Human T follicular helper cells and their impact on IgE and IgG4 production across allergy, malignancy, and IgG4-related disease by Mitsuhiro Akiyama, Waleed Alshehri, Sho Ishigaki, Koichi Saito, Yuko Kaneko

“…Recent studies have underscored the presence of Bcl-6 + Tfh cells not only in secondary lymphoid organs but also within tertiary lymphoid structures at inflammatory sites, emphasizing their pivotal role in disease pathogenesis. Furthermore, Tfh cells have been found to transit between lesion sites, lymph nodes, and peripheral blood, as revealed by T cell receptor repertoire analysis. …”
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Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis by Jiayin Wang, Dandan Jia, Zhiwang Zhang, Dan Wang

“…The disruption of mitochondrial homeostasis is implicated in the pathogenesis of sarcopenia. Exercise training effectively delays the onset of sarcopenia by significantly maintaining mitochondrial homeostasis, including promoting mitophagy, improving mitochondrial biogenesis, balancing mitochondrial dynamics, and maintaining mitochondrial redox. …”
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Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions by Ali Yilmaz, Sumeyya Akyol, Nadia Ashrafi, Nazia Saiyed, Onur Turkoglu, Stewart F. Graham

“…Despite a limited understanding of its pathogenesis, research has implicated abnormal trinucleotide cytosine-adenine-guanine CAG repeat expansion in the huntingtin gene (HTT) as a critical factor. …”
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Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process by Urszula Grzybowska-Chlebowczyk, Paulina Wysocka-Wojakiewicz, Martyna Jasielska, Bożena Cukrowska, Sabina Więcek, Maria Kniażewska, Jerzy Chudek

“…Oxidative stress (OS) has been recently implicated in the disease pathogenesis in inflammatory bowel disease (IBD). The aim of the study was to evaluate oxidative and antioxidative stress status and the risk of the atherosclerotic process in children with IBD and functional gastrointestinal disorders (FGID). …”
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Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus by Shu Li, Shuang Liu, Fan Chen, Yuqi Cheng, Ru Bai, Aiyun Lai, Zhaoping Lu, Jian Xu

“…To explore whether 5-HTTLPR plays a role in the pathogenesis of SLE, we tested 138 SLE patients and 138 age and sex matched health controls (HCs) for 5-HTTLPR by polymerase chain reaction (PCR) and agarose gel electrophoresis. …”
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Healthy individuals genetically at-risk for the development of Pemphigus vulgaris or Alopecia areata share disease-like cytokine dysregulation by Rebekah R. Schwartz, Kristina Seiffert-Sinha, Animesh A. Sinha

“…Cytokines in particular play a pivotal role in the pathogenesis of AID, with proinflammatory cytokines contributing to the initiation and propagation of autoimmune inflammation, whereas anti-inflammatory cytokines facilitate regression of inflammation and recovery from acute phases of the disease. …”
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Treatment Challenges in a Tourette Syndrome Patient with Self-Injurious Behaviour: Case Report and Literature Review by G. Asadauskaitė, G. Jasionytė, M. Karnickas

“…During hospitalization, insomnia was resolved, whereas motor tics and self-harm decreased.Discussion. The pathogenesis of Tourette syndrome emphasizes the dysfunction of neuronal networks in the basal ganglia. …”
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Resistant stomach ulcer at Cushing disease: clinical case by N. V. Novozhilov, Yu. O. Shulpekoa, S. V. Mironov, Ye. K. Baranskaya, A. A. Sheptulin, V. T. Ivashkin

“…During the further investigation: low-dose dexamethasone suppression test, magnetic-resonance tomography (MRI) and computer tomography (CT) of the brain and abdominal cavity data, favoring the Cushing disease (ACTH-producing pituitary adenoma), was obtained. Pathogenesis of chronic stomach ulcer is complex: effect of H.pylori infection, drugs (NSAID, steroids) and hypercorticoidism. …”
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A Thickened Coracohumeral Ligament and Superomedial Capsule Limit Internal Rotation of the Shoulder Joint: Report of Three Cases by Masashi Koide, Junichiro Hamada, Yoshihiro Hagiwara, Kenji Kanazawa, Kazuaki Suzuki

“…Although the precise pathogenesis of frozen shoulder is unclear, thickened capsule and coracohumeral ligament (CHL) have been documented to be one of the most specific manifestations. …”
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RIPK1 in necroptosis and recent progress in related pharmaceutics by Kunhou Yao, Zhihao Shi, Fengya Zhao, Cong Tan, Yixin Zhang, Hao Fan, Yingzhe Wang, Xingwang Li, Jun Kong, Qun Wang, Dingxi Li

“…RIPK1-mediated necroptosis further promotes cell death and inflammation in the pathogenesis of liver injury, skin diseases, and neurodegenerative diseases. …”
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Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin by Giuseppe Stinco, Cinzia Buligan, Enzo Errichetti, Francesca Valent, Pasquale Patrone

“…This finding could be in agreement with a secondary role of blood vessels in the pathogenesis and persistence of psoriatic lesions.…”
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Migraine and restless legs syndrome – is there an association? by D. Bučaitė, J. Normantas, G. Žemgulytė

“…Although the relationship between migraine and restless legs syndrome and their pathogenesis is not fully understood, current research suggests that these diseases may be related. …”
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Alzheimer’s disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function by Akiko Yamakawa, Mutsumi Suganuma, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu

“…The details of AD pathogenesis have not been fully elucidated, and a comprehensive gene expression analysis of the process leading up to the onset of AD would be helpful for understanding the mechanism. …”
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Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis by Jiancheng Lv, Ping-an Chang, Xin Li, Xiao Yang, Jie Han, Hao Yu, Zijian Zhou, Haiwei Yang, Pengchao Li, Jiexiu Zhang, Qiang Lu

“…The findings of this study provide a deep understanding of the circRNA-related competitive endogenous RNA regulatory mechanism in BCa pathogenesis.…”
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Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease by Naphatthakarn Kerdsaeng, Sittiruk Roytrakul, Suwannee Chanprasertyothin, Piangporn Charernwat, Sirintorn Chansirikarnjana, Piyamitr Sritara, Jintana Sirivarasai

“…Significant changes in these proteins can indicate the molecular mechanisms involved in the pathogenesis of AD, and they have the potential to serve as AD biomarkers. …”
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Association of disease activity with programmed cell death 1 and its ligand programmed cell death ligand 1 expressions in lupus patients by Eman Eissa, Rania Kandil, Nehal El-Ghobashy, Walaa Abdelfattah, Zainab Hammouda, Sara Medhat Gadelsayed, Faten Bayoumi

“…Background: Programmed cell death 1(PD-1)/programmed cell death ligand 1 (PD-L1) pathway is an immune checkpoint implicated in immune tolerance and involved in the pathogenesis of several autoimmune diseases. Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple immune dysregulation. …”
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Human Urinary Kallidinogenase Reduces Lipopolysaccharide-Induced Neuroinflammation and Oxidative Stress in BV-2 Cells by Zhongyan Zhao, Zhiyu Xu, Tao Liu, Shixiong Huang, Huai Huang, Xiaoyun Huang

“…Neuroinflammation and oxidative stress both play important roles in the pathogenesis of migraine. Human urinary kallidinogenase (UK) is a tissue kallikrein derived from human urine. …”
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Erenumab effectiveness and safety: comparison of real-life data and clinical trial results by Austėja Dapkutė, K. Ryliškienė

“…Erenumab was the first preventive medication targeted to the pathogenesis of migraine to reach Lithuanian market. …”
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Acute Liver Failure Caused by Amanita phalloides Poisoning by Luca Santi, Caterina Maggioli, Marianna Mastroroberto, Manuel Tufoni, Lucia Napoli, Paolo Caraceni

“…The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which represents the most common and deadly cause of mushroom poisoning. …”
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Psychological Therapies in Patients with Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Osama Altayar, Varun Sharma, Larry J. Prokop, Amit Sood, Mohammad Hassan Murad

“…Psychosocial factors are believed to contribute to the pathogenesis of IBS. Objective. To evaluate the evidence for psychological therapies in IBS treatment. …”
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