The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats by Renata Francik, Jadwiga Kryczyk, Mirosław Krośniak, Mehmet Berköz, Ilona Sanocka, Sławomir Francik

“…Flavonoid derivatives as nonenzymatic antioxidants are important in the pathophysiology of many diseases including neurological disorders (e.g., Alzheimer’s disease) or heart disease. …”
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Spatial transcriptomic analysis identifies epithelium-macrophage crosstalk in endometriotic lesions by Gregory W. Burns, Zhen Fu, Erin L. Vegter, Zachary B. Madaj, Erin Greaves, Idhaliz Flores, Asgerally T. Fazleabas

“…Summary: The mechanisms underlying the pathophysiology of endometriosis, characterized by the presence of endometrium-like tissue outside the uterus, remain poorly understood. …”
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Whole Exome Sequencing Reveals Rare Variants in Genes Associated with Metabolic Disorders in Women with PCOS by Priyal Sharma, Ashutosh Halder, Manish Jain, Manish Tripathi

“…Aims: The objective of this study was to investigate the genetic causes of PCOS by identifying rare variants in genes implicated in its pathophysiology. Settings and Design: This was a hospital-based observational study. …”
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Role of Cox-2 in Vascular Inflammation: An Experimental Model of Metabolic Syndrome by Nicolás F. Renna, Emiliano R. Diez, Carina Lembo, Roberto M. Miatello

“…Lumiracoxib was able to reverse vascular remodeling changes and inflammation, demonstrating the involvement of COX-2 in the pathophysiology of vascular remodeling in this experimental model.…”
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T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease by Uroosa Ibrahim, Gwenalyn Garcia, Amina Saqib, Shafinaz Hussein, Qun Dai

“…T cell histiocyte rich large B cell lymphoma (THRLBCL) is a rare subtype of non-Hodgkin’s lymphoma characterized by malignant B cells with reactive T lymphocytes. The pathophysiology is thought to involve cytokine-mediated evasion of T cell immune response by malignant B cells. …”
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Mucus production and chronic obstructive pulmonary disease, a possible treatment target: zooming in on N-acetylcysteine by Federico Baraldi, Tommaso Bigoni, Maria Pia Foschino Barbaro, Claudio Micheletto, Giulia Scioscia, Alessandro Vatrella, Alberto Papi

“…This narrative review of the literature presents the role of mucus dysfunction in COPD, its pathophysiology, and the rationale for the use of N-acetylcysteine (NAC). …”
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Diagnosis and Management of Peyronie’s Disease: A Clinical Consensus Statement and Recommendations from the Korean Society for Sexual Medicine and Andrology by Dong Soo Kim, Hee Jo Yang, Hyun Cheol Jeong, Ki Hyuck Moon, Dong Sup Lee, Seung Hun Song, Won Ki Lee

“…Despite extensive research, the pathophysiology of this condition remains poorly understood, and standardized diagnostic and treatment protocols are lacking. …”

Predicting the correlation between neurological abnormalities and thyroid dysfunction using artificial neural networks by Dina Falah Noori Al-Sabak, Leila Sadeghi, Gholamreza Dehghan

“…The results indicated significant relationships among cortisol, dopamine, and GABA levels, providing insights into their roles in the pathophysiology of hypothyroidism and its association with neurological disorders. …”
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The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review by Mori Tommaso, Nagaraj Nareshkumar Ragavachetty, Surico Pier Luigi, Zhou Wenjing, Parmar Uday Pratap Singh, D’Esposito Fabiana, Gagliano Caterina, Musa Mutali, Zeppieri Marco

“…This comprehensive review explores the dual nature of OSM and other IL-6 family members in retinal pathophysiology, highlighting their contribution to both degenerative and regenerative processes. …”
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A Novel Hypothesis for Migraine Disease Mechanism: The Creation of a New Attractor Responsible for Migraine Disease Symptoms by Elham Baradari, Farnaz Garehdaghi, Yashar Sarbaz

“…Despite the high prevalence, the pathophysiology of the disease has not been clearly understood yet. …”
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Role of androgen receptors in sexually dimorphic phenotypes in UBE3A-dependent autism spectrum disorder by Yuan Tian, Hui Qiao, KathrynAnn Odamah, Ling-Qiang Zhu, Heng-Ye Man

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Impact of Methamphetamine Abuse: A Rare Case of Rapid Cerebral Aneurysm Growth with Review of Literature by James Fowler, Brian Fiani, Syed A. Quadri, Vladimir Cortez, Mudassir Frooqui, Atif Zafar, Fahad Shabbir Ahmed, Asad Ikram, Anirudh Ramachandran, Javed Siddiqi

“…In this report, we present a patient with repeated and recurrent meth abuse who demonstrated rapid growth of a pericallosal aneurysm over the period of less than two weeks. The pathophysiology of stroke related to meth and ATS abuse is multifactorial with hypertension, tachycardia, and vascular disease postulated as major mechanisms. …”
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Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents by null Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani

“…By fine-tuning drug release profiles and enhancing drug uptake at specific sites, LBDDS can potentially target renin-angiotensin-aldosterone system components, sympathetic nervous system pathways, and endothelial dysfunction, all of which play crucial roles in hypertension pathophysiology. The future of hypertension management using LBDDS is promising, with ongoing reviews focusing on precision medicine approaches, improved biocompatibility, and reduced toxicity. …”
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Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis by Zhijun Jiao, Wenhong Wang, Jie Ma, Shengjun Wang, Zhaoliang Su, Huaxi Xu

“…Our data confirm the functional involvement of Notch pathway in the pathophysiology of RA FLSs which may provide a new target for RA therapy.…”
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Unreliable information and fear: Barriers to vaccination among IBD patients in China by Jingwen Liu, Zelin Yan, Wen Hu, Shuyan Li, Yan Chen

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Orbitopalpebral emphysema in a child after the removal of a giant meningioma: a case report and mini-review by Ebba Katsler, Anders Tolstrup Christiansen, Annika Reynberg Langkilde, Jane Skjøth-Rasmussen

“…Furthermore, our aim is to discuss the findings and the pathophysiology in relation to cases found in literature. …”
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Corticolimbic circuitry as a druggable target in schizophrenia spectrum disorders: a narrative review by Abigail Gee, Paola Dazzan, Anthony A. Grace, Gemma Modinos

“…This review synthesises recent developments examining corticolimbic dysfunction in the pathophysiology of SSD, with a focus on neuroimaging advances and related novel methodologies that enable the integration of data across different scales. …”
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A Comparison of Dysautonomias Comorbid with Cyclic Vomiting Syndrome and with Migraine by Gisela Chelimsky, Shruti Madan, Amer Alshekhlee, Elizabeth Heller, Kevin McNeeley, Thomas Chelimsky

“…Although CVS and migraine clearly share many of the same comorbidities, they do differ in one important association, suggesting that they may not be identical in pathophysiology. Since OI is common in CVS, treatment strategies could also target this abnormality.…”
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Epigenetic Markers of Renal Function in African Americans by Samantha M. Bomotti, Jennifer A. Smith, Alicia L. Zagel, Jacquelyn Y. Taylor, Stephen T. Turner, Sharon L. R. Kardia

“…This work shows that epigenetic markers may offer valuable new insight into the complex pathophysiology of CKD in African Americans.…”
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Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives by Deshuang Zhang, Dongke Xie, Yi Qu, Dezhi Mu, Shaopu Wang

“…The intricate interactions among toll-like receptor 4 (TLR4), microvascular integrity, immune activation, and the inflammatory milieu are meticulously summarized, offering a sophisticated understanding of NEC pathophysiology. This academic review aims to enhance the etiological comprehension of NEC, promote the development of targeted therapeutic interventions, and impart the significant impact of perinatal factors on the formulation of preventive and curative strategies for the disease.…”
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