Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration by Sara Toulouie, Sean Chang, Julia Pan, Kiersten Snyder, Glenn Yiu

“…A lower arteriole-to-venule ratio may be associated with AMD severity, with narrower arterioles seen in the eyes with geographic atrophy, suggesting a role of the retinal vasculature in AMD pathophysiology. This trial is registered with ClinicalTrials.gov Identifier: NCT00000145.…”
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Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review by Yu-Hsun Chang, Kun-Chi Wu, Kai-Hung Wang, Dah-Ching Ding

“…LGR4–6 regulate the pathophysiology of female reproductive tissues. LGR4–6 are promising therapeutic targets for treating reproductive cancers and other related disorders. …”
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Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised Patient by Madiha M. Alvi, David S. Meyer, Nicholas J. Hardin, James G. deKay, Annis M. Marney, Matthew P. Gilbert

“…The authors review the diagnostic challenges, pathophysiology, and treatment of this condition.…”
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In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors by Halim Sobia Ahsan, Zaheer-Ul-Haq, Khan Ajmal, Al-Rawahi Ahmed, Al-Harrasi Ahmed

“…Uncontrolled activated T cells play a key role in the pathophysiology by stimulating inflammation and autoimmune diseases like arthritis, psoriasis and Crohn’s disease. …”
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Hysterectomy Sparing Management of Uterine Necrosis following Uterine Artery Embolization for Postpartum Hemorrhage by Myriam Chlela, Josette Dawkins, Gregory Lewis

“…UN following UAE can present a clinical challenge to physicians, with the underlying pathophysiology being use of small embolizing particles during UAE and lack of arterial collaterals to embolized areas. …”
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Mechanistic modelling of allergen-induced airways disease in early life by Hannah J. Pybus, Prakrati Dangarh, Man Yin Melanie Ng, Clare M. Lloyd, Sejal Saglani, Reiko J. Tanaka

“…In this study, we developed an in silico model describing the pulmonary immune response to a common allergen, house dust mite, to investigate its downstream impact on the pathophysiology of asthma, including airway eosinophilic inflammation, remodelling, and lung function. …”
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Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents by Mar Quiñones, Cintia Folgueira, Estrella Sánchez-Rebordelo, Omar Al-Massadi

“…These results suggest that in rodents circulating levels of irisin are not involved in the pathophysiology of obesity and could be unrelated to metabolic status; however, further studies should clarify its precise role in states of glucose homeostasis imbalance.…”
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The pathogenesis of COVID-19: Hypercoagulation and D-dimer in thrombotic complications by Leonid DUBEY, Halyna LYTVYN, Olha DOROSH, Nataliya DUBEY, Olena KOZLOVA, Michal PRUC, Nina KUBIKOWSKA, Lukasz SZARPAK, Kavita BATRA, Francesco CHIRICO, Gabriella NUCERA, Svitlana DOAN, Uljana SHEVTSIV

“…In addition, plasmin is involved in the pathophysiology of acute respiratory distress syndrome (ARDS) in SARS and promotes the secretion of cytokines, such as IL-6 and TNF, from activated macrophages. …”
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The potential role of nanobodies in asthma therapy by Baraa Khalid Salah Al-Sheakly, Fatemeh Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Jennifer E. Hundt, Rabih Halwani, Rabih Halwani

“…Asthma is a chronic inflammatory disease of the airways characterized by bronchoconstriction, airway hyperresponsiveness, and mucus production. The pathophysiology of asthma involves a complex interplay of immune cells and mediators, including cytokines, chemokines, and other inflammatory molecules. …”
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The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy by Natalia Simionescu, Radu Zonda, Anca Roxana Petrovici, Adriana Georgescu

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Exploring the association between BDNF related signaling pathways and depression: A literature review by Yuchen Fan, Xinchi Luan, Xuezhe Wang, Hongchi Li, Hongjiao Zhao, Sheng Li, Xiaoxuan Li, Zhenkang Qiu

“…Accumulating studies have revealed that BDNF-related pathways are critical in the pathophysiology of depression, and their interaction can further influence the efficacy of depression treatment. …”
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The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis by Shayan Mardi, Maryam Rashidian, Fatemeh Bastan, Ghazale Molaverdi, Sayed-Hamidreza Mozhgani

“…Despite extensive research, the exact pathophysiology of HTLV infection and its related diseases is enigmatic. …”
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Coronary Artery Spasm: New Insights by Anthony Matta, Frederic Bouisset, Thibault Lhermusier, Fran Campelo-Parada, Meyer Elbaz, Didier Carrié, Jerome Roncalli

“…A wide spectrum of clinical manifestations from silent disease to sudden cardiac death was attributed to this complex entity with unclear pathophysiology. Multiple mechanisms such as the autonomic nervous system, endothelial dysfunction, chronic inflammation, oxidative stress, and smooth muscle hypercontractility are involved. …”
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Identifying Key Biomarkers and Immune Infiltration in Female Patients with Ischemic Stroke Based on Weighted Gene Co-Expression Network Analysis by Haipeng Xu, Kelin He, Rong Hu, YanZhi Ge, Xinyun Li, Fengjia Ni, Bei Que, Yi Chen, Ruijie Ma

“…The immune system may play an important role in the pathophysiology of females with IS. Therefore, it is critical to investigate the key biomarkers and immune infiltration of female IS patients to develop effective treatment methods. …”
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The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (H... by Darshan Hullon, Ghasaq K. Subeh, Yelizaveta Volkova, Karolina Janiec, Adam Trach, Ruslan Mnevets

“…Endothelial dysfunction is a significant component of HFpEF pathophysiology, and glucagon-like peptide-1 receptor (GLP-1R) agonists have shown potential benefits in improving endothelial function. …”
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Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension by Vasilios Papademetriou, Michael Doumas, Charles Faselis, Constantinos Tsioufis, Stella Douma, Eugene Gkaliagkousi, Chrysanthos Zamboulis

“…It is only recently that the profound understanding of the complex anatomy and pathophysiology of the circuit, combined with the accumulation of relevant experimental and clinical data both in animals and in humans, has allowed the development of a more effective and well-promising approach. …”
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Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury by Shataakshi Dube, Tejasvi Matam, Jessica Yen, Henry E. Mang, Pierre C. Dagher, Takashi Hato, Timothy A. Sutton

“…Consequently, we used a mouse with a genetic deletion of Stat3 restricted to the endothelium to examine the role of STAT3 signaling in the pathophysiology of ischemic AKI. In a mouse model of ischemic AKI, the loss of endothelial STAT3 signaling significantly exacerbated kidney dysfunction, morphologic injury, and proximal tubular oxidative stress. …”
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Central amygdala neuroimmune signaling in alcohol use disorder by Mariam Melkumyan, Patrick A. Randall, Yuval Silberman

“…This review delves into how chronic alcohol exposure affects neuroimmune signaling in the CeA, contributing to the pathophysiology of AUD. By focusing on the impact of cytokine expression and glial cell activation, this review aims to elucidate the mechanisms by which neuroinflammation in the CeA influences alcohol-related behaviors. …”
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Exercise Stress Testing in Children with Metabolic or Neuromuscular Disorders by Tim Takken, Wim G. Groen, Erik H. Hulzebos, Cornelia G. Ernsting, Peter M. van Hasselt, Berthil H. Prinsen, Paul J. Helders, Gepke Visser

“…Several characteristics in our patient group were observed, which reflected the differences in pathophysiology of the various disorders. Metabolic profiles during exercises CPET and PXT seem helpful in the evaluation of patients with a MD or NMD.…”
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Decoding the mechanisms behind second primary cancers by Meiyuan Zeng, Anqi Lin, Aimin Jiang, Zhengang Qiu, Hongman Zhang, Shifu Chen, Mingyan Xu, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo

“…This comprehensive analysis contributes to elucidating current research trends in SPC mechanisms and enhances our understanding of the underlying pathophysiology. Furthermore, potential applications of intratumoral microbes, single-cell multi-omics, and metabolomics in investigating SPC mechanisms are also discussed, providing new ideas for follow-up studies.…”
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