Oxygenation targets for endovascular therapy in acute ischemic stroke patients (Oxy-TARGET): protocol for a single-centre, open-label randomised controlled trial by Anxin Wang, Zhengfang Hu, Ruquan Han, Fa Liang, Youxuan Wu, Minyu Jian, Xinyan Wang, Yunzhen Wang, Haiyang Liu, Xuan Hou, Kangda Zhang, Zihui Zhang

“…Therefore, we are conducting a randomised controlled trial (RCT) to evaluate the impact of high-concentration oxygen vs low-concentration normobaric oxygen on early neurological function after EVT.Methods and analysis The Oxy-TARGET trial is an ongoing prospective, open-label, parallel-design RCT being conducted at Beijing Tiantan Hospital, Capital Medical University. …”
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Safety and efficacy of telaprevir in treatment of a chronic hepatitis C in patients of the Russian population included in early access program study by D. T. Abrurakhmanov, V. G. Morozov, I. G. Nikitin, P. O. Bogomolov, N. I. Geyvandova, Ye. N. Bessonova, I. G. Bakulin, V. A. Isakov, K. V. Zhdanov, M. V. Mayevskaya, Ye. A. Nurmukhametova, E. Z. Burnevich, Ye. V. Chesnokov, V. D. Pasechnikov, A. Hill, I. Lonjon-Domanec, S. N. Kizhlo

“…Efficacy and safety of this therapeutic mode were evaluated in intermediate analysis on 16-th week of treatment in 153 patients from Russia who have already reached the 16-th week of treatment or potentially can do so.Material and methods. The study has prospectively included 153 HCV infected patients (genotype 1), with bridging fibrosis or compensated liver cirrhosis who received treatment by telaprevir in combination to peginterferon-alpha and ribavirin for 12 wks with subsequent 12-or 36-week rate of antiviral therapy (AVT) by peginterferon alpha and ribavirin in relation to virologic response and fibrosis severity. …”
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Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients by Long-Shan Ji, Qiu-Tian Gao, Ruo-Wen Guo, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, Xiao-Jun Zhu, Ya-Ting Gao, Xue-Hua Sun, Yue-Qiu Gao, Man Li

“…Two hundred and twenty CHB patients were enrolled in the historical prospective cohort study. Patients were categorized into a treatment group (T-Group: combination therapy with BSF plus ETV) and a control group (C-Group: ETV). …”
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Anxiety and depression in people with epilepsy during and one year after the COVID‐19 pandemic by Iris E. Martínez‐Juárez, Jimena Gonzalez‐Salido, Jimena Colado‐Martinez, Irving Fuentes‐Calvo, Santiago Philibert‐Rosas, E. Rodrigo Velásquez‐Coria, Salvador Martínez‐Medina, Mijail A. Rivas‐Cruz, Eithel Valenzuela‐Mendivil, Karen E. Guzmán‐Sánchez, Elizabeth M. Ruiz‐Peñaflor, Arnold R. Thomson‐Cerna, Emilia M. González‐Villagómez, Jimena Armenta‐Báez, Andrea Santos‐Peyret, Aurelio Jara‐Prado, Adriana Ochoa‐Morales, Daniel Crail‐Meléndez, Ángel Ruiz‐Chow, Mario A. Sebastián‐Díaz

“…Methods We conducted a prospective, observational, and analytical study at the Epilepsy Clinic of the National Institute of Neurology and Neurosurgery (NINN) in Mexico City during the COVID‐19 pandemic. …”
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Lifestyle risk behaviours among adolescents: a two-year longitudinal study of the impact of the COVID-19 pandemic by Nicola Clare Newton, Maree Teesson, Jennifer Debenham, Cath Chapman, Bridie Osman, Lauren Anne Gardner, Fiona Elizabeth Wylie, Katrina Elizabeth Champion

“…Objective To examine changes in the prevalence of six key chronic disease risk factors (the “Big 6”), from before (2019) to during (2021) the COVID-19 pandemic, among a large and geographically diverse sample of adolescents, and whether differences over time are associated with lockdown status and gender.Design Prospective cohort study.Setting Three Australian states (New South Wales, Queensland and Western Australia) spanning over 3000 km.Participants 983 adolescents (baseline Mage=12.6, SD=0.5, 54.8% girl) drawn from the control group of the Health4Life Study.Primary outcomes The prevalence of physical inactivity, poor diet (insufficient fruit and vegetable intake, high sugar-sweetened beverage intake, high discretionary food intake), poor sleep, excessive recreational screen time, alcohol use and tobacco use.Results The prevalence of excessive recreational screen time (prevalence ratios (PR)=1.06, 95% CI=1.03 to 1.11), insufficient fruit intake (PR=1.50, 95% CI=1.26 to 1.79), and alcohol (PR=4.34, 95% CI=2.82 to 6.67) and tobacco use (PR=4.05 95% CI=1.86 to 8.84) increased over the 2-year period, with alcohol use increasing more among girls (PR=2.34, 95% CI=1.19 to 4.62). …”
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Impact of Nutritional Support for Tuberculosis on Intermediate and Terminal Undernutrition and Treatment Outcomes (INSTITUT) study: a protocol for a quasi-experimental study to ass... by Dissou Affolabi, Chelsie Cintron, Madolyn Dauphinais, Attannon Arnauld Fiogbe, Mohammed Fall Dogo, Safiou Ate, Christine Adjonou, Kokou Agossou, Susie Jiaxing Pan, Marius Esse, Benjamin Ade, Komi Séraphin Adjoh, Pranay Sinha, Kobto G Koura

“…Comparing treatment outcomes of PWTB treated in Benin and Togo can help us understand the impact of nutritional support for PWTB.Methods and analysis We designed a programmatic, prospective cohort study to assess the treatment outcomes among persons with pulmonary tuberculosis under programmatic conditions. …”
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The clinical utility of tissue polymerase chain reaction, tissue culture and tissue histology in blood culture-negative infective endocarditis in South Africa – insights from the G... by W Endres, P Mkoko, M Ntsekhe

“…We analysed data from the Groote Schuur Hospital (GSH) Infective Endocarditis Registry, a prospective observational study of adult patients with infective endocarditis. …”
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Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer by Ciao-Sin Chen, Michael P Dorsch, Sarah Alsomairy, Jennifer J Griggs, Reshma Jagsi, Michael Sabel, Amro Stino, Brian Callaghan, Daniel L Hertz

“…Our previous study found evidence that objective functional assessments completed within a smartphone app may differentiate patients with and those without CIPN after treatment. ObjectiveThis prospective, longitudinal observational cohort study aimed to determine the feasibility and accuracy of app-based remote monitoring of CIPN in patients with cancer undergoing neurotoxic chemotherapeutic treatment and to conduct exploratory comparisons of app-based functional CIPN monitoring versus patient-reported outcome–only monitoring. …”
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TEC-ADHERE: Real-World Persistence and Adherence on Dimethyl Fumarate in Patients with Relapsing–Remitting Multiple Sclerosis in the French OroSEP Patient-Support Program by Pierre Labauge, Alain Créange, Thibault Moreau, Jocelyne Nouvet-Gire, Bernard Pedespan, Olivier Heinzlef, Nathalie Texier, Marilyn Gros, Catherine Marti, Marta Ruiz, Mikel Martinez, Giovanni Castelnovo

“…Methods TEC-ADHERE (NCT04221191; 08/19/2019–09/15/2022) was a prospective, non-interventional, phase 4 study to assess the effect of OroSEP on persistence and adherence to dimethyl fumarate (DMF; Tecfidera™) in patients with RRMS. …”
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Parejas heterosexuales serodiscordantes en Chiapas, México. La influencia del género en la expresión de la agencia/Heterosexual HIV-Discordant Couples in Chiapas, Mexico. The Influ... by Francisco Chong-Villareal, Teresa Margarita Torres-López

“…Although the two women experienced their sexuality with men without HIV, to do so, they hid their diagnosis from their prospective partners. They had more difficulties than the two men, in their eagerness to maintain a stable couple relationship. …”
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Anatomical and Functional Outcomes of Vitrectomy with/without Intravitreal Methotrexate Infusion for Management of Proliferative Vitreoretinopathy Secondary to Rhegmatogenous Retin... by Samir El Baha, Mahmoud Leila, Ahmed Amr, Mohamed M. A. Lolah

“…Groups I (established PVR), II (high risk of PVR), and III (no risk of PVR) comprised prospectively recruited study eyes, which received PPV and adjuvant intravitreal MTX infusion equivalent to 400 μg/0.1 mL. …”
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One-Year Review Of Reduced Fetal Movements In Izzat Ali Shah MCH Center: A Predictor Of Poor Perinatal Outcome by Humera Rani, Gulwish Salahuddin, Ayesha Naz, Noreen Majeed, Faiza Safdar, Shazia Rafique

“…The purpose is to reduce perinatal morbidity and mortality. Methodology: This Prospective, Observational study was conducted at Izzat Ali Shah Maternal and child health center, unit III Gynae, Wah medical college Wah Cantt, from January 2019 to December 2019. …”
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Relationship between prenatal mixed heavy metal/metalloid exposure and offspring cognitive and temperament development by XU Zujing, JIANG Yining, XU Jian

“…Objective·To analyze the relationship between prenatal mixed heavy metal/metalloid exposure and the cognitive and temperament development of the offspring.Methods·A prospective birth cohort study was conducted in Shanghai from 2010 to 2012. …”
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Assessment of Birth Preparedness and Complication Readiness among Pregnant Women: A Cross-sectional Study by T Elamathi, K Ananthi, Rimi Singh

“…Materials and Methods: This prospective, double-blinded and randomised clinical study was conducted in the Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre (a tertiary care institute), Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India, from September 2023 to July 2024, with a sample size of 40 patients. …”
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The Impact of Nutritional Status and Tumor-Infiltrating Lymphocytes (CD4+ and CD8+) on Chemotherapy Response in Colorectal Cancer Patients by Lukman K, Septianto R, Rudiman R, Ruchimat T, Sribudiani Y, Nugraha P, Primastari E, Budiman D

“…Regarding chemotherapy responses in patients with colorectal cancer, this study aims to investigate the association between nutritional status and infiltrating lymphocyte counts, specifically CD4+ and CD8+.Materials and Methods: This prospective observational study analyzed the impact of nutritional status using body mass index (BMI) and TILs levels (CD4+/CD8+) on chemotherapy outcomes in CRC patients treated at a tertiary hospital in West Java, Indonesia, from July 2023 to June 2024.Results: Thirty-six research subjects were included. …”
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Transprofessional education in the student discourse: Demand, expectations, risks by A. N. Pinchuk, S. G. Karepova, D. A. Tikhomirov

“…Hence, special attention is drawn to the idea of transprofessional education, which reflects a new direction in future personnel labour market development. The prospects and possibilities of implementing the concept of transprofessionalism in the modern system of higher education require understanding a number of conceptual and practical issues, therefore, it seems urgent and timely to analyse the needs of students themselves in obtaining this type of education.Aim. …”
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Comparative Assessment of 0.5% Levobupivacaine and 0.5% Ropivacaine for Anaesthetic Potency in Mandibular Third Molar Extractions: A Randomised Controlled Trial by Prachi Surolia, Rajanikanth Kambala, Nitin Bhola, Anchal Agarwal

“…Materials and Methods: A prospective, randomised, triple-blind trial was conducted in the Department of Oral and Maxiilofacial Surgery at Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India from November 2023 to May 2024 on 60 healthy patients, aged 18-40 years, who required extraction of an impacted mandibular third molar, were included in the study. …”
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Une gestion plurielle des illégalismes : négociations et contradictions dans la régulation des eaux usées au Maroc by Pierre-Louis Mayaux, Naïma Fezza, Zhour Bouzidi

“…As for the farmers, the perpetuation of their illicit practices does not open up any prospect of genuine development, but rather epitomizes a situation of deadlock and lack of alternative. …”
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Attributable risk factors for asymptomatic malaria and anaemia and their association with cognitive and psychomotor functions in schoolchildren of north-eastern Tanzania. by Geofrey Makenga, Vito Baraka, Filbert Francis, Daniel T R Minja, Samwel Gesase, Edna Kyaruzi, George Mtove, Swabra Nakato, Rashid Madebe, Sif R Søeborg, Kathrine H Langhoff, Helle S Hansson, Michael Alifrangis, John P A Lusingu, Jean-Pierre Van Geertruyden

“…In Africa, children aged 5 to 15 years (school age) comprises more than 50% (>339 million) of the under 19 years population, and are highly burdened by malaria and anaemia that impair cognitive development. For the prospects of improving health in African citizens, understanding malaria and its relation to anaemia in school-aged children, it is crucial to inform targeted interventions for malaria control and accelerate elimination efforts as part of improved school health policy. …”
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Proportion, quality of life and factors associated with perinatal urinary incontinence among pregnant women attending at Muhimbili national hospital by Geofrey P. Chiloleti, Fransia Arda Mushi, Aboud Muhsin, Ally Mwanga

“…Objectives To assess the proportion, quality of life and factors associated with perinatal urinary incontinence among pregnant women admitted to the Muhimbili national hospital. Methodology This prospective cross-sectional study involved 354 pregnant women in perinatal period. …”
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