Upregulation of FOXO3 in New-Onset Type 1 Diabetes Mellitus by Magdalena Zurawek, Marta Fichna, Piotr Fichna, Maria Czainska, Natalia Rozwadowska

“…In conclusion, overexpression of FOXO3 is correlated with the ongoing islet autoimmune destruction and might suggest a potential role for this gene in the pathogenesis of type 1 diabetes mellitus.…”
Get full text

A Structural Bioinformatics-Guided Study of Adenosine Triphosphate-Binding Cassette (ABC) Transporters and Their Substrates by Iqra Younus, Robert C. Ford, Stephen M. Prince

“…Human ABC transporters are closely linked to the pathogenesis of diseases such as cancer, metabolic diseases, and Alzheimer’s disease. …”
Get full text

Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris by Joanna Narbutt, Jolanta Lukamowicz, Jarosław Bogaczewicz, Anna Sysa-Jedrzejowska, Jolanta Dorota Torzecka, Aleksandra Lesiak

“…As most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-α, IL-1, and IL-6 in PV patients in clinical remission. …”
Get full text

Sirt3 Regulates Response to Oxidative Stress by Interacting with BER Proteins in Colorectal Cancer by J. Kabzinski, A. Walczak, I. Majsterek

“…The oxidative damages are well-recognized factors in the pathogenesis of colorectal cancer (CRC). Increased levels of reactive oxygen species (ROS) can lead to oxidative DNA damage, which, if unrepaired, can be an underlying cause of cancerogenic transformation. …”
Get full text

Chromosome 15q13.1q13.2 microdeletion in a foetus with severe congenital heart defects: A case report by Thi Ha Vu, Thi Hai Hoang, Thi Sim Nguyen, Khanh Dung Ho, Thi Kim Phuong Doan

“…While the cause of CHD is not well understood, researchers have identified copy number variations (CNVs) as potential contributors to its pathogenesis. One such CNV is the rare chromosome 15q13 microdeletion, but its role in CHD remains unclear. …”
Get full text

Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease by Yajing Huang, Jingwei Chi, Fanxiang Wei, Yue Zhou, Yihai Cao, Yangang Wang

“…At present, there are more and more studies on the pathogenesis of DKD; mitochondrial dysfunction plays an important role in DKD. …”
Get full text

Autoimmunity related to anti-Nax and anti-ZSCAN1 autoantibodies in adipsic hypernatremia by Akari Nakamura-Utsunomiya

“…In this review, by summarizing a series of studies on Nax and ZSCAN1, which are expressed in the hypothalamus, pituitary gland, and SFO, I would like to describe the current findings of the autoimmune pathogenesis of adipsic hypernatremia.…”
Get full text

Strongyloidiasis: The Cause of Multiple Gastrointestinal Ulcers in an Immunocompetent Individual by Shail Sheth, Fady Asslo, Rabih Hallit, Raymund Sison, Muhammad Afridi, Robert Spira, Joseph DePasquale, Jihad Slim, Jack Boghossian

“…We suggest that the elevated eosinophil count played a central role in the pathogenesis.…”
Get full text

Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosis by Mengzhu Li, Mengxuan Chen, Haiyan Li, Da Gao, Lijun Zhao, Meiling Zhu

“…However, the exact pathogenesis of PD remains unclear, with ferroptosis emerging as one of the key factors driven by iron accumulation and lipid peroxidation. …”
Get full text

Combined Dexamethasone Suppression-Corticotropin-Releasing Hormone Stimulation Test in Studies of Depression, Alcoholism, and Suicidal Behavior by Leo Sher

“…Considerable evidence suggests that HPA dysregulation is involved in the pathogenesis of depressive disorders, alcoholism, and suicidal behavior. …”
Get full text

Study habits among Nigerian secondary school students with brain fag syndrome by Olufemi Morakinyo, Bolanle Adeyemi Ola

“…However, the contributions of study habits to the pathogenesis of this study-related illness deserve more attention than has been given. …”
Get full text

The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I by Maaike Dirckx, Marco W. J. Schreurs, Marissa de Mos, Dirk L. Stronks, Frank J. P. M. Huygen

“…Further research is needed into defining this subset and into the role of autoantibodies in the pathogenesis of CRPS.…”
Get full text

Calcific Uremic Arteriolopathy in Peritoneal Dialysis Populations by Nicholas New, Janaki Mohandas, George T. John, Sharad Ratanjee, Helen Healy, Leo Francis, Dwarakanathan Ranganathan

“…Clinical presentation, diagnosis, pathogenesis and treatment of calcific uremic arteriolopathy in these patients are no different from other patients manifesting with this condition.…”
Get full text

Burkitt’s Lymphoma of the Gastrohepatic Omentum: A Malignant Presentation of Pseudoachalasia by Eric Omar Then, Andrew Ofosu, Prashanth Rawla, Tagore Sunkara, Sriharsha Dadana, Andrea Culliford, Vinaya Gaduputi

“…Pseudoachalasia, in contrast, is a rare entity that causes identical symptoms, but has a divergent underlying pathogenesis. The symptomology in these cases oftentimes occurs secondary to extrinsic compression of the esophagus, mostly attributable to malignancy. …”
Get full text

Mitochondrial Dysfunction in Diabetic Periodontitis: Mechanisms and Therapeutic Potential by Meng L, Wen W

“…Recent evidence suggests that mitochondrial dysfunction plays a crucial role in the pathogenesis and progression of this condition. This review aims to systematically summarize the role and potential mechanisms of mitochondrial dysfunction in diabetic periodontitis. …”
Get full text

A Pathological Analysis of Canaliculitis Concretions: More Than Just Actinomyces by Balaji Perumal, John Andrew Carlson, Dale Robert Meyer

“…Nonfilamentous bacteria may contribute to the pathogenesis of canaliculitis. In addition, the success of bacterial culture can be variable; therefore, pathological analysis can assist in determining the etiology.…”
Get full text

Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation. by Haifei Xu, Juan Ji An, Baoji Xu

“…It remains unknown whether the two mRNA variants play distinct roles in HD pathogenesis. We found that the long HTT 3'UTR was capable of guiding mRNA to neuronal dendrites, suggesting that some long-form HTT mRNA is transported to dendrites for local protein synthesis. …”
Get full text

Pseudotyped Viruses: A Useful Platform for Pre-Clinical Studies Conducted in a BSL-2 Laboratory Setting by Sofiia N. Rizatdinova, Alina E. Ershova, Irina V. Astrakhantseva

“…During the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pseudotyped virus-based assays played a pivotal role in advancing our understanding of virus–cell interactions and the role of its proteins in disease pathogenesis. Such tools facilitated the search for potential therapeutic agents and accelerated epidemiological studies on post-infection and post-vaccination humoral immunity. …”
Get full text

Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy by Rui-Qi Wang, Zhi-Min Deng, Gan-Tao Chen, Fang-Fang Dai, Liang-Bin Xia

“…Additional clinical prospective and experimental studies are required to explore its precise pathogenesis. Through this review, we aim to provide strategies for improvement and treatment approaches for RSA related to obesity. …”
Get full text

The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives by Shangze Li, Wenli Jiang, Fei Chen, Jiao Qian, Jun Yang

“…Recent findings underscore the involvement of TRIM proteins in IVDD pathogenesis, where they regulate stress responses, maintain cellular homeostasis, and influence the functional integrity of nucleus pulposus (NP) and annulus fibrosus (AF) cells. …”
Get full text