The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis by Chu-Yang Xu, Wen-Song Zhang, Hong Zhang, Yan Cao, Hong-Yan Zhou

“…At the same time, we found that these signaling molecules play a critical role in the pathogenesis of keratitis. Thus, we assessed the function of Cx43 during inflammatory corneal disease. …”
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Gestational diabetes mellitus and polycystic ovary syndrome, a position statement from EGOI-PCOS by Paola Quaresima, Samuel H. Myers, Basilio Pintaudi, Basilio Pintaudi, Rosario D’Anna, Rosario D’Anna, Michele Morelli, Vittorio Unfer, Vittorio Unfer

“…In recent years, the Expert Group on Inositol in Basic and Clinical Research and on PCOS (EGOI-PCOS) has sought to better understand the pathogenesis behind polycystic ovary syndrome, in order to accurately diagnose and treat patients according to their individual needs. …”
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Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume in patients with diabetic retinopathy by Trisha Ghosh, Sanjay Kumar Daulat Thakur, Premangshu Ghosh, Trina Sengupta

“…Objective: The objective of this study was to assess the role of inflammation in the pathogenesis of diabetic retinopathy (DR) using the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and to compare these parameter levels between DR and non-DR (NDR) subjects. …”
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Exploration of Lipid Metabolism Alterations in Children with Active Tuberculosis Using UHPLC-MS/MS by Baixu Sun, Fang Liu, Qingqin Yin, Tingting Jiang, Min Fang, Li Duan, Shuting Quan, Xue Tian, Adong Shen, Kaixia Mi, Lin Sun

“…Taken together, plasma lipid metabolites are potentially useful for diagnosis of active TB in children and would provide insights into the pathogenesis of the disease.…”
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Possible involvement of vitamin K insufficiency in the progression of cervical ossification of the posterior longitudinal ligament by Atsushi Kimura, Naoya Taki, Yukinori Hayashi, Yasuyuki Shiraishi, Tsukasa Ohmori, Katsushi Takeshita

“…Thus, vitamin K insufficiency may be involved in the pathogenesis of OPLL and supplementation may represent a novel treatment for this condition.…”
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IgE Plasma Cell Leukemia Harboring t(11;14) and 1q Amplification by Wataru Nakahara, Takahito Ogawa, Hitomi Matsunaga, Yuki Iwasa, Momoka Horita, Mako Ikeda, Mizuki Asako, Sadaharu Iio, Yuki Iwama, Kazumasa Oka, Shuji Ueda

“…Investigating the presence of cytogenetic abnormalities coexisting with t(11;14) is not only useful for evaluating prognosis but also important for understanding the pathogenesis of the disease. Recently, venetoclax, an oral BCL2 inhibitor, has demonstrated promising efficacy in plasma cell neoplasm patients harboring t(11;14). …”
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Development of research on HIV-associated neurocognitive disorder and emerging trends: a visualization analysis via CiteSpace by Tingting Zhou, Xuannan Chen, Yu Lai

“…The hotspots in this field are “neurocognitive impairment,” “central nervous system,” “cerebrospinal fluid,” “HIV-1 tat,” “SIV,” “inflammation,” “infection,” and “pathogenesis.” The current research direction of HAND is focused on exploring the pathogenic mechanism underlying HIV-associated neurocognitive impairment and potential therapeutic targets.ConclusionThis study provides a bibliometric visualization of HAND-related literature to gain insight into the development and frontiers of this research field. …”
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Deep learning-based differential gut flora for prediction of Parkinson's. by Bo Yu, Hang Zhang, Min Zhang

“…Increasing evidence suggested that the gut-brain axis played a crucial role in Parkinson's disease, with changes in the gut microbiota speculated to be involved in the pathogenesis of Parkinson's disease or interfere with its treatment. …”
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The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease by Kemal Ugur Tufekci, Ezgi Civi Bayin, Sermin Genc, Kursad Genc

“…Many lines of evidence suggest that mitochondrial dysfunction plays a central role in the pathogenesis of Parkinson's disease (PD). Several PD-associated genes interface with mitochondrial dynamics regulating the structure and function of the mitochondrial network. …”
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Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke by Xiao-li Liu, Jian-zong Du, Yu-miao Zhou, Qin-fen Shu, Ya-guo Li

“…Clinical and experimental data have demonstrated that inflammation plays fundamental roles in the pathogenesis of ischemic stroke. Interleukin-16 (IL-16) is identified as a proinflammatory cytokine that is a key element in the ischemic cascade after cerebral ischemia. …”
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Potential Biomarkers of the Earliest Clinical Stages of Parkinson’s Disease by Anelya Kh. Alieva, Elena V. Filatova, Aleksey V. Karabanov, Sergey N. Illarioshkin, Petr A. Slominsky, Maria I. Shadrina

“…To understand better the mechanisms underlying the pathogenesis of PD, we analyzed the expression of 10 genes in the peripheral blood of treated and untreated patients with PD. 35 untreated patients with PD and 12 treated patients with Parkinson’s disease (Hoehn and Yahr scores 1-2) were studied. …”
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The role of DNA methylation in the disorders of bone metabolism by B. I. Yalaev, A. V. Tyurin, R. Y. Mirgalieva, R. I. Khusainova

“…Decreases in bone mass and matrix mineralization as well as changes in bone microarchitecture can have different pathogenetic patterns of development and, moreover, there are unknown links of the pathogenesis of osteoporosis. It is possible that DNA methylation is one of these links and a mechanism for epigenetic regulation of gene expression. …”
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Case Report: A 3’ splice site variation in RORB exon 3 associated with idiopathic generalized epilepsy in a child by Dandan Shi, Nannan Li, Caifang Fan, Qiang Luo

“…Our findings offer valuable insights into the role of RORB in epilepsy pathogenesis, and the splice site variant identified in this study further expands the mutational spectrum of the RORB gene.…”
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The effect of neutrophil-lymphocyte ratio and thrombocyte index on inflammation in patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome by Vildan Gungorer, Alaaddin Yorulmaz, Husamettin Vatansev, Sukru Arslan

“…Background: The periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is the most common periodic fever syndrome in childhood. Its pathogenesis and etiology remain unknown. This study aimed to determine whether or not the neutrophil-to-absolute lymphocyte ratio (NLR) and thrombocyte indices could be used as subclinical inflammation markers in healthy control group children and children with PFAPA syndrome during the attacks and attack-free periods. …”
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Changes in Immunoreactivity of Sensory Substances within the Enteric Nervous System of the Porcine Stomach during Experimentally Induced Diabetes by Michał Bulc, Katarzyna Palus, Jarosław Całka, Łukasz Zielonka

“…One of the most frequently reported disorders associated with diabetes is gastrointestinal (GI) disturbance. Although pathogenesis of these complications is multifactorial, the complicity of the enteric nervous system (ENS) in this respect has significant importance. …”
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Optical Coherence Tomography (Angiography) Biomarkers in the Assessment and Monitoring of Diabetic Macular Edema by Corina-Iuliana Suciu, Vlad-Ioan Suciu, Simona-Delia Nicoara

“…At the same time, various parameters have been attributed the role of biomarkers creating the frame for new monitoring and treatment strategies and offering new insights into the pathogenesis of diabetic retinopathy and diabetic macular edema. …”
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Analysis of Gene Expression in Cyclooxygenase-2-Overexpressed Human Osteosarcoma Cell Lines by Jeong A. Han, Ji-Yeon Kim, Jong-Il Kim

“…To understand the mechanism of action of COX-2 in the pathogenesis of osteosarcoma, we compared gene expression patterns between three stable COX-2-overexpressing cell lines and three control cell lines derived from U2OS human osteosarcoma cells. …”
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Comprehensive Landscape of ARID Family Members and Their Association with Prognosis and Tumor Microenvironment in Hepatocellular Carcinoma by Ji Sun, Nan-sheng Cheng

“…The ARID family plays key roles in the pathogenesis and development of human cancers. The potential of several functional genes used as novel biomarkers has attracted more and more attention. …”
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Helicobacter pylori Infection and Hepatobiliary Pathology by S. V. German, I. P. Bobrovnitsky

“…However, some researchers report data against the involvement of H. pylori in the pathogenesis of various hepatobiliary diseases.Conclusion.  …”
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Central Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut by Mehari Endale, H. Ibrahim Aksoylar, Kasper Hoebe

“…Recent studies highlight the importance of the host genome and microflora interactions in the pathogenesis of mucosal inflammation including IBD. Specifically, genome-wide (GWAS) and also next-generation sequencing (NGS)—including whole exome or genome sequencing—have uncovered a large number of susceptibility loci that predispose to autoimmune diseases and/or the two phenotypes of IBD. …”
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