Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 by Omar Ramos-Lopez, Lidia Daimiel, Ana Ramírez de Molina, Diego Martínez-Urbistondo, Juan A. Vargas, J. Alfredo Martínez

“…Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments.…”
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The Chemical Composition of Endotoxin Isolated from Intestinal Strain of Desulfovibrio desulfuricans by Jolanta Lodowska, Daniel Wolny, Marzena Jaworska-Kik, Sławomir Kurkiewicz, Zofia Dzierżewicz, Ludmiła Węglarz

“…There are suggestions that they take part in the pathogenesis of periodontitis and some gastrointestinal inflammatory disorders, such as ulcerative colitis or Crohn’s disease. …”
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A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration by Hongfan Yang, Haofei Huang, Kunlin Pu

“…Despite extensive research efforts, the underlying molecular mechanisms remain elusive, necessitating innovative approaches to identify specific genes involved in the pathogenesis of AMD and to elucidate their functional mechanisms. …”
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Serum Level of the Angiotensin-Converting Enzyme in Patients with Idiopathic Acute Optic Neuritis: A Case-Control Study by Heshmatollah Ghanbari, Alireza Dehghani, Awat Feizi, Arman Amirkhani, Mohsen Pourazizi

“…To evaluate the serum level of angiotensin-converting enzyme (ACE) as an important component of the renin-angiotensin system (RAS) in optic neuritis (ON) compared to the healthy control group in the context investigating the possible role of ACE in ON pathogenesis. Methods. This case-control study was conducted on patients with ON and healthy controls. …”
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Exploration on Molecular Mechanism of Reversal Effect of Compound Danshen Tablets on Hepatic Fibrosis Based on Network Pharmacology by Minling Cao, Jingyue Fan, Xiaoli Yang, Meifeng Shi, Shanshan Lin, Xiaoling Chi

“…TNF, IL-10, TGF-1, and EGF and FOXO and MAPK signaling pathways play a key role in the pathogenesis of hepatic fibrosis. Based on the results of this study, the mechanism of action of compound Danshen tablets in the treatment of hepatic fibrosis may be associated with the regulation of FoxO and MAPK signaling pathways and inhibition of TNF, IL-10, TGF-1, and EGF.…”
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Possible Relation between Lack of Posterior Vitreous Detachment and Severe Endogenous Endophthalmitis by Kazuhiko Umazume, Jun Suzuki, Yoshihiko Usui, Yoshihiro Wakabayashi, Hiroshi Goto

“…PVD may be related to the pathogenesis and aggravation of EE.…”
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Self-Centered Function of Adaptive Immunity in Regulation of Immune Responses and in Tolerance by Silvana Balzar

“…The search for common mechanisms underlying the pathogenesis of chronic inflammatory conditions has crystalized the concept of continuous dual resetting of the immune repertoire (CDR) as a basic principle of the immune system function. …”
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hsa-miR-548d-3p: a potential microRNA to target nucleocapsid and/or capsid genes in multiple members of the Flaviviridae family by H. W. Cayatineto, S. T. Hakim

“…MicroRNAs (miRNAs) are non-coding molecules involved in growth, development, cell proliferation, protein synthesis, apoptosis, and pathogenesis. These small molecules are even being used as gene suppressors in antiviral therapeutics, inhibiting viral replication. …”
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The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma by Junying Lu, Lingxin Xiong, Xiaohao Zhang, Zhongmin Liu, Shiji Wang, Chao Zhang, Jingtong Zheng, Guoqiang Wang, Ruipeng Zheng, Jodie L. Simpson, Fang Wang

“…To understand the role of lower airway dysbiosis in the pathogenesis of asthma, in this article, we review the published reports about the lung microbiome of healthy controls, provide an outlook on the contribution of lower airway dysbiosis to asthma, especially steroid-resistant asthma, and discuss the potential therapies targeted for lower airway dysbiosis.…”
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Microbial alpha diversity in the intestine negatively correlated with disease duration in patients with Meniere’s disease by Fumihiro Mochizuki, Manabu Komori, Jun Shimizu, Yoshiyuki Sasano, Yusuke Ito, Michael E. Hoffer, Yoshishige Miyabe, Izumi Koizuka

“…Although there is known to be endolymphatic hydrops involved in the pathological process, the pathogenesis of the disease is still largely unclear. …”
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Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration by Jialiu Zeng, Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo, Chih Hung Lo

“…Gut dysbiosis, which results in a leaky intestinal barrier, exacerbates inflammation and plays a significant role in linking obesity to the pathogenesis of neuroinflammation and neurodegeneration through the gut-brain/gut-brain-liver axis. …”
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Effects of Trace Metal Profiles Characteristic for Autism on Synapses in Cultured Neurons by Simone Hagmeyer, Katharina Mangus, Tobias M. Boeckers, Andreas M. Grabrucker

“…Various recent studies revealed that biometal dyshomeostasis plays a crucial role in the pathogenesis of neurological disorders such as autism spectrum disorders (ASD). …”
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G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells by Matthew Vassey, Rininta Firdaus, Akhmed Aslam, Lee M. Wheldon, Neil J. Oldfield, Dlawer A. A. Ala’Aldeen, Karl G. Wooldridge

“…Modulation of the cell cycle of host cells is likely to contribute to the pathogenesis of meningococcal disease.…”
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Overexpression of SFPQ Improves Cognition and Memory in AD Mice by Jinshan Tie, Hongxiang Wu, Wei Liu, Yuying Li, Lu Li, Suju Zhao, Zhijiao Yuan, Khan Mahmood, Shaochun Chen, Huidong Wu

“…Alzheimer’s disease (AD) is a complex neurodegenerative disorder with multifaceted pathogenesis, which has been extensively investigated, yet effective treatments remain lacking. …”
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Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis by Qianlei Wang, James Asenso, Ning Xiao, Jinzhang Gao, Feng Xiao, Jiajie Kuai, Wei Wei, Chun Wang

“…In this paper, the effects of LA on RA pathogenesis will be summarized from the perspective of the production, transport, and metabolism of synoviocytes and immune cells. …”
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Common biomarkers of idiopathic pulmonary fibrosis and systemic sclerosis based on WGCNA and machine learning by Ning Shan, Yu Shang, Yaowu He, Zhe Wen, Shangwei Ning, Hong Chen

“…As the most common type of ILD, the pathogenesis of idiopathic pulmonary fibrosis (IPF) has not been fully elucidated. …”
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Therapeutic potential of mesenchymal stem cells and stem cell-derived extracellular vesicles in tuberculosis of various localizations: A review by Veronika V. Shumko, Andrei I. Gorelov, Anna N. Remezova, Yanina G. Ivanova, Alexandr N. Muraviov, Natalia M. Yudintceva, Tatiana I. Vinogradova, Anna A. Gorelova

“…These properties of MSCs and stem cell-derived EV are of interest in the treatment of tuberculosis infection, because an integral part of the pathogenesis of tuberculosis is the creation of specific granulomas and the formation of fibrosis.…”
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Rare histological presentation of adenomatoid odontogenic tumor: A series of three unique cases by Bhanu Priya, Priya Kumar, Jeyaseelan Augustine, Rewa Malhotra, Aadithya B. Urs

“…Through this series, we add one case of each category and attempt to discuss its pathogenesis and prognosis.…”
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Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model by Tianhang Luo, Jixin Shu, Zhengmao Lu, Ting Han, Guoen Fang, Xuchao Xue

“…It is unclear whether and how caveolin-1 (Cav-1) in EPCs contributes to the pathogenesis of MODS. The present study is aimed at investigating the potential role of Cav-1 in EPCs during MODS. …”
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Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice by Abu-Rish Eman Y., Elhayek Shada Y., Mohamed Yehia S., Hamad Islam, Bustanji Yasser

“…Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy. Therefore, the most recent guidelines for immunotoxicological evaluation of drugs were consulted to investigate the immunomodulatory effects of lamotrigine, a newer antiepileptic drug, in BALB/c mice. …”
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