Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression by Rosaria Alba Merendino, Giuseppe Di Pasquale, Filippo De Luca, Laura Di Pasquale, Edoardo Ferlazzo, Gabriella Martino, Maura Carmela Palumbo, Fortunato Morabito, Sebastiano Gangemi

“…In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.…”
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Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity by Martin Regensburger, Iryna Prots, Beate Winner

“…Alterations in stem cell proliferation, differentiation, and survival as well as neurite outgrowth and spine formation have been related to different aspects in PD pathogenesis. Therefore, neurogenesis in the adult brain provides an ideal model to study disease mechanisms and compounds. …”
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Clinical and laboratory importance of detecting Helicobacter pylori coccoid forms for the selection of treatment by Nikita Gladyshev, Maria Taame, Viacheslav Kravtsov

“…Modern studies are aimed at understanding the role of coccoid forms of H. pylori in the survival of the population of these bacteria and at clarifying their role in the pathogenesis of gastrointestinal diseases. It is not known whether it is necessary to evaluate the contamination of a given morphological form of a bacterium of the gastric mucosa in clinical practice and its influence on the development of diseases etc. …”
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CXCL13 Promotes Proliferation of Mesangial Cells by Combination with CXCR5 in SLE by Zhanyun Da, Liuxia Li, Jin Zhu, Zhifeng Gu, Bo You, Ying Shan, Si Shi

“…The results of our study elaborated that high expression of CXCL13 could be involved in the pathogenesis of LN.…”
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Early-Onset Chronic Inflammatory Disease Associated with Maternal Microchimerism by Tomoaki Ishikawa, Yoshihiko Sakurai, Tomohiro Takeda, Hiroshi Suzuki

“…Although HLA typing revealed no noninherited maternal antigens in lymphocytes, female cells were demonstrated in the patient’s skin and lymph nodes, suggesting that maternal microchimerism might be involved in the pathogenesis of fever without source in infants.…”
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Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease by Cui Zhang, Weigang Shu, Guangxi Zhou, Jian Lin, Feifei Chu, Huili Wu, Zhanju Liu

“…Neutrophils have been found to play an important role in the pathogenesis of inflammatory bowel disease (IBD), and anti-TNF-α mAb (i.e., infliximab) therapy is demonstrated to be effective in the induction of clinical remission and mucosal healing in these patients. …”
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Canine urothelial cell model to study intracellular bacterial community development by uropathogenic Escherichia coli. by Jessica M Gilbertie, Breanna J Sheahan, Shelly L Vaden, Megan E Jacob

“…However, the role of IBCs has not been explored in the pathogenesis of canine recurrent UTIs. In this study, we identified IBCs in both urine and bladder tissue from dogs with UPEC associated UTIs. …”
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Infectious hematopoietic necrosis (review) by K. A. Balakhnina, V. P. Melnikov

“…The paper provides a brief description of the IHN causative agent, describes its epidemiology, pathogenesis, clinical signs, post-mortem lesions, diagnostic tests, infection control and prevention measures. …”
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Perbandingan Asupan Makan Dan Aktifitas Fisik Pada Remaja Berdasarkan Status Gizi by Susmiati, Nur Indrawaty Lipoeto, Zifrianthi Minanda Putri

“…Effective treatment and prevention of obesity is achievable if its pathogenesis is known comprehensively. The objective of this research is to study and compare dietary intake and physical activities among adolescents between obese and normal ones. …”
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Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis by Jun-Hua Li, Jie-Ping Yu, Hong-Gang Yu, Xi-Ming Xu, Liang-Liang Yu, Jin Liu, He-Sheng Luo

“…Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF-κB. …”
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Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease by William Z. Suo, Longxuan Li

“…Recent studies have indicated the possible involvement of GRK, primarily GRK2 and GRK5, dysfunction in the pathogenesis of AD. It seems that mild, soluble, β-amyloid accumulation can lead to a reduced membrane (functional) and an elevated cytosolic GRK2/5. …”
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The cellular distribution of P2X7, P2Y6, and P2Y12 during or after pilocarpine-induced status epilepticus and literature review by Yue Li, Fengru Tang, Yumin Luo

“…Our literature review revealed that P2X7, P2Y6, and P2Y12 are expressed in different cells during epilepsy pathogenesis. Therefore, we studied the protein expression patterns of the purinergic receptors P2X7, P2Y6, and P2Y12 in the normal mice hippocampus, as well as during or after pilocarpine-induced status epilepticus (DPISE or APISE). …”
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Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications by Mehrdad Afarid, Ehsan Namvar, Fatemeh Sanie-Jahromi

“…Brain-derived neurotrophic factor and the vascular endothelial growth factor have pivotal roles in the pathogenesis of diabetic retinopathy. They have neuroprotective effects on the retina. …”
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Thrombotic Complications in Inflammatory Bowel Disease by A. V. Borota, A. A. Borota, E. V. Onishchenko

“…In turn, the activation of the coagulation cascade may trigger the inflammatory response, which eventually leads to the formation of a vicious circle between chronic inflammation and thrombosis. The pathogenesis of thrombosis in inflammatory colon diseases is a multifactor process, which remains to be understood.Conclusion.The management of patients with IBD in combination with thromboembolic complications requires an individual multidisciplinary approach. …”
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A Case of Familial Mediterranean Fever with Extensive Lymphadenopathy and Complex Heterozygous Genotype Presenting in the Fourth Decade by Jawad Al-Khafaji, Fran Ganz-Lord, Venkata Rajesh Konjeti, Aaron D. Viny

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The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome by Blazej Misiak, Marta Krolik, Anna Kukowka, Anna Lewera, Przemyslaw Leszczynski, Joanna Stankiewicz-Olczyk, Ryszard Slezak

“…Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). Aims. The aim of this study was to evaluate the role of −786T/C polymorphism in the etiology of MS and assess previously reported interaction with cigarette smoking. …”
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Thyroid-Like Follicular Carcinoma of the Kidney in a Young Patient with History of Pediatric Acute Lymphoblastic Leukemia by William W. Wu, Julia T. Chu, Ali Nael, Sherif A. Rezk, Stephen G. Romansky, Lisa Shane

“…The development of TLFCK in a young patient with history of lymphoblastic leukemia is interesting and suggests that genes involved in leukemogenesis may also be important for TLFCK pathogenesis. Recognition of TLFCK is important to distinguish it from other conditions that show thyroid-like features, as a misdiagnosis can result in adverse patient care.…”
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Biliothoracic Fistula after Microwave Ablation of Liver Metastasis : Literature Review by Valentina Tassi, Claudia Mosillo, Massimiliano Mutignani, Roberto Cirocchi, Mark Ragusa, Sergio Bracarda, Giovanni Passalacqua, Gabriele Marinozzi, Massimiliano Allegritti

“…We reviewed aetiology, pathogenesis, clinical picture, diagnostic possibilities, and therapeutic options for biliothoracic fistula developed after microwave ablation of liver metastasis. …”
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The effect of acromegaly on thyroid disease by Caiyan Mo, Liyong Zhong

“…Recent studies have reported that the IGF-1 receptor (IGF-1R) plays an important role in the pathogenesis of TAO, and the IGF-1R inhibitor teprotumumab involves significantly improved disease endpoints in patients with active TAO. …”
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Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota by Blanca S. Noriega, Marcos A. Sanchez-Gonzalez, Daria Salyakina, Jonathan Coffman

“…Recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. …”
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