New treatment options for generalized myasthenia gravis by Antanas Vaitkus, J. Čiauškaitė, M. Malakauskaitė, M. Baublytė

“…Increasing attention is being paid to antibodies against acetylcholine receptors (AChRs) and other structures of the neuromuscular junction that are important in pathogenesis of myasthenia gravis. Drugs are being developed that target specific links in the immune system to reduce the risk of systemic adverse effects. …”
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In silico Analysis of Human Endothelial Cell-specific Molecule 1 and Interleukin-6 Genetic Variants Involved in Coronary Artery Disease by Vineet Kulkarni, Sukanya Shetty, Roopa Bhandary, Yanglem Mary

“…Further in vitro studies are necessary to validate these findings and their potential role in the pathogenesis of coronary artery disease.…”
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Hemophagocytic Lymphohistiocytosis in a Patient with Classical Hodgkin Lymphoma by G. Hyun, K. J. Robbins, N. Wilgus, L. Grosso, S. D. Goyal

“…Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome that can be associated with inherited genetic mutations, malignancy, autoimmune disorders, and viral infections. Though the pathogenesis is not fully known, HLH is understood to be a reactive process in the setting of uncontrolled activation of macrophages, CD8+ cytotoxic lymphocytes, and other immune cells. …”
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Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement by Qian Wang, Xuefei Tian, Yuyang Wang, Yan Wang, Jialin Li, Tingting Zhao, Ping Li

“…Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). …”
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Supplementation with Branched-Chain Amino Acids Induces Unexpected Deleterious Effects on Astrocyte Survival and Intracellular Metabolism with or without Hyperammonemia: A Prelimin... by Ting Wang, Kazuyuki Suzuki, Toshimi Chiba, Keisuke Kakisaka, Yasuhiro Takikawa

“…Ammonia is a key component in the pathogenesis of hepatic encephalopathy. Branched-chain amino acids (BCAA) have been reported to improve the symptoms of HE induced by hyperammonemia; however, we recently reported that ammonia increases intracellular levels of BCAA and exerts toxic effects on astrocytes. …”
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Autophagy Mediates MMP-2 Expression in Glaucomatous Trabecular Meshwork Cells by Yan-Ling Xiao, Xiao-Rui Wang, Kejing Ye, Wan-Zhu Chen, Bing-Ru Zheng, Yi-Hong Huang, Yu-Yu Wu

“…Autophagy may be involved in the pathogenesis of POAG via regulating the expression of MMP-2 and, subsequently, the deposition of the extracellular matrix.…”
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Comparative evaluation of calretinin immunohistochemical expression in calcifying odontogenic cyst and ameloblastoma by Maryam Mahdizadeh, Nazanin Mahdavi, Ali Bijani, Fatima Bijani

“…Conclusions it is concluded that calretinin does not play a role in the pathogenesis and histogenesis of COC epithelium, but since ghost cells are caused by a degenerative process, the possibility of involving calretinin as an apoptotic factor in the formation of these cells is supported.…”
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Mechanisms of trematodiases pathogenicity: the presence of the secretory proteins from the liver fluke Opisthorchis felineus in the gallbladder tissues of the patients with chronic... by M. Y. Pakharukova, A. V. Kovner, A. N. Trigolubov, E. N. Fedin, E. S. Mikhailova, S. G. Shtofin, A. I. Autenshlyus, V. A. Mordvinov

“…The results are important for understanding the molecular mechanisms of opisthorchiasis pathogenesis, as well as for improvement of the immunodiagnostics of the opisthorchiasis and opisthorchiasis-related diseases.…”
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Immature granulocytes predict severe acute pancreatitis independently of systemic inflammatory response syndrome by Michał Lipiński, Grażyna Rydzewska

“…Tumor necrosis factor α (TNF-α) and interleukin-1 (IL-1) play a critical role in the pathogenesis systemic inflammatory response syndrome (SIRS) and severity of AP. …”
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Pyroptosis-Related Signature Predicts the Progression of Ulcerative Colitis and Colitis-Associated Colorectal Cancer as well as the Anti-TNF Therapeutic Response by Yumei Ning, Kun Lin, Jun Fang, Xiaojia Chen, Xinyi Hu, Lan Liu, Qiu Zhao, Haizhou Wang, Fan Wang

“…Ulcerative colitis (UC) is a complex intestinal inflammation with an increasing risk of colitis-associated colorectal cancer (CAC). However, the pathogenesis is still unclear between active UC and inactive UC. …”
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The mitochondria as a potential therapeutic target in cerebral I/R injury by Susu Fang, Susu Fang, Wenzhou Huang, Wenzhou Huang, Xinhui Qu, Xinhui Qu, Wen Chai

“…Accumulating data supports a paradigm whereby cerebral ischemia/reperfusion (I/R) injury is coupled with impaired mitochondrial function, contributing to the pathogenesis of ischemic stroke. Herein, we review recent evidence demonstrating a heterogeneous mitochondrial response following cerebral I/R injury, placing a specific focus on mitochondrial protein modifications, reactive oxygen species, calcium (Ca2+), inflammation, and quality control under experimental conditions using animal models.…”
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BMSCs Interactions with Adventitial Fibroblasts Display Smooth Muscle Cell Lineage Potential in Differentiation and Migration That Contributes to Neointimal Formation by Y. Wendan, J. Changzhu, S. Xuhong, C. Hongjing, S. Hong, Y. Dongxia, X. Fang

“…Our results indicate that the pathogenesis of vascular remodeling might perform via TGF-β1/Smad3 signal transduction pathways.…”
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Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3 by Imama Maslahah, Mohammad Saifur Rohman, Nashi Widodo, Agustina Tri Endharti, Didik Utomo

“…The human renin gene has been widely known to be involved in essential hypertension (EH) pathogenesis. Genetic variant C-5434T of REN enhancer contributed to renin gene transcription and serum renin regulation. …”
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Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease by Junhua Huang, Shuwan Zhang

“…Disrupted endothelial permeability plays a crucial role in the vasculitis pathogenesis of Kawasaki disease (KD), which leads to pathological vascular leak and facilitates inflammatory cell infiltration in vascular lesions; however, the mechanisms involved in the development of endothelial barrier dysfunction during KD vasculitis are still largely unclear. …”
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Morroniside Ameliorates Endotoxin-Induced Uveitis by Regulating the M1/M2 Polarization Balance of Macrophages by Wenjie Li, Lin Liu, Ziwei Zhang, Hong Lu

“…Inflammation is closely associated with the pathogenesis of various ocular diseases. Uveitis is a condition characterized by the inflammation of the uvea and ocular tissues that causes extreme pain, decreases visual acuity, and may eventually lead to blindness. …”
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Inhibition of macrophage polarization and pyroptosis in collagen-induced arthritis through MSC-exo and ginsenoside Rh2 by Zhongsheng Zhou, Shuhui Wu, Yang Li, Pu Shao, Jinlan Jiang

“…Conclusion This research contributes to a deeper understanding of RA’s pathogenesis and presents new potential targeted therapeutic interventions. …”
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Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide by Hamid Azizi-Malekabadi, Mahmoud Hosseini, Masoume Pourganji, Hoda Zabihi, Mohsen Saeedjalali, Akbar Anaeigoudari

“…Neuroimmune factors have been proposed as the contributors to the pathogenesis of sickness behaviors. The effects of female gonadal hormones on both neuroinflammation and depression have also been well considered. …”
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Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes by Alessandro P. Delitala, Giovanni M. Pes, Hoda M. Malaty, Gavino Pisanu, Giuseppe Delitala, Maria P. Dore

“…Although H. pylori seroprevalence was similar in LADA, T1D, and T2D, anti-CagA positivity was significantly increased among patients with autoimmune diabetes, suggesting that more virulent H. pylori strains might be a trigger for immune mechanisms involved in their pathogenesis.…”
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Therapeutic Effect of Ginsenoside Rd on Experimental Autoimmune Encephalomyelitis Model Mice: Regulation of Inflammation and Treg/Th17 Cell Balance by Bo Jin, Chixiao Zhang, Yu Geng, Mei Liu

“…Immoderate autoimmune responses of Th17 cells and dysfunction of Treg cells critically contribute to the pathogenesis of MS and EAE. Our previous study showed that Ginsenoside Rd effectively ameliorated the clinical severity in EAE mice, but the mechanism remains unclear. …”
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Cascading expression of ApiAP2 transcription factors controls daughter cell assembly in Toxoplasma gondii. by Maanasa Bhaskaran, Venkat Mudiyam, Thomas Mouveaux, Emmanuel Roger, Mathieu Gissot

“…Pathogenesis of Toxoplasma gondii in the intermediate host is based on the tachyzoite ability to divide rapidly to produce significant amount of daughter cells in a reduce time frame. …”
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