The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy by M. L. Perepechaeva, A. Yu. Grishanova, E. A. Rudnitskaya, N. G. Kolosova

“…These data suggest that the Cyp1a2 and Cyp1b1 enzymes are involved in the pathogenesis of AMD-like retinopathy of OXYS rats and are possible therapeutic targets of SkQ1.…”
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Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review by Adekunle Babajide Rowaiye, Lorretha Chinonye Emenyonu, Ezinne Janefrances Nwonu, Okiemute Ajiroghene Okpalefe, Joseph Akwoba Ogugua, Victor Oluwatoyin Akinseye, Gordon Chukwuma Ibeanu

“…Both in vivo and in vitro experiments, and human clinical trials have proven a marked efficacy of these bioactive molecules in suppressing the key enzyme biomarkers that modulate T2D pathogenesis. Based on empirical research, the consumption of soybean products and ingredients is associated with a lower incidence of T2D. …”
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Molecular Age-Related Changes in the Anterior Segment of the Eye by Luis Fernando Hernandez-Zimbron, Rosario Gulias-Cañizo, María F. Golzarri, Blanca Elizabeth Martínez-Báez, Hugo Quiroz-Mercado, Roberto Gonzalez-Salinas

“…Among the principal causes of age-dependent alterations in the anterior segment of the eye, we found the mutation of the TGF-β gene and loss of autophagy in addition to oxidative stress, which contributes to the pathogenesis of degenerative diseases. Conclusions. In this review, we summarize the current knowledge regarding some of the molecular mechanisms related to aging in the anterior segment of the eye. …”
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High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement? by Alena Sekerkova, Martin Fuchs, Eva Cecrdlova, Veronika Svachova, Ivana Kralova Lesna, Ilja Striz, Helena Tlaskalova-Hogenova

“…Of the parameters tested in noninfectious colitis, atypical-pANCA on ethanol-fixed granulocytes appears to be a suitable serological marker of food protein-induced proctitis/proctocolitis and suggests a possible involvement of an autoimmune mechanisms in the pathogenesis of this disease.…”
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NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration by Jiangyuan Gao, Ruozhou Tom Liu, Sijia Cao, Jing Z. Cui, Aikun Wang, Eleanor To, Joanne A. Matsubara

“…The major pathways associated with its pathogenesis include oxidative stress and inflammation in the early stages of AMD. …”
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Progress of research on management of skin graft-versus-host disease following allogeneic hematopoietic stem cell transplantation (异基因造血干细胞移植皮肤急性移植物抗宿主病管理的研究进展)... by FU Yuxin (符玉欣), ZHOU Ting (周婷)

“…By reviewing of related studies, this paper summarized pathogenesis, clinical classification, prevention and treatment and nursing measures of acute skin graft-versus-host disease(aGVHD) following allogeneic HSCT, and put forward relevant management advice, in order to provide reference for clinical nurses in the early period of prevention, early detection and timely intervention on aGVHD. …”
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Association Between Resting Heart Rate and the Risk of Incident Hypertension Among Older Chinese Adults: A Prospective Cohort Study by Shiyu Lou, Zihan Yu, Yizhu Song, Dechen Liu

“…ABSTRACT Examining the role of resting heart rate (RHR) in hypertension risk could improve our understanding of its pathogenesis. However, most relevant studies have been conducted in developed countries such as the United States and Brazil, with no evidence for the older Chinese population. …”
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Disentangling the genetic overlap between ischemic stroke and obesity by Ren Yang, Tangfeng Zhang, Feng Han

“…The identification of CHAF1A, CEP192, ULK4, CYP2D6, AS3MT, and WARS2 as potential functional genes common to both obesity and IS enriched our understanding of their genetic interplay, potentially advanced our grasp of their pathogenesis and therapeutic targets.…”
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Role of Rutin on Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells by Azizah Ugusman, Zaiton Zakaria, Kien Hui Chua, Nor Anita Megat Mohd Nordin, Zaleha Abdullah Mahdy

“…Oxidative stress plays an important role in the pathogenesis of various cardiovascular diseases, including atherosclerosis. …”
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Metabolic Activity in Human Intermuscular Adipose Tissue Directs the Response of Resident PPARγ⁺ Macrophages to Fatty Acids by Xiaoying Chen, Sebastian Ludger Schubert, Aline Müller, Miguel Pishnamaz, Frank Hildebrand, Mahtab Nourbakhsh

“…Thus, future in-depth studies on IMAT-resident PPARγ⁺ macrophage action mechanisms will elucidate the role of skeletal muscle in the pathogenesis of human metabolic dysfunction.…”
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Decreased Breg/Th17 Ratio Improved the Prognosis of Patients with Ulcerative Colitis by Xue Bing, Liang Linlang, Chen Keyan

“…To investigate the effects of regulatory B (Breg) cells and T helper 17 (Th17) cells on pathogenesis of ulcerative colitis, explore the clinical significance of Breg/Th17 ratio on the prognosis of ulcerative colitis, and provide the theoretical basis for the targeted therapy, diagnosis, and prognosis of the disease. …”
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Postbiotics From Lactobacillus Johnsonii Activates Gut Innate Immunity to Mitigate Alcohol‐Associated Liver Disease by Ruopeng Yin, Tao Wang, Jingzu Sun, Huanqin Dai, Yuting Zhang, Ningning Liu, Hongwei Liu

“…Abstract Prolonged alcohol consumption disrupts the gut microbiota and the immune system, contributing to the pathogenesis of alcohol‐associated liver disease (ALD). …”
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Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia by Toni Spence, Philip J. Allsopp, Alison J. Yeates, Maria S. Mulhern, J. J. Strain, Emeir M. McSorley

“…Uncontrolled, increased proinflammatory responses are a contributing factor to the pathogenesis of preeclampsia. The Th1/Th2 cytokine shift theory, characterised by bias production of Th2 anti-inflammatory cytokine midgestation, was frequently used to reflect the maternal immune response in pregnancy. …”
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Interleukin-32γ in the Control of Acute Experimental Chagas Disease by Yarlla L. L. Braga, José R. C. Neto, Arthur W. F. Costa, Muriel V. T. Silva, Marcos V. Silva, Mara R. N. Celes, Milton A. P. Oliveira, Leo A. B. Joosten, Fátima Ribeiro-Dias, Rodrigo S. Gomes, Juliana R. Machado

“…We evaluated the influence of IL-32γ on the immune response profile, pathogenesis of myocarditis in acute experimental CD, and control of the disease. …”
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lncRNA FR215775 Regulates Th2 Differentiation in Murine Allergic Rhinitis by Yue Ma, Le Shi, Keqing Zhao, Chunquan Zheng

“…These results may provide significant insights into AR pathogenesis and offer new treatment targets for alleviating AR.…”
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Association of endothelial nitric oxide synthase (NOS3) rs2070744 variant with advanced retinopathy of prematurity: a case–control study and meta-analysis by Aneta Choręziak-Michalak, Dawid Szpecht, Tomasz Woźniak, Anna Chmielarz-Czarnocińska, Patrycja Gazińska, Anna Gotz-Więckowska, Ewa Strauss

“…Investigating gene variants associated with vascular responses in ROP may provide valuable insights into its pathogenesis and identify risk or protective factors. …”
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High-Yield Generation of Glucose-Responsive Pseudoislets From Murine Insulinoma Cells for Studies and Longitudinal Monitoring of Graft Survival by Grisell C. Gonzalez, Chris M. Li, Ilaria Pasolini, Sophia I. Pete, Connor Verheyen, Sofia M. Vignolo, Teresa De Toni, Aaron A. Stock, Alice A. Tomei

“…Overall, this platform provides an accessible protocol for generating high yields of 3D pseudoislets and non-invasive longitudinal monitoring of graft survival in different models offer advantages over primary islets for optimization and mechanistic studies of β cell biology, drug discovery, T1D pathogenesis and prevention, and β cell transplantation.…”
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Understanding and addressing the global impact: A systematic review and cross-sectional bibliometric analysis of Langya henipavirus and pre-existing severe henipaviruses by Jian-Di Li, Yu-Qing Liu, Rong-Quan He, Zhi-Guang Huang, Wan-Ying Huang, Hong Huang, Zhi-Hong Liu, Gang Chen

“…Current research focuses on “zoonosis,” “vaccine,” and “pathogenesis,” whereas future areas may include “molecular docking,” “immunoinformatics,” “climate change,” “antibodies,” “vaccines,” “glycoprotein,” and “ephrin-b2.” …”
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Proliferating CLL cells express high levels of CXCR4 and CD5 by Daniel Friedman, Drshika P. Mehtani, Jennifer B. Vidler, Piers E. M. Patten, Robbert Hoogeboom

“…Thus, this study defines the phenotype and functional characteristics of dividing CLL cells identifying a novel subclonal population that underlies CLL pathogenesis and may drive clinical outcomes.…”
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Aberrant T Helper 17 Cells and Related Cytokines in Bone Marrow Microenvironment of Patients with Acute Myeloid Leukemia by Tian Tian, Shuang Yu, Min Wang, Cunzhong Yuan, Hua Zhang, Chunyan Ji, Daoxin Ma

“…Our findings suggest that Th17 and related cytokines may be implicated in AML pathogenesis.…”
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