Changes of plasma cytokines content in Graves’ orbitopathy patients, could be potential markers by Ying Fu, Yuanyuan Zhang, Yaxin An, Bin Cao, Dong Zhao

“…Conclusions: ECM1, ENO1, and GPX3 were associated with the presence of the GO group and may be good biomarkers that play an important role in the pathogenesis of GO.…”
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Pediatric pneumonia – A clinico-pathological study by Pragati A. Sathe, Monalisa Dash, Pradeep Vaideeswar, Sunil Karande, Lamk Kadiyani

“…Autopsy has an important role in providing insights into the pathogenesis of pneumonia and suggests inappropriate antibiotic exposure. …”
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The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis by A. S. Nazrun, M. Norazlina, M. Norliza, S. Ima Nirwana

“…Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorptive activity. …”
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CD154: An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis by Nada Alaaeddine, Ghada S. Hassan, Daniel Yacoub, Walid Mourad

“…This paper presents an overview of the interaction of CD154 with its various receptors and outlines its role in the pathogenesis of systemic lupus erythematosus and rheumatoid arthritis. …”
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IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis by Muhammad Babar Khawar, Muddasir Hassan Abbasi, Nadeem Sheikh

“…It was found to induce the expression of various inflammatory cytokines including TNF-α, IL-6, and IL-1β as well as macrophage inflammatory protein-2 (MIP-2) and has been reported previously to be involved in the pathogenesis and progression of a number of inflammatory disorders, namely, inflammatory bowel disease (IBD), gastric inflammation and cancer, rheumatoid arthritis, and chronic obstructive pulmonary disease (COPD). …”
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Key Cell Types and Biomarkers in Heart Failure Identified through Analysis of Single-Cell and Bulk RNA Sequencing Data by Ying Kong, Ning Yang, Zhiqing Luo, Ruiting Huang, Quhuan Li

“…Although the role of inflammation in HF pathogenesis is well-known, the specific cell types and regulatory molecules involved remain poorly understood. …”
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The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth by Tamilselvan Subramani, Vidhya Rathnavelu, Noorjahan Banu Alitheen

“…Since inflammation is the prerequisite for gingival overgrowth, mast cells and its protease enzymes also play a vital role in the pathogenesis of gingival fibrosis. Drugs targeting these proteins are currently under consideration as antifibrotic treatments. …”
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The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus by Joshua A. David, William J. Rifkin, Piul S. Rabbani, Daniel J. Ceradini

“…Oxidative damage caused by free radicals has long been known to contribute to the pathogenesis and progression of TIIDM and its complications. …”
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Fatal H1N1-Related Acute Necrotizing Encephalopathy in an Adult by Yu-Jin Lee, D. Scott Smith, Vivek A. Rao, Robert D. Siegel, Jon Kosek, Carol A. Glaser, Alexander C. Flint

“…This case of fatal ANE in an adult is consistent with the hypothesis generated from pediatric cases that the host immune response, and not direct viral invasion of the CNS, is responsible for pathogenesis of ANE.…”
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Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis. by Fazal Shirazi, Dimitrios Farmakiotis, Yuanqing Yan, Nathaniel Albert, Kim-Anh Do, Dimitrios P Kontoyiannis

“…Fly models of obesity bear intriguing similarities to the pathophysiology of insulin resistance and diabetes in humans, and can provide new insights into the pathogenesis and treatment of infections in obese and diabetic patients.…”
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Shifting the paradigm of type 1 diabetes: a narrative review of disease-modifying therapies by Alexander J. O’Donovan, Seth Gorelik, Seth Gorelik, Laura M. Nally

“…T1D is an autoimmune condition involving destruction of pancreatic beta cells leading to insulin deficiency, hyperglycemia, and long-term insulin dependence. The pathogenesis of T1D is classified into stages, with the first signal being the detection of autoantibodies without any glycemic changes. …”
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Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19 by Alhasan Alsalman, Mohammad A. Al-Mterin, Eyad Elkord

“…Immunosuppressive cells including T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs) are key players in immunological tolerance and immunoregulation; however, they contribute to the pathogenesis of different diseases including infections. …”
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Graph Convolutional Network with Neural Collaborative Filtering for Predicting miRNA-Disease Association by Jihwan Ha

“…Therefore, much effort has been devoted to discovering the pivotal roles of miRNAs in disease incidence to understand the underlying pathogenesis of human diseases. However, identifying miRNA–disease associations using biological experiments is inefficient in terms of cost and time. …”
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Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection by Yoko Ozawa, Toshihide Kurihara, Kazuo Tsubota, Hideyuki Okano

“…Understanding pathogenesis at the molecular level is the first step toward developing new therapeutic approaches. …”
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Environmental and Genetic Variables Influencing Mitochondrial Health and Parkinson’s Disease Penetrance by Alessandra Zanon, Peter P. Pramstaller, Andrew A. Hicks, Irene Pichler

“…There is strong evidence that impairment of mitochondrial function plays a key role in the pathogenesis of PD. The two key PD genes related to mitochondrial function are Parkin (PARK2) and PINK1 (PARK6), and also mutations in several other PD genes, including SNCA, LRRK2, DJ1, CHCHD2, and POLG, have been shown to induce mitochondrial stress. …”
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Patogenesis of White Spot Virus Infection (WSV) on Black Tiger Shrimp (Penaeus Monodon Fab.) by M. Alifuddin, D. Dana, M. Eidman, M.B. Malole, F.H. Pasaribu

“… The pathogenesis determination of white spot disease on tiger shrimp to study effect of various white spot virus concentrations on pathological changes was conducted by water borne infection with the several of viral concentration within 60 minute using black tiger shrimp post larvae. …”
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HTLV-1 Tax-mediated inhibition of FOXO3a activity is critical for the persistence of terminally differentiated CD4+ T cells. by David Olagnier, Alexandre Sze, Samar Bel Hadj, Cindy Chiang, Courtney Steel, Xiaoying Han, Jean-Pierre Routy, Rongtuan Lin, John Hiscott, Julien van Grevenynghe

“…Overall this study provides new mechanistic insight into the strategies used by HTLV-1 to increase long-term maintenance of Tax+CD4+ T lymphocytes during the early stages of HTLV-1 pathogenesis.…”
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Deciphering the Immune Subtypes and Signature Genes: A Novel Approach Towards Diagnosing and Prognosticating Severe Asthma Through Interpretable Machine Learning by Yue Hu, Yating Lin, Bo Peng, Chunyan Xiang, Wei Tang

“…This study delves into the intricate etiology of asthma, emphasizing the pivotal roles of immune cells such as T cells, eosinophils, and mast cells in its pathogenesis. The recent emergence of monoclonal antibodies, including mepolizumab, reslizumab, and benralizumab, offers therapeutic promise, yet their efficacy varies due to the heterogeneous nature of asthma. …”
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D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology by John P. Crow, John C. Marecki, Misty Thompson

“…Further insights into the intracellular transport and tissue-specific compartmentalization of D-serine within the CNS will aid in the understanding of the role of D-serine in the pathogenesis of ALS.…”
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Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases by Themis Thoudam, Jae-Han Jeon, Chae-Myeong Ha, In-Kyu Lee

“…Long-term stimulation of the inflammasome instigates chronic inflammation, leading to the pathogenesis of metabolic diseases. In this review, we summarize the current understanding of MAM and its association with inflammation-mediated metabolic diseases.…”
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