The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development by Soeun Hwang, Junhee Park, Seo-Young Koo, Si-Yeon Lee, Yunju Jo, Dongryeol Ryu, Heounjeong Go, Chang-Woo Lee

“…Abstract Receptor-mediated signaling could be modulated by ubiquitination of pathway intermediates, but the role of such modification in the pathogenesis of inflammation and inflammation-related cancer is lesser known. …”
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Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients by Xiangsheng Wang, Yan Gao, Ruirui Jiang

“…Sudden sensorineural hearing loss (SSNHL) is an otologic emergency, and metabolic disturbance is involved in its pathogenesis. This study recruited 20 SSNHL patients and 20 healthy controls (HCs) and collected their serum samples. …”
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Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer’s Disease by Yuan Sun, Xue Song Yin, Hong Guo, Rong Kun Han, Rui Dong He, Li Jun Chi

“…Inflammatory mediators are closely associated with the pathogenesis of neurodegenerative changes in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). …”
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Identification of the immune infiltration and biomarkers in ulcerative colitis based on liquid–liquid phase separation-related genes by Zhixing Hong, Shilin Fang, Haihang Nie, Jingkai Zhou, Yuntian Hong, Lan Liu, Qiu Zhao

“…We determined the seven high accuracy diagnostic genes of UC patients and provide a new perspective on immunoregulation in UC pathogenesis. And suggest patient stratification and candidate targets for precision treatment based on hub genes screened.…”
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The role of microRNAs in learning and long-term memory by L. N. Grinkevich

“…Moreover, impaired microRNA biogenesis is one of the causes of the pathogenesis of mental disorders, neurodegenerative illnesses and senile dementia, which are often accompanied by deterioration in the learning ability and by memory impairment. …”
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The impact of gut microbiome on neuro-autoimmune demyelinating diseases by Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold

“…Similarly, NMOSD exhibits gut microbiota alterations linked to disease severity, with Streptococcus and Clostridium perfringens being significant contributors, suggesting a gut–CNS interaction in pathogenesis. Prebiotic and probiotic interventions can modify gut microbiota, reduce inflammatory markers, and improve patient outcomes, indicating the therapeutic potential of targeting gut microbiota in managing MS. …”
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Exploring the association between BDNF related signaling pathways and depression: A literature review by Yuchen Fan, Xinchi Luan, Xuezhe Wang, Hongchi Li, Hongjiao Zhao, Sheng Li, Xiaoxuan Li, Zhenkang Qiu

“…Depression is a debilitating mental disease that inflicts significant harm upon individuals and society, yet effective treatment options remain elusive. At present, the pathogenesis of multiple depression is not fully clear, but its occurrence can be related to biological or environmental pathways, among which Brain-derived neurotrophic factor (BDNF) can unequivocally act on two downstream receptors, tyrosine kinase receptor (TrkB) and the p75 neurotrophin receptor (p75NTR), then affect the related signal pathways, affecting the occurrence and development of depression. …”
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Viral infection induces expression of novel phased microRNAs from conserved cellular microRNA precursors. by Peng Du, Jianguo Wu, Jiayao Zhang, Shuqi Zhao, Hong Zheng, Ge Gao, Liping Wei, Yi Li

“…They uncover new mechanisms and complexity of virus-host interactions that may have important implications for further studies on the evolution of cellular small RNA biogenesis that impact pathogen infection, pathogenesis, as well as organismal development.…”
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Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in Men by Nikola Hadzi-Petrushev, Katerina Dimovska, Nikola Jankulovski, Dine Mitrov, Mitko Mladenov

“…Oxidative stress and inflammation contribute to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD), and the control of lipid status by statins may help to stop the progression of NAFLD. …”
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LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling by Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, Ruiqin Xie

“…Long non-coding RNAs (lncRNAs) play many important roles in gene regulation and disease pathogenesis. Here, we sought to determine that mitochondrial dynamic related lncRNA (MDRL) modulates NLRP3 inflammasome activation and apoptosis of vascular smooth muscle cells (VSMCs) and protects arteries against atherosclerosis. …”
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Epigenetic regulation of the nuclear genome associated with mitochondrial dysfunction in Leber’s hereditary optic neuropathy (LHON) by Aswathy P. Nair, Ambika Selvakumar, Janani Gopalarethinam, B. Abishek Kumar, Balachandar Vellingiri, Mohana Devi Subramaniam

“…In addition to primary mitochondrial DNA (mtDNA) mutations, there are also other environmental and epigenetic factors involved in the pathogenesis of LHON. One of the most common locations for deadly pathogenic mutations in humans is the human complex I accessory NDUFS4 subunit gene. …”
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NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease by Honglei Guo, Xiao Bi, Ping Zhou, Shijian Zhu, Wei Ding

“…The nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney disease (CKD); however, its exact role in glomerular injury and tubulointerstitial fibrosis is still undefined. …”
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Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level by Jinhui Ma, Wanshou Guo, Zirong Li, Bailiang Wang, Shirui Li, Peng Wang

“…The IL-33 deserves particular attention in the pathogenesis of ONFH.…”
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The ACE2/Apelin Signaling, MicroRNAs, and Hypertension by Lai-Jiang Chen, Ran Xu, Hui-Min Yu, Qing Chang, Jiu-Chang Zhong

“…The deregulation of microRNAs, a class of short and small noncoding RNAs, has been shown to involve cardiovascular remodeling and pathogenesis of hypertension via the activation of the Ang II/AT1R pathway. …”
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Oxidative Stress Markers in Patients with Metabolic Syndrome by Axana Rodríguez Núñez, Jorge Calá Fernández, Haydee Cruz Vadell, Miguel Ángel Montoya Deler

“…Oxidative stress plays an important role in the pathogenesis of the metabolic syndrome because it affects the function of pancreatic beta cells and alters glucose transport in muscle and adipose tissue.…”
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Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease mice by Sanggeon Park, Mijeong Park, Eun Joo Kim, Jeansok J. Kim, Jeiwon Cho, Yeowool Huh

“…These findings elucidate that distinct physiological perturbations in CA1 and CA3 place cells, coupled with disrupted hippocampal theta rhythmicity in CA1, potentially orchestrate the impairment of hippocampal-dependent spatial learning and memory in AD pathogenesis.…”
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The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation by Asmaa Ibrahim Gomaa, Nermine Ahmed Ehsan, Ahmed A. Elrefaei, Mervat Mohamed Sultan, Maha Mohamed Elsabaawy

“…Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation. …”
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A Rare Case of Proximal Junctional Failure with Delayed Infection after Adult Spinal Deformity Surgery: A Report of Two Cases by Takuro Iwami, Mitsuru Yagi, Eijiro Okada, Satoshi Suzuki, Satoshi Nori, Osahiko Tsuji, Narihito Nagoshi, Kota Watanabe, Nobuyuki Fujita, Masaya Nakamura, Morio Matsumoto

“…Additional studies on this phenomenon are warranted to elucidate the pathogenesis of this complication.…”
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Cellular Mechanisms of Multiple Myeloma Bone Disease by Angela Oranger, Claudia Carbone, Maddalena Izzo, Maria Grano

“…Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden.…”
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IL-37 attenuated HPV induced inflammation of oral epithelial cells via inhibiting PI3K/AKT/mTOR by Yahong Shi, Ning Liu, Yunfang Bai, Kunshan Li, Chencong Li, Yujiao Hou

“…These findings contribute valuable insights into the intricate pathogenesis of HPV-induced inflammation and may pave the way for the development of innovative treatments for this condition.…”
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