Chorea Hyperglycemia Basal Ganglia Syndrome in a 63-Year-Old Male by Michael Sperling, Roshan Bhowansingh

“…We also present a commentary on the current understanding of the pathophysiology and treatment and how this was applied to our patient. …”
Get full text

Fluoxetine for reducing postoperative cognitive dysfunction in elderly patients after total knee replacement: study protocol for a single-centre, double-blind, randomised, parallel... by Yusheng Yao, Hong Ye, Yushan Wu, Daoyi Lin, Lulu Yu, Jiaxin Chen

“…Introduction Postoperative cognitive dysfunction (POCD) is a common complication following major surgical procedures. The underlying pathophysiology is poorly understood, but the role of neuroinflammation is strongly implicated. …”
Get full text

Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat by Quynh Vo, Timothy P. Gilmour, Kala Venkiteswaran, Jidong Fang, Thyagarajan Subramanian

“…Understanding the pathophysiology of these sleep pattern disturbances is critical to find effective treatments. 24-hour polysomnography (PSG), the gold standard for sleep studies, has never been used to test sleep dysfunction in the standard 6-OHDA lesioned hemiparkinsonian (HP) rat PD model. …”
Get full text

The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype) by A. Hannemann, E. Weiss, D. C. Rees, S. Dalibalta, J. C. Ellory, J. S. Gibson

“…Sickle cell disease (SCD) is one of the commonest severe inherited disorders, but specific treatments are lacking and the pathophysiology remains unclear. Affected individuals account for well over 250,000 births yearly, mostly in the Tropics, the USA, and the Caribbean, also in Northern Europe as well. …”
Get full text

Recognizing Cognitive and Psychiatric Changes in the Post-Highly Active Antiretroviral Therapy Era by Adriana Carvalhal, Jean-Guy Baril, Frederic Crouzat, Joss De Wet, Patrice Junod, Colin Kovacs, Nancy Sheehan

“…While there remains uncertainty with respect to the pathophysiology surrounding these disorders, their adverse implications are increasingly recognized. …”
Get full text

Chikungunya: From Hypothesis to Evidence of Increased Severe Disease and Fatalities by Carlos Brito, Melissa Barreto Falcão, Maria de Fatima Pessoa Militão de Albuquerque, Thiago Cerqueira-Silva, Maria Glória Teixeira, Rafael Freitas de Oliveira Franca

“…Studies were identified through PubMed using the search terms “chikungunya”, “death”, “severe”, “pathogenesis”, and “pathophysiology”.…”
Get full text

Co-expression of glutamatergic and autism-related genes in the hippocampus of male mice with disturbances of social behavior by I. L. Kovalenko, A. G. Galyamina, D. A. Smagin, N. N. Kudryavtseva

“…These results can serve as a confirmation of the participation of the glutamatergic system in the pathophysiology of the autistic spectrum disorder.…”
Get full text

Enhanced Temporal Coupling between Thalamus and Dorsolateral Prefrontal Cortex Mediates Chronic Low Back Pain and Depression by Hong Li, Qiaoyan Song, Ruya Zhang, Youlong Zhou, Yazhuo Kong

“…Our results emphasized that thalamic pathways underlying prefrontal cortex might play a key role in regulating chronic pain and depression of the pathophysiology of LDH.…”
Get full text

Are Onconeural Antibodies a Clinical Phenomenology in Paraneoplastic Limbic Encephalitis? by Hongliang Zhang, Chunkui Zhou, Limin Wu, Fengming Ni, Jie Zhu, Tao Jin

“…The finding of highly specific antibodies directed against onconeural antigens has revolutionized the diagnosis and promoted the understanding of these syndromes and led to the current hypothesis of an autoimmune pathophysiology. Accumulating data strongly suggested direct pathogenicity of these antibodies. …”
Get full text

Novel Human Induced Pluripotent Stem Cell-Based Model for Retinal Pigment Epithelial Cells to Reveal Possible Disease Mechanisms for Macular Degeneration in Pseudoxanthoma Elasticu... by Taina Viheriälä, Heidi Hongisto, Lyydia Saari, Marika Oksanen, Tanja Ilmarinen, Suvi Väärämäki, Hannu Uusitalo, Pasi Nevalainen, Heli Skottman

“…The exact mechanism for the retinal pathophysiology is not known, and patients have variable symptoms and findings. …”
Get full text

Imaging flow cytometry reveals the mechanism of equine arteritis virus entry and internalization by Agata Kublicka, Daria Lorek, Agata Mikołajczyk-Martinez, Grzegorz Chodaczek, Aleksandra Chwirot, Barbara Bażanów, Anna Karolina Matczuk

Get full text

Severe Bioprosthetic Mitral Valve Stenosis and Heart Failure in a Young Woman with Systemic Lupus Erythematosus by Siddharth Wartak, Isaac Akkad, Adnan Sadiq, Gregory Crooke, Manfred Moskovits, Robert Frankel, Gerald Hollander, Jacob Shani

“…This case highlights the pathophysiology of lupus causing stenosis of prosthetic valves and low ejection cardiomyopathy.…”
Get full text

Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies by Xinyuejia Huang, Linglong Xiao, Mengqi Wang, Yang Wu, Hao Deng, Wei Wang

“…In addition, we present the advantages and limitations of these models and discuss their future in helping further understand the pathophysiology and advanced treatment. Here, we highlight current frontline treatment approaches for OCD, including neuromodulation and surgical interventions, and propose potential future directions. …”
Get full text

Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay by Caterina Mammi, Matilde Calanchini, Antonella Antelmi, Francesca Cinti, Giuseppe M. C. Rosano, Andrea Lenzi, Massimiliano Caprio, Andrea Fabbri

Get full text

The Effect of Endotoxin-Induced Inflammation on the Activity of the Somatotropic Axis in Sheep by Maciej Wójcik, Dorota Anna Zieba, Joanna Bochenek, Agata Krawczyńska, Marcin Barszcz, Alina Gajewska, Hanna Antushevich, Andrzej Przemysław Herman

“…The hypothalamic-pituitary-somatotropic (HPS) axis controls many physiological and pathophysiological processes. The phenomenon of insensitivity to growth hormone resistance (GHres) was previously reported to be due to the development of inflammation. …”
Get full text

Interrelation of irritable bowel syndrome and bacterial overgrowth: is there any? by Yu. A. Kucheryavy, S. V. Cheryomushkin, Ye. A. Mayevskaya, Ye. A. Sutugina

“…From positions of pathophysiology it is possible to believe, that the IBS causes background for development of BOS, on the contrary, BOS increases risk of IBS development. …”
Get full text

Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system by Andrea Pedroni, Elanur Yilmaz, Lisa Del Vecchio, Prabesh Bhattarai, Inés Talaya Vidal, Yu-Wen E. Dai, Konstantinos Koutsogiannis, Caghan Kizil, Konstantinos Ampatzis

“…The classification and characterization of the IcNS presented here serve as a valuable resource for further exploration into the mechanisms underlying heart functionality and the pathophysiology of associated cardiac disorders.…”
Get full text

Intracranial artery dolichoectasia: What should the neurologist know? by Lorena Dellagnesi Depieri, Renan Rodrigues Neves Ribeiro do Nascimento, Lorena Souza Viana

“…To minimize the risk of misdiagnosis, we briefly elucidated the pathophysiology of IADE, correlating it with clinical and radiological features. …”
Get full text

Advanced Imaging Modalities in the Detection of Cerebral Vasospasm by Jena N. Mills, Vivek Mehta, Jonathan Russin, Arun P. Amar, Anandh Rajamohan, William J. Mack

“…The pathophysiology of cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is complex and is not entirely understood. …”
Get full text

Study of an outbreak of jaundice in Rajshahi, Bangladesh: a sociodemographic and clinical manifestation by Mahi Mubassira, Muntasir Alam Muhib, Syed Abeed-Ul-Haque, Sanzida Khanam, Faruk Hasan

“…Blood and urine samples were tested via an automated clinical chemistry analyzer to confirm the pathophysiology. Moreover, sociodemographic status, food habits and living areas were considered for the patients. …”
Get full text