Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized,... by Jan H. Driedger, Julian Schröter, PROTECT-Study Group, Steffen Syrbe, Afshin Saffari

“…It has thus been hypothesized, that the critical time window for mTOR inhibitors may lie in early infancy, before TSC-related symptoms such as early-onset epilepsy and infantile spasms as sign of disruptive brain maturation occur. No controlled prospective clinical trials have evaluated the effect of pre-symptomatic mTOR inhibitor therapy on neuropsychological manifestations in TSC patients under two years of age. …”
Get full text

Use of flavor capsule cigarettes and their preliminary impact on smoking cessation in Mexico: an exploratory study by Rosibel Rodríguez-Bolaños, Paula Ramírez-Palacios, Katia Gallegos-Carrillo, Arlette Chávez-Iñiguez, Daimarelys Lara, Deborah J. Ossip, Ana Paula Cupertino, Francisco Cartujano-Barrera

“…However, biochemically verified abstinent at Month 3 was higher among participants who smoke FCCs compared to participants who smoke non-FCCs, although the difference was not statistically significant. Prospective and adequately powered comparisons must be made between individuals who smoke FCCs and non-FCCs to effectively assess differences in smoking abstinence, and the reasons for these differences.…”
Get full text

A Blueprint for the Problem Formulation Phase of EPA-Type Ecological Risk Assessments for 316(b) Determinations by Webster Van Winkle, William P. Dey, Steve M. Jinks, Mark S. Bevlhimer, Charles C. Coutant

“…Multiple lines of evidence from different levels of analysis, obtained using both prospective and retrospective techniques, provide a broader perspective on the magnitude of potential effects and associated uncertainties and risks. …”
Get full text

Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial by Patrick J E Bindels, Arthur M Bohnen, Gijs Elshout, Suzanne G M A Pasmans, Karlijn F van Halewijn

“…Objective To assess the effectiveness of a potent topical corticosteroid (TCS) as an initial treatment in primary care for children with moderate flare-ups of atopic dermatitis (AD), compared to starting on a mild TCS.Design An observational prospective cohort study with an embedded pragmatic multicentre open-label randomised controlled trial.Setting A total of 53 general practices in the southwest of the Netherlands took part in the study.Participants 209 children aged 3 months to 17 years diagnosed with AD (International Classification of Primary Care codes S87 or S88) who visited their general practitioner (GP) for AD or received repeat prescriptions for AD in the previous 12 months were included in the cohort study through the general practices. …”
Get full text

Serum Soluble Interleukin-2 Receptor Does Not Differentiate Complex Regional Pain Syndrome from Other Pain Conditions in a Tertiary Referral Setting by K. D. Bharwani, M. Dirckx, D. L. Stronks, W. A. Dik, F. J. P. M. Huygen

“…In order to further validate this marker in the diagnostic workup of CRPS, we conducted this prospective cohort study in which we determined sIL-2R levels in patients that were referred to our tertiary referral center with a suspicion of CRPS in a limb, and subsequently compared sIL-2R levels between the patients that were diagnosed with CRPS (CRPS group) and those who were not (no CRPS group). …”
Get full text

Factors Associated with Healthcare-Seeking Behavior among Health Profession Students in Selected Universities in Southwestern Uganda. by Wamaani, Hannington Gamukama, Olum, Ronald, Ajuna, Noble, Atwijukire, Humphrey, Kabami, Jane, Asiimwe, John Baptist

“…The link to the questionnaire was sent to prospective participants via WhatsApp platform or email between September and November 2021. …”
Get full text

Career Development Programs and Employee Performance in Kanungu District, South Western Uganda by Ainebyona, Alex, Moses, Agaba

“…The findings indicated a Pearson correlation of .0.961** which showed a positive but statistically significant relationship between career planning prospects and employee performance meaning that have personal career plan, providing career advisory services, having career development plan and internal and external programs that develop staff as well as self-assessment tools would result into better employee performance. …”
Get full text

Phase II study with sorafenib plus radiotherapy for advanced HCC with portal and/or hepatic vein tumor thrombosis by Yirui Zhai, Liming Wang, Hong Zhao, Fan Wu, Lingxia Xin, Feng Ye, Wei Sun, Yan Song, Lijuan Niu, Huiying Zeng, Jingbo Wang, Yuan Tang, Yongwen Song, Yueping Liu, Hui Fang, Ningning Lu, Hao Jing, Shunan Qi, Wenwen Zhang, Shulian Wang, Ye-Xiong Li, Jianxiong Wu, Bo Chen

“…Methods: Registered at ClinicalTrials.gov (NCT03535259), this phase II single-arm prospective trial targeted patients with HCC with portal or hepatic vein tumor thrombosis, liver minus gross tumor volume >700 ml, and Eastern Cooperative Oncology Group Performance Status scores of 0 or 1. …”
Get full text

The association between physician sex and patient outcomes: a systematic review and meta-analysis by Kiyan Heybati, Ashton Chang, Hodan Mohamud, Raj Satkunasivam, Natalie Coburn, Arghavan Salles, Yusuke Tsugawa, Ryo Ikesu, Natsumi Saka, Allan S. Detsky, Dennis T. Ko, Heather Ross, Mamas A. Mamas, Angela Jerath, Christopher J. D. Wallis

“…Methods This random-effects meta-analysis was conducted according to the PRISMA guidelines and prospectively registered on PROSPERO. MEDLINE and EMBASE were searched from inception to October 4th, 2023, and supplemented by a hand-search of relevant studies. …”
Get full text

Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia by Selamawit Wondale Begizew, Bethelhem Birhanu Muluneh, Taye Mezgebu Ashine, Asnakech Zekiwos Heliso, Getachew Ossabo Babore, Elias Ezo Ereta, Sentayehu Admasu Saliya, Awoke Girma Hailu, Elias Nigusu Abdisa

“…This study aimed to evaluate the incidence of seizure-related injuries and identify their predictors among epileptic patients undergoing follow-up treatment at selected public hospitals in Central Ethiopia, in 2023. A prospective follow-up study was carried out in selected public hospitals in central Ethiopia. …”
Get full text

Real-life study on the effectiveness and safety of sofosbuvir/velpatasvir-based antiviral agents for hepatitis C eradication in Chinese patients by Jiayi Wang, Lingyao Du, Dongmei Zhang, Chen Zhou, Yilan Zeng, Miao Liu, Xing Cheng, Xiaona Song, Han Chen, Ning Han, Enqiang Chen, Hong Tang

“…Methods: In this real-world prospective observational study, we recruited patients from the West China Hospital and Public Health Clinical Center of Chengdu in China. …”
Get full text

miR-1458 is inhibited by low concentrations of Vitamin B6 and targets TBX6 to promote the formation of spermatogonial stem cells in Rugao Yellow Chicken by Qingqing Geng, Cai Hu, Ziduo Zhao, Zhe Wang, Fufu Cheng, Jing Chen, Qisheng Zuo, Yani Zhang

“…Spermatogonial stem cells (SSCs) have vast application prospects in livestock and poultry production, genetic engineering, and medical research. …”
Get full text

Tailored BEST Exercise Protocol in Heart Failure Rehabilitation by Kevin Triangto, Basuni Radi, Bambang Budi Siswanto, Tresia Fransiska Ulianna Tambunan, Teuku Heriansyah, Alida Rosita Harahap, Aria Kekalih, Ade Meidian Ambari, Bambang Dwiputra, Dwita Rian Desandri, Hajime Katsukawa, Anwar Santoso

“…Methods In this etiologic study with prospective cohort design, all participants underwent a three-month cardiac rehabilitation program using the BEST Exercise Protocol. …”
Get full text

Characteristics of e-scooter and bicycle injuries at a university hospital in a large German city – a one-year analysis by Frederik Hartz, Philipp Zehnder, Tobias Resch, Gregor Römmermann, Victoria Hartmann, Markus Schwarz, Chlodwig Kirchhoff, Peter Biberthaler, Michael Zyskowski

“…The objective of this prospective cross-sectional study was to gather detailed information regarding the patient demographics, accident mechanisms, and injury patterns of e-scooter riders in comparison to cyclists. …”
Get full text

Maternal Macronutrient Intake and Associated Risk for Gestational Diabetes Mellitus: Results from the BORN2020 Study by Antigoni Tranidou, Ioannis Tsakiridis, Emmanuela Magriplis, Aikaterini Apostolopoulou, Violeta Chroni, Eirini Tsekitsidi, Ioustini Kalaitzopoulou, Nikolaos Pazaras, Michail Chourdakis, Themistoklis Dagklis

“…<b>Methods:</b> Data were prospectively collected from the Greek BORN2020 epidemiologic pregnant cohort, which included 797 pregnant women, of whom 14.7% were diagnosed with GDM. …”
Get full text

Impact of Flexor Tendon Traction Tenolysis on Clinical Outcomes in Open A1 Pulley Release for Trigger Finger by Shalimar Abdullah, BMBS, MS, Syed Jeffrey Syed Ahmad Kabeer, MBChB, MD, Lim Chia Hua, MD, Jamari Sapuan, MD, MS, Parminder Singh Gill, MBBS, MS, Elaine Soh Zi Fan, MBBS, MD

“…Outcomes assessed include finger range of motion, hand function (Disabilities of the Arm, Shoulder, and Hand [QuickDASH] score), complications (eg, digital nerve injury, superficial infection, and residual trigger finger), and surgery duration. Methods: A prospective study was conducted from January 2018 to June 2019, involving patients with grade II–III trigger finger requiring surgical intervention. …”
Get full text

Quality of life in early breast cancer patients after adjuvant accelerated partial-breast irradiation (APBI) in randomized trial by Petr Burkon, Iveta Selingerova, Miroslav Vrzal, Milos Holanek, Oldrich Coufal, Katerina Polachova, Vera Andraskova, Sachin R. Jhawar, Pavel Slampa, Tomas Kazda, Marek Slavik

“…This single-institution prospective randomized study compares the health-related quality of life (HRQoL) between women treated with the highly conformal-external beam APBI technique and those with the more commonly used moderately hypofractionated whole breast irradiation (hypo-WBI). …”
Get full text

Individualized Tailor-Made Dietetic Intervention Program at Schools Enhances Eating Behaviors and Dietary Habits in Obese Hispanic Children of Low Socioeconomic Status by Leticia Elizondo-Montemayor, Diana Moreno-Sànchez, Norma G. Gutierrez, Fabiola Monsivais-Rodriguez, Ubaldo Martinez, Ana C. Lamadrid-Zertuche, Martin M. Hernandez-Torre

“…Aim. to implement an individualized, face-to-face, parent supported, and school-partnership dietetic intervention to promote healthy eating habits and decrease body mass index. Prospective school year dietetic intervention of 101 obese, Hispanic, low-socioeconomic school-age children representative of Monterrey, Mexico, consisted of anthropometrics, dietetic assessment, energy-restriction tailor-made daily menus, and parental education every three weeks. …”
Get full text

Atrial fibrillation outcomes in patients from Asia and non-Asia countries: insights from GARFIELD-AF by Karen Pieper, Xian-hong Fang, Kai Sun, Ajay K Kakkar, Saverio Virdone, Shinya Goto, Gloria Kayani, Zhi-Cheng Jing, John Camm, Chun-Yan Cheng, Tian-Yu Lian, Xi-Jie Zhu, Xian-Mei Li

“…Background Differences in the clinical outcomes and level of risk among Asian versus non-Asian patients with atrial fibrillation (AF) have been sparsely investigated.Objective To provide a contemporary prospective comparison of outcomes for newly diagnosed patients with AF, between Asian and non-Asian regions.Methods Six Asian countries (China, Japan, India, Singapore, South Korea and Thailand) and 29 countries outside Asia participated in the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF) study. …”
Get full text

Exploring the assessment of post-cardiac valve surgery pulmonary complication risks through the integration of wearable continuous physiological and clinical data by Lixuan Li, Yuekong Hu, Zhicheng Yang, Zeruxin Luo, Jiachen Wang, Wenqing Wang, Xiaoli Liu, Yuqiang Wang, Yong Fan, Pengming Yu, Zhengbo Zhang

“…This study leverages wearable technology and machine learning algorithms to preoperatively identify high-risk individuals, thereby enhancing clinical decision-making for the mitigation of PPCs. Methods A prospective study was conducted at the Department of Cardiovascular Surgery of West China Hospital, Sichuan University, from August 2021 to December 2022. …”
Get full text