Relative Contributions of Intracranial Pressure and Intraocular Pressure on Lamina Cribrosa Behavior by Junfei Tong, Deepta Ghate, Sachin Kedar, Linxia Gu

“…The influences of these pressure are dependent on sclera material properties, which might explain the pathogenesis of ocular hypertension and normal-tension glaucoma.…”
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Free radicals and their impact on health and antioxidant defenses: a review by Nisansala Chandimali, Seon Gyeong Bak, Eun Hyun Park, Hyung-Jin Lim, Yeong-Seon Won, Eun-Kyung Kim, Sang-Ik Park, Seung Jae Lee

“…Oxidative stress results in the damage of critical biomolecules like DNA, proteins, and lipids, contributing to the pathogenesis of various diseases. Chronic conditions such as cancer, cardiovascular diseases, neurodegenerative disorders, and inflammatory diseases have been strongly associated with the harmful effects of free radicals. …”
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Hepatic Overexpression of GRP94 in a Rabbit Model of Parenteral Nutrition-Associated Liver Disease by Xueping Zhu, Xiaomin Zhang, Lingling Yu, Yumin Xu, Xing Feng, Jian Wang

“…To use a rabbit model of parenteral nutrition-associated liver disease (PNALD) to study changes of the endoplasmic reticulum stress (ERS) marker glucose regulatory protein 94 (GRP94) and determine its role in the pathogenesis of PNALD. Methods. A rabbit PNALD model total parenteral nutrition (TPN) group was established. …”
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Cholestatic Hepatocellular Injury with Azathioprine: A Case Report and Review of the Mechanisms of Hepatotoxicity by Joseph Romagnuolo, DC Sadowski, E Lalor, L Jewell, ABR Thomson

“…The components of azathioprine, 6-mercaptopurine and the imidazole group, may play different roles in the pathogenesis of hepatotoxicity. The strong association with male sex, and perhaps with human leukocyte antigen type, suggests a genetic predisposition of unknown type. …”
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Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional study by Nevin Yilmaz, Isil Turan Bakirci, Busra Sahin, Gokhan Bolluk, Esra Can, Huri Dedeakayogullari

“…These associations suggest a potential role for survivin in the pathogenesis of placental complications and warrant further investigation through longitudinal studies.…”
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BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens by Amanda Contreras, Darin L. Wiesner, Brock Kingstad-Bakke, Woojong Lee, John P. Svaren, Bruce S. Klein, M. Suresh

“…Results presented in this manuscript implicate dysregulated Tregs in the pathogenesis of airway hypersensitivities, asthma, and other allergic disorders.…”
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Comparison of the sequences of the viral capsid protein 1 and viral capsid protein 2 encoded genes in symptomatic and asymptomatic cases of canine parvovirus 2 in dogs by Mohammed Al-Saadi, Amer Nubgan, Ali Hadi Abbas

“…Understanding these genetic variations provides critical insights into CPV-2 pathogenesis and could inform improved vaccination strategies to mitigate the virus’s impact in endemic regions.…”
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Selecting drug formulation for the treatment and prevention of retinal disorders by O.V. Filippova

“…Among them, age-related macular degeneration (AMD) leads to significant visual impairment and irreversible blindness in millions of patients worldwide. The causes and pathogenesis of AMD remain elusive, however, xanthophylls, i.e., lutein and zeaxanthin, are known to provide benefits in terms of the prevention and treatment for early AMD.…”
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Coexistence of anti-glomerular basement membrane disease and IgA nephropathy: an illustrative case and comprehensive literature review by Zewei Chen, Dechao Xu, Fangzheng Cui, Huihui Hou, Zhiguo Mao, Xiang Gao

“…The clinical characteristics of these patients demonstrate that the anti-GBM disease combined with IgAN tends to be milder with a more indolent course and a better prognosis than the classic anti-GBM disease, and its potential pathogenesis deserves to be further explored.…”
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Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration by Junyu Zhang, Yu Zhou

“…The cellular and molecular pathogenesis of initiation and development of AMD remain poorly delineated. …”
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Identification of Aberrantly Expressed miRNAs in Gastric Cancer by Dan Liu, Xiaowei Hu, Hongfeng Zhou, Guangyue Shi, Jin Wu

“…The noncoding components of the genome, including miRNA, can contribute to pathogenesis of gastric cancer. Their expression has been profiled in many human cancers, but there are a few published studies in gastric cancer. …”
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Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review by Yu-Hsun Chang, Kun-Chi Wu, Kai-Hung Wang, Dah-Ching Ding

“…It has been implicated in the pathogenesis of high-grade serous ovarian cancer. LGR6, while less studied, shares functional similarities with LGR5 and can maintain stemness. …”
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The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review by Mariateresa Giglio, Alberto Corriero, Angela Preziosa, Giustino Varrassi, Filomena Puntillo

“…It is associated with increased social and sanitary costs due to the difficulty of adequately treating it. Its pathogenesis is still poorly understood, even if a mounting body of evidence suggests a pivotal role in inflammation and immunity, which may be triggered by an infection and/or a trauma. …”
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Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation by Hongyan Zhao, Ning Zhao, Peng Zheng, Xiaohong Xu, Meijie Liu, Dan Luo, Huihui Xu, Dahong Ju

“…Numerous studies have examined the pathogenesis of osteoporosis. The causes of osteoporosis include endocrine factors, nutritional status, genetic factors, physical factors, and immune factors. …”
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The First Infant Bloodstream Infection Caused by Pantoea dispersa in China: A Case Report and Literature Review by Yu W, Sun Z, Wang M, Li Z, Zhang C, Sun Y, Wang S

“…While there are numerous reports documenting P. agglomerans as a cause of human infections in clinical settings, instances of P. dispersa leading to human pathogenesis are comparatively rare, and the clinical manifestations associated with P. dispersa infections remain largely underexplored. …”
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Rehabilitation of Knee Osteoarthritis with Conception of "Muscles and Bones, Arthralgia and Flaccidity, Asthenia and Sthenia, Dynamic and Static, Hardness and Softness" by Jiemei GUO, Peng CHEN, Yan XIAO, Junjun HE, Yingjie ZHANG, Youxin SU

“…The coordination of muscles and bones refers to the basic pathogenesis characteristics of dysfunction caused by KOA, starting from the disease position, and adopting corresponding rehabilitation treatments to achieve the purpose of strengthening the muscles and bones. …”
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A Case of Hypocalcemia with Severe Vitamin D Deficiency following Treatment for Graves’ Disease with Methimazole by Kazuyuki Miyashita, Tetsuyuki Yasuda, Hideaki Kaneto, Akio Kuroda, Tetsuhiro Kitamura, Michio Otsuki, Yasuyuki Okamoto, Noboru Hamada, Munehide Matsuhisa, Iichiro Shimomura

“…Vitamin D deficiency is increasing worldwide, and it has been more recently shown to relate to the pathogenesis of Graves’ disease. However, vitamin D deficiency as a cause of hypocalcemia has received little attention. …”
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Clinicopathological and molecular analyses of uterine carcinosarcomas using next-generation sequencing: A single-center experience by Ezgi Genç Erdoğan, Tülin D. Yalta, Nuray Can, Necdet Süt, Ebru Taştekin, Ufuk Usta, Fulya Öz Puyan, Fatma E. Usturalı Keskin, Busem B. Kurt

“…Materials and Methods: In this study, we included 12 cases diagnosed with uterine carcinosarcomas and examined the changes in oncogenes that play a role in UCS pathogenesis. For the analysis of mutation, the clinicopathological data were compared with the variations in the DNA-based gene panel consisting of 12 genes and 1237 variants in the UCS using the NGS method. …”
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METTL14 modulates the progression and ferroptosis of colitis by regulating the stability of m6A-modified GPX4 by Yuhua Chen, Weicong Fan, Ying Lyu, Jingsheng Liao, Ying Zhou

“…Nevertheless, the specific relationship between N6-methyladenosine (m6A) modification at RNA transcription levels and UC pathogenesis remains unclear. We established UC cell models and mouse models through dextran sulfate sodium (DSS) induction. …”
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Paroxysmal sympathetic hyperactivity in brain damage (scientific review). Part 1 by O.V. Kravets, V.A. Sedinkin, V.V. Yekhalov, Yu.O. Ploshchenko, O.O. Zozulya

“…There is a disengagement theory and a model of the excitation-inhibition relationship of the PSH pathogenesis. In 2014, an expert consensus group proposed a PSH-assessment measure (PSH-AM), which can not only serve as a reliable diagnostic criterion but also stratify the severity of PSH. …”
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