Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue by Ennio Giulio Favalli, Francesco Grossi, Alberto Batticciotto, Matteo Filippini, Simone Parisi, Ombretta Viapiana, Paolo Gisondi, Paolo Dapavo, Lorenzo Dagna, Filippo De Braud

“…Malignancy may be a major comorbidity in subjects with spondyloarthritis (SpA) as the result of multifactorial mechanisms, from disease pathogenesis to the iatrogenic effect of immunomodulating drugs. …”
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Presence of Serum Antinuclear Antibodies Does Not Impact Outcomes in HBV-Related Acute-on-Chronic Liver Failure by Lin Lin, Bin Lin, Qing Lan, Longgen Liu, Jianchun Lu, Xiujun Zhang, Shuqin Zheng, Yuan Xue

“…Positive ANA is frequent in HBV-related ACLF, and it does not seem to be associated with poor outcomes, but the pathogenesis of ACLF may be different between ANA (+) and ANA (−) groups.…”
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Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases by Ye. A. Poluektova, Yu. O. Sidorina, S. Yu. Kuchumova, A. V. Korolev, O. S. Shifrin

“…The role of microflora in pathogenesis of this group of diseases becomes more and more obvious. …”
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Collaborative management of severe periodontal-endodontic lesion with intense lip sucking: a case report by Yanfei Sun, Xiaofang Zhao, Mingchao Wang, Xiangkun Sun, Kunzhou Mei, Yameng Zhang, Yanwen Cui, Fang Yang

“…Initial clinical examination revealed gingival recession, Grade III mobility, deep periodontal pocket, and alveolar bone loss without obvious pathogenesis. The therapeutic schedule encompassed behavioral modification, the repeated application of various dental splints due to splint breakage caused by strong lip-sucking habits, and root canal therapy. …”
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Asymmetrical labium majus enlargement (CALME) in childhood: A series of clinical cases by Zalina K. Batyrova, Zaira Kh. Kymykova, Elena V. Uvarova, Alina S. Badlaeva, Aleksandra V. Asaturova, Polina V. Kulabukhova, Fatima Sh. Mamedova, Vladimir D. Chuprynin, Irina A. Yagovkina

“…Childhood asymmetry labium majus enlargement (CALME) is a rare, benign disease of pre-pubertal age characterized by non-neoplastic unilateral proliferation of the soft tissues of the vulva without a peripheral capsule. The pathogenesis of CALME is not completely clear. Generally, the only treatment method is surgery because it is necessary to verify the diagnosis and exclude the neoplastic process. …”
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Changes in optic nerve head microvasculature following disc hemorrhage absorption in glaucomatous eyes by Jooyoung Yoon, Kyung Rim Sung, Ko Eun Kim, Hyo Ji Han, Joon Mo Kim

“…This finding suggests that DH pathogenesis may be associated with changes in optic disc vasculature, contributing to glaucomatous progression.…”
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A Case-Control Association Study of RANTES (-28C>G) Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey by Nilufer Sahin-Calapoglu, Serpil Demirci, Mustafa Calapoglu, Baris Yasar

“…Recent studies have revealed that inflammatory processes are involved in the pathogenesis of Parkinson’s disease (PD). Multiple lines of evidence have suggested that chemokines and their receptors are involved in several neurodegenerative disorders. …”
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Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy by Qingchao Shang, Qingchao Shang, Pei Zhang, Xiao Lei, Lehui Du, Baolin Qu

“…Macrophage plays an important role in homeostasis and immunity, and dysfunctional macrophage polarization is believed to be associated with the pathogenesis of tissue fibrosis and tumor progression. …”
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Construction and Antiapoptosis Activities of Recombinant Adenoviral Expression Vector Carrying EBV Latent Membrane Protein 2A by Xishuang Liu, Yu Gao, Bing Luo, Youan Zhao

“…The results indicate that LMP2A might play an important role in pathogenesis of EBV-associated gastric cancer (EBVaGC). …”
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MicroRNA in Cervical Cancer: OncomiRs and Tumor Suppressor miRs in Diagnosis and Treatment by Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Takashi Iwata, Eiichiro Tominaga, Kyoko Tanaka, Daisuke Aoki

“…MicroRNAs (miRNAs) are implicated in posttranscriptional regulation of gene expression and in the pathogenic mechanisms of cancer, suggesting their importance in diagnosis and treatment. miRNAs may have roles in the pathogenesis of cervical cancer based on the increases or decreases in several specific miRNAs found in patients with this disease. …”
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Dose and strain dependent lethality of Usutu virus in an Ifnar−/− mouse model by Johanna M. Duyvestyn, Eleanor M. Marshall, Peter J. Bredenbeek, Barry Rockx, Martijn J. van Hemert, Marjolein Kikkert

“…While usually mild or asymptomatic in humans, neurological disorders are increasingly observed, which has boosted interest and the need for better understanding of the pathogenesis of various USUV lineages. In this study we inoculated interferon α/β receptor knockout (Ifnar−/−) mice with decreasing doses of USUV, monitoring symptoms and survival to determine a less lethal dose, and we directly compared isolates from three different viral lineages. …”
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Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides by Bing Wei, Ran Zhang, Jingbo Zhai, Junfeng Zhu, Fangli Yang, Dan Yue, Xiaoyi Liu, Changlong Lu, Xun Sun

“…Dysregulated immune responses are involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis. …”
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Unveiling the omics tapestry of B-acute lymphoblastic leukemia: bridging genomics, metabolomics, and immunomics by Yin Le, Shicong Zhu, Hongling Peng, Zhihua Wang

“…Our findings indicate that the PI3K-Akt signaling pathway is significantly enriched across all groups, highlighting its critical role in B-ALL pathogenesis and progression. Furthermore, metabolomic analysis revealed that lipid metabolism, ferroptosis, and glutathione metabolism are closely linked to disease progression. …”
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Transcriptome sequencing reveals regulatory genes associated with neurogenic hearing loss by Fengfeng Jia, Fang Wang, Song Li, Yunhua Cui, Yongmei Yu

“…In conclusion, our study contributes to the understanding of hearing loss pathogenesis and offers potential targets for molecular diagnostics and gene-based therapies. …”
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Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. by Elliott D SoRelle, Lauren E Haynes, Katherine A Willard, Beth Chang, James Ch'ng, Heather Christofk, Micah A Luftig

“…Therefore, defining the dynamics and heterogeneity of EBV lytic reactivation is a high priority to better understand pathogenesis and therapeutic potential. In this study, we applied single-cell techniques to analyze diverse fate trajectories during lytic reactivation in three B cell models. …”
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The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease by Xudong Sha, Jiayuan Lin, Kexin Wu, Jia Lu, Zhihua Yu

“…Abstract Microglia are progressively activated by inflammation and exhibit phagocytic dysfunction in the pathogenesis of neurodegenerative diseases. Lipid-droplet-accumulating microglia were identified in the aging mouse and human brain; however, little is known about the formation and role of lipid droplets in microglial neuroinflammation of Alzheimer’s disease (AD). …”
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Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain by Han-Chung Lee, Kai-Leng Tan, Pike-See Cheah, King-Hwa Ling

“…Since both human and mouse models of DS brain exhibit less neurons and a higher percentage of cells with astrocytic phenotypes, understanding the role of JAK-STAT signaling in DS brain development will provide novel insight into its role in the pathogenesis of DS brain and may serve as a potential target for the development of effective therapy to improve DS cognition.…”
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Neuroprotective Transcription Factors in Animal Models of Parkinson Disease by François-Xavier Blaudin de Thé, Hocine Rekaik, Alain Prochiantz, Julia Fuchs, Rajiv L. Joshi

“…The characterization of these animal models has provided valuable insights into various mechanisms of PD pathogenesis. Therefore, the dissection of the mechanisms and survival signalling pathways engaged by these transcription factors to protect mDA neuron from degeneration can suggest novel therapeutic strategies. …”
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AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer by Guansong Zheng, Zhaojie Yan, Junrong Zou, Junrong Zou, Junrong Zou, Xiaofeng Zou, Keqiang Chai, Guoxi Zhang

“…The AR signaling pathway plays a pivotal role in the pathogenesis of prostate cancer. While existing anti-androgen treatments show initial efficacy, they ultimately do not succeed in halting the advancement to CRPC. …”
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HMGB1 Box A gene therapy to alleviate bleomycin-induced pulmonary fibrosis in rats by Rathasapa Patarat, Suchanart Chuaybudda, Sakawdaurn Yasom, Apiwat Mutirangura

“…The effective treatment for pulmonary fibrosis remains unknown. The upstream pathogenesis of pulmonary fibrosis may involve cellular senescence of the lung tissue. …”
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