The Molecular Effects of SGLT2i Empagliflozin on the Autophagy Pathway in Diabetes Mellitus Type 2 and Its Complications by Ranin Saad, Hagar Tadmor, Offir Ertracht, Nakhoul Nakhoul, Farid Nakhoul, Farber Evgeny, Shaul Atar

“…The disturbance of autophagy is involved in the pathogenesis of diabetic nephropathy. We aim to investigate the molecular effect of sodium-glucose transporter 2 inhibitor (SGLT2i) on the expression of ATG5 and its downstream collaborator LC3-II in diabetic nice model. …”
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Correlation between Peripheral T Cell Subsets and the Activity of Thyroid-Associated Ophthalmopathy by Hong Hu, Liang Liang, Qian Ge, Xing Jiang, Zhizheng Fu, Chun Liu, Jian Long

“…T cells play an important role in the pathogenesis of TAO. However, our knowledge of the circulating T cell subsets in TAO is limited. …”
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The Impact of Antiretroviral Therapy on Liver Function Among Pregnant Women Living with HIV in Co-Existence with and Without Pre-Eclampsia by Kay-Lee E. Strauss, Wendy N. Phoswa, Kabelo Mokgalaboni

“…Therefore, this review examines the pathogenesis of PE and the impact of ART on liver function in PWLWHIV with and without PE. …”
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Graves’ ophthalmopathy: the clinical and psychosocial outcomes of different medical interventions – a systematic review by Maralyn Druce, Ejaz Ansari, Oyinlola Maria Bello

“…Recently, a deeper understanding of the underlying pathogenesis has led to the development of novel treatment options.Aims The purpose of this review is to explore the current literature on conventional and novel treatment modalities and to evaluate which interventions provide the most favourable psychological and clinical outcomes in patients with moderate to severe, active Grave’s ophthalmopathy. …”
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The Polymorphisms with Cataract Susceptibility Impair the EPHA2 Receptor Stability and Its Cytoprotective Function by Jin Yang, Dan Li, Qi Fan, Lei Cai, Xiaodi Qiu, Peng Zhou, Yi Lu

“…Thus, our study not only sheds the light on the potential cytoprotective function of EPHA2 signaling in lens but also provides the cellular mechanisms underlying the pathogenesis of age-related cataract.…”
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Spermatozoal Fractalkine Signaling Pathway Is Upregulated in Subclinical Varicocele Patients with Normal Seminogram and Low-Level Leucospermia by Salwa M. Abo El-khair, Mohammad A. Gaballah, Mamdouh M. Abdel-Gawad, Sherif Refaat M. Ismail, Ayman Z. Elsamanoudy

“…These could cooperate in the pathogenesis of delayed fertility in males with subclinical varicocele.…”
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Conclusion: Our findings have shed light on the impact of GADD45B in the pathogenesis of COPD, thereby offering a promising target for intervention in clinical settings.…”
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Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren’s Syndrome by Yu-Ching Lee, Keng-Chang Tsai, Sy-Jye Leu, Tuan-Jen Wang, Chia-Yu Liu, Yi-Yuan Yang

“…Taken together, these results suggested that high affinity IgG RFs can be generated in patients with Sjögren’s syndrome and may play an important role in the pathogenesis of this autoimmune disease.…”
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Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study by Chengqing Zhong, Rong Liu, Cheng Luo, Sisi Jiang, Li Dong, Rui Peng, Fuqiang Guo, Pu Wang

“…The current observations may contribute to the understanding of the pathogenesis of JME.…”
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Neutrophils: From Inflammatory Bowel Disease to Colitis-Associated Colorectal Cancer by Chen T, Liu J, Hang R, Chen Q, Wang D

“…Consequently, a comprehensive review of the functional roles of neutrophils in IBD and CAC is essential for advancing our understanding of IBD pathogenesis and identifying potential therapeutic targets.Keywords: inflammatory bowel disease, colitis-associated colorectal cancer, neutrophil, neutrophil extracellular traps…”
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Fifth Lumbar Vertebral Shape in Early-Stage Lumbar Spondylolysis: Three-Dimensional Bone Morphology Analysis Using Homologous Models by Yuji Yamane, Hajime Toda, Masaki Katayose

“…Our study may be valuable in elucidating spondylolysis pathogenesis and may contribute to early detection and prevention.…”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…Numerous methods can be used for confirmation or refutation of NAFLD pathogenesis hypotheses. It is necessary to choose the optimal way of NAFLD modelling, allowing to reveal certain part of pathologic mechanisms of disease and to determine strategy of hepatotropic treatment according to determined task.…”
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Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives by Hubo Yang, Xuefeng Zhang, Zongming Jia, He Wang, Jixiang Wu, Xuedong Wei, Yuhua Huang, Wenying Yan, Yuxin Lin

“…., genes, non-coding RNAs, metabolites, natural products and drug components, were manually collected and functionally compared as drivers/inducers, suppressors/inhibitors, and biomarkers according to their regulatory patterns in PCa ferroptosis and pathogenesis. The state-of-the-art techniques for ferroptosis-related data integration, knowledge identification, and translational application to PCa theranostics were discussed from a combinative perspective of artificial intelligence-powered modelling and advanced material-oriented therapeutic scheme design. …”
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SIAE Rare Variants in Juvenile Idiopathic Arthritis and Primary Antibody Deficiencies by Eirini Sevdali, Elena Tsitsami, Maria Tsinti, Evangelia Farmaki, Efimia Papadopoulou-Alataki, Anastasios E. Germenis, Matthaios Speletas

“…Considering the distinct pathogenesis of the two main subtypes of JIA, autoinflammatory systemic (sJIA) and autoimmune oligo/polyarticular (aJIA), and a predisposition to autoimmunity displayed by patients and families with primary antibody deficiencies (PADs), the aim of our study was to analyze whether SIAE rare variants are associated with both the phenotype of JIA and the autoimmunity risk in families with PADs. …”
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Identification and Validation of Pivotal Genes in Osteoarthritis Combined with WGCNA Analysis by Yang C, Chen X, Liu J, Wang W, Sun L, Xie Y, Chang Q

“…Through the integration of protein-protein interaction (PPI) analysis, validation in animal models and ROC curve analysis, four pivotal genes (GADD45B, CLDN5, HILPDA and CDKN1B) were finally identified.Conclusion: In conclusion, these identified key genes could serve as novel targets for predicting and treating OA, offering fresh insights into its etiology and pathogenesis.Keywords: osteoarthritis, bioinformatics analysis, WGCNA, GSE data…”
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Gene Expression of IGF1, IGF1R, and IGFBP3 in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy: Preliminary Study by Dorota Romaniuk, Malgorzata W. Kimsa, Barbara Strzalka-Mrozik, Magdalena C. Kimsa, Adam Kabiesz, Wanda Romaniuk, Urszula Mazurek

“…In conclusion, our study indicated IGF1 and IGF1R differential expression in ERMs, but not in PBMCs, of diabetic and nondiabetic patients, suggesting that these factors can be involved in the pathogenesis or progression of proliferative vitreoretinal disorders. …”
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Therapeutic potential of Garlic (Allium sativum L.) on new models of asthma immune pathobiology: A review by VR Bataduwaarachchi, DCJ Liyanage, SMN Hansanie, HDSM Perera, LG D'Cruz

“…It also reduces vital key proinflammatory mediators, including IL-6, PGE2, and COX2, which are vital in asthma pathogenesis. Garlic (Allium sativum L.) compounds further suppress inflammatory response via modulation of NF-κB/IκB expression. …”
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Flavonoid Naringenin: A Potential Immunomodulator for Chlamydia trachomatis Inflammation by Abebayehu N. Yilma, Shree R. Singh, Lisa Morici, Vida A. Dennis

“…Inflammation induced by C. trachomatis contributes greatly to the pathogenesis of disease. Here we evaluated the anti-inflammatory capacity of naringenin, a polyphenolic compound, to modulate inflammatory mediators produced by mouse J774 macrophages infected with live C. trachomatis. …”
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A system approach to the modeling of fungal infections of the wheat leaf by S. V. Nikolaev, U. S. Zubairova, E. S. Skolotneva, E. A. Orlova, D. A. Afonnikov

“…Currently, studies on the mechanisms of the pathogenesis of plant diseases and their distribution in crops are intensively conducted in Russia and the world. …”
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Phenotypic Characterization of Circulating CD4+ T Cells in ANCA-Associated Vasculitis by Sandra Lilliebladh, Åsa Johansson, Åsa Pettersson, Sophie Ohlsson, Thomas Hellmark

“…T cell-mediated immune responses are thought to play an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitides (AAV). …”
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