Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis by Joachim Sieper, Juergen Braun

“…The arthritogenic peptide hypothesis trying to explain the pathogenesis of AS is based on that very immune function assuming that also self peptides can be presented. …”
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The emerging role of 12/15-lipoxygenase in ischemic stroke by Xuening Wang, Qiuji Shao, Yuan Gao

“…The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), a member of the lipoxygenase family that metabolizes arachidonic acid, has been implicated in the pathogenesis of numerous central nervous system (CNS) diseases. …”
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The glucocorticoid hypothesis of depression: history and perspectives by G. T. Shishkina, N. N. Dygalo

“…The review also addresses the implication of GR and BDNF interplay in the pathogenesis of stress-related disorders.…”
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Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy? by Anna R. Carta, Augusta Pisanu, Ezio Carboni

“…Recent studies indicate that neuroinflammation, specifically reactive microglia, plays important roles in PD pathogenesis. Moreover, after the discovery of infiltrating activated Limphocytes in the substantia nigra (SN) of PD patients, most recent research supports a role of immune-mediated mechanisms in the pathological process leading to chronic neuroinflammation and dopaminergic degeneration. …”
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Latanoprost Induced Iris Pigment Epithelial and Ciliary Body Cyst Formation in Hypermetropic Eyes by Abhijit Anand Mohite, Rangarajan V. Prabhu, Thomas Ressiniotis

“…The cysts subsided with discontinuation of Latanoprost, thereby demonstrating a causal relationship. We discuss the pathogenesis of such cysts and advocate using of serial ultrasound biomicroscopic (UBM) images to monitor them. …”
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A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder by Didakamiwan Khonglah, Arghya Pal, Nitu Mallik, Debes Ray, Malay Ghosal, Rudraprasad Acharya

“…Background: C-reactive protein (CRP) is an acute phase reactant that is implicated in the pathogenesis of major depressive disorder (MDD), due to its role in the execution of various important neurological events, including neurogenesis, mediation of neural plasticity, and synaptic transmission. …”
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Bilateral Ganglion Cysts of the Ligamentum Flavum in the Cervical Spine Causing a Progressive Cervical Radiculomyelopathy and Literature Review by Juneki Kim, Jin-gyu Choi, Byung-chul Son

“…Bilateral occurrence and associated subluxation of the involved cervical segments again support the degenerative pathogenesis of ganglion cysts of the ligamentum flavum in the cervical spine.…”
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VMAT2-Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson's Disease by Tonya N. Taylor, W. Michael Caudle, Gary W. Miller

“…Taken together, these studies demonstrate that reduced vesicular storage of monoamines and the resulting disruption of the cytosolic environment may play a role in the pathogenesis of parkinsonian symptoms and neurodegeneration. …”
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Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis by Weiqian Chen, Qin Wang, Yini Ke, Jin Lin

“…In the early stage of RA, neutrophils migrate into the articular cavity, become activated, and exert their function in an inflammatory process, suggesting an essential role of neutrophils in the initial events contributing to the pathogenesis of RA. Solid evidence exists that supports the contribution of neutrophil extracellular traps (NETs) to the production of autoantibodies against citrullinated proteins which can trigger the immune reaction in RA. …”
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Advanced Role of Neutrophils in Common Respiratory Diseases by Jinping Liu, Zhiqiang Pang, Guoqiang Wang, Xuewa Guan, Keyong Fang, Ziyan Wang, Fang Wang

“…They participate in the clearance of exogenous pathogens and endogenous cell debris and play an essential role in the pathogenesis of many respiratory diseases. However, the pathological mechanism of neutrophils remains complex and obscure. …”
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Chlamydophila psittaci pneumonia followed by lower gastrointestinal ischemic necrosis: a case report by Shifeng Shao, Jun Liu, Zhenbing Wu, Shasha Wu

“…While C. psittaci infections are usually not life-threatening, the pathogenesis and associated complications are not yet fully understood.Case descriptionA 54-year-old male was hospitalized due to a cough, accompanied by expectoration and dyspnea. …”
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Relapsing Remitting Multiple Sclerosis in X-Linked Charcot-Marie-Tooth Disease with Central Nervous System Involvement by Georgios Koutsis, Georgia Karadima, Paraskewi Floroskoufi, Maria Raftopoulou, Marios Panas

“…Although this may be a chance association, the increasing number of cases with CMTX and MS, especially with mutations involving the CNS, may imply some causative effect and provide insights into MS pathogenesis.…”
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Th22 Cells/IL-22 Serves as a Protumor Regulator to Drive Poor Prognosis through the JAK-STAT3/MAPK/AKT Signaling Pathway in Non-Small-Cell Lung Cancer by Yinan Yao, Guangdie Yang, Guohua Lu, Jiani Ye, Luyun Cui, Zhu Zeng, Junjun Chen, Jianying Zhou

“…The present study is aimed at investigating the biological effect of Th22 cells/IL-22 and its molecular mechanism in the pathogenesis process of non-small-cell lung cancer (NSCLC). …”
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Role of Extracellular Hemoglobin in Thrombosis and Vascular Occlusion in Patients with Sickle Cell Anemia by Zhou Zhou, Molly Behymer, Prasenjit Guchhait

“…The Hb-bound VWF multimers are elevated parallely with the level of ECHb in patients' plasma, and is associated with the pathogenesis of thrombosis and vascular occlusion in SCA.…”
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Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases by Punita Kalia, Rohini Ravindran Nair, Suresh Singh Yadav

“…Exportins, critical mediators of nuclear export, have emerged as potential players in cancer pathogenesis. However, their precise roles and prognostic significance in colon adenocarcinoma remain elusive. …”
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Matrix metalloproteinase-12 by M2 macrophages induced epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyps. by Joo-Hoo Park, Jae-Min Shin, Hyun-Woo Yang, Tae Hoon Kim, Seung Hoon Lee, Ok Sarah Shin, Il-Ho Park

“…These findings suggest that MMP-12 expression in M2 macrophages induces EMT in nasal epithelial cells and may contribute to the pathogenesis of CRSwNP.…”
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Microlipophagy from Simple to Complex Eukaryotes by Ravinder Kumar, Colin Arrowood, Micah B. Schott, Taras Y. Nazarko

“…Apart from its role in generating energy and free fatty acids for membrane repair, growth, and the formation of new membranes, lipophagy emerges as a key player in other cellular processes and disease pathogenesis. While fungal, plant, and algal cells use microlipophagy, the most prominent form of lipophagy in animal cells is macrolipophagy. …”
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Nuclear Factor Erythroid 2-Related Factor 2 Intervenes the Release of Neutrophil Extracellular Traps during Lipopolysaccharide-Induced Acute Lung Injury in Mice by Junying Lu, Guilan Xiong, Hongxiang Li, Dong Zhang, Xiaohao Zhang

“…The pathogenesis of acute lung injury is complex. Studies have demonstrated the role of neutrophil extracellular traps (NETs) in the process of lipopolysaccharide (LPS)-induced acute lung injury (ALI). …”
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Brain gliomas new transcriptomic discoveries from differentially expressed genes to therapeutic targets by Shiwen Pei, Zhiquan Jiang, Hongwei Cheng

“…Abstract Gliomas are a prevalent form of primary malignant brain tumor, yet the intricate molecular mechanisms underlying its pathogenesis remain unclear. This study aimed to identify new genetic targets linked to glioma by analyzing microarray datasets to uncover genetic factors involved in its onset and progression. …”
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Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. by So-Yon Lim, Tiffany Chan, Rebecca S Gelman, James B Whitney, Kara L O'Brien, Dan H Barouch, David B Goldstein, Barton F Haynes, Norman L Letvin

“…These findings call into question the premise that CCL3L CNV is important in HIV/SIV pathogenesis.…”
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