The occurrence of wheat crown rot correlates with the microbial community and function in rhizosphere soil by Yajiao Wang, Jian Feng, Jianhai Gao, Sen Han, Qiusheng Li, Lingxiao Kong, Yuxing Wu

“…These findings contribute to understanding WCR pathogenesis and offer practical resources for its management.…”
Get full text

Anti-proliferative and photodynamic activities of Senna didymobotrya (Fresen.) leaf alkaloid-rich extracts against breast cancer cells by Kolawole A. Olofinsan, Heidi Abrahamse, Blassan P. George

“…Conclusion Although the in silico analysis suggests that the plant-identified alkaloid phytoconstituents inhibition of estrogen receptor-alpha, human epidermal growth factor receptor-2 and progesterone receptor proteins involved in breast cancer pathogenesis could explain a possible mechanism for the observed anticancer effect, more detailed in vitro molecular experiments are necessary to confirm these findings.…”
Get full text

Exploring the microbiome-gut-testis axis in testicular germ cell tumors by Sona Ciernikova, Aneta Sevcikova, Michal Mego

“…Dysbiosis in the gut or testicular microbiomes may contribute to altered immune responses, inflammation, and hormonal imbalances, potentially playing a role in the pathogenesis of TGCTs. Concurrently, seminal microbiomes have been linked to variations in sperm quality, fertility potential, and possibly cancer susceptibility, underscoring the need for further evaluation. …”
Get full text

Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma by Shu-Qin Jia, Jian-Jun Ren, Pei-De Dong, Xing-Kai Meng

“…By exposure of different injuries and different hepatocarcinogenic regimens, the mature hepatocytes can no longer effectively regenerate; stem cells are involved in the pathogenesis of hepatocellular carcinoma. Methods. Immunohistochemistry was performed on 107 paraffin-embedded hepatocellular carcinoma specimens with the marker of hepatocyte and hepatocellular carcinoma (HepPar1), biliary differentiation (CK7,CK19), haemopoietic stem cell (HSC) (c-kit/CD117, CD34, and Thy-1/CD90), HPC specific markers (OV-6), and Ki-67, p53 protein. …”
Get full text

A study of serum prolactin in dermatological diseases in a tertiary care hospital of Assam by Talukdar C, Boro B

“…Conclusions: Prolactin may play a role in the pathogenesis of psoriasis, alopecia areata, and vitiligo; and may serve as a biochemical marker of disease severity in patients with psoriasis and alopecia areata. …”
Get full text

lncRNA RUNDC3A-AS1 Regulates Proliferation and Apoptosis of Thyroid Cancer Cells via the miR-151b/SNRPB Axis by Yan Deng, Jie Wu, Xin Li

“…Many previous reports have confirmed that lncRNA is involved in the pathogenesis of THCA. However, the role and mechanism of lncRNA RUNDC3A-AS1 in THCA have not been studied. …”
Get full text

A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni by Nádia Regina Borim Zuim, Silmara Marques Allegretti, Arício Xavier Linhares, Luiz Augusto Magalhães, Eliana Maria Zanotti-Magalhães

“…The increased pathogenesis of the Schistosoma mansoni BH strain compared with the SJ strain has been attributed to the number of granulomas formed in experimental infections, which increase the mortality in definitive hosts. …”
Get full text

A Combination of Serum Biomarkers in Elderly Patients with Sarcopenia: A Cross-Sectional Observational Study by Lin Ying, Qin Zhang, Yun-mei Yang, Jian-ying Zhou

“…Background. The pathogenesis of sarcopenia in the elderly has not yet been fully understood. …”
Get full text

Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors by Francesca De Felice, Claudia Marchetti, Innocenza Palaia, Daniela Musio, Ludovico Muzii, Vincenzo Tombolini, Pierluigi Benedetti Panici

“…Advances in understanding the role of immune system in the pathogenesis of cancer have led to the rapid evolvement of immunotherapy, which might establish a sustained immune system response against recurring cancer cells. …”
Get full text

The Effect of Periodontitis on Expression of Interleukin-21: A Systematic Review by Archana Mootha, Sankari Malaiappan, N. D. Jayakumar, Sheeja S. Varghese, Julie Toby Thomas

“…Current evidence shows that these inflammatory mediators have a definitive role in the pathogenesis of various systemic diseases with an inflammatory component. …”
Get full text

Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols by Tingting DENG, Jinchan PI, Xiaoping PENG, Yufei YAO, Yiquan LI, Wenjuan LI

“…Reactive oxygen species (ROS) imbalance and mitochondrial dysfunction played critical roles in the pathogenesis of cardiovascular diseases which are the leading cause of death worldwide. …”
Get full text

VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis by Genxiang Rong, Zhenyu Zhang, Wenjing Zhan, Minnan Chen, Jingjing Ruan, Cailiang Shen

“…Our findings may provide a new direction for the clinical diagnosis and treatment of OA and insights into its pathogenesis.…”
Get full text

Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications by Eleftheria Papachristoforou, Vaia Lambadiari, Eirini Maratou, Konstantinos Makrilakis

“…Regarding DM specifically, previous experimental and clinical studies have pointed to the fact that oxidative stress probably plays a major role in the pathogenesis and development of diabetic complications. …”
Get full text

IL-8, IL-10, TGF-β, and GCSF Levels Were Increased in Severe Persistent Allergic Asthma Patients with the Anti-IgE Treatment by Arzu D. Yalcin, Atil Bisgin, Reginald M. Gorczynski

“…However, recent studies focused on cell-based mechanisms for the pathogenesis of allergic asthma. Objectives. In this study, we compare the anti-IgE treatment modality in the dynamics of immune system cytokine levels in severe persistent asthma (SPA) patients who had no other any allergic disease, newly diagnosed allergic asthma patients and healthy volunteers. …”
Get full text

Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies by Yanjiao Zhang, Kaile Ma, Xinyi Fang, Yuxin Zhang, Runyu Miao, Huifang Guan, Jiaxing Tian

“…This article reviews the role of ion homeostasis in the pathogenesis of metabolic diseases and assesses its potential as a therapeutic target. …”
Get full text

Nitric Oxide - Its Importance in Swallowing, Inflammatory Bowel Disease and Cirrhotic Cardiomyopathy by ABR Thomson

“…The role of nitric oxide in the pathogenesis of esophageal motility disorders remains to be established.…”
Get full text

A Study of Serum Adiponectin Levels in Patients with Polycystic Ovarian Syndrome and its Correlation with Various Cardiometabolic Risk Markers by G. Surendra Prasad, Uma Kaimal Saikia, Ashok Krishna Bhuyan, Abhamoni Baro

“…Background: Polycystic ovarian syndrome (PCOS) is the most common metabolic disorder in the reproductive age group, the pathogenesis of which is constantly evolving with the discovery of novel molecules and the lookout for potential therapeutic targets. …”
Get full text

Influence of Natural Honey on Biochemical and Hematological Variables in AIDS: A case study by Noori S. Al-Waili, Thia N. Al-Waili, Ali N. Al-Waili, Khelod S. Saloom

“…NO and prostaglandin play a role in pathogenesis of AIDS. The study was designed to assess the effect of natural honey on prostaglandins and NO levels, blood indices and biochemical tests in a 40 year-old woman with AIDS. …”
Get full text

Epithelial and immune transcriptomic characteristics and possible regulatory mechanisms in asthma exacerbation: insights from integrated studies by Ye Liu, Yue Li, Ruhao Wu, Yu Wang, Pengfei Li, Tianci Jiang, Ke Wang, Yize Liu, Zhe Cheng

“…This study was aimed at gaining important new insights into the heterogeneity of epithelial and immune cells and elucidating key regulatory genes involved in the pathogenesis of asthma exacerbation.MethodsFunctional enrichment, pseudotime, metabolism and cell-cell communication analyses of epithelial cells and immune cells in single-cell RNA sequencing (scRNA-seq) dataset were applied. …”
Get full text

Unveiling the Emerging Role of Xanthine Oxidase in Acute Pancreatitis: Beyond Reactive Oxygen Species by Chenxia Han, Yaling Wu, Juan Rong, Qing Xia, Dan Du

“…Considerable preclinical and clinical studies have been conducted over many decades to investigate the role of XO in the pathogenesis of AP and its potential targeting therapeutic value. …”
Get full text