Genetics of Myasthenia Gravis: A Case-Control Association Study in the Hellenic Population by Zoi Zagoriti, Marianthi Georgitsi, Olga Giannakopoulou, Fotios Ntellos, Socrates J. Tzartos, George P. Patrinos, Konstantinos Poulas

“…We focused on three candidate genes which have been clearly associated with several autoimmune diseases, aiming to investigate their potential implication in MG pathogenesis. These are interferon regulatory factor 5 (IRF-5), TNFα-induced protein 3 (TNFAIP3), also known as A20, and interleukin-10 (IL-10), key molecules in the regulation of immune function. …”
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Tendon-Derived Stem Cell Differentiation in the Degenerative Tendon Microenvironment by Chang Liu, Jing-wan Luo, Ke-ke Zhang, Long-xiang Lin, Ting Liang, Zong-ping Luo, Yong-qing Zhuang, Yu-long Sun

“…Tendinopathy is prevalent in athletic and many occupational populations; nevertheless, the pathogenesis of tendinopathy remains unclear. Tendon-derived stem cells (TDSCs) were regarded as the key culprit for the development of tendinopathy. …”
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Brucella modulates secretory trafficking via multiple type IV secretion effector proteins. by Sebenzile Myeni, Robert Child, Tony W Ng, John J Kupko, Tara D Wehrly, Stephen F Porcella, Leigh A Knodler, Jean Celli

“…Taken together, these findings demonstrate that Brucella modulates secretory trafficking via multiple T4SS effector proteins that likely act coordinately to promote Brucella pathogenesis.…”
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Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice... by Revathee Rajajendram, Chau Ling Tham, Mohamad Nadeem Akhtar, Mohd Roslan Sulaiman, Daud Ahmad Israf

“…The interaction between airway epithelium and inflammatory mediators plays a key role in the pathogenesis of asthma. In vitro studies evaluated the inhibitory effects of 3-(2,5-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMPF-1), a synthetic chalcone analogue, upon inflammation in the A549 lung epithelial cell line. …”
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Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro by Miao Liu, Wen-jie Xie, Xu Zhang, Wei Wu, Guang Li, Lu Wang

“…Abstract Background Macrophages play an important role in the pathogenesis of ulcerative colitis (UC). We will explore the effects of sodium butyrate (SB) on macrophage function. …”
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Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression by Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

“…Abstract Histone deacetylase-5 (HDAC5) is implicated in the pathogenesis of depression and the mechanistic pathways underlying the effects of antidepressant medications. …”
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Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study by Esra Cataltepe, Eda Ceker, Ayse Fadiloglu, Fatih Gungor, Nermin Karakurt, Zekeriya Ulger, Hacer Dogan Varan

“…Abstract Background Chronic inflammation is increasingly recognized as a crucial contributor to sarcopenia pathogenesis, but accurate diagnosis remains a challenge. …”
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Yersinia Infection with Clostridium Difficile Colitis by M.J. Fishman, M.A. Noble, H.J. Freeman

“…Antibimic associated diarrhea appears to be largely due to Closcridium difficile and may have, at least in part. a toxin mediated pathogenesis. Because a poor correlation exists between measurable toxin titres and symptoms, additional copathogenic factors may be important. …”
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Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats by Madhavan Nampoothiri, Jessy John, Nitesh Kumar, Jayesh Mudgal, Gopalan Kutty Nampurath, Mallikarjuna Rao Chamallamudi

“…Aluminium, a neurotoxic agent in humans, has been implicated in the pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral and biochemical effects of aluminium in rats with special emphasis on memory centres, namely, hippocampus and frontal cortex. …”
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Replication-transcription complex of coronaviruses: functions of individual viral non-structural subunits, properties and architecture of their complexes by E. L. Mishchenko, V. A. Ivanisenko

“…This indicates that there may be common mechanisms of coronavirus pathogenesis and, therefore, potential therapeutic targets for each virus may be the same. …”
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Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals by Yuanqing Wang, Yuanqing Wang, Xiaojie Jiang, Yuan Xi, Siqi Wei, Songyi Ning, Wen Zhang, Wen Zhang

“…Further research is needed to explore the functional roles of these cycloviruses in viral pathogenesis, particularly how they may influence host immunity and contribute to chronic infections. …”
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Association of Fibrinogen Aα Thr312Ala (rs6050) Polymorphism with Venous Thrombosis and Chronic Thromboembolic Pulmonary Hypertension: A Meta-Analysis by Han Cheng MM, Haozhe Yang BM, Yantong Zhang BM, Zhanxu Wei MM, Lei Xia BM, Jing Yang PhD

“…Chronic thromboembolic pulmonary hypertension (CTEPH) typically arises from acute pulmonary embolism. The pathogenesis of them involves multiple risk factors such as genetic predisposition. …”
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Elevated Transforming Growth Factor-β2 in the Aqueous Humor: A Possible Explanation for High Rate of Capsular Contraction Syndrome in High Myopia by Keke Zhang, Xiangjia Zhu, Minjie Chen, Xinghuai Sun, Jin Yang, Peng Zhou, Yi Lu

“…Elevated TGF-β2 levels in high myopic cataract patients may play an important role in the pathogenesis of capsular contraction syndrome.…”
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Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits by Qi Yu, Zhengcao Liu, Ahmed Bilal Waqar, Bo Ning, Xianghong Yang, Masashi Shiomi, Mark J. Graham, Rosanne M. Crooke, Enqi Liu, Sijun Dong, Jianglin Fan

“…Increased plasma levels of C-reactive protein (CRP) are closely associated with cardiovascular diseases, but whether CRP is directly involved in the pathogenesis of atherosclerosis is still under debate. …”
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IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome by Min Guo, Rui Yan, Hongmei Yao, Liqin Duan, Meng Sun, Zheng Xue, Yongping Jia

“…We propose that IRF-1 may be implicated in macrophage pyroptosis in the pathogenesis of AS and ACS. Methods. Patients with stable angina, unstable angina, acute myocardial infarction, and clinical presentation of chest pain were enrolled. …”
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The Association Between the Presence of Human Facial Mites Demodex (Acari, Demodicidae) and Dermatological Symptoms in Rosacea Patients in Central Anatolia, Türkiye by Merve Kahraman, Zübeyda Akın Polat, Mustafa Esen, Feride Çoban Gül

“…Conclusion: This study provides evidence suggesting a potential role for Demodex mites in the pathogenesis of rosacea, specifically in relation to skin symptoms such as burning, pain, and stinging. …”
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Hydrogen-Rich Saline Inhibits NLRP3 Inflammasome Activation and Attenuates Experimental Acute Pancreatitis in Mice by Jian-Dong Ren, Jie Ma, Jun Hou, Wen-Jin Xiao, Wei-Hua Jin, Juan Wu, Kai-Hua Fan

“…Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. …”
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Expression profiles of miR-101-3p and miR-431-5p as potential diagnostic biomarkers for rheumatoid arthritis by Mohamed M. Sadaty, Salma M. Mekhemer, Shaimaa Abdel-Ghany, Amira R. El-Ansary, Rana Mohamed, Nashaat N. Kamal, Hussein Sabit

“…These findings contribute to a deeper understanding of RA pathogenesis and suggest that miR-101-3p may serve as a valuable biomarker for early disease detection and potentially improved patient management. …”
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Chromosome-level genome assembly of the sweet potato rot nematode Ditylenchus destructor by Yiwei Yang, Ruirui Feng, Bo Hong, Yuchuan Fang, Chen Liu, Kui Wang, Deliang Peng, Yingmei Li, Huan Peng, Qing Chang

“…This high-quality reference genome will serve as a valuable genomic resource for future research aimed at understanding the pathogenesis of D. destructor and developing effective control strategies.…”
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Beneficial microbiome and diet interplay in early-onset colorectal cancer by Zhengyuan Zhou, Linda Kleis, Ana Depetris-Chauvin, Stefanie Jaskulski, Victoria Damerell, Karin B Michels, Biljana Gigic, Ute Nöthlings, Gianni Panagiotou

“…We aim here to shed light on the complex interplay between diet and gut microbiome in the pathogenesis and prevention of early-onset CRC (EO-CRC). …”
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