The Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post‐Traumatic Stress Disorder by Fernando Hinostroza, Michele M. Mahr

“…Also, our findings underscore alterations within the reward system, prefrontal cortex, hippocampus, amygdala, basal ganglia, and hypothalamic–pituitary–adrenal axis that contribute to the pathophysiology of AUD. Our results support the notion that a biopsychosocial framework is essential for contemporary addiction treatment, particularly in the context of alcohol addiction and PTSD. …”
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Patent Foramen Ovale in Patients with Sickle Cell Disease and Stroke: Case Presentations and Review of the Literature by Sheila Razdan, John J. Strouse, Rakhi Naik, Sophie Lanzkron, Victor Urrutia, Jon R. Resar, Linda M. S. Resar

“…Although individuals with sickle cell disease (SCD) are at increased risk for stroke, the underlying pathophysiology is incompletely understood. Intracardiac shunting via a patent foramen ovale (PFO) is associated with cryptogenic stroke in individuals without SCD. …”
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Diagnosis Using CCTA and Management of Anomalous Right Coronary Artery from the Opposite Sinus by Asma Mursleen, Gregory Hartlage, Aarti Patel, Eric E. Harrison, C. Alberto Morales

“…In this paper a case of 20 yo M with right coronary artery from left sinus is going to be presented with a discussion on pathophysiology, diagnosis, and management.…”
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Maternal education, health profession and cigarette smoking are decisive factors for self-medication in children by parents by Duborija-Kovacevic Natasa, Martinovic Milica, Belojevic Goran, Lausevic Dragan, Asanin Bogdan

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Analysis of small extracellular vesicles from dried blood spots by Rikke Bæk, Jenni Kathrine Sloth, Mohammad Mehedi Hasan, Getnet Midekessa, Getnet Midekessa, Malene Møller Jørgensen, Malene Møller Jørgensen

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Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles by Marta Machado-Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreira

“…Inflammatory mechanisms triggered by microglial cells are involved in the pathophysiology of several brain disorders, hindering repair. …”
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Eosinophilic esophagitis in the “atopic march”: dupilumab as an “umbrella” strategy for multiple coexisting atopic diseases by Nicola Lutzu, Nicola Lutzu, Agnese Favale, Mauro Demurtas, Stefano Del Giacco, Stefano Del Giacco, Sara Onali, Sara Onali, Massimo Claudio Fantini, Massimo Claudio Fantini

“…EoE is a chronic T2 inflammatory disease, believed to be a member of the “atopic march”, due to multiple similarities with other atopic diseases, ranging from epidemiology to genetics and pathophysiology. Although often co-existing in the same patient, these diseases are still treated as separated entities by different specialists, resulting in polypharmacy and chronic use of steroids. …”
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Global Trends in LADA Type Diabetes Research: A Bibliometric Analysis of Publications from Web of Science and Scopus, 1994–2024 by Khatimya Kudabayeva, Bibigul Tleumagambetova, Yerlan Bazargaliyev, Raikul Kosmuratova, Aliya Zhylkybekova

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Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions by Grace Kuo, Ramhari Kumbhar, William Blair, Valina L. Dawson, Ted M. Dawson, Xiaobo Mao

“…This review delves into the pivotal role of α-syn, the key agent in α-synucleinopathy pathophysiology, and provides a survey of potential therapeutics that target cell-to-cell spread of pathologic α-syn. …”
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Impact of hyper- and hypothermia on cellular and whole-body physiology by Toshiaki Iba, Yutaka Kondo, Cheryl L. Maier, Julie Helms, Ricard Ferrer, Jerrold H. Levy

“…Key factors in heatstroke pathophysiology involve mitochondrial thermal damage and excessive oxidative stress, which drive apoptosis and necrosis. …”
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Eptinezumab-jjmr, a humanized monoclonal specific to Calcitonin Gene Related Peptide, for the preventive treatment of migraine in adults by Amnon A. Berger, Joseph Keefe, Cain W. Stark, Matthew Moore, Giovanni F. Ramírez, Julia R. Cucarola, Andrew H. Han, Alan D. Kaye, Latha Ganti

“…It is a prevalent disorder that causes significant, worldwide disability, morbidity, suffering, and costs. The pathophysiology of migraines is actively studied, though recent research points to an initiating event causing migraine generation, that is then propagated by other brain regions, a significant one being the trigeminocervical complex. …”
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Role of TLR4  rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease by Ran Ao, Ying Wang, Dao-Rong Zhnag, Ya-Qi Du

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The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women by M. Holecki, J. Chudek, A. Więcek, M. Titz-Bober, J. Duława

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Evaluation of zonulin levels in patients with migraine by Gözde Ülfer, Burcu Polat, Ahmet Yabalak, Çağrı Çakıcı

“…Abstract Background Zonulin regulates permeability in blood–brain and intestinal barriers. The pathophysiology of migraine is based on the effect of neurogenic inflammation. …”
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Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10Lt/J and TALLYHO/JngJ by Edward H. Leiter, Marjorie Strobel, Adam O'Neill, David Schultz, Andrew Schile, Peter C. Reifsnyder

“…Although the T2D pathophysiology in both TALLYHO/JngJ and NONcNZO10/LtJ is remarkably similar, their genetic etiologies are clearly different, underscoring the genetic heterogeneity underlying T2D in humans.…”
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Pedicled Radial Forearm “Free” Flap for Intraoral Reconstruction Based on an Unexpectedly High Origin of the Radial Artery—Case Report by Marino Lupi-Ferandin, Dinko Martinovic, Ante Pojatina, Ante Mihovilovic, Ema Puizina, Sasa Ercegovic, Ivana Stula, Josko Bozic, Slaven Lupi-Ferandin

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Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro by Li B, Dong B, Xie L, Li Y

“…In contrast, widely available natural plant molecules offer multiple targeting pathways that uniquely modify the typical pathophysiology of AR through immunomodulatory processes. …”
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Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress by Qiong Wang, Feng Shao, Weiwen Wang

“…Impairments of cognitive flexibility, which are modulated by the monoaminergic system of the prefrontal cortex (PFC), are increasingly recognized as an important component of the pathophysiology and treatment of depression. However, the downstream molecular mechanisms remain unclear. …”
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The Potential for Cellular Therapy Combined with Growth Factors in Spinal Cord Injury by Jack Rosner, Pablo Avalos, Frank Acosta, John Liu, Doniel Drazin

“…Research is being conducted in the following areas: pathophysiology, cellular therapies (Schwann cells, embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, olfactory ensheathing cells), growth factors (BDNF), inhibitory molecules (NG2, myelin protein), and combination therapies (cell grafts and neurotrophins, cotransplantation). …”
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Glutaraldehyde-Polymerized Hemoglobin: In Search of Improved Performance as Oxygen Carrier in Hemorrhage Models by Anca D. Farcas, Vlad Al Toma, Ioana Roman, Bogdan Sevastre, Florina Scurtu, Radu Silaghi-Dumitrescu

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