Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus by Nikolaos Vrachnis, Panagiotis Belitsos, Stavros Sifakis, Konstantinos Dafopoulos, Charalambos Siristatidis, Kalliopi I. Pappa, Zoe Iliodromiti

“…Previous Gestational Diabetes Mellitus (pGDM) is a common condition and has been associated with future development of Type 2 Diabetes Mellitus (T2DM) and Metabolic Syndrome (MS) in women affected. The pathogenesis and risk factors implicated in the development of these conditions later in the lives of women with pGDM are not as yet fully understood. …”
Get full text

Adenine-induced animal model of chronic kidney disease: current applications and future perspectives by Qiao Yang, Songya Su, Nan Luo, Gang Cao

“…Despite significant advances in our understanding of the pathogenesis of CKD, there are still no treatments that can effectively combat CKD, which underscores the urgent need for further study into the pathological mechanisms underlying this condition. …”
Get full text

Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease by Ishaq A. Viringipurampeer, Abu E. Bashar, Cheryl Y. Gregory-Evans, Orson L. Moritz, Kevin Gregory-Evans

“…In recent years, inflammation has also been highlighted although whether inflammatory mediators play a central role in pathogenesis or a more minor secondary role has yet to be established. …”
Get full text

ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway by Liang Jiang, Shuai Zhang, Ning An, Guoqing Chai, Changhong Ye

“…Herein, we sought to investigate whether ASPM is involved in the pathogenesis of ATC and the underlying mechanisms. Methods. …”
Get full text

The DNA Replication Stress Hypothesis of Alzheimer’s Disease by Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov

“…A well-recognized theory of Alzheimer’s disease (AD) pathogenesis suggests ectopic cell cycle events to mediate neurodegeneration. …”
Get full text

Pregnancy with Concomitant Chorioangioma and Placental Mesenchymal Dysplasia: A Rare Placental Abnormality by Wu Qichang, Wang Wenbo, Zheng Liangkai, Kong Hui, He Xiaoqin, Sun Li, Xu Yasong

“…The case represents a rare placental abnormality whose pathogenesis and molecular basis need further research. …”
Get full text

Subjective Visual Vertical in PD Patients with Lateral Trunk Flexion by F. Gandor, D. Basta, D. Gruber, W. Poewe, G. Ebersbach

“…Since deviation of the subjective visual vertical (SVV) is a well-recognized feature of disorders involving vestibular processing, we analyzed SVV angles in 30 PD patients with and without LTF to assess the possible role of vestibular dysfunction in the pathogenesis of LTF in PD. Quantification of SVV was obtained using a simple bedside test. …”
Get full text

Pediatric Nasal Lobular Capillary Hemangioma by Jordan M. Virbalas, John P. Bent, Sanjay R. Parikh

“…The shifting nomenclature reflects an evolving understanding of the underlying pathogenesis. We review the histopathology of and current epidemiological data pertaining to LCH which suggests that the development of these lesions may involve a hyperactive inflammatory response influenced by endocrine factors. …”
Get full text

Perbandingan Tingkat Keparahan Infeksi Sekunder Virus Dengue pada Keempat Serotipe di Indonesia: Systematic Review by Annelin Kurniati, Ahmad Fandi, Mardhatillah Sariyanti, Ety Febrianti, Debie Rizqoh

“…Objectives: To knew the distribution of virus serotypes in an area and determined the pathogenesis of the disease, which can cause severe manifestations in patients with secondary infections. …”
Get full text

Spatiotemporal Pattern of Neuroinflammation After Impact-Acceleration Closed Head Injury in the Rat

“…<p>Inflammatory processes have been implicated in the pathogenesis of traumatic brain damage. We analyzed the spatiotemporal expression pattern of the proinflammatory key molecules: interleukin-1<mml:math alttext="$eta$"> <mml:mi>&#x03B2;</mml:mi> </mml:math>, interleukin-6, tumor necrosis factor-<mml:math alttext="$alpha$"> <mml:mi>&#x03B1;</mml:mi> </mml:math>, and inducible nitric oxide synthase in a rat closed head injury (CHI) paradigm. 51 rats were used for RT-PCR analysis after CHI, and 18 for immunocytochemistry. …”
Get full text

Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis by Hamza Erdoğdu, Mehmet Bayraktar, Ahmet Uyanıkoğlu, Oruç Aslan, Nihayet Bayraktar, Ali Öztürk

“…Conclusions: Investigating the role of cytokines, oxidative stress and other biochemical parameters in the pathogenesis and course of the disease may contribute to a better understanding of the disease process and its therapeutic value. …”
Get full text

Antitumoral and Anti-inflammatory Roles of Somatostatin and Its Analogs in Hepatocellular Carcinoma by Argyrios Periferakis, Georgios Tsigas, Aristodemos-Theodoros Periferakis, Ioana Anca Badarau, Andreea-Elena Scheau, Mircea Tampa, Simona Roxana Georgescu, Andreea Cristiana Didilescu, Cristian Scheau, Constantin Caruntu

“…The complexity of the treatment is also justified by the unique pathogenesis of HCC that involves intricate processes such as chronic inflammation, fibrosis, and multiple molecular carcinogenesis events. …”
Get full text

M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p by Shan Chen, Jian Liu, Lilei Zhu

“…These findings provide new insights into the pathogenesis of periodontitis.…”
Get full text

Motor Control and Neural Plasticity through Interhemispheric Interactions by Naoyuki Takeuchi, Yutaka Oouchida, Shin-Ichi Izumi

“…Here, we review the interhemispheric interactions and mechanisms underlying the pathogenesis of these interactions and propose rehabilitative approaches for appropriate cortical reorganization.…”
Get full text

The Role of FRMD7 in Idiopathic Infantile Nystagmus by Rachel J. Watkins, Mervyn G. Thomas, Chris J. Talbot, Irene Gottlob, Sue Shackleton

“…Currently 45 mutations within FRMD7 have been associated with IIN, confirming the importance of FRMD7 in the pathogenesis of the disease. Although mutations in FRMD7 are known to cause IIN, very little is known about the function of the protein. …”
Get full text

Isolation of Viral Biofilms From HTLV-1 Chronically Infected T Cells and Integrity Analysis by Coline Arone, Hélène Dutartre, Delphine Muriaux

“…Yet, the molecular and functional intricacies of viral biofilms remain largely unexplored, despite their pivotal role in understanding retroviral pathogenesis. In this study, we optimized a protocol to isolate HTLV-1 biofilms from chronically infected T cells, facilitating their structural and molecular characterization using proteomic and super-resolution microscopy analyses. …”
Get full text

Mechanistic study of the effect of a high-salt diet on the intestinal barrier by Li Chen, Junrui Tang, Yanglin Xia, Jie Wang, Li-na Xia

“…This finding suggests that HSD may contribute to the pathogenesis of various diseases.…”
Get full text

Autophagy in Immune-Related Renal Disease by Xin Ye, Xu-jie Zhou, Hong Zhang

“…The understanding of the pathogenesis and regulatory mechanisms of autophagy in these renal diseases may lead to the identification of new diagnostic targets and refined therapeutic modulation.…”
Get full text

A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals by Jianping Zhou, Yuting Xi, Ting Wu, Xiaoyu Zeng, Jun Yuan, Lei Peng, Hao Fu, Ce Zhou

“…In this review, we discuss the key effects of mitochondrial dynamics and mitophagy on the pathogenesis of UC, with a particular focus on the cellular energy metabolism, oxidative stress, apoptosis, and immunoinflammatory activities. …”
Get full text

Isolation and Identification of Individual Intestinal Bacteria Associated with Waist Circumference Increase by Sahar Salih Hussein, Asal Aziz Tawfeeq

“…Therefore intestinal flora plays an intermediary role in the metabolism and inflammation and is involved in the pathogenesis of diabetes type 2 and obesity. Objectives: This study aimed to draw the relationship between identified intestinal bacterial types on increasing the waist circumference among study participants. …”
Get full text