Exploring nagZ as a virulence biomarker and treatment target in Enterobacter cloacae by Xianggui Yang, Xuejing Yu, Li Zhou, Dan Wang, Weixian Chen

“…Conclusions These findings underscore the crucial role of nagZ in E. cloacae pathogenesis and highlight its potential as a novel therapeutic target for treating infections caused by this pathogen.…”
Get full text

High-risk Pseudomonas aeruginosa clones harboring β-lactamases: 2024 update by Verónica Roxana Flores-Vega, Santiago Partida-Sanchez, Miguel A. Ares, Vianney Ortiz-Navarrete, Roberto Rosales-Reyes

Get full text

First Combined in Vivo X-Ray Tomography and High-Resolution Molecular Electron Paramagnetic Resonance (EPR) Imaging of the Mouse Knee Joint Taking into Account the Disappearance Ki... by Nicolas Bézière, Christophe Decroos, Karen Mkhitaryan, Elizabeth Kish, Frédéric Richard, Stéphanie Bigot-Marchand, Sylvain Durand, Florence Cloppet, Caroline Chauvet, Marie-Thérèse Corvol, François Rannou, Yun Xu-Li, Daniel Mansuy, Fabienne Peyrot, Yves-Michel Frapart

“…Although laboratory data clearly suggest a role for oxidants (dioxygen and free radicals derived from dioxygen) in the pathogenesis of many age-related and degenerative diseases (such as arthrosis and arthritis), methods to image such species in vivo are still very limited. …”
Get full text

Magnesium and Vascular Changes in Hypertension by Ana Rosa Cunha, Bianca Umbelino, Margarida L. Correia, Mario Fritsch Neves

“…Many factors have been implicated in the pathogenesis of hypertension, including changes in intracellular concentrations of calcium, sodium, potassium, and magnesium. …”
Get full text

Whole exome sequencing identifies genomic alterations in proximal and distal colorectal cancer by Ryia-Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Sheau Sean Khor, Sazuita Saidin, Mohd Ridhwan Abd Razak, Norshahidah Mahamad Nadzir, Zuraini Abd. Razak, Isa Mohamed Rose, Ismail Sagap, Luqman Mazlan, Nadiah Abu, Rahman Jamal

“…However, further study in a larger series of samples coupled with functional studies will be required to confirm the identified variants and determine their roles in the pathogenesis of proximal and distal CRCs. …”
Get full text

Recent Pathophysiological Aspects of Peyronie’s Disease: Role of Free Radicals, Rationale, and Therapeutic Implications for Antioxidant Treatment—Literature Review by Gianni Paulis, Gennaro Romano, Luca Paulis, Davide Barletta

“…In recent years, numerous studies demonstrated the role played by oxidative stress in PD pathogenesis, and other studies have described successful use of antioxidants in PD treatment. …”
Get full text

Influence of Mast Cells in Drug-Induced Gingival Overgrowth by Tamilselvan Subramani, Vidhya Rathnavelu, Swee Keong Yeap, Noorjahan Banu Alitheen

“…The purpose of this paper is to access the roles played by MCs in gingival overgrowth to hypothesize a relationship between these highly specialized cells in the pathogenesis of DIGO.…”
Get full text

Application progress of Traditional Chinese Medicine nursing techniques for patients with cough variant asthma (中医护理技术在咳嗽变异性哮喘中的应用进展) by WANG Yanli (王彦丽), WANG Yingzhe (王英哲), XUE Li (薛丽)

“…This article summarizes the pathogenesis of CVA and the application effects of TCM nursing technology in CVA patients, aiming to provide reference and evidence support for improving the clinical symptoms of CVA patients and improving the quality of life. …”
Get full text

Induction of MASH in three-dimensional bioprinted human liver tissue. by Vaidehi Joshi, Dwayne Carter, Alice E Chen, Keith Murphy, J William Higgins, Mediha Gurel, Daisy Chilin Fuentes, Sara Brin Rosenthal, Kathleen M Fisch, Tatiana Kisseleva, David A Brenner

“…Inadequate human "MASH in a dish" models have limited our advances in understanding MASH pathogenesis and in drug discovery. This study uses complex multicellular 3D bioprinting, combining hepatocytes with nonparenchymal cells in physiologically relevant cell ratios using biocompatible hydrogels to generate bioinks Bioprinted human liver tissues consisting of the four major cell types, (hepatocytes, liver endothelial cells, Kupffer cells, and hepatic stellate cells) are generated from cells purified from normal human livers, using this complex bioprinting platform. …”
Get full text

REALIZATION OF THE PHENOTYPIC EFFECT OF CHROMOSOMAL ABERRATIONS IN HUMANS by K. N. Grinberg, V. I. Kukharenko

“…It is conceivable that chromosomal aberrations strengthen the evolutionarily conditioned variability towards the delay of maturation of cellular and tissue structures, which is the key link in the pathogenesis associated with chromosomal imbalance.…”
Get full text

Inflammatory Characteristics of Stenotic Aortic Valves: A Comparison between Rheumatic and Nonrheumatic Aortic Stenosis by Lars Wallby, Thora Steffensen, Lena Jonasson, Mats Broqvist

“…The similarities regarding the localisation of calcification indicate that the valve anomaly/morphology can influence the pathogenesis of aortic stenosis. Finally, our findings highlight the question of a postinflammatory valvular disease of other causes than rheumatic fever.…”
Get full text

Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies by Androulla N. Miliotou, Andria Kotsoni, Lefteris C. Zacharia

“…The role of adrenergic receptors in the pathogenesis of Alzheimer’s disease and other tauopathies is poorly understood or investigated. …”
Get full text

Correction of Thrombocytopenia with Thrombopoietin Receptor Agonists in Patients with Liver Cirrhosis Before Elective Surgery or Invasive Procedures by T. A. Deeva, M. V. Maevskaya, V. T. Ivashkin

“…Aim: to review the pathogenesis of thrombocytopenia and possible ways of its correction in patients with liver cirrhosis before elective surgical interventions or invasive procedures to optimize clinical practice.Key points. …”
Get full text

Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells by Vaibhav Tiwari, Deepak Shukla

“…A third herpesvirus, human herpesvirus-8 (HHV-8), is crucial for the pathogenesis of Kaposi’s sarcoma, a common AIDS-related tumor of eyelid and conjunctiva. …”
Get full text

Helicobacter pylori Infection, Chronic Inflammation, and Genomic Transformations in Gastric MALT Lymphoma by Magdalena Witkowska, Piotr Smolewski

“…This paper is a review of the current knowledge on etiology, pathogenesis, treatment, and follow-up of gastric MALT lymphoma.…”
Get full text

The Effect of Smoking on SIRT3 and Selected Biochemical Variables in Patients with Parkinson’s Disease by Noor Abdulsatar Majeed, Mohammed Bahry Hassin

“…Conclusion: The observed alterations in biochemical variables suggest that smoking may contribute to the dysregulation of essential cellular processes in PD pathogenesis.…”
Get full text

Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma by Kei Nagai, Hiroaki Tachi, Kohei Inoue, Atsushi Ueda

“…Unfortunately, our rare case lacks a basis in renal pathology or evidence of links between the pathogenesis of malignant mesothelioma, cryoglobulinemia, and nephrotic syndrome. …”
Get full text

Novel heterozygous ASH1L nonsense variant involved in mild intellectual disability by Baoqiong Liao, Baoqiong Liao, Wuming Xie, Shuwen He

“…Our findings contribute to understanding the neurodevelopmental pathogenesis of mild ID in patients with the ASH1L nonsense variant mutation.…”
Get full text

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis by Xiang-Tian Meng, Yun-Yue Shi, Hong Zhang, Hong-Yan Zhou

“…It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. …”
Get full text

Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus by Elena Gkrouzman, Kyriakos A. Kirou, Surya V. Seshan, James M. Chevalier

“…Secondary causes of minimal change disease (MCD) account for a minority of cases compared to its primary or idiopathic form and provide ground for consideration of common mechanisms of pathogenesis. In this paper we report a case of a 27-year-old Latina woman, a renal transplant recipient with systemic lupus erythematosus (SLE), who developed nephrotic range proteinuria 6 months after transplantation. …”
Get full text