 culture-positive UTI cases and 105 age- and gender-matched culture-negative controls. …”
Get full text

The effect of pressurized intraperitoneal aerosolized chemotherapy on the surgical treatment outcomes of ovarian cancer with peritoneal carcinomatosis by A. S. Dzasochov, A. A. Kostin, V. L. Astashov, A. B. Turiev, A. D. Uskov, M. A. Andreeva

“…To analyze the effect of PIPAC, used in addition to the standard combined treatment of ovarian cancer with peritoneal carcinomatosis, on the clinical outcome of surgical treatment and long-term results.Patients and methods. Our prospective randomized open-label controlled trial included 169 patients with newly diagnosed ovarian cancer with peritoneal carcinomatosis. …”
Get full text