Identification of mitophagy-related biomarkers and immune infiltration in polycystic ovarian syndrome by bioinformatic study by Hongjuan Ye, Xicheng Wang, Zhiying He

“…In this study, we aimed to investigate the potential prognostic value of mitophagy-related genes in PCOS patients and to analyze their role in immune infiltration during PCOS pathogenesis and progression. Methods: Training datasets were used for differential expression genes. …”
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Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases by Muneo Yamaguchi, Shintaro Nakao, Mitsuru Arima, Iori Wada, Yoshihiro Kaizu, Feng Hao, Shigeo Yoshida, Koh-hei Sonoda

“…ROCK is involved in angiogenesis and hyperpermeability and also in the pathogenesis of various pathologies such as inflammation and fibrosis. …”
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MANF overexpression ameliorates oxidative stress-induced apoptosis of human nucleus pulposus cells by facilitating mitophagy through promoting MFN2 expression by Liang Ma, Xiangyu Meng, Tuerhongjiang Abudurexiti, Yuntao Liu, Jiang Gao, Weibin Sheng

“…These results provide novel insights into the pathogenesis of IDD.…”
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Potential Health Implications of the Consumption of Thermally-Oxidized Cooking Oils – a Review by Falade Ayodeji Osmund, Oboh Ganiyu, Okoh Anthony Ifeanyi

“…Furthermore, several in vivo studies had suggested that consumption of thermally-oxidized cooking oils might not be healthy as it might negatively influence the lipid profile (increased low density lipoprotein (LDL), decreased high density lipoprotein (HDL) and elevated cholesterol level), haematological system (alteration in concentration of heamoglobin (Hb), packed cell volume (PCV), white blood cell (WBC) count, neutrophil and lymphocyte counts), kidney function, and induce lipid peroxidation and oxidative stress which have been associated with the pathogenesis of various degenerative diseases. Therefore, thermal oxidation seems not to provide any health benefit, as it deteriorates cooking oils and the consumption of the oils may predispose consumers to various disease conditions that may ensue from free radical generation, thereby having deleterious effect on human health.…”
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Vitamin D Receptor Genetic Variations May Associate with the Risk of Developing Late Fracture-Related Infection in the Chinese Han Population by Xing-qi Zhao, Kun Chen, Hao-yang Wan, Si-ying He, Han-jun Qin, Bin Yu, Nan Jiang

“…Further studies are required to assess the role of genetic variations in BsmI, FokI, and GATA in the pathogenesis of late FRI.…”
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Anaplasma phagocytophilum AFAP targets the host nucleolus and inhibits induced apoptosis by Daxiu Zhang, Lifeng Yu, Hui Tang, Hua Niu, Hua Niu, Hua Niu

“…Thus, the proteomic analysis of AFAP-interacting proteins and determination of AFAP with anti-apoptotic activity may help elucidate the role of this T4SS effector protein in HGA pathogenesis.…”
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Gene Regulatory Network of Human GM-CSF-Secreting T Helper Cells by Szabolcs Éliás, Angelika Schmidt, David Gomez-Cabrero, Jesper Tegnér

“…GM-CSF produced by autoreactive CD4-positive T helper cells is involved in the pathogenesis of autoimmune diseases, such as multiple sclerosis. …”
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Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy by Jian-Hui Zhang, Hong-Ping Yu, Ying Chen, Qian Chen, Xiao-Ling Zheng, Jie-Wei Luo, Li Zhang

“…Conclusions This specific case elucidates the pathological characteristics of both diseases while investigating the intricate connections and lesion correlations that may occur between them, offering novel insights into their pathogenesis.…”
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Serum Levels of TNF-α, IL-12/23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional Study by Aikaterini Kyriakou, Aikaterini Patsatsi, Timoleon-Achilleas Vyzantiadis, Dimitrios Sotiriadis

“…These results confirm the important role of TNF-α in the pathogenesis of nail psoriasis and may suggest that anti-TNF agents could be more beneficial in psoriatic nail disease than agents targeting IL-12/23 p40 or IL-17 and its receptors.…”
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PPAR-α regulates metabolic remodelling and participates in myocardial fibrosis in patients with atrial fibrillation of rheumatic heart disease by Xiaoying Hu, Daisong Jiang, Zheng Zhang, Zhenmei An

“…PPAR-α may participate in the pathogenesis of myocardial fibrosis in rheumatic heart disease AF by regulating glucose metabolism, lipid metabolism, and mitochondrial function.…”
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Research progress of Traditional Chinese Medicine nursing techniques for chronic obstructive pulmonary disease (慢性阻塞性肺疾病中医护理技术研究进展) by WANG Shuohan (王烁涵), HAN Lingyu (韩凌宇), ZHANG Li (张丽), DONG Mei (东梅)

“…This paper briefly discussed the etiology and pathogenesis of COPD in Traditional Chinese Medicine, and summarized clinical application of Traditional Chinese Medicine nursing techniques for patients with COPD, in order to provide reference for clinical nursing practice. …”
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Toxin and capsule production by Bacillus cereus biovar anthracis influence pathogenicity in macrophages and animal models. by Treenate Jiranantasak, Andrew P Bluhm, Donald J Chabot, Arthur Friedlander, Richard Bowen, Ian A McMillan, Ted L Hadfield, Airn Hartwig, Jason K Blackburn, Michael H Norris

“…To date, only a few studies have investigated the effect of variations in Bcbva sporulation, toxin, and capsule synthesis on animal and macrophage pathogenicity compared to B. anthracis, therefore more research is needed to gain a better understanding of the pathogenesis of this emerging infection. Here, we report that Bcbva can multiply and vegetatively survive on nutrient-rich media for a minimum of six days while generating spores. …”
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Polymorphisms within Genes Coding for IL-17A and F and Their Receptor as Clinical Hallmarks in Ankylosing Spondylitis by Joanna Wielińska, Jerzy Świerkot, Katarzyna Kolossa, Bartosz Bugaj, Monika Chaszczewska-Markowska, Sławomir Jeka, Katarzyna Bogunia-Kubik

“…IL-17A and IL-17F together with their coreceptor (IL-17RA/RC) were reported to play a significant role in the pathogenesis of spondyloarthritis. The group of axial spondyloarthritis comprises ankylosing spondylitis (AS), a rheumatic disease characterized by chronic inflammation of the joints in the spine. …”
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Linking Complement C3 and B Cells in Nasal Polyposis by Ulrike Werner, Axel Künstner, Maren Drenckhan, Ralph Pries, Karl-Ludwig Bruchhage, Hauke S. Busch, Claus Bachert, Barbara Wollenberg

“…To date, there is only scattered knowledge on the source and regulation of the central complement factors in the pathogenesis of nasal polyps. Here, we aim to study complement signatures, especially the C3-C3aR axis, and focus on cellular sources and targets in nasal polyps. …”
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T Cell Repertoire and Inflammatory Bowel Disease by Kenneth Croitoru, David KH Wong, Maria E Baca-Estrada

“…The relationship to the etiology and pathogenesis of IBD remains to be defined.…”
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Malignant Glioma in the Cerebellum Presenting as Multiple Small Lesions by Takashi Mamiya, Shinji Shimato, Toshihisa Nishizawa, Takashi Yamanouchi, Kojiro Ishikawa, Makoto Ito, Masato Abe, Kyozo Kato

“…We describe the details of the case and discuss the pathogenesis of this unique presentation of malignant glioma with the literatures.…”
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In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma by Yongfa Dai, Jing Li, Hong Wen, Jie Liu, Jianling Li

“…Although there have been many studies about APA, the pathogenesis of this disease is not yet fully understood. …”
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Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review by Ren Y, Chen G, Hong Y, Wang Q, Lan B, Huang Z

“…Gut microbiota plays an important role in the pathogenesis of CIRI, and its potential biological effects have received extensive attention. …”
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Cyanin Chloride Inhibits Hyperbaric Pressure-Induced Decrease of Intracellular Glutamate-Aspartate Transporter in Rat Retinal Müller Cells by Xiaomin Chen, Yue Wang, Fangfang Han, Min Ke

“…Glaucoma is the leading cause of irreversible blindness throughout the world. The pathogenesis of glaucoma is complex, and neuroprotection is a crucial aspect of therapy. …”
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Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia by Efrat Broide, Ram Reifen, Shay Matalon, Zipi Berkovich, Haim Shirin

“…The role of iron transport proteins in the pathogenesis of anemia in patients with diabetes mellitus (T2DM) is still unclear. …”
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